{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:32Z","timestamp":1785772472141,"version":"3.56.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Scientific Research Project of Health and Wellness Commission of \u200c\u200cShanghai Pudong New Area","award":["PW2024D-15"],"award-info":[{"award-number":["PW2024D-15"]}]},{"name":"Shanghai Natural Science Foundation of China","award":["23ZR1456300"],"award-info":[{"award-number":["23ZR1456300"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"DOI":"10.1007\/s10103-026-04976-4","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:41:15Z","timestamp":1785724875000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["10.6\u00a0\u03bcm laser moxibustion can improve oxidative stress and abnormal energy metabolism in liver of hypothyroidism rats through Nrf2\/HO-1 and Nrf2\/PGC-1\u03b1\/TFAM pathways"],"prefix":"10.1007","volume":"41","author":[{"given":"Linfu","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-8970","authenticated-orcid":false,"given":"Xueyong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-0209","authenticated-orcid":false,"given":"Zouqin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-8167","authenticated-orcid":false,"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"4","key":"4976_CR1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41574-021-00625-8","volume":"18","author":"L Heged\u00fcs","year":"2022","unstructured":"Heged\u00fcs L, Bianco AC, Jonklaas J et al (2022) Primary hypothyroidism and quality of life. Nat Rev Endocrinol 18(4):230\u2013242","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"4976_CR2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/joim.13410","volume":"291","author":"DS Ross","year":"2022","unstructured":"Ross DS (2022) Treating hypothyroidism is not always easy: when to treat subclinical hypothyroidism, TSH goals in the elderly, and alternatives to levothyroxine monotherapy. J Intern Med 291(2):128\u2013140","journal-title":"J Intern Med"},{"issue":"4","key":"4976_CR3","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/s42255-024-00986-0","volume":"6","author":"RA Sinha","year":"2024","unstructured":"Sinha RA, Yen PM (2024) Metabolic Messengers: Thyroid Hormones [J]. Nat Metab 6(4):639\u2013650","journal-title":"Nat Metab"},{"issue":"4","key":"4976_CR4","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1469-185X.2000.tb00054.x","volume":"75","author":"AJ Hulbert","year":"2000","unstructured":"Hulbert AJ (2000) Thyroid hormones and their effects: a new perspective. Biol Rev Camb Philos Soc 75(4):519\u2013631","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"10444","key":"4976_CR5","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1016\/S0140-6736(24)00342-8","volume":"403","author":"M Fleseriu","year":"2024","unstructured":"Fleseriu M, Christ-Crain M, Langlois F et al (2024) Hypopituitarism. Lancet 403(10444):2632\u20132648","journal-title":"Lancet"},{"issue":"1","key":"4976_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2165\/11598070-000000000-00000","volume":"72","author":"D Khandelwal","year":"2012","unstructured":"Khandelwal D, Tandon N (2012) Overt and subclinical hypothyroidism: who to treat and how [J]. Drugs 72(1):17\u201333","journal-title":"Drugs"},{"issue":"10101","key":"4976_CR7","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/S0140-6736(17)30703-1","volume":"390","author":"L Chaker","year":"2017","unstructured":"Chaker L, Bianco AC, Jonklaas J et al (2017) Hypothyroidism. Lancet 390(10101):1550\u20131562","journal-title":"Lancet"},{"key":"4976_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914605","author":"P Vidal-Cevallos","year":"2023","unstructured":"Vidal-Cevallos P, Mur\u00faa-Beltr\u00e1n Gall S, Uribe M et al (2023) Understanding the relationship between nonalcoholic fatty liver disease and thyroid disease. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241914605","journal-title":"Int J Mol Sci"},{"key":"4976_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165927","author":"DM Tanase","year":"2020","unstructured":"Tanase DM, Gosav EM, Neculae E et al (2020) Hypothyroidism-induced nonalcoholic fatty liver disease (HIN): mechanisms and emerging therapeutic options. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21165927","journal-title":"Int J Mol Sci"},{"key":"4976_CR10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4103\/abr.abr_538_24","volume":"14","author":"SH Rastegar-Moghaddam","year":"2025","unstructured":"Rastegar-Moghaddam SH, Kiumarsi Z, Mirani A et al (2025) Aminoguanidine Improved Liver Function and Attenuated Oxidative Stress in Hypothyroid Rats by Propylthiouracil [J]. Adv Biomed Res 14:64","journal-title":"Adv Biomed Res"},{"key":"4976_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6757154","volume":"2016","author":"A Mancini","year":"2016","unstructured":"Mancini A, Di Segni C, Raimondo S et al (2016) Thyroid hormones, oxidative stress, and inflammation. Mediators Inflamm 2016:6757154","journal-title":"Mediators Inflamm"},{"issue":"9","key":"4976_CR12","doi-asserted-by":"publisher","first-page":"e15682","DOI":"10.14814\/phy2.15682","volume":"11","author":"M Hosseini","year":"2023","unstructured":"Hosseini M, Behehsti F, Marefati N et al (2023) Nano-selenium relieved hepatic and renal oxidative damage in hypothyroid rats [J]. Physiol Rep 11(9):e15682","journal-title":"Physiol Rep"},{"key":"4976_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","volume":"524","author":"D Tsikas","year":"2017","unstructured":"Tsikas D (2017) Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem 524:13\u201330","journal-title":"Anal Biochem"},{"key":"4976_CR14","doi-asserted-by":"publisher","first-page":"115617","DOI":"10.1016\/j.taap.2021.115617","volume":"426","author":"J Sun","year":"2021","unstructured":"Sun J, Hong Z, Shao S et al (2021) Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo [J]. Toxicol Appl Pharmacol 426:115617","journal-title":"Toxicol Appl Pharmacol"},{"key":"4976_CR15","doi-asserted-by":"publisher","first-page":"155465","DOI":"10.1016\/j.phymed.2024.155465","volume":"128","author":"S Xu","year":"2024","unstructured":"Xu S, Chen Y, Miao J et al (2024) Esculin inhibits hepatic stellate cell activation and CCl(4)-induced liver fibrosis by activating the Nrf2\/GPX4 signaling pathway [J]. Phytomedicine 128:155465","journal-title":"Phytomedicine"},{"key":"4976_CR16","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.redox.2018.07.002","volume":"18","author":"XJ Zhao","year":"2018","unstructured":"Zhao XJ, Yu HW, Yang YZ et al (2018) Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1\/Nrf2 pathway [J]. Redox Biol 18:124\u2013137","journal-title":"Redox Biol"},{"key":"4976_CR17","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.freeradbiomed.2022.08.021","volume":"190","author":"DV Chartoumpekis","year":"2022","unstructured":"Chartoumpekis DV, Ziros PG, Habeos IG et al (2022) Emerging roles of Keap1\/Nrf2 signaling in the thyroid gland and perspectives for bench-to-bedside translation. Free Radic Biol Med 190:276\u2013283","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"4976_CR18","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","volume":"78","author":"B Fromenty","year":"2023","unstructured":"Fromenty B, Roden M (2023) Mitochondrial alterations in fatty liver diseases. J Hepatol 78(2):415\u2013429","journal-title":"J Hepatol"},{"issue":"3","key":"4976_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.14218\/JCTH.2020.00027","volume":"8","author":"T Kizivat","year":"2020","unstructured":"Kizivat T, Maric I, Mudri D et al (2020) Hypothyroidism and Nonalcoholic Fatty Liver Disease: Pathophysiological Associations and Therapeutic Implications [J]. J Clin Transl Hepatol 8(3):347\u2013353","journal-title":"J Clin Transl Hepatol"},{"issue":"4","key":"4976_CR20","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1371\/journal.pbio.0030101","volume":"3","author":"TC Leone","year":"2005","unstructured":"Leone TC, Lehman JJ, Finck BN et al (2005) PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis [J]. PLoS Biol 3(4):e101","journal-title":"PLoS Biol"},{"issue":"4","key":"4976_CR21","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.7150\/ijbs.68873","volume":"18","author":"Q Li","year":"2022","unstructured":"Li Q, Tan J-X, He Y et al (2022) Atractylenolide III ameliorates non-alcoholic fatty liver disease by activating hepatic adiponectin receptor 1-mediated AMPK pathway. Int J Biol Sci 18(4):1594\u20131611","journal-title":"Int J Biol Sci"},{"issue":"11","key":"4976_CR22","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1161\/01.RES.0000338597.71702.ad","volume":"103","author":"CA Piantadosi","year":"2008","unstructured":"Piantadosi CA, Carraway MS, Babiker A et al (2008) Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 103(11):1232\u20131240","journal-title":"Circ Res"},{"key":"4976_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00435","author":"AP Gureev","year":"2019","unstructured":"Gureev AP, Shaforostova EA, Popov VN (2019) Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1\u03b1 signaling pathways. Front Genet. https:\/\/doi.org\/10.3389\/fgene.2019.00435","journal-title":"Front Genet"},{"key":"4976_CR24","doi-asserted-by":"publisher","first-page":"1612008","DOI":"10.3389\/fendo.2025.1612008","volume":"16","author":"J Qin","year":"2025","unstructured":"Qin J, Liu T, Zhang X et al (2025) Wheat grain moxibustion ameliorates oxidative stress in PTU-induced hypothyroid rats via cAMP\/PKA pathway activation [J]. Front Endocrinol (Lausanne) 16:1612008","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"4976_CR25","first-page":"781","volume":"36","author":"D Liu","year":"2016","unstructured":"Liu D, Yang Z (2016) [Modern research progress of the safety effects of moxibustion smoke] [J]. Zhongguo Zhen Jiu 36(7):781\u2013783","journal-title":"Zhongguo Zhen Jiu"},{"issue":"2","key":"4976_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1136\/acupmed-2015-010914","volume":"34","author":"J Huang","year":"2016","unstructured":"Huang J, Lim MY, Zhao B et al (2016) PM2.5 and ash residue from combustion of moxa floss. Acupunct Med 34(2):101\u2013106","journal-title":"Acupunct Med"},{"issue":"9","key":"4976_CR27","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1093\/qjmed\/hcv008","volume":"108","author":"J Huang","year":"2015","unstructured":"Huang J, Lim MY, Zhao B et al (2015) PM10 mass concentration and oxidative capacity of moxa smoke [J]. QJM 108(9):705\u2013710","journal-title":"QJM"},{"key":"4976_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/783704","volume":"2014","author":"J Xu","year":"2014","unstructured":"Xu J, Deng H, Shen X (2014) Safety of moxibustion: a systematic review of case reports. Evid Based Complement Alternat Med 2014:783704","journal-title":"Evid Based Complement Alternat Med"},{"issue":"6","key":"4976_CR29","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3899\/jrheum.200217","volume":"48","author":"L Zhao","year":"2021","unstructured":"Zhao L, Cheng K, Wu F et al (2021) Effect of Laser Moxibustion for Knee Osteoarthritis: A Multisite, Double-blind Randomized Controlled Trial [J]. J Rheumatol 48(6):924\u2013932","journal-title":"J Rheumatol"},{"issue":"4","key":"4976_CR30","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s10103-019-02863-9","volume":"35","author":"L Lin","year":"2020","unstructured":"Lin L, Cheng K, Tan MT et al (2020) Comparison of the effects of 10.6-\u00b5m infrared laser and traditional moxibustion in the treatment of knee osteoarthritis. Lasers Med Sci 35(4):823\u2013832","journal-title":"Lasers Med Sci"},{"issue":"2","key":"4976_CR31","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1142\/S0192415X08005722","volume":"36","author":"X Shen","year":"2008","unstructured":"Shen X, Ding G, Deng H et al (2008) Infrared radiation spectrum of acupuncture point on patients with coronary heart disease. Am J Chin Med 36(2):211\u2013218","journal-title":"Am J Chin Med"},{"issue":"1","key":"4976_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-024-01838-1","volume":"26","author":"H Mao","year":"2024","unstructured":"Mao H, Jin M, Xie L et al (2024) Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial. Breast Cancer Res 26(1):80","journal-title":"Breast Cancer Res"},{"issue":"6","key":"4976_CR33","first-page":"972","volume":"42","author":"F Jing","year":"2022","unstructured":"Jing F, Wen P, Xiangyun W et al (2022) Efficacy of stimulating Mingmen (GV4) and Guanyuan (CV4) on kidney deficiency in rat model: laser irradiation traditional moxibustion [J]. J Tradit Chin Med 42(6):972\u2013979","journal-title":"J Tradit Chin Med"},{"key":"4976_CR34","doi-asserted-by":"crossref","unstructured":"Iravani S, Cai L, Ha L et al (2020) Moxibustion at \u2018Danzhong\u2019 (RN17) and \u2018Guanyuan\u2019 (RN4) for fatigue symptom in patients with depression [J]. Medicine 99","DOI":"10.1097\/MD.0000000000019197"},{"issue":"5","key":"4976_CR35","first-page":"525","volume":"42","author":"JY Zhao","year":"2022","unstructured":"Zhao JY, Yan J, Wang HY et al (2022) [Effect of wheat-grain moxibustion on the expression of 5-HT and cortisol in the serum, and MR and GR in the hippocampus in rats with hypothyroidism complicated with depression] [J]. Zhongguo Zhen Jiu 42(5):525\u2013532","journal-title":"Zhongguo Zhen Jiu"},{"issue":"1","key":"4976_CR36","first-page":"310","volume":"16","author":"JH Hwang","year":"2018","unstructured":"Hwang JH, Jung HW, Kang SY et al (2018) Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats. Exp Ther Med 16(1):310\u2013320","journal-title":"Exp Ther Med"},{"issue":"1","key":"4976_CR37","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1186\/s12967-023-04250-z","volume":"21","author":"H Luo","year":"2023","unstructured":"Luo H, Gong R, Zheng R et al (2023) Dose-effect of long-snake-like moxibustion for chronic fatigue syndrome: a randomized controlled trial [J]. J Transl Med 21(1):430","journal-title":"J Transl Med"},{"issue":"2","key":"4976_CR38","first-page":"144","volume":"44","author":"W Gao","year":"2024","unstructured":"Gao W, Sun Z, Chen X et al (2024) Heat-sensitive moxibustion combined with Xiangwu powder for erectile dysfunction with kidney deficiency and blood stasis: a randomized controlled trial [J]. Zhongguo Zhen Jiu 44(2):144\u2013148","journal-title":"Zhongguo Zhen Jiu"},{"issue":"1","key":"4976_CR39","first-page":"49","volume":"40","author":"C Yu","year":"2020","unstructured":"Yu C, Wang X, Wu QF et al (2020) [Epidemiological characteristics of acupuncturists who are sensitive to stimulation of moxa smoke: a face-to-face sectional survey based on 733 participants] [J]. Zhongguo Zhen Jiu 40(1):49\u201353","journal-title":"Zhongguo Zhen Jiu"},{"issue":"2","key":"4976_CR40","first-page":"409","volume":"43","author":"LI Yingshuai","year":"2023","unstructured":"Yingshuai LI, Yan LI (2023) Progress in the study of -deficiency constitution in terms of Traditional Chinese Medicine: a narrative review [J]. J Tradit Chin Med 43(2):409\u2013416","journal-title":"J Tradit Chin Med"},{"issue":"5","key":"4976_CR41","first-page":"825","volume":"42","author":"F Xisheng","year":"2022","unstructured":"Xisheng F, Xiaoyi DU, Lijia P et al (2022) An infrared thermographic analysis of the sensitization acupoints of women with primary dysmenorrhea [J]. J Tradit Chin Med 42(5):825\u2013832","journal-title":"J Tradit Chin Med"},{"issue":"7","key":"4976_CR42","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.jcma.2016.12.007","volume":"80","author":"HN Wei","year":"2017","unstructured":"Wei HN, Jiang LP, Xiong B et al (2017) Characteristic patterns of normal meridian acupoint temperature [J]. J Chin Med Assoc 80(7):419\u2013426","journal-title":"J Chin Med Assoc"},{"issue":"1","key":"4976_CR43","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3233\/BMR-210297","volume":"36","author":"H Tan","year":"2023","unstructured":"Tan H, Tumilty S, Chapple C et al (2023) Acupoints sensitization in people with and without chronic low back pain:A matched-sample cross-sectional study [J]. J Back Musculoskelet Rehabil 36(1):137\u2013146","journal-title":"J Back Musculoskelet Rehabil"},{"issue":"4","key":"4976_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284381","volume":"18","author":"BH Mi","year":"2023","unstructured":"Mi BH, Wang XZ, Yang JW et al (2023) Thermographic evaluation of acupoints in lower limb region of individuals with osteoarthritis: a cross-sectional case-control study protocol. PLoS One 18(4):e0284381","journal-title":"PLoS One"},{"issue":"3","key":"4976_CR45","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3350\/cmh.2014.20.3.237","volume":"20","author":"R Heidari","year":"2014","unstructured":"Heidari R, Niknahad H, Jamshidzadeh A et al (2014) Factors affecting drug-induced liver injury: antithyroid drugs as instances [J]. Clin Mol Hepatol 20(3):237\u2013248","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"4976_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.acthis.2009.07.004","volume":"113","author":"E Cano-Europa","year":"2011","unstructured":"Cano-Europa E, Blas-Valdivia V, Franco-Colin M et al (2011) Methimazole-induced hypothyroidism causes cellular damage in the spleen, heart, liver, lung and kidney [J]. Acta Histochem 113(1):1\u20135","journal-title":"Acta Histochem"},{"issue":"1","key":"4976_CR47","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40164-020-00191-1","volume":"9","author":"H Zhang","year":"2020","unstructured":"Zhang H, Kong Q, Wang J et al (2020) Complex roles of cAMP-PKA-CREB signaling in cancer [J]. Exp Hematol Oncol 9(1):32","journal-title":"Exp Hematol Oncol"},{"key":"4976_CR48","doi-asserted-by":"publisher","first-page":"838248","DOI":"10.3389\/fphar.2022.838248","volume":"13","author":"X Zhao","year":"2022","unstructured":"Zhao X, Cao Y, Jin H et al (2022) Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1 [J]. Front Pharmacol 13:838248","journal-title":"Front Pharmacol"},{"key":"4976_CR49","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.toxlet.2021.10.010","volume":"354","author":"L Ramh\u00f8j","year":"2022","unstructured":"Ramh\u00f8j L, Svingen T, Fr\u00e4drich C et al (2022) Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring [J]. Toxicol Lett 354:44\u201355","journal-title":"Toxicol Lett"},{"issue":"1","key":"4976_CR50","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41572-022-00357-7","volume":"8","author":"L Chaker","year":"2022","unstructured":"Chaker L, Razvi S, Bensenor IM et al (2022) Hypothyroidism [J]. Nat Rev Dis Primers 8(1):30","journal-title":"Nat Rev Dis Primers"},{"key":"4976_CR51","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","volume":"53","author":"Q Ma","year":"2013","unstructured":"Ma Q (2013) Role of nrf2 in oxidative stress and toxicity [J]. Annu Rev Pharmacol Toxicol 53:401\u2013426","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"4976_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04367-1","volume":"21","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Wang S, Wu J et al (2023) Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy. J Transl Med 21(1):510","journal-title":"J Transl Med"},{"key":"4976_CR53","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1146\/annurev.physiol.65.092101.142558","volume":"65","author":"PL Jorgensen","year":"2003","unstructured":"Jorgensen PL, Hakansson KO, Karlish SJ (2003) Structure and mechanism of Na,K-ATPase: functional sites and their interactions. Annu Rev Physiol 65:817\u2013849","journal-title":"Annu Rev Physiol"},{"key":"4976_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1457010","volume":"15","author":"SA O\u2019rourke","year":"2024","unstructured":"O\u2019rourke SA, Shanley LC, Dunne A (2024) The Nrf2-HO-1 system and inflammaging. Front Immunol 15:1457010","journal-title":"Front Immunol"},{"key":"4976_CR55","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.freeradbiomed.2021.12.001","volume":"179","author":"QM Chen","year":"2022","unstructured":"Chen QM (2022) Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury. Free Radic Biol Med 179:133\u2013143","journal-title":"Free Radic Biol Med"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04976-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-026-04976-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04976-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:03:30Z","timestamp":1785769410000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-026-04976-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4976"],"URL":"https:\/\/doi.org\/10.1007\/s10103-026-04976-4","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"17 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"177"}}