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Additionally, trial registries (ClinicalTrials.gov and ReBEC), grey literature, and manual search were checked. Two reviewers independently performed study selection, data extraction, and risk of bias assessment using the RoB 2 tool. Given the heterogeneity in included studies, only a descriptive analysis was undertaken.\u00a0From 2,450 potentially eligible studies, three randomized clinical trials were selected for full-text analysis, and included. These studies comprising 462 MIH-affected molars and incisors in patients aged 6\u201314 years. Follow-up ranged from 1 to 6 months. Interventions included diode lasers (808\u00a0nm, 980\u00a0nm) and a low-power Er: YAG protocol (0.4\u00a0W, 40\u00a0mJ, 10\u00a0Hz), compared with fluoride varnish, GLUMA desensitizer, or CPP-ACPF mousse. All studies reported DH reduction across groups; however, no statistically significant differences were observed between laser and other desensitizing treatments. Two studies were rated as high risk of bias, and one showed some concerns.\u00a0Available evidence remains limited and heterogeneous due to few included studies and an overall fragile evidence base, indicating that laser therapy may reduce DH in MIH-affected teeth. Well-designed and standardized randomized clinical trials are still needed to strengthen the evidence base. (PROSPERO registration: CRD42024608626).<\/jats:p>","DOI":"10.1007\/s10103-026-04830-7","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:43:34Z","timestamp":1773297814000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diode and er: YAG laser therapy versus other desensitizing treatments for dentin hypersensitivity in molar-incisor hypomineralization: a systematic review"],"prefix":"10.1007","volume":"41","author":[{"given":"Eliane Cardoso","family":"Cappellaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Fogliato","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Lopes","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleber Paradzinski","family":"Cavalheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tathiane Larissa","family":"Lenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"4830_CR1","first-page":"114","volume":"4","author":"KL Weerheijm","year":"2003","unstructured":"Weerheijm KL (2003) Molar incisor hypomineralisation (MIH). 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