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Thirty patients with chronic apical periodontitis(AP) were allocated into two groups: Group SL\u2013SWEEPS laser activated irrigation(<jats:italic>n<\/jats:italic>\u2009=\u200915) and Group PUI\u2013passive ultrasonic irrigation(<jats:italic>n<\/jats:italic>\u2009=\u200915). Bacteriological samples were taken before(S1) and after chemomechanical preparation(S2), and then after final irrigation activation(S3). The levels of total bacteria and <jats:italic>Streptococci<\/jats:italic> were measured by means of PCR. Blood samples were collected before and 3rd day after treatment. Enzyme-linked immunosorbent assay was used to measure the levels of IL-1\u03b2. The bacterial reduction showed no differences between groups after chemo-mechanical treatment and after irrigant activation(<jats:italic>p<\/jats:italic>\u2009=\u20090.590). Post-treatment IL-1\u03b2 levels were lower than pretreatment levels in both groups(<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). SL or PUI application in addition to chemomechanical preparation has similar effects on total bacterial level and inflammation detected by IL-1\u03b2 in patients with AP.<\/jats:p>","DOI":"10.1007\/s10103-024-04117-9","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T07:02:04Z","timestamp":1721113324000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Is SWEEPS better than PUI in reducing intracanal bacteria and inflammation in cases of apical periodontitis?"],"prefix":"10.1007","volume":"39","author":[{"given":"Yelda Erdem","family":"Hepsenoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0354-5108","authenticated-orcid":false,"given":"Seyda","family":"Ersahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Gundogar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Ozcelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"7","key":"4117_CR1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/j.1600-0714.2009.00788.x","volume":"38","author":"D Gazivoda","year":"2009","unstructured":"Gazivoda D, Dzopalic T, Bozic B, Tatomirovic Z, Brkic Z, Colic M (2009) Production of proinflammatory and immunoregulatory cytokines by inflammatory cells from periapical lesions in culture. 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