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This single-arm observational study was undertaken to describe the healing dynamics, pain outcomes, feasibility and tolerability of adjuvant visible incoherent polarised (VIP) phototherapy in patients with chronic skin defects who were managed with full standard care, and to examine whether outcomes varied with the principal clinical problem and treatment duration.<\/jats:p>\n                  <jats:p>\n                    A prospective, single-arm cohort of 50 patients (38 females, 12 males; mean age 69.4 years) was observed. Adjuvant VIP phototherapy (626\u00a0nm; 2 mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) was applied alongside the standard conservative and surgical wound care received by all patients, for 10\u201320\u00a0min per field, two to three times daily; the continuous emission mode was changed to a pulsed mode (5\u00a0Hz) after 7\u201310 days. Wound area was assessed planimetrically in a representative case, and pain on a 0\u201310 numeric scale. No sham-irradiated control group was included.\n                  <\/jats:p>\n                  <jats:p>\n                    Positive healing dynamics were recorded in 92% of the cohort and complete defect closure in 52% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926). In the chronic-pain subgroup (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917), pain was reduced in 12 patients and resolved in 5. Improvement was associated with the principal clinical problem (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200910.406;\n                    <jats:italic>df<\/jats:italic>\n                    \u2009=\u20093;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015) and with therapy duration (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20098.630;\n                    <jats:italic>df<\/jats:italic>\n                    \u2009=\u20093;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035). Two patients reported mild, transient local reactions; no severe adverse events occurred.\n                  <\/jats:p>\n                  <jats:p>In this uncontrolled cohort, adjuvant VIP phototherapy was feasible, well tolerated and accompanied by favourable healing and pain outcomes. Because no control group was studied, these findings cannot be attributed to the light itself and are hypothesis-generating; randomised, sham-controlled trials are required.<\/jats:p>","DOI":"10.1007\/s10103-026-04933-1","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:43:28Z","timestamp":1782287008000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant visible incoherent polarised phototherapy in chronic skin defects: a single-arm prospective observational cohort study"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-1971","authenticated-orcid":false,"given":"Michal","family":"Trnka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katar\u00edna","family":"Zif\u010d\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Dulansk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1n","family":"P\u00e1nik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"4933_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/000331979704800111","volume":"48","author":"CV Ruckley","year":"1997","unstructured":"Ruckley CV (1997) Socioeconomic Impact of Chronic Venous Insufficiency and Leg Ulcers. 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The phototherapy was administered as an adjunct to routine clinical wound care. In accordance with the national legislation of the Slovak Republic, a study of this type (an established adjuvant treatment delivered as part of routine care) did not require separate approval by an ethics committee. This exemption is therefore regarded as equivalent to ethical approval for the purposes of this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent to the adjuvant phototherapy was obtained from all individual participants. Confidentiality of personal data was fully respected, and no identifiable data (such as name or birth number) are reported.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}