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This prospective single-arm interventional clinical study evaluated adults with mild-to-moderate facial laxity who underwent three full-face 40.68-MHz unipolar RF treatment sessions at 4-week intervals. The primary endpoint was the change in VECTRA-derived three-dimensional facial volumetric parameters from baseline to Week 20. Secondary outcomes included Cutometer-derived skin elasticity parameters (R2 and R5), Global Aesthetic Improvement Scale (GAIS), FACE-Q satisfaction scores, visual analog scale (VAS) pain scores, and adverse event monitoring. Of the 30 enrolled participants, 26 completed follow-up and were included in the final analysis. By Week 20, VECTRA 3D analysis demonstrated modest volume reductions in the cheek (\u2212\u20092.2 mL), jowl (\u2212\u20091.7 mL), and submental region (\u2212\u20092.9 mL). Skin elasticity parameters increased over time, with R2 increasing from 0.62 to 0.69 and R5 from 0.53 to 0.59. GAIS improvement was observed in 88.5% of participants, and the mean FACE-Q score increased to 72.4\u2009\u00b1\u200910.1. Treatment was well tolerated, with low mean pain scores (VAS 1.2\u2009\u00b1\u20090.9). Only transient erythema and mild edema were reported, with no serious adverse events observed. Three sessions of 40.68-MHz unipolar RF were associated with modest measurable improvements in facial contour and skin elasticity that were maintained during the 20-week observation period, with good tolerability and no serious adverse events. Because this was an uncontrolled single-arm study, these findings should be interpreted as preliminary and require confirmation in controlled studies with longer follow-up.<\/jats:p>","DOI":"10.1007\/s10103-026-04956-8","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:50Z","timestamp":1784869370000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Facial contour modulation and skin tightening using 40.68-MHz unipolar radiofrequency"],"prefix":"10.1007","volume":"41","author":[{"given":"Jungbin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisu","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Ho","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"3","key":"4956_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00266-009-9361-9","volume":"33","author":"BS Atiyeh","year":"2009","unstructured":"Atiyeh BS, Dibo SA (2009) Nonsurgical nonablative treatment of aging skin: radiofrequency technologies between aggressive marketing and evidence-based efficacy. 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