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The injured sciatic nerves of the rats in the control group were left to heal spontaneously, whereas HILT (120 J\/session and 1064 nm) and photobiomodulation therapy (PBM) (2.4 J\/session and 650 nm) were started immediately after surgery and performed once every 3 days (10 session in total) during the postoperative period. Electrophysiological evaluations were conducted before surgery and at the end of the healing period. The Sciatic Functional Index (SFI) was assessed before surgery and at the end of the healing period. The ratio of the inner axonal diameter to the total outer axonal diameter (g-ratio) and schwann cells per square micrometer were histomorphometrically evaluated.\u00a0At the end of the 30-day healing period, significantly better SFI scores were noted in the HILT group compared with PBM (p=0.002) and control (p &lt; 0.001) groups. HILT exhibited positive effects on latency and duration values when compared PBM (p=0.002, p=0.014) and control (p=0.003, p &lt; 0.001) groups. The number of nerves with an optimum g-ratio was higher in the HILT group which indicates a better rate of myelination.\u00a0Functional, histomorphometric, and electrophysiological investigations of the present study revealed that HILT seems to be a superior treatment modality for peripheral nerve regeneration.<\/jats:p>","DOI":"10.1007\/s10103-025-04334-w","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T02:19:43Z","timestamp":1738981183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of high-intensity versus photobiomodulation therapy (PBM) on the regeneration of the sciatic nerve following crush injury: an animal study"],"prefix":"10.1007","volume":"40","author":[{"given":"Kemal Atakan","family":"Bayburt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurettin","family":"Diker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Serif","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dogan","family":"Dolanmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"4334_CR1","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1046\/j.1460-9568.1999.00754.x","volume":"11","author":"PH Jensen","year":"1999","unstructured":"Jensen PH, Li J-Y, Dahlstr\u00f6m A, Dotti CG (1999) Axonal transport of synucleins is mediated by all rate components. 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All methods were performed in accordance with ARRIVE guideline 2.0 (Animal Research: Reporting of In Vivo Experiments) and regulations. This study was approved by the Institutional Review Board and Ethical Committee of Animal Research Center Bezmialem Vakif University (Date and No. of Papers: 2021\/229).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"81"}}