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A total of 39 patients diagnosed with peri-implantitis were divided into three groups based on the treatment protocols used: Mechanical Debridement, Diode Laser, and Combined Treatment. Probing depth, clinical attachment level, modified plaque index, gingival index, and PISF volume measurements were recorded at baseline and at weeks 4 and 12. S100A8 levels in PISF samples were measured by ELISA. During the 12-week follow-up period, statistically significant improvements in clinical parameters were observed in all groups compared with baseline (p\u2009&lt;\u20090.05). In the intergroup comparison, the most significant decrease and statistical superiority in mPI and GI values were observed in the combined treatment group (p\u2009&lt;\u20090.001). Although there was no statistically significant difference among the groups in probing depth and clinical attachment gain, the greatest numerical improvement was observed in the combined group. Despite clinical improvement, no significant change in total S100A8 levels was detected between groups or over time (p\u2009&gt;\u20090.05). The combined use of mechanical debridement and a diode laser in the treatment of peri-implantitis is more effective at reducing clinical signs of inflammation than either method used alone. However, the lack of correlation between S100A8 levels and clinical improvement suggests that this biomarker may not be sensitive in short-term follow-up of treatment.<\/jats:p>","DOI":"10.1007\/s10103-026-04925-1","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:29:21Z","timestamp":1782268161000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of 940\u00a0nm diode laser adjunct to mechanical debridement on S100A8 levels and clinical parameters in peri-implantitis treatment"],"prefix":"10.1007","volume":"41","author":[{"given":"Akif","family":"Nalbant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Ebru","family":"Olgun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Hendek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"\u00c7a\u011flayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"issue":"s6","key":"4925_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1600-0501.2012.02541.x","volume":"23","author":"A Mombelli","year":"2012","unstructured":"Mombelli A, M\u00fcller N, Cionca N (2012) The epidemiology of peri-implantitis. 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