{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:58:34Z","timestamp":1785571114317,"version":"3.56.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To evaluate efficacy and safety of dual-depth 25-pin insulated microneedle radiofrequency (RF) treatment for periorbital wrinkles and skin elasticity. This observational study included 32 adults aged 30\u201360 years with baseline Fitzpatrick Wrinkle Assessment Scale (FWAS) scores of 4 or higher. Patients underwent three microneedle RF treatment sessions at 4-week intervals. The protocol employed a duty-controlled, dual-shot mechanism to sequentially deliver thermal energy to 1.5\u00a0mm and 1.0\u00a0mm depths within a single needle insertion. Outcomes were assessed at baseline and weeks 16 and 24 using blinded FWAS grading, Antera 3D imaging, Cutometer R2\/R5\/R7, patient satisfaction, and safety monitoring. The mean FWAS score decreased from 5.44\u2009\u00b1\u20090.80 at baseline to 3.38\u2009\u00b1\u20090.61 at week 24 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Quantitative imaging revealed relevant reductions in average wrinkle depth, maximum wrinkle depth, and the indentation index, while R2, R5, and R7 increased throughout follow-up (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). At week 24, 90.63% of patients were satisfied or very satisfied. The mean procedure time was 7.2\u2009\u00b1\u20091.4\u00a0min, and the mean pain score was 3.3\u2009\u00b1\u20090.9. Adverse events were limited to transient mild erythema and edema, resulting in an average downtime of 1.5\u2009\u00b1\u20090.5 days. The dual-depth, 25-pin insulated microneedle RF protocol demonstrated clinical utility and a favorable safety profile as a minimally invasive option for periorbital rejuvenation. By delivering targeted dermal thermal stimulation without repeated mechanical passes, the procedure improved wrinkle severity and skin elasticity with short treatment time and limited recovery burden.\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04942-0","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:12:49Z","timestamp":1784272369000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual-depth 25-pin insulated microneedle radiofrequency for moderate-to-severe periorbital wrinkles"],"prefix":"10.1007","volume":"41","author":[{"given":"Kyung Tae","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Ho","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"issue":"6","key":"4942_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1089\/wound.2021.0082","volume":"11","author":"DB Abbas","year":"2022","unstructured":"Abbas DB, Lavin CV, Fahy EJ et al (2022) Standardizing dimensionless cutometer parameters to determine in vivo elasticity of human skin. 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Int J Cosmet Sci Aug 44(4):414\u2013420. https:\/\/doi.org\/10.1111\/ics.12779","journal-title":"Int J Cosmet Sci Aug"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04942-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-026-04942-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04942-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:46:10Z","timestamp":1785570370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-026-04942-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4942"],"URL":"https:\/\/doi.org\/10.1007\/s10103-026-04942-0","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"26 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Public Institutional Bioethics Committee designated by the Ministry of Health and Welfare, Republic of Korea (IRB No. P01-202511-01-072). Written informed consent to participate in the study was obtained from all participants prior to enrollment. All data were collected and analyzed in a de-identified manner to protect participant confidentiality.","order":1,"name":"Ethics","label":"Human ethics and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Clinical trial number: not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent for publication of anonymized clinical data and images was obtained from all participants. Participants were informed that anonymized data and images may be published in scientific journals.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"153"}}