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This study evaluates the efficacy and safety of the fractional 1064\u00a0nm Nd:YAG picosecond laser in a Vietnamese cohort, addressing unique challenges posed by Asian skin\u2019s high melanin content. 44 Vietnamese participants treated at the University Medical Center of Ho Chi Minh City for facial skin rejuvenation were retrospectively analyzed. Outcomes were assessed via standardized imaging and patient-reported satisfaction scores, with statistical analyses applied to evaluate changes in skin indices and identify epidemiological correlations. Measurements using the VISIA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    system indicated statistically significant reductions in wrinkles, spots, and texture irregularities starting from the first month of treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and sustained through three months (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Adverse effects were minimal, with transient erythema being the most common (68.18%), and pain levels were generally mild to moderate. Epidemiological analysis revealed that prolonged sun exposure adversely affected UV spot improvement (\n                    <jats:italic>p =<\/jats:italic>\n                    \u2009\u20090.01), while consistent mask-wearing correlated with enhanced outcomes for pigmentation reduction (\n                    <jats:italic>p =<\/jats:italic>\n                    \u2009\u20090.03). This study underscores the fractional 1064\u00a0nm Nd:YAG picosecond laser\u2019s effectiveness as a safe and versatile tool for skin rejuvenation, particularly for Asian populations prone to post-inflammatory hyperpigmentation. Recommendations for consistent photoprotection and addressing environmental factors further optimize results. Future studies should explore long-term outcomes and comparative efficacy with alternative modalities.\n                  <\/jats:p>","DOI":"10.1007\/s10103-025-04453-4","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T21:28:01Z","timestamp":1745357281000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fractional 1064\u00a0nm Nd:YAG picosecond laser for Asian skin rejuvenation: clinical efficacy and the role of photoprotective behaviours"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-758X","authenticated-orcid":false,"given":"Thai Van Thanh","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0514-3135","authenticated-orcid":false,"given":"Phuong Thao","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vi Anh","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc Hung","family":"Ta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3612-9979","authenticated-orcid":false,"given":"Alessandra","family":"Zevini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Barini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"4453_CR1","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1002\/lsm.23382","volume":"53","author":"CSM Wong","year":"2021","unstructured":"Wong CSM, Chan MWM, Shek SYN, Yeung CK, Chan HHL (2021) Fractional 1064 Nm picosecond laser in treatment of melasma and skin rejuvenation in Asians, A prospective study. 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Approval was granted by the Ethics Committee for Basic Biomedical Research, pursuant to Decision No. 3004\/Q\u0110-BV\u0110HYD dated December 23, 2020, issued by the Director of the University Medical Center Ho Chi Minh City.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data and photographs.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"DM, RB, and AZ are employed at El.En. Group. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"209"}}