{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:36:17Z","timestamp":1788280577798,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018778","name":"Al-Azhar University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018778","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A port-wine stain (PWS) is a congenital capillary abnormality with an incidence of 0.3\u20130.5%. Although several other types of lasers have been used to treat PWSs, few studies have focused on the factors that affect the outcome of 577-nm yellow lasers. We aimed to assess the efficacy and prognostic factors affecting the PWS treatment by 577-nm yellow laser. This study was carried out on 42 patients with PWS. Each patient received 6\u201310 treatment sessions with a 577-nm yellow laser at 4-week intervals. Treatment efficacy was considered adequate when improvement of \u2265\u200980% of the lesion occurred. After treatment, marked improvement occurred in 7 (16.7%) patients, moderate improvement in 17 (40.5%) patients, mild improvement in 10 (23.8%) and 8 (19%) patients showed poor improvement. There was a significant association between improvement and gender of the patients and site of lesion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001, respectively). However, linear regression analysis showed that the site of the lesion can significantly predict the improvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while other baseline characteristics were not associated and cannot act as predictors for improvement. Yellow laser is a successful therapy choice for PWS, with a statistically significant improvement and minimal adverse effects. No significant association was found between improvement following laser therapy and baseline parameters, except for the location of PWS.\n                  <\/jats:p>","DOI":"10.1007\/s10103-025-04350-w","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T23:20:14Z","timestamp":1739488814000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and prognostic factors for successful treatment of port-wine stains by 577-nm yellow laser: a cohort study on 42 patients"],"prefix":"10.1007","volume":"40","author":[{"given":"Essamelden M.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem L.","family":"Abdel-Aleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofreh","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Rageh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"issue":"6","key":"4350_CR1","first-page":"376","volume":"37","author":"G Ma","year":"2019","unstructured":"Ma G, Han Y, Ying H et al (2019) Comparison of two generation photosensitizers of PsD-007 and hematoporphyrin monomethyl ether photodynamic therapy for treatment of Port-Wine Stain: a retrospective study. Photobiomodul Photomed Laser Surg 37(6):376\u2013380","journal-title":"Photobiomodul Photomed Laser Surg"},{"issue":"7","key":"4350_CR2","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1039\/c9pp00079h","volume":"18","author":"M Zutt","year":"2019","unstructured":"Zutt M (2019) Laser treatment of vascular dermatological diseases using a pulsed dye laser (595 nm) in combination with a Neodym:YAG-laser (1064 nm). Photochem Photobiol Sci 18(7):1660\u20131668","journal-title":"Photochem Photobiol Sci"},{"issue":"4","key":"4350_CR3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/j.1365-2230.1997.tb01053.x","volume":"22","author":"CM Mills","year":"1997","unstructured":"Mills CM, Lanigan SW, Hughes J, Anstey AV (1997) Demographic study of port wine stain patients attending a laser clinic: family history, prevalence of naevus anaemicus and results of prior treatment. Clin Exp Dermatol 22(4):166\u2013168","journal-title":"Clin Exp Dermatol"},{"issue":"2","key":"4350_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/14764172.2017.1368669","volume":"20","author":"MI van Raath","year":"2018","unstructured":"van Raath MI, Bambach CA, Dijksman LM et al (2018) Prospective analysis of the port-wine stain patient population in the Netherlands in light of novel treatment modalities. J Cosmet Laser Ther 20(2):77\u201384","journal-title":"J Cosmet Laser Ther"},{"issue":"2","key":"4350_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/lsm.22436","volume":"48","author":"TD Griffin Jr","year":"2016","unstructured":"Griffin TD Jr, Foshee JP, Finney R, Saedi N (2016) Port wine stain treated with a combination of pulsed dye laser and topical rapamycin ointment. Lasers Surg Med 48(2):193\u2013196","journal-title":"Lasers Surg Med"},{"issue":"5","key":"4350_CR6","doi-asserted-by":"publisher","first-page":"376","DOI":"10.5144\/0256-4947.2018.376","volume":"38","author":"HM Musalem","year":"2018","unstructured":"Musalem HM, Alshaikh AA, Tuleimat LM, Alajlan S (2018) Outcome with topical sirolimus for port wine stain malformations after unsatisfactory results with pulse dye laser treatment alone. Ann Saudi Med 38(5):376\u2013380","journal-title":"Ann Saudi Med"},{"issue":"1","key":"4350_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/lsm.22548","volume":"49","author":"K Greveling","year":"2017","unstructured":"Greveling K, Prens EP, van Doorn MB (2017) Treatment of port wine stains using pulsed Dye Laser, Erbium YAG Laser, and topical rapamycin (sirolimus)-A randomized controlled trial. Lasers Surg Med 49(1):104\u2013109","journal-title":"Lasers Surg Med"},{"issue":"7","key":"4350_CR8","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1080\/09546634.2017.1306018","volume":"28","author":"EJ Doh","year":"2017","unstructured":"Doh EJ, Ohn J, Kim MJ et al (2017) Prospective pilot study on combined use of pulsed dye laser and 1% topical rapamycin for treatment of nonfacial cutaneous capillary malformation. J Dermatolog Treat 28(7):672\u2013677","journal-title":"J Dermatolog Treat"},{"issue":"6","key":"4350_CR9","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s13555-021-00607-8","volume":"11","author":"V Yepuri","year":"2021","unstructured":"Yepuri V, Patil AD, Fritz K et al (2021) Light-based devices for the Treatment of Facial Erythema and Telangiectasia. Dermatol Ther (Heidelb) 11(6):1879\u20131887","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"5","key":"4350_CR10","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/bjd.12204","volume":"168","author":"JA Savas","year":"2013","unstructured":"Savas JA, Ledon JA, Franca K et al (2013) Pulsed dye laser-resistant port-wine stains: mechanisms of resistance and implications for treatment. Br J Dermatol 168(5):941\u2013953","journal-title":"Br J Dermatol"},{"issue":"7","key":"4350_CR11","doi-asserted-by":"publisher","first-page":"e0235657","DOI":"10.1371\/journal.pone.0235657","volume":"15","author":"MI van Raath","year":"2020","unstructured":"van Raath MI, Chohan S, Wolkerstorfer A et al (2020) Clinical outcome measures and scoring systems used in prospective studies of port wine stains: a systematic review. PLoS ONE 15(7):e0235657","journal-title":"PLoS ONE"},{"issue":"1","key":"4350_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10103-018-2606-6","volume":"34","author":"Y Kapicioglu","year":"2019","unstructured":"Kapicioglu Y, Sarac G, Cenk H (2019) Treatment of erythematotelangiectatic rosacea, facial erythema, and facial telangiectasia with a 577-nm pro-yellow laser: a case series. Lasers Med Sci 34(1):93\u201398","journal-title":"Lasers Med Sci"},{"issue":"4","key":"4350_CR13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1473-2165.2002.00071.x","volume":"1","author":"S Laube","year":"2002","unstructured":"Laube S, Lanigan SW (2002) Laser treatment of rosacea. J Cosmet Dermatol 1(4):188\u2013195","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"4350_CR14","first-page":"37","volume":"30","author":"ZF Jasim","year":"2004","unstructured":"Jasim ZF, Woo WK, Handley JM (2004) Long-pulsed (6-ms) pulsed dye laser treatment of rosacea-associated telangiectasia using subpurpuric clinical threshold. Dermatol Surg 30(1):37\u201340","journal-title":"Dermatol Surg"},{"issue":"6","key":"4350_CR15","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1111\/jocd.12963","volume":"18","author":"EM Mohamed","year":"2019","unstructured":"Mohamed EM, Mohamed Tawfik K, Hassan Ahmad W (2019) Successful treatment of facial vascular skin diseases with a 577-nm pro-yellow laser. J Cosmet Dermatol 18(6):1675\u20131679","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"4350_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/14764170701280693","volume":"9","author":"M Adamic","year":"2007","unstructured":"Adamic M, Troilius A, Adatto M et al (2007) Vascular lasers and IPLS: guidelines for care from the European Society for Laser Dermatology (ESLD). J Cosmet Laser Ther 9(2):113\u2013124","journal-title":"J Cosmet Laser Ther"},{"issue":"6","key":"4350_CR17","first-page":"892","volume":"30","author":"MM Selim","year":"2004","unstructured":"Selim MM, Kelly KM, Nelson JS et al (2004) Confocal microscopy study of nerves and blood vessels in untreated and treated port wine stains: preliminary observations. Dermatol Surg 30(6):892\u2013897","journal-title":"Dermatol Surg"},{"issue":"5","key":"4350_CR18","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1046\/j.1365-2133.1998.02219.x","volume":"138","author":"CM Nguyen","year":"1998","unstructured":"Nguyen CM, Yohn JJ, Huff C et al (1998) Facial port wine stains in childhood: prediction of the rate of improvement as a function of the age of the patient, size and location of the port wine stain and the number of treatments with the pulsed dye (585 nm) laser. Br J Dermatol 138(5):821\u2013825","journal-title":"Br J Dermatol"},{"issue":"15","key":"4350_CR19","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1056\/NEJM199804093381504","volume":"338","author":"CM van der Horst","year":"1998","unstructured":"van der Horst CM, Koster PH, de Borgie CA et al (1998) Effect of the timing of treatment of port-wine stains with the flash-lamp-pumped pulsed-dye laser. N Engl J Med 338(15):1028\u20131033","journal-title":"N Engl J Med"},{"issue":"9","key":"4350_CR20","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1056\/NEJM199808273390917","volume":"339","author":"AN Kauvar","year":"1998","unstructured":"Kauvar AN, Geronemus RG (1998) Treatment of port-wine stains. N Engl J Med 339(9):635\u2013636","journal-title":"N Engl J Med"},{"key":"4350_CR21","first-page":"27","volume":"8","author":"LA Brightman","year":"2015","unstructured":"Brightman LA, Geronemus RG, Reddy KK (2015) Laser treatment of port-wine stains. Clin Cosmet Investig Dermatol 8:27\u201333","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"9","key":"4350_CR22","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1007\/s00403-023-02640-3","volume":"315","author":"FJ Eckembrecher","year":"2023","unstructured":"Eckembrecher FJ, Eckembrecher DG, Camacho I et al (2023) A review of treatment of port-wine stains with pulsed dye laser in fitzpatrick skin type IV-VI. Arch Dermatol Res 315(9):2505\u20132511","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"4350_CR23","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/lsm.20788","volume":"41","author":"K Minkis","year":"2009","unstructured":"Minkis K, Geronemus RG, Hale EK (2009) Port wine stain progression: a potential consequence of delayed and inadequate treatment? Lasers Surg Med 41(6):423\u2013426","journal-title":"Lasers Surg Med"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-025-04350-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-025-04350-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-025-04350-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:20:31Z","timestamp":1771399231000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-025-04350-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4350"],"URL":"https:\/\/doi.org\/10.1007\/s10103-025-04350-w","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]},"assertion":[{"value":"19 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in accordance with the Declaration of Helsinki and was approved by the Research Ethics committee of Al-Azhar University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written consent was obtained from all participants after being informed about the nature of the study including consent for participation and publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}