{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:02:17Z","timestamp":1792350137792,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012990","name":"Universit\u00e0 degli Studi di Siena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012990","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Medical laser hair removal is a common treatment for both aesthetic and pathological conditions, permitting the reduction of dark and thick terminal hairs and increasing the number of vellus hairs. This study aims to present the clinical outcomes and safety of a new approach for hair removal, combining Nd: YAG (1064\u00a0nm), diode (808\u2013810\u00a0nm), and Alexandrite (755\u00a0nm) lasers in a rotational regimen. From January 2022 to December 2023, 60 patients underwent a complete course of hair removal treatment, which included three sessions with Nd: YAG (1064\u00a0nm), diode (808\u2013810\u00a0nm), and Alexandrite (755\u00a0nm) lasers in a rotational regimen. Follow-up visits were conducted three and six months after the last treatment session to assess the results. Across all treated body areas, the hair reduction at six months was 75.07%, with a significant reduction in hair thickness and an increase in vellus hairs. Additionally, the treatment was well-tolerated, with patients reporting only slight discomfort during laser irradiation, reflected by average pain scores of 2\/4. No long-term adverse effects were observed, and transient side effects, such as erythema and perifollicular edema, resolved within days. This new rotational regimen for laser hair removal has proven to be effective, safe, and satisfactory for patients. The tailored approach enhances the treatment\u2019s efficacy and ensures comprehensive targeting of various hair types and colors. This protocol promises a significant advancement in the field of laser hair removal, offering a reliable and patient-friendly solution for long-term hair reduction.<\/jats:p>","DOI":"10.1007\/s10103-025-04592-8","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T04:52:28Z","timestamp":1755579148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medical laser hair removal: a new rotational approach"],"prefix":"10.1007","volume":"40","author":[{"given":"Stefano","family":"Bacchini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Marco","family":"Tomassini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Oddo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cuomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishith","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren Matthew","family":"Rozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Pacifici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"issue":"6","key":"4592_CR1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1080\/14764172.2019.1605449","volume":"21","author":"MM Thomas","year":"2019","unstructured":"Thomas MM, Houreld NN (2019) The in\u2019s and outs of laser hair removal: a mini review. J Cosmet Laser Ther 21(6):316\u2013322","journal-title":"J Cosmet Laser Ther"},{"issue":"5","key":"4592_CR2","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/lsm.1136","volume":"29","author":"GB Altshuler","year":"2001","unstructured":"Altshuler GB et al (2001) Extended theory of selective photothermolysis. Lasers Surg Med 29(5):416\u2013432","journal-title":"Lasers Surg Med"},{"issue":"2","key":"4592_CR3","first-page":"e2021185","volume":"92","author":"R Cuomo","year":"2021","unstructured":"Cuomo R et al (2021) Management of skin damage of health workers\u2019 face: the role of plastic surgery in the time of pandemic. Acta Biomed 92(2):e2021185","journal-title":"Acta Biomed"},{"issue":"1","key":"4592_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/lsm.22185","volume":"46","author":"S Grunewald","year":"2014","unstructured":"Grunewald S et al (2014) Long-term efficacy of linear-scanning 808 nm diode laser for hair removal compared to a scanned alexandrite laser. Lasers Surg Med 46(1):13\u201319","journal-title":"Lasers Surg Med"},{"issue":"3","key":"4592_CR5","first-page":"400","volume":"89","author":"C Brandi","year":"2018","unstructured":"Brandi C et al (2018) Face rejuvenation: a new combinated protocol for biorevitalization. Acta Biomed 89(3):400\u2013405","journal-title":"Acta Biomed"},{"issue":"1","key":"4592_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1046\/j.1365-4362.2003.01744.x","volume":"42","author":"I Galadari","year":"2003","unstructured":"Galadari I (2003) Comparative evaluation of different hair removal lasers in skin types IV, V, and VI. Int J Dermatol 42(1):68\u201370","journal-title":"Int J Dermatol"},{"issue":"1","key":"4592_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5978\/islsm.17-OR-4","volume":"26","author":"T Omi","year":"2017","unstructured":"Omi T (2017) Static and dynamic modes of 810 Nm diode laser hair removal compared: a clinical and histological study. Laser Ther 26(1):31\u201337","journal-title":"Laser Ther"},{"issue":"7","key":"4592_CR8","first-page":"622","volume":"27","author":"C Handrick","year":"2001","unstructured":"Handrick C, Alster TS (2001) Comparison of long-pulsed diode and long-pulsed alexandrite lasers for hair removal: a long-term clinical and histologic study. Dermatol Surg 27(7):622\u2013626","journal-title":"Dermatol Surg"},{"issue":"4","key":"4592_CR9","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1177\/12034754231174852","volume":"27","author":"F Mallat","year":"2023","unstructured":"Mallat F et al (2023) Adverse events of light-assisted hair removal: an updated review. J Cutan Med Surg 27(4):375\u2013387","journal-title":"J Cutan Med Surg"},{"key":"4592_CR10","doi-asserted-by":"publisher","unstructured":"Lim B et al (2023) Using generative artificial intelligence tools in cosmetic surgery: A study on rhinoplasty, facelifts, and blepharoplasty procedures. J Clin Med. https:\/\/doi.org\/10.3390\/jcm12206524","DOI":"10.3390\/jcm12206524"},{"issue":"5","key":"4592_CR11","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1080\/08941939.2021.2008553","volume":"35","author":"G Fasano","year":"2022","unstructured":"Fasano G et al (2022) The regenerative effects of botulinum toxin A: new perspectives. J Invest Surg 35(5):1074\u20131075","journal-title":"J Invest Surg"},{"key":"4592_CR12","doi-asserted-by":"crossref","unstructured":"Rao J, Goldman MP (2005) Prospective, comparative evaluation of three laser systems used individually and in combination for axillary hair removal. Dermatol Surg, 31(12): pp. 1671-6; discussion 1677","DOI":"10.1097\/00042728-200512000-00007"},{"key":"4592_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jpra.2024.03.016","volume":"41","author":"J Han","year":"2024","unstructured":"Han J et al (2024) Treatment of atrophic acne scarring with fractional microplasma radiofrequency: a multicentric experience. JPRAS Open 41:25\u201332","journal-title":"JPRAS Open"},{"issue":"2","key":"4592_CR14","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/jocd.12213","volume":"15","author":"G Nisi","year":"2016","unstructured":"Nisi G et al (2016) Carbon dioxide therapy and hyaluronic acid for cosmetic correction of the nasolabial folds. J Cosmet Dermatol 15(2):169\u2013175","journal-title":"J Cosmet Dermatol"},{"issue":"4","key":"4592_CR15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.5152\/balkanmedj.2012.033","volume":"29","author":"S Karaca","year":"2012","unstructured":"Karaca S, Kacar SD, Ozuguz P (2012) Comparison of SHR mode IPL system with alexandrite and ND: YAG lasers for leg hair reduction. Balkan Med J 29(4):401\u2013405","journal-title":"Balkan Med J"},{"issue":"11","key":"4592_CR16","first-page":"1013","volume":"28","author":"G Moreno-Arias","year":"2002","unstructured":"Moreno-Arias G, Castelo-Branco C, Ferrando J (2002) Paradoxical effect after IPL photoepilation. Dermatol Surg 28(11):1013\u20131016","journal-title":"Dermatol Surg"},{"issue":"4","key":"4592_CR17","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1473-2165.2006.00269.x","volume":"5","author":"MS Lolis","year":"2006","unstructured":"Lolis MS, Marmur ES (2006) Paradoxical effects of hair removal systems: a review. J Cosmet Dermatol 5(4):274\u2013276","journal-title":"J Cosmet Dermatol"},{"issue":"9","key":"4592_CR18","first-page":"893","volume":"16","author":"NJ Youssef","year":"2017","unstructured":"Youssef NJ et al (2017) Long-term comparison of a large spot vacuum assisted handpiece vs the small spot size traditional handpiece of the 800 Nm diode laser. J Drugs Dermatol 16(9):893\u2013898","journal-title":"J Drugs Dermatol"},{"issue":"1","key":"4592_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s10103-007-0515-1","volume":"24","author":"A Sadighha","year":"2009","unstructured":"Sadighha A, Mohaghegh G, Zahed (2009) Meta-analysis of hair removal laser trials. Lasers Med Sci 24(1):21\u201325","journal-title":"Lasers Med Sci"},{"issue":"4","key":"4592_CR20","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3109\/14764172.2011.594057","volume":"13","author":"GS Pai","year":"2011","unstructured":"Pai GS et al (2011) Safety and efficacy of low-fluence, high-repetition rate versus high-fluence, low-repetition rate 810-nm diode laser for permanent hair removal\u2013a split-face comparison study. J Cosmet Laser Ther 13(4):134\u2013137","journal-title":"J Cosmet Laser Ther"},{"issue":"4","key":"4592_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3109\/14764172.2015.1007062","volume":"17","author":"U Paasch","year":"2015","unstructured":"Paasch U, Wagner JA, Paasch HW (2015) Novel 755-nm diode laser vs. conventional 755-nm scanned alexandrite laser: side-by-side comparison pilot study for thorax and axillary hair removal. J Cosmet Laser Ther 17(4):189\u2013193","journal-title":"J Cosmet Laser Ther"},{"issue":"11","key":"4592_CR22","first-page":"1255","volume":"10","author":"MA Nilforoushzadeh","year":"2011","unstructured":"Nilforoushzadeh MA et al (2011) Comparison between sequentional treatment with diode and alexandrite lasers versus alexandrite laser alone in the treatment of hirsutism. J Drugs Dermatol 10(11):1255\u20131259","journal-title":"J Drugs Dermatol"},{"issue":"4","key":"4592_CR23","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/lsm.22226","volume":"46","author":"B Koo","year":"2014","unstructured":"Koo B et al (2014) A comparison of two 810 diode lasers for hair removal: low fluence, multiple pass versus a high fluence, single pass technique. Lasers Surg Med 46(4):270\u2013274","journal-title":"Lasers Surg Med"},{"key":"4592_CR24","doi-asserted-by":"crossref","unstructured":"Khoury JG, Saluja R, Goldman MP (2008) Comparative evaluation of long-pulse alexandrite and long-pulse nd:yag laser systems used individually and in combination for axillary hair removal. Dermatol Surg, 34(5):665\u201370","DOI":"10.1097\/00042728-200805000-00011"},{"issue":"10","key":"4592_CR25","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1007\/s00105-010-2021-9","volume":"61","author":"S Hammes","year":"2010","unstructured":"Hammes S et al (2010) [New approach to photoepilation. Diode laser with SHR (Super hair Removal) compared to alexandrite laser]. Hautarzt 61(10):880\u2013884","journal-title":"Hautarzt"},{"issue":"23","key":"4592_CR26","first-page":"4501","volume":"19","author":"G Nisi","year":"2015","unstructured":"Nisi G et al (2015) Effect of repeated subcutaneous injections of carbon dioxide (CO2) on inflammation linked to hypoxia in adipose tissue graft. Eur Rev Med Pharmacol Sci 19(23):4501\u20134506","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"6","key":"4592_CR27","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1111\/tbj.12659","volume":"22","author":"R Cuomo","year":"2016","unstructured":"Cuomo R et al (2016) Modified arrow flap technique for nipple reconstruction. Breast J 22(6):710\u2013711","journal-title":"Breast J"},{"issue":"6","key":"4592_CR28","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1080\/08941939.2016.1240837","volume":"30","author":"C D\u2019Aniello","year":"2017","unstructured":"D\u2019Aniello C et al (2017) Superior pedicle mammaplasty without parenchymal incisions after massive weight loss. J Invest Surg 30(6):410\u2013420","journal-title":"J Invest Surg"},{"key":"4592_CR29","doi-asserted-by":"crossref","unstructured":"Seth IL, Cevik B, Sofiadellis J, Ross F, Cuomo R, Rozen R (2024) WM, Utilizing GPT-4 and generative artificial intelligence platforms for surgical education: an experimental study on skin ulcers. Eur J Plast Surg 47:19","DOI":"10.1007\/s00238-024-02162-9"},{"key":"4592_CR30","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jpra.2024.01.006","volume":"39","author":"I Seth","year":"2024","unstructured":"Seth I et al (2024) Impact of nutrition on skin wound healing and aesthetic outcomes: a comprehensive narrative review. JPRAS Open 39:291\u2013302","journal-title":"JPRAS Open"},{"key":"4592_CR31","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jpra.2024.03.009","volume":"40","author":"R Phan","year":"2024","unstructured":"Phan R et al (2024) Free hemi-hamate arthroplasty: a review of donor site outcomes. JPRAS Open 40:206\u2013214","journal-title":"JPRAS Open"},{"issue":"13","key":"4592_CR32","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1007\/s00266-024-03952-z","volume":"48","author":"B Lim","year":"2024","unstructured":"Lim B et al (2024) Exploring the unknown: evaluating chatGPT\u2019s performance in uncovering novel aspects of plastic surgery and identifying areas for future innovation. Aesthet Plast Surg 48(13):2580\u20132589","journal-title":"Aesthet Plast Surg"},{"key":"4592_CR33","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.bjps.2024.06.010","volume":"95","author":"B Lim","year":"2024","unstructured":"Lim B et al (2024) Cutaneous amyloidosis mimicking basal cell carcinoma: a case series and literature review. J Plast Reconstr Aesthet Surg 95:340\u2013348","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"11 Suppl","key":"4592_CR34","first-page":"s14","volume":"8","author":"M Braun","year":"2009","unstructured":"Braun M (2009) Permanent laser hair removal with low fluence high repetition rate versus high fluence low repetition rate 810 nm diode laser\u2013a split leg comparison study. J Drugs Dermatol 8(11 Suppl):s14\u2013s17","journal-title":"J Drugs Dermatol"},{"issue":"2","key":"4592_CR35","first-page":"185","volume":"11","author":"EF Bernstein","year":"2012","unstructured":"Bernstein EF, Basilavecchio L, Plugis J (2012) Bilateral axilla hair removal comparing a single wavelength alexandrite laser with combined multiplexed alexandrite and Nd:YAG laser treatment from a single laser platform. J Drugs Dermatol 11(2):185\u2013190","journal-title":"J Drugs Dermatol"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-025-04592-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-025-04592-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-025-04592-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:24:54Z","timestamp":1771399494000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-025-04592-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4592"],"URL":"https:\/\/doi.org\/10.1007\/s10103-025-04592-8","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"11 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"339"}}