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Fractional CO\u2082 laser represents a promising therapeutic option to improve scar quality through collagen remodeling and dermal reorganization. This retrospective study analysed eight patients (six males and two females, mean age 71\u2009\u00b1\u200910 years) with nasal post-surgical scars after BCC excision and flap reconstruction. All patients underwent two sessions of fractional CO\u2082 laser in Deep Pulse or High Pulse modes, with a two-month interval between treatments. Clinical outcomes were evaluated using the Patient and Observer Scar Assessment Scale (POSAS) and three-dimensional profilometry with the Antera 3D system before treatment and two months after the last session. A statistically significant improvement was observed in both patient-reported (overall opinion\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0007; thickness\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) and observer-reported parameters (vascularity\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007; thickness\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005; pliability\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02; overall opinion\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.00004). Antera 3D analysis showed a mean reduction in scar depression of 23.5% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). All patients developed transient erythema and edema that were resolved within a week. Fractional CO\u2082 laser proved to be a safe and effective method to improve nasal post-surgical scars, enhancing texture, vascularity, and contour.\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04827-2","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:32:37Z","timestamp":1777689157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fractional CO2 laser treatment of post-surgical nasal scars: a retrospective analysis on 8 patients"],"prefix":"10.1007","volume":"41","author":[{"given":"Emanuele Maria","family":"Cipollini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mariano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Morini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Guarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gratteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zappia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata","family":"Dattola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cannarozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"issue":"21","key":"4827_CR1","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1056\/NEJMra044151","volume":"353","author":"AI Rubin","year":"2005","unstructured":"Rubin AI, Chen EH, Ratner D (2005) Basal-cell carcinoma. 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