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Laser systems (CO\u2082, Nd: YAG, PDL) offer a less invasive approach using selective photothermolysis, addressing functional and aesthetic concerns in anatomically sensitive areas. This narrative review summarizes the current clinical data on laser-based strategies for non-melanoma skin cancers (NMSC), focusing on treatment parameters, patient\/lesion selection, oncologic outcomes (clearance and recurrence), and safety. A targeted search of PubMed, Embase, and Scopus up to May 2026 was synthesized narratively. For low-risk BCC, Nd: YAG lasers showed a 3.1% recurrence rate (7.9-year follow-up), while CO\u2082 lasers reported 9.4% (2.1-year follow-up). Pulsed dye laser (PDL) monotherapy was less reliable, with 38% recurrence. Evidence for cSCC remains limited, focusing on in situ disease and combined regimens. Integrating Reflectance Confocal Microscopy (RCM) and Laser-Assisted Drug Delivery (LADD) significantly improves oncologic efficacy and treatment depth. Laser therapy, particularly Nd: YAG and CO\u2082 systems, represents a viable tissue-sparing option primarily for low-risk BCC. However, evidence for cSCC remains limited and suggests higher recurrence rates, necessitating cautious patient selection.<\/jats:p>","DOI":"10.1007\/s10103-026-04899-0","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:23:03Z","timestamp":1780708983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laser-based therapies in the management of non-melanoma skin cancers: a narrative review"],"prefix":"10.1007","volume":"41","author":[{"given":"Francesco","family":"Russano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Brugnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Dall\u2019Olmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Callegarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Del Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcodomenico","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Camuccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Scafuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rastrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mocellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"issue":"22","key":"4899_CR1","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.2217\/fon.15.180","volume":"11","author":"X Wu","year":"2015","unstructured":"Wu X, Elkin EE, Marghoob eAA (2015) Burden of basal cell carcinoma in USA. 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