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The Bioptron group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930) received BLT for 10\u00a0min, twice weekly, along with an educational program for four weeks. The control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930) received the same educational program only. Outcomes were measured using Schirmer\u2019s test (Schirmer I) for basal tear secretion, Tear Break-Up Time (TBUT) for tear film stability, and the Dry Eye-related Quality of Life Score (DEQS) for quality of life (QOL).\u00a0Both groups exhibited significant improvements post-treatment compared to pre-treatment in all variables, with greater percentage changes from baseline in the BLT group. Between-group comparisons revealed significantly higher improvements in the BLT group: Schirmer\u2019s test (Schirmer I) improved by MD\u2009=\u20098.7 (95% CI: 7.64\u20139.76;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), TBUT by MD\u2009=\u20092.97 (95% CI: 1.7\u20134.3;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007), and DEQS decreased by MD\u2009=\u2009\u2212\u200924.1 (95% CI: \u221237 to \u2212\u200917.1;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Compared with standardized education alone, adjunctive Bioptron light therapy significantly enhanced tear secretion, tear film stability, and patient-reported symptoms, suggesting its potential as an effective non-pharmacological option for managing dry eye in postmenopausal women. The trial was registered at Clinical Trials.gov (Identifier: NCT05964673)\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04807-6","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T01:51:43Z","timestamp":1770169903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled trial"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-9616","authenticated-orcid":false,"given":"Ehab","family":"Mohamed Elsayed Saad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Magdy Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Mohamed Yousef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Shahat Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"3","key":"4807_CR1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/13697137.2020.1849087","volume":"24","author":"P Garcia-Alfaro","year":"2021","unstructured":"Garcia-Alfaro P, Garcia S, Rodriguez I, Verg\u00e9s C (2021) Dry eye disease symptoms and quality of life in perimenopausal and postmenopausal women. 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Researchers registered the study at ClinicalTrials.gov (Identifier: NCT05964673) and conducted interventions from May to July 2023. The study adhered to institutional research committee ethical standards, the Helsinki Declaration of 1964, and its subsequent updates or similar ethical principles. All participants provided their informed consent before enrollment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"NCT05964673.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}}],"article-number":"20"}}