{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:57:44Z","timestamp":1785513464533,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006702","name":"Universidade Do Estado Do Rio De Janeiro","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006702","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus and are associated with prolonged healing, increased hospitalization, and risk of amputation. Low-level laser therapy (LLLT), a non-invasive and low-cost modality, has shown potential to accelerate wound healing by promoting tissue repair, cellular proliferation, and improved microcirculation. This study aimed to descriptively evaluate healing outcomes in patients with DFUs treated with LLT combined with conventional treatment care with conventional treatment alone. This prospective observational comparative study included 11 adults with diabetes and active neuropathic DFUs treated at a public podiatry outpatient clinic in Rio de Janeiro, Brazil (June 2023\u2013July 2024). Participants were prospective screened and allocated to conventional treatment (CT,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095; 6 ulcers) or LLLT plus CT (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096; 9 ulcers). Healing progression was assessed using the Pressure Ulcer Scale for Healing (PUSH), evaluating wound area, tissue type, and exudate. In the CT group, 1 ulcer (17%) healed completely, 2 (33%) improved, 2 (33%) remained unchanged, and 1 (17%) worsened. In the LLLT group, 5 ulcers (55.5%) healed completely and 4 (44.5%) improved, with no lesions worsening. The LLLT group also demonstrated shorter mean healing time, fewer clinical visits, and greater tissue repair than CT alone. The descriptive findings suggest that adjunctive LLLT may represent a promising supportive strategy for DFU management in real world outpatient care. Due to the observational design, non-random allocation, and limited sample size, causal inference cannot be established. Future randomized controlled trials are needed to confirm these findings.\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04968-4","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:33:18Z","timestamp":1785465198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low-level laser therapy and conventional treatment for diabetic foot ulcers: a case series"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-493X","authenticated-orcid":false,"given":"Ariane Silva","family":"Pires","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-2349","authenticated-orcid":false,"given":"Andr\u00e9 Luiz Bandeira Dionizio","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysa Rodrigues","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Gleidson","family":"de Azevedo-Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Cabral Pereira","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Ferracioli Siqueira","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisadora Vaz","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Maiara Ferreira Barreto","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-0443","authenticated-orcid":false,"given":"Eugenio Fuentes P\u00e9rez","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"issue":"3","key":"4968_CR1","doi-asserted-by":"publisher","first-page":"e68767","DOI":"10.1590\/1983-1447.2017.03.68767","volume":"38","author":"JMTS Silva","year":"2017","unstructured":"Silva JMTS, Haddad MCFL, Rossaneis MA, Vannuch MTO, Marcon SS (2017) Factors associated with foot ulceration of people with diabetes mellitus living in rural areas. 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The study was conducted in accordance with the principles of the Declaration of Helsinki and with Resolutions No. 466\/2012 and No. 510\/2016 of the Brazilian National Health Council.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors consent to the publication of this manuscript.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The requirement for informed consent was waived, as this research involved only the analysis of secondary data collected from existing electronic medical records of the Clinical Podiatry Service at the Diabetes Outpatient Clinic of Policl\u00ednica Piquet Carneiro, without any direct contact or intervention with participants.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"174"}}