{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:24:10Z","timestamp":1772119450650,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Foreign Expert Project of Anhui Provincial Science and Technology Department","award":["S202234017"],"award-info":[{"award-number":["S202234017"]}]},{"name":"Tianjin Health Research Project","award":["TJWJ2024QN026"],"award-info":[{"award-number":["TJWJ2024QN026"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"DOI":"10.1007\/s10103-025-04619-0","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:33:42Z","timestamp":1758501222000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical efficacy of conbercept combined with micropulse laser in patients with polypoidal choroidal vasculopathy"],"prefix":"10.1007","volume":"40","author":[{"given":"Qingyan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"issue":"3","key":"4619_CR1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ophtha.2020.08.006","volume":"128","author":"CMG Cheung","year":"2021","unstructured":"Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK (2021) Polypoidal choroidal vasculopathy: consensus nomenclature and Non-Indocyanine green angiograph diagnostic criteria from the Asia-Pacific ocular imaging society PCV workgroup. Ophthalmology 128(3):443\u2013452. https:\/\/doi.org\/10.1016\/j.ophtha.2020.08.006Epub 2020 Aug 11","journal-title":"Ophthalmology"},{"issue":"4","key":"4619_CR2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.oret.2019.10.019","volume":"4","author":"BJ Fenner","year":"2020","unstructured":"Fenner BJ, Ting DSW, Tan ACS, Teo K, Chan CM, Mathur R, Yeo IYS, Wong TY, Wong EYM, Cheung CMG (2020) Real-world treatment outcomes of age-related macular degeneration and polypoidal choroidal vasculopathy in Asians. Ophthalmol Retina 4(4):403\u2013414. https:\/\/doi.org\/10.1016\/j.oret.2019.10.019","journal-title":"Ophthalmol Retina"},{"issue":"5","key":"4619_CR3","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3390\/jcm4050782","volume":"4","author":"CW Wong","year":"2015","unstructured":"Wong CW, Wong TY, Cheung CM (2015) Polypoidal choroidal vasculopathy in Asians. J Clin Med 4(5):782\u2013821. https:\/\/doi.org\/10.3390\/jcm4050782","journal-title":"J Clin Med"},{"issue":"2","key":"4619_CR4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1097\/IAE.0000000000003666","volume":"43","author":"KYC Teo","year":"2023","unstructured":"Teo KYC, Vyas C, Sun C, Cheong KX, Chakravarthy U, FIVE-YEAR INCIDENCE OF FELLOW, EYE NEOVASCULAR INVOLVEMENT IN AGE-RELATED MACULAR DEGENERATION AND POLYPOIDAL CHOROIDAL VASCULOPATHY IN AN ASIAN POPULATION (2023) Retina 43(2):294\u2013302. https:\/\/doi.org\/10.1097\/IAE.0000000000003666","journal-title":"Retina"},{"issue":"11","key":"4619_CR5","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.ophtha.2014.06.016","volume":"121","author":"Y Li","year":"2014","unstructured":"Li Y, You QS, Wei WB, Xu J, Chen CX, Wang YX, Xu L, Jonas JB (2014) Polypoidal choroidal vasculopathy in adult Chinese: the Beijing eye study. Ophthalmology 121(11):2290\u20132291. https:\/\/doi.org\/10.1016\/j.ophtha.2014.06.016. (Epub 2014 Aug 8)","journal-title":"Ophthalmology"},{"key":"4619_CR6","unstructured":"Chawla H, Blair K, Vohra V, Polypoidal Choroidal V (2023) Mar 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan&#8211"},{"issue":"1","key":"4619_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010274","volume":"12","author":"B Sabal","year":"2022","unstructured":"Sabal B, Teper S, Wyl\u0119ga\u0142a E (2022) Subthreshold micropulse laser for diabetic macular edema: a review. J Clin Med 12(1):274. https:\/\/doi.org\/10.3390\/jcm12010274","journal-title":"J Clin Med"},{"issue":"7","key":"4619_CR8","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1007\/s12325-017-0559-y","volume":"34","author":"P Scholz","year":"2017","unstructured":"Scholz P, Altay L, Fauser S (2017) A review of subthreshold micropulse laser for treatment of macular disorders. Adv Ther 34(7):1528\u20131555. https:\/\/doi.org\/10.1007\/s12325-017-0559-yEpub 2017 May 24","journal-title":"Adv Ther"},{"issue":"1","key":"4619_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12886-022-02331-z","volume":"22","author":"M Zeng","year":"2022","unstructured":"Zeng M, Chen X, Song Y, Cai C (2022) Subthreshold micropulse laser photocoagulation versus half-dose photodynamic therapy for acute central serous chorioretinopathy. BMC Ophthalmol 22(1):110. https:\/\/doi.org\/10.1186\/s12886-022-02331-z","journal-title":"BMC Ophthalmol"},{"issue":"6","key":"4619_CR10","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/s41573-023-00671-z","volume":"22","author":"Y Cao","year":"2023","unstructured":"Cao Y, Langer R, Ferrara N (2023) Targeting angiogenesis in oncology, ophthalmology and beyond. Nat Rev Drug Discov 22(6):476\u2013495. https:\/\/doi.org\/10.1038\/s41573-023-00671-zEpub 2023 Apr 11","journal-title":"Nat Rev Drug Discov"},{"key":"4619_CR11","doi-asserted-by":"publisher","first-page":"44687","DOI":"10.1038\/srep44687","volume":"7","author":"SL Park","year":"2017","unstructured":"Park SL, Chung TW, Kim S, Hwang B, Kim JM, Lee HM, Cha HJ, Seo Y, Choe SY, Ha KT, Kim G, Yun SJ, Park SS, Choi YH, Kim BK, Kim WT, Cha EJ, Patterson C, Kim WJ, Moon SK (2017) HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway. Sci Rep 7:44687. https:\/\/doi.org\/10.1038\/srep44687","journal-title":"Sci Rep"},{"issue":"21","key":"4619_CR12","doi-asserted-by":"publisher","first-page":"14542","DOI":"10.1074\/jbc.M802139200","volume":"283","author":"J Niu","year":"2008","unstructured":"Niu J, Azfer A, Zhelyabovska O, Fatma S, Kolattukudy PE (2008) Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). J Biol Chem 283(21):14542\u201314551. https:\/\/doi.org\/10.1074\/jbc.M802139200","journal-title":"J Biol Chem"},{"issue":"3","key":"4619_CR13","doi-asserted-by":"publisher","first-page":"H1043","DOI":"10.1152\/ajpheart.01018.2010","volume":"301","author":"CK Buharalioglu","year":"2011","unstructured":"Buharalioglu CK, Song CY, Yaghini FA, Ghafoor HU, Motiwala M, Adris T, Estes AM, Malik KU (2011) Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylation. Am J Physiol Heart Circ Physiol 301(3):H1043\u2013H1055. https:\/\/doi.org\/10.1152\/ajpheart.01018.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"4619_CR14","doi-asserted-by":"publisher","first-page":"11997","DOI":"10.1038\/s41598-024-62536-8","volume":"14","author":"H Xie","year":"2024","unstructured":"Xie H, Ju H, Lu J, Wang X, Peng H (2024) Comparative study on the efficacy of conbercept and aflibercept in the treatment of neovascular age-related macular degeneration. Sci Rep 14(1):11997. https:\/\/doi.org\/10.1038\/s41598-024-62536-8","journal-title":"Sci Rep"},{"issue":"5","key":"4619_CR15","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1097\/IAE.0000000000000875","volume":"36","author":"J Qu","year":"2016","unstructured":"Qu J, Cheng Y, Li X, Yu L, Ke X, AURORA Study Group (2016) Efficacy of intravitreal injection of conbercept in polypoidal choroidal vasculopathy. Retina 36(5):926\u2013937. https:\/\/doi.org\/10.1097\/IAE.0000000000000875","journal-title":"Retina"},{"issue":"5","key":"4619_CR16","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.oret.2023.10.024","volume":"8","author":"ME Brelen","year":"2024","unstructured":"Brelen ME, Ho M, Li S, Ng DSC, Yip YWY, Lee WS, Chen LJ, Young AL, Tham CC, Pang CP (2024) Comparing half-dose photodynamic therapy with subthreshold micropulse laser for the treatment of central serous chorioretinopathy. Ophthalmol Retina 8(5):490\u2013498. https:\/\/doi.org\/10.1016\/j.oret.2023.10.024","journal-title":"Ophthalmol Retina"},{"issue":"1","key":"4619_CR17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ophtha.2022.08.012","volume":"130","author":"N Lois","year":"2023","unstructured":"Lois N, Campbell C, Waugh N, Azuara-Blanco A, Maredza M, Mistry H, McAuley D, Acharya N, Aslam TM, Bailey C, Chong V, Downey L, Eleftheriadis H, Fatum S, George S, Ghanchi F, Groppe M, Hamilton R, Menon G, Saad A, Sivaprasad S, Shiew M, Steel DH, Talks JS, Doherty P, McDowell C, Clarke M, DIAMONDS Study Group (2023) Diabetic macular edema and diode subthreshold micropulse laser: A randomized Double-Masked noninferiority clinical trial. Ophthalmology 130(1):14\u201327. https:\/\/doi.org\/10.1016\/j.ophtha.2022.08.012Epub 2022 Aug 13","journal-title":"Ophthalmology"},{"issue":"1","key":"4619_CR18","doi-asserted-by":"publisher","first-page":"10034","DOI":"10.1038\/s41598-019-46515-y","volume":"9","author":"E Midena","year":"2019","unstructured":"Midena E, Micera A, Frizziero L, Pilotto E, Esposito G, Bini S (2019) Sub-threshold micropulse laser treatment reduces inflammatory biomarkers in aqueous humour of diabetic patients with macular edema. Sci Rep 9(1):10034. https:\/\/doi.org\/10.1038\/s41598-019-46515-y","journal-title":"Sci Rep"},{"issue":"1","key":"4619_CR19","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/IAE.0000000000002356","volume":"40","author":"E Midena","year":"2020","unstructured":"Midena E, Bini S, Martini F, Enrica C, Pilotto E, Micera A, Esposito G, Vujosevic S, CHANGES OF AQUEOUS HUMOR M\u00dcLLER CELLS\u2019 BIOMARKERS IN HUMAN PATIENTS AFFECTED BY DIABETIC MACULAR EDEMA AFTER SUBTHRESHOLD MICROPULSE LASER TREATMENT (2020) Retina 40(1):126\u2013134. https:\/\/doi.org\/10.1097\/IAE.0000000000002356","journal-title":"Retina"},{"key":"4619_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.preteyeres.2016.03.001","volume":"52","author":"N Piri","year":"2016","unstructured":"Piri N, Kwong JM, Gu L, Caprioli J (2016) Heat shock proteins in the retina: focus on HSP70 and alpha crystallins in ganglion cell survival. Prog Retin Eye Res 52:22\u201346. https:\/\/doi.org\/10.1016\/j.preteyeres.2016.03.001","journal-title":"Prog Retin Eye Res"},{"key":"4619_CR21","doi-asserted-by":"crossref","unstructured":"Sivaprasad S, Elagouz M, McHugh D, Shona O, Dorin G (2010 Nov-Dec) Micropulsed diode laser therapy: evolution and clinical applications. Surv Ophthalmol 55(6):516\u2013530 Epub 2010 Sep 20. PMID: 20850854","DOI":"10.1016\/j.survophthal.2010.02.005"},{"issue":"3","key":"4619_CR22","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1007\/s40123-023-00698-w","volume":"12","author":"C Iovino","year":"2023","unstructured":"Iovino C, Iodice CM, Pisani D, Rosolia A, Testa F, Giannaccare G, Chhablani J, Simonelli F (2023) Yellow subthreshold micropulse laser in retinal diseases: an in-depth analysis and review of the literature. Ophthalmol Ther 12(3):1479\u20131500. https:\/\/doi.org\/10.1007\/s40123-023-00698-w. (Epub 2023 Mar 18. PMID: 36933125; PMCID: PMC10164197)","journal-title":"Ophthalmol Ther"},{"issue":"2","key":"4619_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020242","volume":"8","author":"M Gaw\u0119cki","year":"2019","unstructured":"Gaw\u0119cki M (2019) Micropulse laser treatment of retinal diseases. J Clin Med 8(2):242. https:\/\/doi.org\/10.3390\/jcm8020242","journal-title":"J Clin Med"},{"issue":"1","key":"4619_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s13643-021-01864-6","volume":"10","author":"AC Tricco","year":"2021","unstructured":"Tricco AC, Thomas SM, Lillie E, Veroniki AA, Hamid JS, Pham B, Lee T, Agarwal A, Sharpe JP, Scott A, Warren R, Brahmbhatt R, Macdonald E, Janoudi G, Muni RH, Francisconi CLM, Richter T, Straus SE (2021) Anti-vascular endothelial growth factor therapy for age-related macular degeneration: a systematic review and network meta-analysis. Syst Rev 10(1):315. https:\/\/doi.org\/10.1186\/s13643-021-01864-6","journal-title":"Syst Rev"},{"issue":"9","key":"4619_CR25","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.ophtha.2023.04.014","volume":"130","author":"PH Gabrielle","year":"2023","unstructured":"Gabrielle PH, Delyfer MN, Glacet-Bernard A, Conart JB, Uzzan J, Kodjikian L, Arndt C, Tadayoni R, Soudry-Faure A, Creuzot Garcher CP, Surgery (2023) Tissue plasminogen activator, antiangiogenic agents, and Age-Related macular degeneration study: A randomized controlled trial for submacular hemorrhage secondary to Age-Related macular degeneration. Ophthalmology 130(9):947\u2013957. https:\/\/doi.org\/10.1016\/j.ophtha.2023.04.014Epub 2023 Apr 22","journal-title":"Ophthalmology"},{"issue":"10447","key":"4619_CR26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0140-6736(24)00687-1","volume":"404","author":"TL Jackson","year":"2024","unstructured":"Jackson TL, Desai R, Wafa HA, Wang Y, Peacock J, Peto T, Chakravarthy U, Dakin H, Wordsworth S, Lewis C, Clinch P, Ramazzotto L, Neffendorf JE, Lee CN, O\u2019Sullivan JM, Reeves BC (2024) STAR study group. Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial. Lancet 404(10447):44\u201354. https:\/\/doi.org\/10.1016\/S0140-6736(24)00687-1","journal-title":"Lancet"},{"key":"4619_CR27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000365487","volume":"53","author":"Y Sakurada","year":"2015","unstructured":"Sakurada Y, Nakamura Y, Yoneyama S, Mabuchi F, Gotoh T, Tateno Y, Sugiyama A, Kubota T, Iijima H (2015) Aqueous humor cytokine levels in patients with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. Ophthalmic Res 53:2\u20137","journal-title":"Ophthalmic Res"},{"key":"4619_CR28","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1167\/iovs.18-24387","volume":"60","author":"R Agrawal","year":"2019","unstructured":"Agrawal R, Balne PK, Wei X, Bijin VA, Lee B, Ghosh A, Narayanan R, Agrawal M, Connolly J (2019) Cytokine profiling in patients with exudative age-related macular degeneration and polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci 60:376\u2013382","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4619_CR29","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.1167\/iovs.11-7913","volume":"53","author":"S Sasaki","year":"2012","unstructured":"Sasaki S, Miyazaki D, Miyake K, Terasaka Y, Kaneda S, Ikeda Y, Funakoshi T, Baba T, Yamasaki A, Inoue Y (2012) Associations of IL-23 with polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci 53:3424\u20133430","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4619_CR30","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.ophtha.2006.12.021","volume":"114","author":"M Kikuchi","year":"2007","unstructured":"Kikuchi M, Nakamura M, Ishikawa K, Suzuki T, Nishihara H, Yamakoshi T, Nishio K, Taki K, Niwa T, Hamajima N, Terasaki H (2007) Elevated C-reactive protein levels in patients with polypoidal choroidal vasculopathy and patients with neovascular age-related macular degeneration. Ophthalmology 114:1722\u20131727","journal-title":"Ophthalmology"},{"key":"4619_CR31","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012464","volume":"97","author":"K Zhang","year":"2018","unstructured":"Zhang K, Chen Y, Sun X, Zhong Q, Lin L, Gao Y, Hong F (2018) Periocular triamcinolone acetonide injection for treating polypoidal choroidal vasculopathy concurrent with hemorrhagic retinal detachment. Medicine (Baltimore) 97:e12464","journal-title":"Medicine (Baltimore)"},{"key":"4619_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2147\/OPTH.S385827","volume":"17","author":"P Sen","year":"2023","unstructured":"Sen P, Manayath G, Shroff D, Salloju V, Dhar P (2023) Polypoidal choroidal vasculopathy: an update on diagnosis and treatment. Clin Ophthalmol 17:53\u201370. https:\/\/doi.org\/10.2147\/OPTH.S385827","journal-title":"Clin Ophthalmol"},{"key":"4619_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100865","volume":"79","author":"R Kaye","year":"2020","unstructured":"Kaye R, Chandra S, Sheth J, Boon CJF, Sivaprasad S, Lotery A (2020) Central serous chorioretinopathy: an update on risk factors, pathophysiology and imaging modalities. Prog Retin Eye Res 79:100865. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100865","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"4619_CR34","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41421-023-00588-2","volume":"9","author":"X Zhu","year":"2023","unstructured":"Zhu X, Meng J, Han C, Wu Q, Du Y, Qi J, Wei L, Li H, He W, Zhang K, Lu Y (2023) Ccl2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. Cell Discov 9(1):94. https:\/\/doi.org\/10.1038\/s41421-023-00588-2","journal-title":"Cell Discov"},{"issue":"21","key":"4619_CR35","doi-asserted-by":"publisher","first-page":"15680","DOI":"10.3390\/ijms242115680","volume":"24","author":"D Deliyanti","year":"2023","unstructured":"Deliyanti D, Suphapimol V, Ang P, Tang X, Jayasimhan A, Wilkinson-Berka JL (2023) Early depletion of neutrophils reduces retinal inflammation and neovascularization in mice with Oxygen-Induced retinopathy. Int J Mol Sci 24(21):15680. https:\/\/doi.org\/10.3390\/ijms242115680","journal-title":"Int J Mol Sci"},{"issue":"12","key":"4619_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1479","volume":"12","author":"LB Ferreira","year":"2023","unstructured":"Ferreira LB, Williams KA, Best G, Haydinger CD, Smith JR (2023) Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non-infectious uveitis. Clin Transl Immunol 12(12):e1479. https:\/\/doi.org\/10.1002\/cti2.1479","journal-title":"Clin Transl Immunol"},{"issue":"9","key":"4619_CR37","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1097\/IAE.0000000000000157","volume":"34","author":"T Agawa","year":"2014","unstructured":"Agawa T, Usui Y, Wakabayashi Y, Okunuki Y, Juan M, Umazume K, Kezuka T, Takeuchi M, Yamauchi Y, Goto H (2014) Profile of intraocular immune mediators in patients with age-related macular degeneration and the effect of intravitreal bevacizumab injection. Retina 34(9):1811\u20131818. https:\/\/doi.org\/10.1097\/IAE.0000000000000157","journal-title":"Retina"},{"issue":"1","key":"4619_CR38","doi-asserted-by":"publisher","first-page":"e0147346","DOI":"10.1371\/journal.pone.0147346","volume":"11","author":"J Hu","year":"2016","unstructured":"Hu J, Leng X, Hu Y, Atik A, Song X, Li Z, Liu Y, Lu L (2016) The features of inflammation factors concentrations in aqueous humor of polypoidal choroidal vasculopathy. PLoS ONE 11(1):e0147346. https:\/\/doi.org\/10.1371\/journal.pone.0147346","journal-title":"PLoS ONE"},{"issue":"4","key":"4619_CR39","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/bjophthalmol-2017-310284","volume":"102","author":"S Sakamoto","year":"2018","unstructured":"Sakamoto S, Takahashi H, Tan X, Inoue Y, Nomura Y, Arai Y, Fujino Y, Kawashima H, Yanagi Y (2018) Changes in multiple cytokine concentrations in the aqueous humour of neovascular age-related macular degeneration after 2 months of Ranibizumab therapy. Br J Ophthalmol 102(4):448\u2013454. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-310284Epub 2017 Aug 1","journal-title":"Br J Ophthalmol"},{"issue":"13","key":"4619_CR40","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1167\/iovs.61.13.39","volume":"61","author":"Y Kato","year":"2020","unstructured":"Kato Y, Oguchi Y, Omori T, Shintake H, Tomita R, Kasai A, Ogasawara M, Sugano Y, Itagaki K, Ojima A, Machida T, Sekine H, Sekiryu T (2020) Complement activation products and cytokines in pachychoroid neovasculopathy and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 61(13):39. https:\/\/doi.org\/10.1167\/iovs.61.13.39","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4619_CR41","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6958752","volume":"2016","author":"Q Long","year":"2016","unstructured":"Long Q, Cao X, Bian A, Li Y (2016) C3a increases VEGF and decreases PEDF mRNA levels in human retinal pigment epithelial cells. BioMed Res Int 2016:6958752. https:\/\/doi.org\/10.1155\/2016\/6958752","journal-title":"BioMed Res Int"},{"issue":"10","key":"4619_CR42","first-page":"7147","volume":"14","author":"T Sun","year":"2022","unstructured":"Sun T, Bai J, Wang M, Liu L, Peng Q (2022) Cytokine profiling in patients with polypoidal choroidal vasculopathy before and after intravitreal injection of Ranibizumab. Am J Transl Res 14(10):7147\u20137155","journal-title":"Am J Transl Res"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-025-04619-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-025-04619-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-025-04619-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:24:35Z","timestamp":1771399475000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-025-04619-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4619"],"URL":"https:\/\/doi.org\/10.1007\/s10103-025-04619-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5290451\/v1","asserted-by":"object"}]},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,22]]},"assertion":[{"value":"18 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants were fully briefed on the potential risks and complications associated with the study procedures. Each participant expressed their understanding of these aspects and provided their informed consent by signing the consent form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Anhui NO.2\u00a0Provincial People\u2019s hospital ((R)2022-012).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Statement"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"378"}}