{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:28:37Z","timestamp":1786980517047,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universidade Federal Dos Vales Do Jequitinhonha E Mucuri"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inflammation is a complex biological response that, when uncontrolled, contributes to the development and worsening of several pathological conditions. Identifying safe and effective anti-inflammatory strategies remains an important therapeutic challenge. In this context, medicinal plants and photobiomodulation therapy (PBM) have emerged as promising approaches due to their immunomodulatory potential.\u00a0This study aimed to investigate the anti-inflammatory properties of the aqueous extract from\n                    <jats:italic>Desmodium heterophyllum<\/jats:italic>\n                    (AEDh), alone and in combination with PBM, using a carrageenan-induced paw edema model.\u00a0AEDh was obtained, chemically characterized through high-resolution mass spectrometry, and evaluated for cytotoxicity and nitric oxide (NO) production in J774A.1 and RAW 264.7 macrophages. In vivo anti-inflammatory activity was assessed in BALB\/c mice subjected to carrageenan-induced paw edema and treated with AEDh (50\u2013250\u00a0mg\/kg), PBM (780\u00a0nm, 70 mW, 35\u00a0J\/cm\u00b2), or their combination. Paw thickness was measured for up to 4\u00a0h post-induction, and cytokine levels (IL-1\u03b2, IL-6, TNF, IFN-\u03b3) were quantified by enzyme-linked immunosorbent assay (ELISA).\u00a0AEDh showed no cytotoxicity at the concentrations tested and significantly reduced NO production in vitro. In vivo, both AEDh and PBM reduced paw edema, with the combined treatment\u2014especially AEDh at 250 mg\/kg\u2014producing a more pronounced effect, comparable to dexamethasone. The combination also markedly reduced pro-inflammatory cytokines, particularly IL-1\u03b2 and IL-6, supporting a synergistic action.\u00a0AEDh demonstrated relevant anti-inflammatory and immunomodulatory activity, which was further enhanced when combined with PBM. These findings highlight the therapeutic potential of integrating herbal medicine and photobiomodulation as a safe and effective strategy for managing inflammatory conditions. Keywords: Desmodium heterophyllum; Photobiomodulation; Cytokines; Synergistic effect; Low-level laser therapy.\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04822-7","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:03:49Z","timestamp":1771657429000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic anti-inflammatory effects of the aqueous extract from Desmodium heterophyllum and photobiomodulation in a carrageenan-induced paw edema model"],"prefix":"10.1007","volume":"41","author":[{"given":"T\u00e1ssio Malber","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-3536","authenticated-orcid":false,"given":"Diego Mendes","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-7491","authenticated-orcid":false,"given":"Gracim\u00e9rio","family":"Jos\u00e9 Guarneire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerilson Marques","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Maria","family":"Abr\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Gustavo Vilela","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendha Sena","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-0919","authenticated-orcid":false,"given":"Sandra Bertelli Ribeiro","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-8527","authenticated-orcid":false,"given":"Caio C\u00e9sar de Souza","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-8947","authenticated-orcid":false,"given":"Alessandra de Paula","family":"Carli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-4910","authenticated-orcid":false,"given":"Murilo Xavier","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"4822_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456","volume":"3","author":"KL Rock","year":"2008","unstructured":"Rock KL, Kono H (2008) The inflammatory response to cell death. Annu Rev Pathol 3:99\u2013126","journal-title":"Annu Rev Pathol"},{"key":"4822_CR2","doi-asserted-by":"crossref","unstructured":"Chaplin DD (2010) Overview of the immune response. J Allergy Clin Immunol 125(2 Suppl 2):S3\u201323. Available from: https:\/\/www.jacionline.org\/article\/S0091-6749(09)02837-1\/fulltext","DOI":"10.1016\/j.jaci.2009.12.980"},{"issue":"18","key":"4822_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184367","volume":"20","author":"KR Patil","year":"2019","unstructured":"Patil KR, Mahajan UB, Unger BS, Goyal SN, Belemkar S, Surana SJ et al (2019) Animal models of inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals. Int J Mol Sci 20(18):4367. https:\/\/doi.org\/10.3390\/ijms20184367","journal-title":"Int J Mol Sci"},{"key":"4822_CR4","doi-asserted-by":"publisher","first-page":"112292","DOI":"10.1016\/j.intimp.2024.112292","volume":"135","author":"AB Mart\u00ednez-Rizo","year":"2024","unstructured":"Mart\u00ednez-Rizo AB, Fosado-Rodr\u00edguez R, Torres-Romero JC, Lara-Riegos JC, Ram\u00edrez-Camacho MA, Arroyo Herrera LA et al (2024) Models in vivo and in vitro for the study of acute and chronic inflammatory activity: a comprehensive review. Int Immunopharmacol 135:112292. https:\/\/doi.org\/10.1016\/j.intimp.2024.112292","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"4822_CR5","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3390\/ph3051614","volume":"3","author":"T Mizushima","year":"2010","unstructured":"Mizushima T (2010) Molecular mechanism for various pharmacological activities of NSAIDs. Pharmaceuticals (Basel) 3(5):1614\u20131636. https:\/\/doi.org\/10.3390\/ph3051614","journal-title":"Pharmaceuticals (Basel)"},{"issue":"Suppl 2","key":"4822_CR6","doi-asserted-by":"publisher","first-page":"S78","DOI":"10.1007\/s000110050284","volume":"47","author":"JR Vane","year":"1998","unstructured":"Vane JR, Botting RM (1998) Anti-inflammatory drugs and their mechanism of action. Inflamm Res 47(Suppl 2):S78\u201387. https:\/\/doi.org\/10.1007\/s000110050284","journal-title":"Inflamm Res"},{"issue":"6","key":"4822_CR7","doi-asserted-by":"publisher","first-page":"385","DOI":"10.5001\/omj.2011.101","volume":"26","author":"A Al-Saeed","year":"2011","unstructured":"Al-Saeed A (2011) Gastrointestinal and cardiovascular risk of nonsteroidal anti-inflammatory drugs. Oman Med J 26(6):385\u2013391. https:\/\/doi.org\/10.5001\/omj.2011.101","journal-title":"Oman Med J"},{"key":"4822_CR8","doi-asserted-by":"crossref","unstructured":"World Health Organization (2008) Herbal medicine research and global health: an ethical analysis. Bull World Health Organ 86(8):577\u2013656. Available from: http:\/\/www.who.int\/bulletin\/volumes\/86\/8\/07-042820.pdf","DOI":"10.2471\/BLT.08.056366"},{"issue":"6","key":"4822_CR9","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s12272-013-0216-4","volume":"37","author":"W Li","year":"2014","unstructured":"Li W, Sun YN, Yan XT, Yang SY, Kim S, Chae D et al (2014) Anti-inflammatory and antioxidant activities of phenolic compounds from desmodium caudatum leaves and stems. Arch Pharm Res 37(6):721\u2013727. https:\/\/doi.org\/10.1007\/s12272-013-0216-4","journal-title":"Arch Pharm Res"},{"issue":"4","key":"4822_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3109\/13880209.2010.520346","volume":"49","author":"KJ Ma","year":"2011","unstructured":"Ma KJ, Zhu ZZ, Yu CH, Zhang H, Liu J, Qin LP (2011) Analgesic, anti-inflammatory, and antipyretic activities of the ethanol extract from desmodium caudatum. Pharm Biol 49(4):403\u2013407. https:\/\/doi.org\/10.3109\/13880209.2010.520346","journal-title":"Pharm Biol"},{"key":"4822_CR11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.indcrop.2016.06.012","volume":"90","author":"J Guo","year":"2016","unstructured":"Guo J, Feng X, Zhou S, Yan WX, Meng D (2016) Potential anti-Alzheimer\u2019s disease activities of the roots of Desmodium caudatum. Ind Crops Prod 90:94\u20139. https:\/\/doi.org\/10.1016\/j.indcrop.2016.06.012","journal-title":"Ind Crops Prod"},{"issue":"6","key":"4822_CR12","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1093\/asj\/sjab025","volume":"41","author":"GE Glass","year":"2022","unstructured":"Glass GE (2022) Photobiomodulation: the clinical applications of low-level light therapy. Aesthet Surg J 41(6):723\u201338. https:\/\/doi.org\/10.1093\/asj\/sjab025","journal-title":"Aesthet Surg J"},{"issue":"1","key":"4822_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.12788\/j.sder.0023","volume":"32","author":"P Avci","year":"2013","unstructured":"Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N et al (2013) Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg 32(1):41\u201352. https:\/\/doi.org\/10.12788\/j.sder.0023","journal-title":"Semin Cutan Med Surg"},{"issue":"5","key":"4822_CR14","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.bjps.2020.12.059","volume":"74","author":"GE Glass","year":"2021","unstructured":"Glass GE (2021) Photobiomodulation: a review of the molecular evidence for low level light therapy. J Plast Reconstr Aesthet Surg 74(5):1050\u201360. https:\/\/doi.org\/10.1016\/j.bjps.2020.12.059","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"8","key":"4822_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084483","volume":"25","author":"ML Hern\u00e1ndez-Bule","year":"2024","unstructured":"Hern\u00e1ndez-Bule ML, Naharro-Rodr\u00edguez J, Bacci S, Fern\u00e1ndez-Guarino M (2024) Unlocking the power of light on the skin: a comprehensive review on photobiomodulation. Int J Mol Sci 25(8):4483. https:\/\/doi.org\/10.3390\/ijms25084483","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4822_CR16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1089\/pho.2009.2487","volume":"28","author":"AC Renno","year":"2010","unstructured":"Renno AC, McDonnell PA, Crovace MC, Zanotto ED, Laakso L (2010) Effect of 830 Nm laser phototherapy on osteoblasts grown in vitro on biosilicate scaffolds. Photomed Laser Surg 28(1):131\u2013133. https:\/\/doi.org\/10.1089\/pho.2009.2487","journal-title":"Photomed Laser Surg"},{"issue":"1","key":"4822_CR17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1590\/S0102-33062013000100007","volume":"27","author":"F Borghetti","year":"2013","unstructured":"Borghetti F, de Lima EC, Silva LCR (2013) A simple procedure for the purification of active fractions in aqueous extracts of plants with allelopathic properties. Acta Bot Bras 27(1):50\u20133. https:\/\/doi.org\/10.1590\/S0102-33062013000100007","journal-title":"Acta Bot Bras"},{"key":"4822_CR18","doi-asserted-by":"publisher","DOI":"10.1201\/9781315533247","volume-title":"Janeway\u2019s immunobiology","author":"K Murphy","year":"2016","unstructured":"Murphy K, Weaver C (2016) Janeway\u2019s immunobiology, 9th ed. Garland Science, New York","edition":"9th ed"},{"key":"4822_CR19","volume-title":"Janeway\u2019s immunobiology","author":"K Murphy","year":"2022","unstructured":"Murphy K, Weaver C (2022) Janeway\u2019s immunobiology, 10th ed. W.W. Norton & Company, New York","edition":"10th ed"},{"key":"4822_CR20","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jep.2018.10.010","volume":"231","author":"F Formaggio-Neto","year":"2019","unstructured":"Formaggio-Neto F et al (2019) Anti-inflammatory action of an alkaloid, fraction and extract from alchornea glandulosa in mice. J Ethnopharmacol 231:66\u201372. https:\/\/doi.org\/10.1016\/j.jep.2018.10.010","journal-title":"J Ethnopharmacol"},{"key":"4822_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.phytochem.2013.02.006","volume":"89","author":"EM Cruz","year":"2013","unstructured":"Cruz EM, Costa GC, Gomes RM, Nascimento FRF, Mota ML, Silva J\u00fanior WJ et al (2013) Leishmanicidal activity of cecropia pachystachya flavonoids: arginase Inhibition and altered mitochondrial DNA arrangement. Phytochemistry 89:71\u201377. https:\/\/doi.org\/10.1016\/j.phytochem.2013.02.006","journal-title":"Phytochemistry"},{"key":"4822_CR22","volume-title":"Inibi\u00e7\u00e3o Da arginase de leishmania Por fra\u00e7\u00f5es do Extrato etan\u00f3lico de cecropia pachystachya [disserta\u00e7\u00e3o de mestrado]","author":"EM Cruz","year":"2009","unstructured":"Cruz EM (2009) Inibi\u00e7\u00e3o Da arginase de leishmania Por fra\u00e7\u00f5es do Extrato etan\u00f3lico de cecropia pachystachya [disserta\u00e7\u00e3o de mestrado]. Funda\u00e7\u00e3o Oswaldo Cruz, Salvador"},{"key":"4822_CR23","volume-title":"Efeito Da cecropia pachystachya Na inflama\u00e7\u00e3o e no estresse oxidativo Na \u00falcera g\u00e1strica Induzida Por Naproxeno Em Camundongos [disserta\u00e7\u00e3o de mestrado]","author":"DS Martins","year":"2017","unstructured":"Martins DS (2017) Efeito Da cecropia pachystachya Na inflama\u00e7\u00e3o e no estresse oxidativo Na \u00falcera g\u00e1strica Induzida Por Naproxeno Em Camundongos [disserta\u00e7\u00e3o de mestrado]. Universidade Federal do Cear\u00e1, Fortaleza"},{"key":"4822_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jep.2016.02.004","volume":"185","author":"SV Muller","year":"2016","unstructured":"Muller SV et al (2016) Anti-inflammatory and antioxidant activities of aqueous extract of cecropia glaziovii leaves. J Ethnopharmacol 185:255\u2013262. https:\/\/doi.org\/10.1016\/j.jep.2016.02.004","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"4822_CR25","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3724\/abbs.2024008","volume":"56","author":"C Chu","year":"2024","unstructured":"Chu C, Ru H, Chen Y, Xu J, Wang C, Jin Y (2024) Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-\u03baB\/MAPK signaling pathway. Acta Biochim Biophys Sin (Shanghai) 56(6):905\u2013915. https:\/\/doi.org\/10.3724\/abbs.2024008","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"7","key":"4822_CR26","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1002\/jcp.30759","volume":"237","author":"S Mirzaei","year":"2022","unstructured":"Mirzaei S, Saghari S, Bassiri F, Raesi R, Zarrabi A, Hushmandi K et al (2022) NF-\u03baB as a regulator of cancer metastasis and therapy response. J Cell Physiol 237(7):2770\u20132795. https:\/\/doi.org\/10.1002\/jcp.30759","journal-title":"J Cell Physiol"},{"issue":"7","key":"4822_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167320","volume":"1870","author":"F Huang","year":"2024","unstructured":"Huang F, Gao J, Li A, Mizokami A, Matsuda M, Aoki K et al (2024) Activation of NF-\u03baB signaling regulates ovariectomy-induced bone loss and weight gain. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870(7):167320. https:\/\/doi.org\/10.1016\/j.bbadis.2024.167320","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"9","key":"4822_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092901","volume":"27","author":"JM Al-Khayri","year":"2022","unstructured":"Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ (2022) Flavonoids as potential anti-inflammatory molecules. Molecules 27(9):2901. https:\/\/doi.org\/10.3390\/molecules27092901","journal-title":"Molecules"},{"key":"4822_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-03851-x","volume":"23","author":"X Yang","year":"2023","unstructured":"Yang X, Liu Y, Zhong C, Hu J, Xu S, Zhang P et al (2023) Total flavonoids of Chrysanthemum indicum inhibit acute pancreatitis through suppressing apoptosis and inflammation. BMC Complement Med Ther 23:23. https:\/\/doi.org\/10.1186\/s12906-023-03851-x","journal-title":"BMC Complement Med Ther"},{"issue":"2","key":"4822_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.2174\/1872213X13666190426164124","volume":"13","author":"G Mart\u00ednez","year":"2019","unstructured":"Mart\u00ednez G, Mijares MR, De Sanctis JB (2019) Effects of flavonoids and derivatives on immune cell responses. Recent Pat Inflamm Allergy Drug Discov 13(2):84\u2013104. https:\/\/doi.org\/10.2174\/1872213X13666190426164124","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"issue":"3","key":"4822_CR31","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s10103-017-2376-6","volume":"33","author":"JH Lee","year":"2018","unstructured":"Lee JH, Chiang MH, Chen PH, Ho ML, Lee HE, Wang YH (2018) Anti-inflammatory effects of low-level laser therapy on human periodontal ligament cells. Lasers Med Sci 33(3):469\u2013477. https:\/\/doi.org\/10.1007\/s10103-017-2376-6","journal-title":"Lasers Med Sci"},{"issue":"4","key":"4822_CR32","doi-asserted-by":"publisher","first-page":"R116","DOI":"10.1186\/ar4296","volume":"15","author":"ACA Alves","year":"2013","unstructured":"Alves ACA, Vieira RP, Leal-Junior ECP, dos Santos SA, Ligeiro AP, Albertini R et al (2013) Effect of low-level laser therapy on inflammatory mediators in acute joint inflammation. Arthritis Res Ther 15(4):R116. https:\/\/doi.org\/10.1186\/ar4296","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"4822_CR33","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.prp.2013.07.006","volume":"209","author":"RV Gon\u00e7alves","year":"2013","unstructured":"Gon\u00e7alves RV, Sarandy MM, da Matta SL, Novaes RD, Pinto MV (2013) Effects of photobiomodulation vs. Brassica oleracea extract on skin wounds in rats. Pathol Res Pract 209(10):648\u201353. https:\/\/doi.org\/10.1016\/j.prp.2013.07.006","journal-title":"Pathol Res Pract"},{"issue":"5","key":"4822_CR34","doi-asserted-by":"publisher","first-page":"786","DOI":"10.5530\/pj.2023.15.107","volume":"15","author":"K Olascuaga-Castillo","year":"2023","unstructured":"Olascuaga-Castillo K, Castillo-Medina O, Villacorta-Zavaleta M, Lopez D, Altamirano-Sarmiento D, Caceres-Andonaire E et al (2023) Phytochemical screening and anti-inflammatory activity of Desmodium molliculum. Pharmacogn J 15(5):786\u2013790. https:\/\/doi.org\/10.5530\/pj.2023.15.107","journal-title":"Pharmacogn J"},{"key":"4822_CR35","doi-asserted-by":"publisher","first-page":"115668","DOI":"10.1016\/j.jep.2022.115668","volume":"298","author":"MR Assun\u00e7\u00e3o Ferreira","year":"2022","unstructured":"Assun\u00e7\u00e3o Ferreira MR, Daniele-Silva A, de Almeida LF, Dos Santos ECF, Barbosa Machado JC, Mac\u00e1rio, de Oliveira A et al (2022) Safety evaluation of aqueous extract from Eugenia uniflora leaves. J Ethnopharmacol 298:115668. https:\/\/doi.org\/10.1016\/j.jep.2022.115668","journal-title":"J Ethnopharmacol"},{"key":"4822_CR36","doi-asserted-by":"publisher","first-page":"9554011","DOI":"10.1155\/2022\/9554011","volume":"2022","author":"SV S\u00e1nchez-De-La-Rosa","year":"2022","unstructured":"S\u00e1nchez-De-La-Rosa SV, Lazalde-Ramos BP, Morales-Velazquez G, Z\u00fa\u00f1iga-Gonz\u00e1lez GM, G\u00f3mez-Meda BC, S\u00e1nchez-Rivera SO et al (2022) Genotoxic and antigenotoxic evaluation of Annona muricata extracts in rodents. Biomed Res Int 2022:9554011. https:\/\/doi.org\/10.1155\/2022\/9554011","journal-title":"Biomed Res Int"},{"key":"4822_CR37","doi-asserted-by":"publisher","first-page":"112086","DOI":"10.1016\/j.jep.2019.112086","volume":"243","author":"GR Villas Boas","year":"2019","unstructured":"Villas Boas GR, Rodrigues Lemos JM, de Oliveira MW, Dos Santos RC, Stefanello da Silveira AP, Bacha FB et al (2019) Preclinical safety evaluation of aqueous extract from Mangifera indica. J Ethnopharmacol 243:112086. https:\/\/doi.org\/10.1016\/j.jep.2019.112086","journal-title":"J Ethnopharmacol"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04822-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-026-04822-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04822-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:36:51Z","timestamp":1781635011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-026-04822-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4822"],"URL":"https:\/\/doi.org\/10.1007\/s10103-026-04822-7","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"assertion":[{"value":"15 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"35"}}