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Outcome measures include melanin index (MI), erythema index (EI), stratum corneum hydration (SCH), sebum and dermal density on all facial sites. The treatment duration, participant\u2019s satisfaction score and physician\u2019s global assessment (PGA) score, pain score, bleeding score, erythema score and other side effects were evaluated.\u00a0A total of 20 participants completed the entire course. The participant\u2019s satisfaction score and PGA score increased progressively over time. Compared with the control side, the treatment side exhibited a shorter treatment time and lower pain score, but higher bleeding score. Dermal density increased gradually following FMR treatment and was statistically significant higher at 3 months than that at other follow-up time points. There were no statistically significant differences between the treatment and control sides in participant\u2019s satisfaction score, PGA score, erythema score, erythema duration and edema duration, MI, EI, SCH, sebum and dermal density at the forehead, cheek and chin of at any follow-up time point.\u00a0FMR is effective and safe for skin photoaging and acne scar. Peninsula Timerevert Needle\n                    <jats:sup>TM<\/jats:sup>\n                    offers the advantages of less pain and shorter treatment duration comparing with EndyMed, but is associated with a higher incidence of bleeding.\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04946-w","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:30:32Z","timestamp":1783672232000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fractional microneedle radiofrequency for photoaging and atrophic acne scar: a split-face clinical observation of two devices"],"prefix":"10.1007","volume":"41","author":[{"given":"Yan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Qing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Xuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing Hua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"4946_CR1","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s40257-021-00632-5","volume":"22","author":"LL Guan","year":"2021","unstructured":"Guan LL, Lim HW, Mohammad TF (2021) Sunscreens and photoaging: a review of current literature. 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