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The patients were treated with a fixed orthodontic appliance (FOA). Subjects were randomised into an experimental group (a PBM group irradiated with an LED light source with wavelengths of 625\u00a0nm, 660\u00a0nm and 850\u00a0nm simultaneously and an irradiance of 16 mW\/cm\u00b2) and a placebo control group that received non-therapeutic irradiation with visible light. PBM therapy began within the first 2 days of appliance insertion and was administered twice weekly for 4 weeks. The rate of tooth movement (a change in distance at the same selected point on the occlusal plane of the tooth determined by measurements on 3D models), the presence of gingival hypertrophy (with a free gingival margin of at least 1\u00a0mm occlusal to the enamel-cement junction), the plaque index (PI), the sulcus bleeding index (SBI) and the subjective pain sensation using the visual analogue scale (VAS) were monitored. In the experimental PBM group (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200914), the rate of movement with the FOA was statistically significantly higher at both 1 week of placement (0.5\u00a0mm [95%CI: 0.4\u20130.8]) and 4 weeks (1.1\u00a0mm [95%CI: 0.8\u20131.4]) than in the placebo group (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200918), where the values were (0.4\u00a0mm [95%CI: 0.2\u20130.5]) at 1 week and (0.6\u00a0mm [95%CI: 0.4\u20130.9]) at 4 weeks. A lower incidence of gingival hypertrophy was observed in the PBM group (21.4%) than in the placebo group (55.6%) after 4 weeks (Mann-Whitney U-test,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). PBM with LED accelerated orthodontic tooth movement during the levelling and alignment phase and reduced the incidence of gingival hypertrophy.\n                  <\/jats:p>","DOI":"10.1007\/s10103-025-04444-5","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T23:59:22Z","timestamp":1744934362000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of led photobiomodulation on tooth movement, gingival hypertrophy and pain in response to treatment with fixed orthodontic appliance"],"prefix":"10.1007","volume":"40","author":[{"given":"Anja","family":"Sedej","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nika","family":"Svetina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aljaz","family":"Golez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenija","family":"Cankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Ban Frangez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Frangez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Ovsenik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidija","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"issue":"4","key":"4444_CR1","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.ajodo.2005.12.013","volume":"129","author":"RS Masella","year":"2006","unstructured":"Masella RS, Meister M (2006) Current concepts in the biology of orthodontic tooth movement. 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