{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:46:43Z","timestamp":1793746003273,"version":"4.6.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"PT. Taisho Pharmaceutical Indonesia, Tbk (EzerraTM)."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Until now, fractional CO2 laser has been the gold standard for photodamage skin treatment. Topical therapy modalities can accelerate the wound healing process and influence the treatment results. However, no standardized topical therapy exists for subjects after fractional CO2 laser procedures.\u00a0This research aims to determine the efficacy and safety of a cream combination of Stimu-tex AS\u2122 (Spent Grain Wax, Argania Spinosa Kernel Oil, Butyrospermum Parkii (Shea Butter Extract) and Saccharide Isomerate after fractional CO2 laser treatment.\u00a0A split-face, double-blinded, and randomized study was conducted in 2021 with 20 subjects, each given two types of creams, A and B, following fractional CO2 laser procedure. Subjects will apply cream A and cream B to each side of the face according to the randomization results. One of the creams was a moisturizing combination cream with a combination of Stimu-tex AS\u2122 (Spent Grain Wax, Argania Spinosa Kernel Oil, Butyrospermum Parkii (Shea Butter Extract), and Saccharide Isomerate. Meanwhile, another cream was a placebo. The outcome assessment of this research was carried out subjectively and objectively. The subjective assessment was evaluated using the visual analogue scale (VAS). In contrast, the objective assessment evaluated the degree of erythema using the clinical erythema assessment score (CEA), dermoscopic examination, transepidermal water loss (TEWL) examination with TEWAmeter, and skin capacitance (SCap) with corneometer. This assessment was carried out before the laser procedure, 15\u00a0min, on the third day, and\n                    <jats:sup>h<\/jats:sup>\n                    the seventh day after the laser procedure.\u00a0There are 20 subjects recruited into the study, with a split face method, resulting in 40 sample sizes. Significant differences between the experimental and placebo groups were obtained in the assessing of the CEA scale on the third day after the procedure. Meanwhile, on the seventh day after the procedure, significant results were obtained on the TEWL examination with TEWAmeter, SCap with Corneometer, and the degree of erythema using the CEA score. Apart from that, each group had no complaints about adverse events or serious adverse events (SAEs).\u00a0The combination cream provides good results after the fractional CO2 laser procedure, by reducing the degree of erythema, increasing SCap, and reducing TEWL. Furthermore, this combination cream is safe to use because there were no reports of SAEs.\n                  <\/jats:p>","DOI":"10.1007\/s10103-025-04703-5","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T03:10:21Z","timestamp":1761275421000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of combination cream of stimu-tex AS\u2122 (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-6716","authenticated-orcid":false,"given":"Irma Bernadette S.","family":"Sitohang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Arimuko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8578-5834","authenticated-orcid":false,"given":"Lilik","family":"Norawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyntia","family":"Yulyana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy Satria","family":"Nugraha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vashty","family":"Amanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsy","family":"Indrafatina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inasa","family":"Amalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"2","key":"4703_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3889\/oamjms.2016.062","volume":"4","author":"A Petrov","year":"2016","unstructured":"Petrov A (2016) Efficiency of carbon dioxide fractional laser in skin resurfacing. 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Written informed consent was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"453"}}