{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:21:24Z","timestamp":1790803284684,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2023-00302193"],"award-info":[{"award-number":["RS-2023-00302193"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2024IP0066-1"],"award-info":[{"award-number":["2024IP0066-1"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00214125"],"award-info":[{"award-number":["RS-2023-00214125"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"DOI":"10.1007\/s10103-024-04154-4","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T04:15:27Z","timestamp":1722485727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of combined intense pulsed light and cyclosporine 0.05% eyedrops in ocular surface matrix metalloproteinase-9 levels in patients with moderate-to-severe MGD"],"prefix":"10.1007","volume":"39","author":[{"given":"Yoo Young","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonha","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Seok","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7225-6580","authenticated-orcid":false,"given":"Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"2","key":"4154_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","volume":"5","author":"The definition and","year":"2007","unstructured":"The definition and (2007) Classification of dry eye disease: report of the definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul Surf 5(2):75\u201392","journal-title":"Ocul Surf"},{"key":"4154_CR2","doi-asserted-by":"crossref","unstructured":"Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K et al (2011) The International Workshop on Meibomian Gland Dysfunction: Executive Summary. Investigative Ophthalmology & Visual Science 52(4):1922\u20131929","DOI":"10.1167\/iovs.10-6997a"},{"key":"4154_CR3","doi-asserted-by":"crossref","unstructured":"Nelson JD, Shimazaki J, Benitez-del-Castillo JM, Craig JP, McCulley JP, Den S et al (2011) The International Workshop on Meibomian Gland Dysfunction: Report of the Definition and Classification Subcommittee. Investigative Ophthalmology & Visual Science 52(4):1930\u20131937","DOI":"10.1167\/iovs.10-6997b"},{"issue":"5","key":"4154_CR4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/ICL.0b013e31821bc7c5","volume":"37","author":"DR Korb","year":"2011","unstructured":"Korb DR, Blackie CA (2011) Meibomian gland therapeutic expression: quantifying the applied pressure and the limitation of resulting pain. Eye Contact Lens 37(5):298\u2013301","journal-title":"Eye Contact Lens"},{"issue":"2","key":"4154_CR5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/01.ICL.0000060998.20142.8D","volume":"29","author":"MC Olson","year":"2003","unstructured":"Olson MC, Korb DR, Greiner JV (2003) Increase in tear film lipid layer thickness following treatment with warm compresses in patients with meibomian gland dysfunction. Eye Contact Lens 29(2):96\u201399","journal-title":"Eye Contact Lens"},{"issue":"3","key":"4154_CR6","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0039-6257(86)90035-4","volume":"31","author":"RB Nussenblatt","year":"1986","unstructured":"Nussenblatt RB, Palestine AG (1986) Cyclosporine: immunology, pharmacology and therapeutic uses. Surv Ophthalmol 31(3):159\u2013169","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"4154_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3341\/kjo.2011.25.6.369","volume":"25","author":"YS Byun","year":"2011","unstructured":"Byun YS, Rho CR, Cho K, Choi JA, Na KS, Joo CK (2011) Cyclosporine 0.05% ophthalmic emulsion for dry eye in Korea: a prospective, multicenter, open-label, surveillance study. Korean J Ophthalmol 25(6):369\u2013374","journal-title":"Korean J Ophthalmol"},{"key":"4154_CR8","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s10792-014-9901-4","volume":"34","author":"H Devec\u0131","year":"2014","unstructured":"Devec\u0131 H, Kobak S (2014) The efficacy of topical 0.05% cyclosporine A in patients with dry eye disease associated with Sj\u00f6gren\u2019s syndrome. Int Ophthalmol 34:1043\u20131048","journal-title":"Int Ophthalmol"},{"key":"4154_CR9","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.2147\/OPTH.S139894","volume":"11","author":"SJ Dell","year":"2017","unstructured":"Dell SJ (2017) Intense pulsed light for evaporative dry eye disease. Clin Ophthalmol 11:1167\u20131173","journal-title":"Clin Ophthalmol"},{"key":"4154_CR10","doi-asserted-by":"publisher","first-page":"817","DOI":"10.2147\/OPTH.S130706","volume":"11","author":"SJ Dell","year":"2017","unstructured":"Dell SJ, Gaster RN, Barbarino SC, Cunningham DN (2017) Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction. Clin Ophthalmol 11:817\u2013827","journal-title":"Clin Ophthalmol"},{"key":"4154_CR11","doi-asserted-by":"publisher","first-page":"3684963","DOI":"10.1155\/2020\/3684963","volume":"2020","author":"S Wei","year":"2020","unstructured":"Wei S, Ren X, Wang Y, Chou Y, Li X (2020) Therapeutic effect of intense pulsed light (IPL) combined with Meibomian Gland expression (MGX) on Meibomian Gland Dysfunction (MGD). J Ophthalmol 2020:3684963","journal-title":"J Ophthalmol"},{"issue":"3","key":"4154_CR12","doi-asserted-by":"publisher","first-page":"e0246245","DOI":"10.1371\/journal.pone.0246245","volume":"16","author":"KY Shin","year":"2021","unstructured":"Shin KY, Lim DH, Moon CH, Kim BJ, Chung T-Y (2021) Intense pulsed light plus meibomian gland expression versus intense pulsed light alone for meibomian gland dysfunction: a randomized crossover study. PLoS ONE 16(3):e0246245","journal-title":"PLoS ONE"},{"issue":"12","key":"4154_CR13","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1097\/ICO.0b013e31823cc098","volume":"31","author":"P Prabhasawat","year":"2012","unstructured":"Prabhasawat P, Tesavibul N, Mahawong W (2012) A Randomized double-masked study of 0.05% Cyclosporine Ophthalmic Emulsion in the treatment of Meibomian Gland Dysfunction. Cornea 31(12):1386\u20131393","journal-title":"Cornea"},{"issue":"1","key":"4154_CR14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10792-022-02389-0","volume":"43","author":"HS Chung","year":"2023","unstructured":"Chung HS, Han YE, Lee H, Kim JY, Tchah H (2023) Intense pulsed light treatment of the upper and lower eyelids in patients with moderate-to-severe meibomian gland dysfunction. Int Ophthalmol 43(1):73\u201382","journal-title":"Int Ophthalmol"},{"issue":"4","key":"4154_CR15","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s10103-021-03482-z","volume":"37","author":"JY Han","year":"2022","unstructured":"Han JY, Lee Y, Nam S, Moon SY, Lee H, Kim JY et al (2022) Effect of intense pulsed light using acne filter on eyelid margin telangiectasia in moderate-to-severe meibomian gland dysfunction. Lasers Med Sci 37(4):2185\u20132192","journal-title":"Lasers Med Sci"},{"issue":"2","key":"4154_CR16","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1097\/ICO.0000000000001779","volume":"38","author":"R Arita","year":"2019","unstructured":"Arita R, Mizoguchi T, Fukuoka S, Morishige N (2019) Multicenter Study of intense pulsed light therapy for patients with refractory meibomian gland dysfunction. Cornea 38(2):e4","journal-title":"Cornea"},{"key":"4154_CR17","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ajo.2016.06.025","volume":"169","author":"R Arita","year":"2016","unstructured":"Arita R, Minoura I, Morishige N, Shirakawa R, Fukuoka S, Asai K et al (2016) Development of Definitive and Reliable Grading scales for Meibomian Gland Dysfunction. Am J Ophthalmol 169:125\u2013137","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"4154_CR18","doi-asserted-by":"publisher","first-page":"101339","DOI":"10.1016\/j.clae.2020.05.008","volume":"44","author":"H Lee","year":"2021","unstructured":"Lee H, Han YE, Park SY, Lee JH, Chung HS, Moon SY et al (2021) Changes in the expression of matrix metalloproteinase-9 after intense pulsed light therapy combined with meibomian gland expression in moderate and severe meibomian gland dysfunction. Cont Lens Anterior Eye 44(3):101339","journal-title":"Cont Lens Anterior Eye"},{"key":"4154_CR19","doi-asserted-by":"crossref","unstructured":"Lee Y, Jang JH, Nam S, Lee K, Kim J, Kim JY et al (2022) Investigation of prognostic factors for intense pulsed light treatment with a vascular filter in patients with moderate or severe meibomian gland dysfunction. J Clin Med 11(16)","DOI":"10.3390\/jcm11164724"},{"key":"4154_CR20","unstructured":"Toyos RBC, Youngerman S (2005) Case report: dry\u2013eye symptoms improve with intense pulsed light treatment. EyeWorld News Magazine"},{"issue":"1","key":"4154_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1089\/pho.2014.3819","volume":"33","author":"R Toyos","year":"2015","unstructured":"Toyos R, McGill W, Briscoe D (2015) Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study. Photomed Laser Surg 33(1):41\u201346","journal-title":"Photomed Laser Surg"},{"key":"4154_CR22","doi-asserted-by":"publisher","first-page":"618206","DOI":"10.1155\/2014\/618206","volume":"2014","author":"D Piccolo","year":"2014","unstructured":"Piccolo D, Di Marcantonio D, Crisman G, Cannarozzo G, Sannino M, Chiricozzi A et al (2014) Unconventional use of intense pulsed light. Biomed Res Int 2014:618206","journal-title":"Biomed Res Int"},{"issue":"11","key":"4154_CR23","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1007\/s40265-015-0432-8","volume":"75","author":"AR Thode","year":"2015","unstructured":"Thode AR, Latkany RA (2015) Current and emerging therapeutic strategies for the treatment of Meibomian Gland Dysfunction (MGD). Drugs 75(11):1177\u20131185","journal-title":"Drugs"},{"issue":"3","key":"4154_CR24","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/ICO.0000000000000735","volume":"35","author":"S Vegunta","year":"2016","unstructured":"Vegunta S, Patel D, Shen JF (2016) Combination therapy of intense Pulsed Light Therapy and Meibomian Gland expression (IPL\/MGX) can improve Dry Eye symptoms and meibomian gland function in patients with refractory Dry Eye: a retrospective analysis. Cornea 35(3):318\u2013322","journal-title":"Cornea"},{"issue":"5","key":"4154_CR25","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s10792-019-01278-3","volume":"40","author":"S Yurttaser Ocak","year":"2020","unstructured":"Yurttaser Ocak S, Karakus S, Ocak OB, Cakir A, Bolukbasi S, Erden B et al (2020) Intense pulse light therapy treatment for refractory dry eye disease due to meibomian gland dysfunction. Int Ophthalmol 40(5):1135\u20131141","journal-title":"Int Ophthalmol"},{"issue":"1","key":"4154_CR26","doi-asserted-by":"publisher","first-page":"6700","DOI":"10.1038\/s41598-023-33526-z","volume":"13","author":"JH Jang","year":"2023","unstructured":"Jang JH, Lee K, Nam SH, Kim J, Kim JY, Tchah H et al (2023) Comparison of clinical outcomes between intense pulsed light therapy using two different filters in meibomian gland dysfunction: prospective randomized study. Sci Rep 13(1):6700","journal-title":"Sci Rep"},{"issue":"8","key":"4154_CR27","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1001\/archopht.126.8.1046","volume":"126","author":"HD Perry","year":"2008","unstructured":"Perry HD, Solomon R, Donnenfeld ED, Perry AR, Wittpenn JR, Greenman HE et al (2008) Evaluation of topical cyclosporine for the treatment of dry eye disease. Arch Ophthalmol 126(8):1046\u20131050","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"4154_CR28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/01.ico.0000176611.88579.0a","volume":"25","author":"HD Perry","year":"2006","unstructured":"Perry HD, Doshi-Carnevale S, Donnenfeld ED, Solomon R, Biser SA, Bloom AH (2006) Efficacy of commercially available topical cyclosporine a 0.05% in the treatment of Meibomian Gland Dysfunction. Cornea 25(2):171\u2013175","journal-title":"Cornea"},{"key":"4154_CR29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ajo.2017.08.021","volume":"183","author":"R Liu","year":"2017","unstructured":"Liu R, Rong B, Tu P, Tang Y, Song W, Toyos R et al (2017) Analysis of cytokine levels in tears and clinical correlations after intense pulsed light treating Meibomian Gland Dysfunction. Am J Ophthalmol 183:81\u201390","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"4154_CR30","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/00003226-200007000-00018","volume":"19","author":"K Turner","year":"2000","unstructured":"Turner K, Pflugfelder SC, Ji Z, Feuer WJ, Stern M, Reis BL (2000) Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion. Cornea 19(4):492\u2013496","journal-title":"Cornea"},{"issue":"7","key":"4154_CR31","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1167\/iovs.08-2476","volume":"50","author":"S Chotikavanich","year":"2009","unstructured":"Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ et al (2009) Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci 50(7):3203\u20133209","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-04154-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-024-04154-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-04154-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:41:28Z","timestamp":1738338088000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-024-04154-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4154"],"URL":"https:\/\/doi.org\/10.1007\/s10103-024-04154-4","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"13 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Institutional Review Board (IRB) of the Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (Approval number: 2024-0022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"203"}}