{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:13:42Z","timestamp":1792872822359,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018778","name":"Al-Azhar University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018778","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Androgenic alopecia (AGA) is the most common form of non-scarring hair loss, characterized by marked hair follicle miniaturization. AGA is a challenging skin condition with limited treatment results. Laser light can promote hair growth at specific wavelengths. The efficacy of fractional CO2 laser in scalp AGA treatment was reported in a few studies. We aimed to compare the efficacy of fractional CO2 laser alone versus the combination of fractional CO2 laser with topical dutasteride in the treatment of male AGA. 30 male patients with AGA were enrolled in the study; they were divided into two groups. All patients received three sessions of ablative fractional CO2 laser one month apart on the scalp, where group (I) patients were subjected to laser sessions only, and group (II) patients were subjected to topical dutasteride, first immediately after each session and secondly fifteen days after each session. The evaluation was done according to dermoscopy (DermLite\n                    <jats:sup>\u00ae<\/jats:sup>\n                    DL4) and photographic assessment. Patient satisfaction and side effects were reported. According to the global photo assessment, the combination of fractional CO2 laser with topical dutasteride showed a statistically significant improvement compared to the fractional CO2 laser alone group. The combination of fractional CO2 laser with topical dutasteride is more efficient in improving male androgenic alopecia than fractional CO2 laser alone according to the investigator\u2019s global assessment. There was a significant improvement in all dermoscopic parameters in both groups.\n                  <\/jats:p>","DOI":"10.1007\/s10103-024-04269-8","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T18:36:14Z","timestamp":1736534174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative study between fractional CO2 laser alone versus fractional CO2 laser combined with topical dutasteride in treatment of male androgenic alopecia"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-628X","authenticated-orcid":false,"given":"Sara Ahmed","family":"Galal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Sobh","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4561-8229","authenticated-orcid":false,"given":"Hala Shawky","family":"A. HafizHala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"4269_CR1","doi-asserted-by":"publisher","unstructured":"Arif T, Dorjay K, Adil M, Sami M (2017) Dutasteride in Androgenetic Alopecia: An Update. Curr Clin Pharmacol.;12(1):31\u201335.https:\/\/doi.org\/10.2174\/1574884712666170310111125. PMID: 28294070","DOI":"10.2174\/1574884712666170310111125"},{"issue":"1","key":"4269_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.15171\/jlms.2020.06","volume":"11","author":"M Salah","year":"2020","unstructured":"Salah M, Samy N, Fawzy MM et al (2020) The Effect of the Fractional Carbon Dioxide laser on improving Minoxidil Delivery for the treatment of Androgenetic Alopecia. J Lasers Med Sci 11(1):29\u201336. https:\/\/doi.org\/10.15171\/jlms.2020.06","journal-title":"J Lasers Med Sci"},{"issue":"2","key":"4269_CR3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10103-017-2385-5","volume":"33","author":"E Darwin","year":"2018","unstructured":"Darwin E, Heyes A, Hirt PA, Wikramanayake TC, Jimenez JJ (2018) Low-level laser therapy for the treatment of androgenic alopecia: a review. Lasers Med Sci 33(2):425\u2013434. https:\/\/doi.org\/10.1007\/s10103-017-2385-5Epub 2017 Dec 21. PMID: 29270707","journal-title":"Lasers Med Sci"},{"issue":"1","key":"4269_CR4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00266-018-1248-1","volume":"43","author":"GH Sasaki","year":"2019","unstructured":"Sasaki GH (2019) Review of human hair follicle Biology: Dynamics of niches and Stem Cell Regulation for possible therapeutic hair stimulation for Plastic surgeons. Aesthetic Plast Surg 43(1):253\u2013266. https:\/\/doi.org\/10.1007\/s00266-018-1248-1Epub 2018 Oct 15. PMID: 30324295","journal-title":"Aesthetic Plast Surg"},{"issue":"4","key":"4269_CR5","doi-asserted-by":"publisher","first-page":"e2157","DOI":"10.1097\/GOX.0000000000002157","volume":"7","author":"RJ Dabek","year":"2019","unstructured":"Dabek RJ, Austen WG Jr, Bojovic B (2019) Laser-assisted hair regrowth: fractional laser modalities for the treatment of Androgenic Alopecia. Plast Reconstr Surg Glob Open 7(4):e2157. https:\/\/doi.org\/10.1097\/GOX.0000000000002157PMID: 31321172; PMCID: PMC6554163","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"4269_CR6","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2147\/CIA.S192435","volume":"14","author":"Z Zhou","year":"2019","unstructured":"Zhou Z, Song S, Gao Z, Wu J, Ma J, Cui Y (2019) The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Clin Interv Aging 14:399\u2013406 PMID: 30863034; PMCID: PMC6388756","journal-title":"Clin Interv Aging"},{"issue":"12","key":"4269_CR7","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1111\/j.1468-3083.2011.04183.x","volume":"25","author":"GY Lee","year":"2011","unstructured":"Lee GY, Lee SJ, Kim WS (2011) The effect of a 1550 nm fractional erbium-glass laser in female pattern hair loss. J Eur Acad Dermatol Venereol 25(12):1450\u20131454. https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04183.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"4269_CR8","doi-asserted-by":"crossref","unstructured":"Searle T, Ali FR, Al-Niaimi F (2021) Lessons Learned from the First Decade of Laser-Assisted Drug Delivery. Dermatol Ther (Heidelb).;11(1):93\u2013104. doi: 10.1007\/s13555-020-00478-5. Epub 2021 Jan 19. PMID: 33464473; PMCID: PMC7858718","DOI":"10.1007\/s13555-020-00478-5"},{"issue":"11","key":"4269_CR9","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1097\/00007611-197511000-00009","volume":"68","author":"OT Norwood","year":"1975","unstructured":"Norwood OT (1975) Male pattern baldness: classification and incidence. 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