{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T16:17:53Z","timestamp":1738340273274,"version":"3.35.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Beijing Science and Technology Medical Development Foundation","award":["No. KC2021-JX-0186-64"],"award-info":[{"award-number":["No. KC2021-JX-0186-64"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"DOI":"10.1007\/s10103-024-04176-y","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T03:44:04Z","timestamp":1724989444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of 630\u00a0nm laser on apoptosis, metastasis, invasion and epithelial-to-mesenchymal transition of human lung squamous cell carcinoma H520 cells mediated by hematoporphyrin derivatives"],"prefix":"10.1007","volume":"39","author":[{"given":"Tingting","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shichao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cunzhi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"4176_CR1","doi-asserted-by":"crossref","unstructured":"Bray F et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal for clinicians. 74(3):229\u2013263","DOI":"10.3322\/caac.21834"},{"issue":"8","key":"4176_CR2","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.mayocp.2019.01.013","volume":"94","author":"N Duma","year":"2019","unstructured":"Duma N, Santana-Davila R, Molina JR (2019) Non\u2013small cell Lung Cancer: Epidemiology, Screening, diagnosis, and treatment. Mayo Clin Proc 94(8):1623\u20131640","journal-title":"Mayo Clin Proc"},{"key":"4176_CR3","doi-asserted-by":"crossref","unstructured":"Nooreldeen R, Bach H (2021) Current and Future Development in Lung Cancer diagnosis. Int J Mol Sci, 22(16)","DOI":"10.3390\/ijms22168661"},{"key":"4176_CR4","doi-asserted-by":"crossref","unstructured":"Niu Z et al (2022) Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials. Signal Transduct Target Therapy, 7(1)","DOI":"10.1038\/s41392-022-01200-x"},{"issue":"11","key":"4176_CR5","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.ccell.2022.09.018","volume":"40","author":"SCM Lau","year":"2022","unstructured":"Lau SCM et al (2022) Squamous cell lung cancer: current landscape and future therapeutic options. Cancer Cell 40(11):1279\u20131293","journal-title":"Cancer Cell"},{"key":"4176_CR6","doi-asserted-by":"crossref","unstructured":"Wan Y et al (2021) Conquering the Hypoxia limitation for photodynamic therapy. Adv Mater, 33(48)","DOI":"10.1002\/adma.202103978"},{"key":"4176_CR7","doi-asserted-by":"crossref","unstructured":"Correia JH et al (2021) Photodynamic therapy review: principles, photosensitizers, applications, and future directions. Pharmaceutics, 13(9)","DOI":"10.3390\/pharmaceutics13091332"},{"key":"4176_CR8","unstructured":"Banerjee SM et al (2020) Photodynamic therapy in primary breast Cancer. J Clin Med, 9(2)"},{"key":"4176_CR9","doi-asserted-by":"crossref","unstructured":"Juarranz \u00c1, Gilaberte Y, Gonz\u00e1lez S (2020) Photodynamic therapy (PDT) in Oncology. Cancers, 12(11)","DOI":"10.3390\/cancers12113341"},{"key":"4176_CR10","doi-asserted-by":"crossref","unstructured":"Shanazarov NA et al (2024) Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules. Therapeutic Advances in Chronic Disease, p 15","DOI":"10.1177\/20406223241233206"},{"key":"4176_CR11","doi-asserted-by":"crossref","unstructured":"Udrea AM et al (2023) Photosensitizers-loaded nanocarriers for enhancement of photodynamic therapy in Melanoma Treatment. Pharmaceutics, 15(8)","DOI":"10.3390\/pharmaceutics15082124"},{"key":"4176_CR12","doi-asserted-by":"crossref","unstructured":"Huang Y, Hong W, Wei X (2022) The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol, 15(1)","DOI":"10.1186\/s13045-022-01347-8"},{"issue":"8","key":"4176_CR13","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1158\/0008-5472.CAN-22-0026","volume":"82","author":"VS LeBleu","year":"2022","unstructured":"LeBleu VS, Thiery JP (2022) The Continuing search for causality between epithelial-to-mesenchymal transition and the Metastatic Fitness of Carcinoma Cells. Cancer Res 82(8):1467\u20131469","journal-title":"Cancer Res"},{"key":"4176_CR14","doi-asserted-by":"crossref","unstructured":"Cheng X et al (2022) Insight into the prospects for Tumor Therapy based on photodynamic immunotherapy. Pharmaceuticals, 15(11)","DOI":"10.3390\/ph15111359"},{"key":"4176_CR15","doi-asserted-by":"crossref","unstructured":"Yu Q et al (2023) Recent advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers-mediated photodynamic therapy. Small, 20(16)","DOI":"10.1002\/smll.202305708"},{"issue":"5","key":"4176_CR16","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.ccell.2016.04.004","volume":"29","author":"GP Dotto","year":"2016","unstructured":"Dotto GP, Anil K, Rustgi (2016) Squamous cell cancers: a unified perspective on Biology and Genetics. Cancer Cell 29(5):622\u2013637","journal-title":"Cancer Cell"},{"key":"4176_CR17","doi-asserted-by":"crossref","unstructured":"Friedlaender A et al (2019) Next generation sequencing and genetic alterations in squamous cell lung carcinoma. Where Are We Today? Frontiers in Oncology, p 9","DOI":"10.3389\/fonc.2019.00166"},{"issue":"10066","key":"4176_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0140-6736(16)30958-8","volume":"389","author":"FR Hirsch","year":"2017","unstructured":"Hirsch FR et al (2017) Lung cancer: current therapies and new targeted treatments. Lancet 389(10066):299\u2013311","journal-title":"Lancet"},{"issue":"2","key":"4176_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jtho.2017.11.111","volume":"13","author":"MA Socinski","year":"2018","unstructured":"Socinski MA et al (2018) Current and Emergent Therapy options for Advanced squamous cell Lung Cancer. J Thorac Oncol 13(2):165\u2013183","journal-title":"J Thorac Oncol"},{"issue":"11","key":"4176_CR20","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","volume":"17","author":"X Li","year":"2020","unstructured":"Li X et al (2020) Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Reviews Clin Oncol 17(11):657\u2013674","journal-title":"Nat Reviews Clin Oncol"},{"key":"4176_CR21","doi-asserted-by":"publisher","first-page":"102203","DOI":"10.1016\/j.pdpdt.2021.102203","volume":"33","author":"A Akopov","year":"2021","unstructured":"Akopov A, Papayan G (2021) Photodynamic theranostics of central lung cancer: Present state and future prospects. Photodiagnosis Photodyn Ther 33:102203","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"4176_CR22","doi-asserted-by":"crossref","unstructured":"Chhatre S et al (2021) Survival outcomes with photodynamic therapy, Chemotherapy and Radiation in patients with Stage III or Stage IV Non-small Cell Lung Cancer. Cancers (Basel), 13(4)","DOI":"10.3390\/cancers13040803"},{"issue":"4","key":"4176_CR23","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s10103-020-03080-5","volume":"36","author":"C Lin","year":"2021","unstructured":"Lin C et al (2021) Analysis of the short-term effect of photodynamic therapy on primary bronchial lung cancer. Lasers Med Sci 36(4):753\u2013761","journal-title":"Lasers Med Sci"},{"key":"4176_CR24","doi-asserted-by":"publisher","first-page":"136170","DOI":"10.1016\/j.cej.2022.136170","volume":"442","author":"Y Du","year":"2022","unstructured":"Du Y et al (2022) Glutathione depletion and photosensitizer activation augments efficacy of tumor photodynamic immunotherapy. Chem Eng J 442:136170","journal-title":"Chem Eng J"},{"key":"4176_CR25","doi-asserted-by":"crossref","unstructured":"Heo S-Y et al (2023) Anti-cancer effect of Chlorophyllin-assisted photodynamic therapy to Induce apoptosis through oxidative stress on human cervical Cancer. Int J Mol Sci, 24(14)","DOI":"10.3390\/ijms241411565"},{"issue":"7","key":"4176_CR26","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s43630-024-00601-x","volume":"23","author":"J Hu","year":"2024","unstructured":"Hu J, Wen X, Song J (2024) Hypericin-mediated photodynamic therapy inhibits metastasis and EMT of colorectal cancer cells by regulating RhoA\u2013ROCK1 signaling pathway. Photochem Photobiol Sci 23(7):1361\u20131372","journal-title":"Photochem Photobiol Sci"},{"key":"4176_CR27","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.pdpdt.2019.05.007","volume":"26","author":"Y Jia","year":"2019","unstructured":"Jia Y et al (2019) Photodynamic therapy combined with temozolomide inhibits C6 glioma migration and invasion and promotes mitochondrial-associated apoptosis by inhibiting sodium-hydrogen exchanger isoform 1. Photodiagn Photodyn Ther 26:405\u2013412","journal-title":"Photodiagn Photodyn Ther"},{"key":"4176_CR28","doi-asserted-by":"publisher","first-page":"103831","DOI":"10.1016\/j.pdpdt.2023.103831","volume":"44","author":"C Lin","year":"2023","unstructured":"Lin C et al (2023) Effect of a 630 nm light on vasculogenic mimicry in A549 lung adenocarcinoma cells in vitro. Photodiagn Photodyn Ther 44:103831","journal-title":"Photodiagn Photodyn Ther"},{"issue":"2","key":"4176_CR29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.apsb.2018.12.004","volume":"9","author":"S Qi","year":"2019","unstructured":"Qi S et al (2019) Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway. Acta Pharm Sinica B 9(2):279\u2013293","journal-title":"Acta Pharm Sinica B"},{"key":"4176_CR30","doi-asserted-by":"crossref","unstructured":"Suzuki T et al (2020) Vascular shutdown by photodynamic therapy using Talaporfin Sodium. Cancers, 12(9)","DOI":"10.3390\/cancers12092369"},{"key":"4176_CR31","doi-asserted-by":"publisher","first-page":"112269","DOI":"10.1016\/j.matdes.2023.112269","volume":"233","author":"W Wang","year":"2023","unstructured":"Wang W et al (2023) Intratibial osteosarcoma growth and pulmonary metastasis inhibition by HIPPO signaling pathway-induced photodynamic therapy. Mater Design 233:112269","journal-title":"Mater Design"},{"issue":"9","key":"4176_CR32","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1002\/jcb.30451","volume":"124","author":"Y Yao","year":"2023","unstructured":"Yao Y et al (2023) Elsinochrome a induces cell apoptosis and autophagy in photodynamic therapy. J Cell Biochem 124(9):1346\u20131365","journal-title":"J Cell Biochem"},{"key":"4176_CR33","doi-asserted-by":"publisher","first-page":"102039","DOI":"10.1016\/j.pdpdt.2020.102039","volume":"32","author":"T Ye","year":"2020","unstructured":"Ye T et al (2020) 5-aminolevulinic acid photodynamic therapy inhibits invasion and metastasis of SCL-1 cells probably via MTSS1 and p63 gene related pathways. Photodiagn Photodyn Ther 32:102039","journal-title":"Photodiagn Photodyn Ther"},{"key":"4176_CR34","doi-asserted-by":"publisher","first-page":"213859","DOI":"10.1016\/j.bioadv.2024.213859","volume":"160","author":"T Zhang","year":"2024","unstructured":"Zhang T et al (2024) Synergistic effects of photodynamic therapy and chemotherapy: activating the intrinsic\/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment. Biomaterials Adv 160:213859","journal-title":"Biomaterials Adv"},{"key":"4176_CR35","doi-asserted-by":"publisher","first-page":"103894","DOI":"10.1016\/j.pdpdt.2023.103894","volume":"45","author":"L Zheng","year":"2024","unstructured":"Zheng L et al (2024) A novel photosensitizer DTPP-mediated photodynamic therapy induces oxidative stress and apoptosis through mitochondrial pathways in LA795 cells. Photodiagn Photodyn Ther 45:103894","journal-title":"Photodiagn Photodyn Ther"},{"issue":"4","key":"4176_CR36","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrd.2016.253","volume":"16","author":"A Ashkenazi","year":"2017","unstructured":"Ashkenazi A et al (2017) From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors. Nat Rev Drug Discov 16(4):273\u2013284","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"4176_CR37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrc.2015.17","volume":"16","author":"AR Delbridge","year":"2016","unstructured":"Delbridge AR et al (2016) Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies. Nat Rev Cancer 16(2):99\u2013109","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"4176_CR38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/pin.12507","volume":"67","author":"PL Sun","year":"2017","unstructured":"Sun PL, Sasano H, Gao H (2017) Bcl-2 family in non-small cell lung cancer: its prognostic and therapeutic implications. Pathol Int 67(3):121\u2013130","journal-title":"Pathol Int"},{"key":"4176_CR39","doi-asserted-by":"crossref","unstructured":"Green DR (2022) Caspase activation and inhibition. Cold Spring Harb Perspect Biol, 14(8)","DOI":"10.1101\/cshperspect.a041020"},{"issue":"3","key":"4176_CR40","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","volume":"20","author":"R Singh","year":"2019","unstructured":"Singh R, Letai A, Sarosiek K (2019) Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol 20(3):175\u2013193","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4176_CR41","doi-asserted-by":"crossref","unstructured":"Liu G et al (2017) Role of Autophagy and apoptosis in Non-small-cell Lung Cancer. Int J Mol Sci, 18(2)","DOI":"10.3390\/ijms18020367"},{"key":"4176_CR42","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1146\/annurev-physiol-020518-114320","volume":"81","author":"M Sauler","year":"2019","unstructured":"Sauler M, Bazan IS, Lee PJ (2019) Cell death in the lung: the apoptosis-necroptosis Axis. Annu Rev Physiol 81:375\u2013402","journal-title":"Annu Rev Physiol"},{"issue":"9","key":"4176_CR43","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1080\/15548627.2019.1695398","volume":"16","author":"HK An","year":"2020","unstructured":"An HK et al (2020) CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis. Autophagy 16(9):1598\u20131617","journal-title":"Autophagy"},{"issue":"14","key":"4176_CR44","doi-asserted-by":"publisher","first-page":"23996","DOI":"10.18632\/oncotarget.15098","volume":"8","author":"P Li","year":"2017","unstructured":"Li P et al (2017) Caspase-9: structure, mechanisms and clinical application. Oncotarget 8(14):23996\u201324008","journal-title":"Oncotarget"},{"key":"4176_CR45","doi-asserted-by":"crossref","unstructured":"Debnath P et al (2022) Epithelial\u2013mesenchymal transition and its transcription factors. Biosci Rep, 42(1)","DOI":"10.1042\/BSR20211754"},{"issue":"1","key":"4176_CR46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/1878-0261.12017","volume":"11","author":"KT Yeung","year":"2016","unstructured":"Yeung KT, Yang J (2016) Epithelial\u2013mesenchymal transition in tumor metastasis. Mol Oncol 11(1):28\u201339","journal-title":"Mol Oncol"},{"key":"4176_CR47","doi-asserted-by":"crossref","unstructured":"Sreter KB et al (2024) Resistance to KRAS inhibition in advanced non-small cell lung cancer. Front Oncol, 14","DOI":"10.3389\/fonc.2024.1357898"},{"key":"4176_CR48","doi-asserted-by":"crossref","unstructured":"Hsieh K et al (2023) Radiotherapy and Immunotherapy in Lung Cancer. Biomedicines, 11(6)","DOI":"10.3390\/biomedicines11061642"},{"key":"4176_CR49","doi-asserted-by":"crossref","unstructured":"Li J, Kwok H (2020) Current strategies for treating NSCLC: from Biological mechanisms to Clinical Treatment. Cancers, 12(6)","DOI":"10.3390\/cancers12061587"},{"key":"4176_CR50","doi-asserted-by":"crossref","unstructured":"Zhang H et al (2024) Clinical characteristics and novel strategies of immune checkpoint inhibitor rechallenge therapy for non-small cell lung cancer: a comprehensive review. Front Immunol, 14","DOI":"10.3389\/fimmu.2023.1309055"},{"issue":"18","key":"4176_CR51","doi-asserted-by":"publisher","first-page":"e108647","DOI":"10.15252\/embj.2021108647","volume":"40","author":"S Brabletz","year":"2021","unstructured":"Brabletz S et al (2021) Dynamic EMT: a multi-tool for tumor progression. Embo j 40(18):e108647","journal-title":"Embo j"},{"key":"4176_CR52","doi-asserted-by":"publisher","first-page":"102849","DOI":"10.1016\/j.pdpdt.2022.102849","volume":"38","author":"L Shao","year":"2022","unstructured":"Shao L et al (2022) Effects of Curcumin-mediated photodynamic therapy on autophagy and epithelial-mesenchymal transition of lung cancer cells. Photodiagnosis Photodyn Ther 38:102849","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"5","key":"4176_CR53","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/lsm.22781","volume":"50","author":"AI Musani","year":"2018","unstructured":"Musani AI et al (2018) Photodynamic therapy via navigational bronchoscopy for peripheral lung cancer in dogs. Lasers Surg Med 50(5):483\u2013490","journal-title":"Lasers Surg Med"},{"issue":"6","key":"4176_CR54","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s12328-022-01695-5","volume":"15","author":"H Sato","year":"2022","unstructured":"Sato H et al (2022) Combination of photodynamic therapy and endoscopic mucosal resection for recurrent esophageal squamous cell carcinoma after chemoradiotherapy. Clin J Gastroenterol 15(6):1035\u20131040","journal-title":"Clin J Gastroenterol"},{"issue":"14","key":"4176_CR55","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/1759-7714.14861","volume":"14","author":"K Tamura","year":"2023","unstructured":"Tamura K et al (2023) Mucoepidermoid carcinoma cured by a combination of high-frequency snare and photodynamic therapy: a case report. Thorac Cancer 14(14):1306\u20131310","journal-title":"Thorac Cancer"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-04176-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-024-04176-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-04176-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:44:35Z","timestamp":1738338275000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-024-04176-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4176"],"URL":"https:\/\/doi.org\/10.1007\/s10103-024-04176-y","relation":{},"ISSN":["1435-604X"],"issn-type":[{"type":"electronic","value":"1435-604X"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"assertion":[{"value":"4 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies were in accordance with the ethical standards of the institution or practice at which the studies were conducted.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"228"}}