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The study is a randomized, placebo-controlled clinical trial. Forty-five physically active male individuals were included and randomized into four groups: placebo (PL), PBM, OM, and PBM\u2009+\u2009OM. A red-light emitting diode (LED) (\u03bb\u2009=\u2009650\u00a0nm) was used. Participants in the PBM and PBM\u2009+\u2009OM groups received 144\u00a0J of energy in the right lower limb and\/or underwent bilateral lumbar and pelvic manipulation (OM and PBM\u2009+\u2009OM) before the EIMD protocol. The following variables were analyzed before, immediately after, and 24, 48, and 72\u00a0h post-intervention: creatine kinase (CK), muscle strength, flexibility, and horizontal jump performance. Data normality was assessed using the Kolmogorov-Smirnov test. CK levels were evaluated using the Friedman test, and repeated measures ANOVA was used for the other variables,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05. A distinct recovery pattern was observed in the combined PBM\u2009+\u2009OM group, with increased CK levels only at 24\u00a0h, followed by a pronounced reduction at 72\u00a0h (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Only the PBM\u2009+\u2009OM group presented percentage values near to baseline within 48\u00a0h (-1.4%), in addition to a trend toward early improvement in the horizontal jump within 24\u00a0h. In conclusion, PBM\u2009+\u2009OM may have contributed to improved CK kinetics and selected functional outcomes; however, strength recovery should be interpreted strictly as a non-significant and exploratory trend.\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04907-3","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:29:54Z","timestamp":1781144994000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined effects of photobiomodulation and osteopathic manipulation on the physical performance of young adults subjected to exercise-induced muscle damage: a randomized placebo-controlled trial"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7393-2828","authenticated-orcid":false,"given":"Joyce Cristina","family":"Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-7683","authenticated-orcid":false,"given":"Mayara","family":"Bocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6214-6606","authenticated-orcid":false,"given":"Benilton Alves","family":"Rodrigues Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-4700","authenticated-orcid":false,"given":"Monica Rodrigues Ferreira","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-1427","authenticated-orcid":false,"given":"Hanstter Hallison Alves","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-7693","authenticated-orcid":false,"given":"David Michel","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-2491","authenticated-orcid":false,"given":"Eduardo Vignoto","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"issue":"4","key":"4907_CR1","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1123\/jsr.2020-0364","volume":"30","author":"HL Stedge","year":"2021","unstructured":"Stedge HL, Armstrong K (2021) The Effects of Intermittent Pneumatic Compression on the Reduction of Exercise-Induced Muscle Damage in Endurance Athletes: A Critically Appraised Topic. 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