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Methods: EEB was characterized using HPLC\u2013HRMS and tested for cell viability and nitric oxide (NO) production in RAW 264.7 and J774A.1 macrophages. In vivo, female BALB\/c mice with paw edema were treated with EEB (100 or 200 mg\/kg) alone, combined with LA (808 nm, 120 mW, 3 J, 25 s) at acupoints ST36 and SP6, or local laser. Paw edema was measured up to 4 h post-induction, and cytokine levels (IL-1$\\beta$ and IL-6) were quantified. Results: EEB showed no cytotoxicity and significantly reduced NO production in vitro. Phytochemical analysis revealed a predominance of phenolic compounds, including flavonoids. In vivo, both EEB and LA significantly reduced edema. Notably, the EEB200\u2009+\u2009LA group produced reductions in paw edema and pro-inflammatory cytokines comparable to the dexamethasone group. Conclusion: EEB demonstrated anti-inflammatory activity both in vitro and in vivo. Combining EEB (200 mg\/kg) with LA yielded a more consistent anti-inflammatory response than either treatment alone, particularly in reducing edema and pro-inflammatory cytokines. These findings support further investigation, though larger sample sizes and chronic models are required before clinical claims.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10103-026-04986-2","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T02:17:28Z","timestamp":1786328248000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combination of Bauhinia monandra extract and laser acupuncture reduces carrageenan-induced paw edema"],"prefix":"10.1007","volume":"41","author":[{"given":"Allyne Aparecida Dias","family":"da Silva Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio Carvalho","family":"da Costa Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa Acerbi","family":"Laurindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena Campos","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyane Matos","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerilson Marques","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Mendes","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo Xavier","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Bertelli Ribeiro","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio C\u00e9sar","family":"de Souza Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"de Paula Carli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"4986_CR1","doi-asserted-by":"publisher","unstructured":"Megha KB, Joseph X, Akhil V, Mohanan PV (2021) Cascade of immune mechanism and consequences of inflammatory disorders. 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