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The study was designed as a triple-blinded, randomized controlled clinical trial. The deep pressure pain targeted by 300g monofilament and Visual Analog Scale (VAS, 0-10) scores on right temporal head were assessed were randomly assigned to wearable LLLAT (650 nm, 5 mW, 30 min, about 9 joule each acupoint) on Baihui (GV20) with four Sishencong (EX-HN1) or sham group (n=24 vs 24). The mean VAS pain scores in wearable LLLAT group after GV20 with EX-HN1 acupoint treatment were significantly decreased comparing with sham group. This trial suggested that wearable Low-level Laser Acupoint Therapy 650 nm 5 mW for 30 min each acupoint simultaneously could effectively reduce deep pressure pain on temporal head.<\/jats:p>","DOI":"10.1007\/s10103-026-04877-6","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:10:49Z","timestamp":1778148649000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of GV20-based wearable low-level laser acupoint therapy for pain on head"],"prefix":"10.1007","volume":"41","author":[{"given":"Wen-Fang","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arslan","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Da","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"4877_CR1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1055\/s-0039-1695785","volume":"50","author":"E Doll","year":"2019","unstructured":"Doll E, Threlkeld B, Graff D, Clemons R, Mittel O, Sowell MK, McDonald M (2019) Acupuncture in Adult and Pediatric Headache: A Narrative Review. 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