{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:18:15Z","timestamp":1791429495444,"version":"4.3.3"},"reference-count":153,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade De S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To discuss how distinct pathogenic mechanisms underlying salivary gland dysfunction may influence responsiveness to photobiomodulation (PBM) in patients with hyposalivation and xerostomia. A narrative review was conducted focusing on the biological and clinical factors potentially associated with PBM responsiveness across different etiologies of salivary gland dysfunction, including Sj\u00f6gren\u2019s disease, chemotherapy-induced dysfunction, radiation-induced salivary gland injury, and polypharmacy-associated hyposalivation. Mechanisms related to inflammation, oxidative stress, fibrosis, neurosecretory impairment, residual glandular viability, and persistence of etiological burden across different etiologies of salivary gland dysfunction were comparatively discussed. Therapeutic success assessments were also explored, emphasizing that symptom improvement and enhancement of oral quality of life may occur even in the absence of complete salivary flow normalization. In addition, the currently available evidence regarding PBM responsiveness in distinct etiological scenarios was critically presented, highlighting its heterogeneous and unbalanced distribution across conditions. Future directions involving biologically informed, individualized, and combination-based therapeutic approaches were also discussed. PBM responsiveness should not be interpreted as universally predictable across all etiologies of hyposalivation. Instead, therapeutic outcomes likely depend on several factors. Biologically informed and individualized approaches may contribute to more realistic therapeutic expectations and more personalized management strategies.<\/jats:p>","DOI":"10.1007\/s10103-026-04991-5","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:31:02Z","timestamp":1787113862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Photobiomodulation for salivary gland dysfunction: aligning clinical expectations with etiology-dependent treatment responsiveness"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-2270","authenticated-orcid":false,"given":"Caio Camargo","family":"Calarga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5121-7166","authenticated-orcid":false,"given":"Caio Bruno Tolentino","family":"de Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2659-4703","authenticated-orcid":false,"given":"Cl\u00e1udia Carrara","family":"Cotom\u00e1cio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-1393","authenticated-orcid":false,"given":"Alyne","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"4991_CR1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S76282","author":"A Villa","year":"2014","unstructured":"Villa A, Connell C, Abati S (2014) Diagnosis and management of xerostomia and hyposalivation. Ther Clin Risk Manag. https:\/\/doi.org\/10.2147\/TCRM.S76282","journal-title":"Ther Clin Risk Manag"},{"key":"4991_CR2","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00520-010-0827-8","volume":"18","author":"SB Jensen","year":"2010","unstructured":"Jensen SB, Pedersen AML, Vissink A et al (2010) A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer 18:1039\u20131060. https:\/\/doi.org\/10.1007\/s00520-010-0827-8","journal-title":"Support Care Cancer"},{"key":"4991_CR3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1067\/mpr.2002.128176","volume":"88","author":"AM Diaz-Arnold","year":"2002","unstructured":"Diaz-Arnold AM, Marek CA (2002) The impact of saliva on patient care: A literature review. J Prosthet Dent 88:337\u2013343. https:\/\/doi.org\/10.1067\/mpr.2002.128176","journal-title":"J Prosthet Dent"},{"key":"4991_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105783","volume":"127","author":"A Lin","year":"2022","unstructured":"Lin A, Helgeson ES, Treister NS et al (2022) The impact of head and neck radiotherapy on salivary flow and quality of life: results of the ORARAD study. Oral Oncol 127:105783. https:\/\/doi.org\/10.1016\/j.oraloncology.2022.105783","journal-title":"Oral Oncol"},{"key":"4991_CR5","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.cden.2015.11.003","volume":"60","author":"MD Turner","year":"2016","unstructured":"Turner MD (2016) Hyposalivation and Xerostomia. Dent Clin North Am 60:435\u2013443. https:\/\/doi.org\/10.1016\/j.cden.2015.11.003","journal-title":"Dent Clin North Am"},{"key":"4991_CR6","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s10103-021-03392-0","volume":"37","author":"A Gole\u017e","year":"2022","unstructured":"Gole\u017e A, Frange\u017e I, Cankar K et al (2022) Effects of low-level light therapy on xerostomia related to hyposalivation: a systematic review and meta-analysis of clinical trials. Lasers Med Sci 37:745\u2013758. https:\/\/doi.org\/10.1007\/s10103-021-03392-0","journal-title":"Lasers Med Sci"},{"key":"4991_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1089\/pho.2009.2486","volume":"28","author":"A Sim\u00f5es","year":"2010","unstructured":"Sim\u00f5es A, de Campos L, de Souza DN et al (2010) Laser phototherapy as topical prophylaxis against radiation-induced xerostomia. Photomed Laser Surg 28:357\u2013363. https:\/\/doi.org\/10.1089\/pho.2009.2486","journal-title":"Photomed Laser Surg"},{"key":"4991_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/photonics10060611","volume":"10","author":"L Campos","year":"2023","unstructured":"Campos L, Magliano GC, Hotsumi AM et al (2023) Photobiomodulation therapy mitigates salivary gland damage induced by radioactive iodine ablation. Photonics (Basel) 10:611. https:\/\/doi.org\/10.3390\/photonics10060611","journal-title":"Photonics (Basel)"},{"key":"4991_CR9","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1007\/s00405-023-08425-8","volume":"281","author":"SV Oliveira","year":"2024","unstructured":"Oliveira SV, Batista JVF, Gutierres GG et al (2024) The supportive use of photobiomodulation on salivary glands: a narrative review and meta-analysis. Eur Arch Otorhinolaryngol 281:2793\u20132805. https:\/\/doi.org\/10.1007\/s00405-023-08425-8","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"4991_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfscie.2025.100045","volume":"4","author":"PR Arany","year":"2025","unstructured":"Arany PR (2025) Photobiomodulation therapy. JADA Found Sci 4:100045. https:\/\/doi.org\/10.1016\/j.jfscie.2025.100045","journal-title":"JADA Found Sci"},{"key":"4991_CR11","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.3390\/jcm11123414","volume":"11","author":"A Ferrandez-Pujante","year":"2022","unstructured":"Ferrandez-Pujante A, Pons-Fuster E, L\u00f3pez-Jornet P (2022) Efficacy of Photobiomodulation in Reducing Symptomatology and Improving the Quality of Life in Patients with Xerostomia and Hyposalivation: A Randomized Controlled Trial. J Clin Med 11:3414. https:\/\/doi.org\/10.3390\/jcm11123414","journal-title":"J Clin Med"},{"key":"4991_CR12","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S1053-4296(03)00033-X","volume":"13","author":"A EISBRUCH","year":"2003","unstructured":"EISBRUCH A, RHODUS N, ROSENTHAL D et al (2003) How should we measure and report radiotherapy-induced xerostomia? Semin Radiat Oncol 13:226\u2013234. https:\/\/doi.org\/10.1016\/S1053-4296(03)00033-X","journal-title":"Semin Radiat Oncol"},{"key":"4991_CR13","doi-asserted-by":"crossref","unstructured":"Bjordal JM, Lopes-Martins RAB, Frigo L (2015) Low level laser therapy \u2013 mechanism of action. Lasers in Dentistry. Wiley, pp 27\u201333","DOI":"10.1002\/9781118987742.ch5"},{"key":"4991_CR14","doi-asserted-by":"crossref","unstructured":"Karu TI (2015) Cellular mechanisms of photobiomodulation. Lasers in Dentistry. Wiley, pp 23\u201326","DOI":"10.1002\/9781118987742.ch4"},{"key":"4991_CR15","doi-asserted-by":"publisher","first-page":"100160","DOI":"10.1016\/j.jpap.2023.100160","volume":"13","author":"SK Sharma","year":"2023","unstructured":"Sharma SK, Sardana S, Hamblin MR (2023) Role of opsins and light or heat activated transient receptor potential ion channels in the mechanisms of photobiomodulation and infrared therapy. J Photochem Photobiol 13:100160. https:\/\/doi.org\/10.1016\/j.jpap.2023.100160","journal-title":"J Photochem Photobiol"},{"key":"4991_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s10103-008-0548-0","volume":"24","author":"A Sim\u00f5es","year":"2009","unstructured":"Sim\u00f5es A, Siqueira WL, Lamers ML et al (2009) Laser phototherapy effect on protein metabolism parameters of rat salivary glands. Lasers Med Sci 24:202\u2013208. https:\/\/doi.org\/10.1007\/s10103-008-0548-0","journal-title":"Lasers Med Sci"},{"key":"4991_CR17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/php.12195","volume":"90","author":"L Campos","year":"2014","unstructured":"Campos L, Nicolau J, Arana-Chavez VE, Sim\u00f5es A (2014) Effect of Laser Phototherapy on Enzymatic Activity of Salivary Glands of Hamsters Treated with 5\u2010Fluorouracil. Photochem Photobiol 90:667\u2013672. https:\/\/doi.org\/10.1111\/php.12195","journal-title":"Photochem Photobiol"},{"key":"4991_CR18","doi-asserted-by":"publisher","first-page":"105250","DOI":"10.1016\/j.archoralbio.2021.105250","volume":"131","author":"CC Cotomacio","year":"2021","unstructured":"Cotomacio CC, Calarga CC, Yshikawa BK et al (2021) Wound healing process with different photobiomodulation therapy protocols to treat 5-FU-induced oral mucositis in hamsters. Arch Oral Biol 131:105250. https:\/\/doi.org\/10.1016\/j.archoralbio.2021.105250","journal-title":"Arch Oral Biol"},{"key":"4991_CR19","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1109\/JSTQE.2016.2561201","volume":"22","author":"LF de Freitas","year":"2016","unstructured":"de Freitas LF, Hamblin MR (2016) Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron 22:348\u2013364. https:\/\/doi.org\/10.1109\/JSTQE.2016.2561201","journal-title":"IEEE J Sel Top Quantum Electron"},{"key":"4991_CR20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/php.12864","volume":"94","author":"MR Hamblin","year":"2018","unstructured":"Hamblin MR (2018) Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochem Photobiol 94:199\u2013212. https:\/\/doi.org\/10.1111\/php.12864","journal-title":"Photochem Photobiol"},{"key":"4991_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094863","volume":"23","author":"H Nguyen","year":"2022","unstructured":"Nguyen H, Sangha S, Pan M et al (2022) Oxidative stress and chemoradiation-induced oral mucositis: a scoping review of in vitro, in vivo and clinical studies. Int J Mol Sci 23:4863. https:\/\/doi.org\/10.3390\/ijms23094863","journal-title":"Int J Mol Sci"},{"key":"4991_CR22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1089\/pho.2014.3741","volume":"32","author":"J Saleh","year":"2014","unstructured":"Saleh J, Figueiredo MAZ, Cherubini K et al (2014) Effect of Low-Level Laser Therapy on Radiotherapy-Induced Hyposalivation and Xerostomia: A Pilot Study. Photomed Laser Surg 32:546\u2013552. https:\/\/doi.org\/10.1089\/pho.2014.3741","journal-title":"Photomed Laser Surg"},{"key":"4991_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124095","volume":"9","author":"KJ Jasmer","year":"2020","unstructured":"Jasmer KJ, Gilman KE, Mu\u00f1oz Forti K et al (2020) Radiation-induced salivary gland dysfunction: mechanisms, therapeutics and future directions. J Clin Med 9:4095. https:\/\/doi.org\/10.3390\/jcm9124095","journal-title":"J Clin Med"},{"key":"4991_CR24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1259\/bjr\/66754762","volume":"84","author":"SCH Cheng","year":"2011","unstructured":"Cheng SCH, Wu VWC, Kwong DLW, Ying MTC (2011) Assessment of post-radiotherapy salivary glands. Br J Radiol 84:393\u2013402. https:\/\/doi.org\/10.1259\/bjr\/66754762","journal-title":"Br J Radiol"},{"key":"4991_CR25","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1002\/cncr.22302","volume":"107","author":"P Dirix","year":"2006","unstructured":"Dirix P, Nuyts S, Van den Bogaert W (2006) Radiation-induced xerostomia in patients with head and neck cancer. Cancer 107:2525\u20132534. https:\/\/doi.org\/10.1002\/cncr.22302","journal-title":"Cancer"},{"key":"4991_CR26","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1007\/s00784-015-1488-2","volume":"19","author":"A Villa","year":"2015","unstructured":"Villa A, Wolff A, Aframian D et al (2015) World workshop on oral medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment. Clin Oral Investig 19:1563\u20131580. https:\/\/doi.org\/10.1007\/s00784-015-1488-2","journal-title":"Clin Oral Investig"},{"key":"4991_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115835","volume":"22","author":"NK Toan","year":"2021","unstructured":"Toan NK, Ahn S-G (2021) Aging-related metabolic dysfunction in the salivary gland: a review of the literature. Int J Mol Sci 22:5835. https:\/\/doi.org\/10.3390\/ijms22115835","journal-title":"Int J Mol Sci"},{"key":"4991_CR28","doi-asserted-by":"crossref","unstructured":"Tun\u00e9r J, Ribeiro MS, Sim\u00f5es A (2015) Dosimetry. In: Freitas PM, Sim\u00f5es A (eds) Lasers in Dentistry: Guide for Clinical Practice. pp 48\u201355","DOI":"10.1002\/9781118987742.ch8"},{"key":"4991_CR29","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.70042","author":"CBT de Brito","year":"2025","unstructured":"de Brito CBT, Calarga CC, Lima FS et al (2025) Photosensitivity episodes related to skin color in people treated with dual-wavelength low power laser therapy: a retrospective cohort study. Photodermatol Photoimmunol Photomed. https:\/\/doi.org\/10.1111\/phpp.70042","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"4991_CR30","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s10103-025-04507-7","volume":"40","author":"L Correa","year":"2025","unstructured":"Correa L, Meirelles L, Carneiro RCG et al (2025) Photobiomodulation in the parotid and submandibular glands: a Monte Carlo simulation of photon penetration using 525-nm, 660-nm, and 850-nm wavelengths. Lasers Med Sci 40:269. https:\/\/doi.org\/10.1007\/s10103-025-04507-7","journal-title":"Lasers Med Sci"},{"key":"4991_CR31","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","volume":"366","author":"RI Fox","year":"2005","unstructured":"Fox RI (2005) Sj\u00f6gren\u2019s syndrome. Lancet 366:321\u2013331. https:\/\/doi.org\/10.1016\/S0140-6736(05)66990-5","journal-title":"Lancet"},{"key":"4991_CR32","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/nrrheum.2013.110","volume":"9","author":"G Nocturne","year":"2013","unstructured":"Nocturne G, Mariette X (2013) Advances in understanding the pathogenesis of primary Sj\u00f6gren\u2019s syndrome. Nat Rev Rheumatol 9:544\u2013556. https:\/\/doi.org\/10.1038\/nrrheum.2013.110","journal-title":"Nat Rev Rheumatol"},{"key":"4991_CR33","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3899\/jrheum.090866","volume":"37","author":"G Hern\u00e1ndez-Molina","year":"2010","unstructured":"Hern\u00e1ndez-Molina G, \u00c1vila-Casado C, C\u00e1rdenas-Vel\u00e1zquez F et al (2010) Similarities and differences between primary and secondary Sj\u00f6gren\u2019s syndrome. J Rheumatol 37:800\u2013808. https:\/\/doi.org\/10.3899\/jrheum.090866","journal-title":"J Rheumatol"},{"key":"4991_CR34","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.55563\/clinexprheumatol\/648k4u","volume":"41","author":"JS van Santen","year":"2023","unstructured":"van Santen JS, Assy Z, Bikker FJ et al (2023) The diagnostic power of salivary electrolytes for Sj\u00f6gren\u2019s disease: a systematic literature review and meta-analysis. Clin Exp Rheumatol 41:2511\u20132524. https:\/\/doi.org\/10.55563\/clinexprheumatol\/648k4u","journal-title":"Clin Exp Rheumatol"},{"key":"4991_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2025.1484951","volume":"15","author":"D Muszy\u0144ski","year":"2025","unstructured":"Muszy\u0144ski D, Kucharski R, Marek-Trzonkowska N et al (2025) Treatment of xerostomia in Sj\u00f6gren\u2019s syndrome \u2013 what effect does it have on the oral microbiome? Front Cell Infect Microbiol 15:1\u20138. https:\/\/doi.org\/10.3389\/fcimb.2025.1484951","journal-title":"Front Cell Infect Microbiol"},{"key":"4991_CR36","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41584-025-01268-z","volume":"21","author":"M Ramos-Casals","year":"2025","unstructured":"Ramos-Casals M, Baer AN, Brito-Zer\u00f3n M et al (2025) 2023 International Rome consensus for the nomenclature of Sj\u00f6gren disease. Nat Rev Rheumatol 21:426\u2013437. https:\/\/doi.org\/10.1038\/s41584-025-01268-z","journal-title":"Nat Rev Rheumatol"},{"key":"4991_CR37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/rheumatology\/kel252","volume":"46","author":"C Salliot","year":"2006","unstructured":"Salliot C, Mouthon L, Ardizzone M et al (2006) Sjogren\u2019s syndrome is associated with and not secondary to systemic sclerosis. Rheumatology 46:321\u2013326. https:\/\/doi.org\/10.1093\/rheumatology\/kel252","journal-title":"Rheumatology"},{"key":"4991_CR38","doi-asserted-by":"publisher","first-page":"319","DOI":"10.4103\/IJPM.IJPM_416_17","volume":"61","author":"U Kucuk","year":"2018","unstructured":"Kucuk U, Sarioglu S, Cetin P et al (2018) Histopathological differences between primary Sj\u00f6gren\u2019s syndrome and Sj\u00f6gren\u2019s syndrome accompanied by scleroderma. Indian J Pathol Microbiol 61:319. https:\/\/doi.org\/10.4103\/IJPM.IJPM_416_17","journal-title":"Indian J Pathol Microbiol"},{"key":"4991_CR39","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1002\/art.20093","volume":"50","author":"MN Manoussakis","year":"2004","unstructured":"Manoussakis MN, Georgopoulou C, Zintzaras E et al (2004) Sj\u00f6gren\u2019s syndrome associated with systemic lupus erythematosus: Clinical and laboratory profiles and comparison with primary Sj\u00f6gren\u2019s syndrome. Arthritis Rheum 50:882\u2013891. https:\/\/doi.org\/10.1002\/art.20093","journal-title":"Arthritis Rheum"},{"key":"4991_CR40","first-page":"1098","volume":"14","author":"AP Andonopoulos","year":"1987","unstructured":"Andonopoulos AP, Drosos AA, Skopouli FN et al (1987) Secondary Sj\u00f6gren\u2019s syndrome in rheumatoid arthritis. J Rheumatol 14:1098\u20131103","journal-title":"J Rheumatol"},{"key":"4991_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123551","author":"M Sisto","year":"2022","unstructured":"Sisto M, Ribatti D, Lisi S (2022) Sj\u00f6gren\u2019s syndrome-related organs fibrosis: hypotheses and realities. J Clin Med. https:\/\/doi.org\/10.3390\/jcm11123551","journal-title":"J Clin Med"},{"key":"4991_CR42","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00418-018-1680-y","volume":"150","author":"M Sisto","year":"2018","unstructured":"Sisto M, Lisi S, Ribatti D (2018) The role of the epithelial-to-mesenchymal transition (EMT) in diseases of the salivary glands. Histochem Cell Biol 150:133\u2013147. https:\/\/doi.org\/10.1007\/s00418-018-1680-y","journal-title":"Histochem Cell Biol"},{"key":"4991_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1421436","volume":"15","author":"D Ma","year":"2024","unstructured":"Ma D, Feng Y, Lin X (2024) Immune and non-immune mediators in the fibrosis pathogenesis of salivary gland in Sj\u00f6gren\u2019s syndrome. Front Immunol 15:1421436. https:\/\/doi.org\/10.3389\/fimmu.2024.1421436","journal-title":"Front Immunol"},{"key":"4991_CR44","first-page":"80","volume":"112","author":"KM Leehan","year":"2018","unstructured":"Leehan KM, Pezant NP, Rasmussen A et al (2018) Minor salivary gland fibrosis in Sj\u00f6gren\u2019s syndrome is elevated, associated with focus score and not solely a consequence of aging. Clin Exp Rheumatol 36 Suppl 112:80\u201388","journal-title":"Clin Exp Rheumatol 36 Suppl"},{"key":"4991_CR45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.omtn.2022.09.020","volume":"30","author":"J Yoon","year":"2022","unstructured":"Yoon J, Lee M, Ali AA et al (2022) Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sj\u04e7gren\u2019s syndrome. Mol Ther Nucleic Acids 30:257\u2013269. https:\/\/doi.org\/10.1016\/j.omtn.2022.09.020","journal-title":"Mol Ther Nucleic Acids"},{"key":"4991_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120470","volume":"354","author":"W Zhu","year":"2026","unstructured":"Zhu W, Chen L, Li Y et al (2026) Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sj\u00f6gren\u2019s syndrome by reducing oxidative stress in salivary gland epithelial cells. J Ethnopharmacol 354:120470. https:\/\/doi.org\/10.1016\/j.jep.2025.120470","journal-title":"J Ethnopharmacol"},{"key":"4991_CR47","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/labinvest.2011.190","volume":"92","author":"S Lisi","year":"2012","unstructured":"Lisi S, Sisto M, Lofrumento DD, D\u2019Amore M (2012) Sj\u00f6gren\u2019s syndrome autoantibodies provoke changes in gene expression profiles of inflammatory cytokines triggering a pathway involving TACE\/NF-\u03baB. Lab Invest 92:615\u2013624. https:\/\/doi.org\/10.1038\/labinvest.2011.190","journal-title":"Lab Invest"},{"key":"4991_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092821","volume":"9","author":"M Sisto","year":"2020","unstructured":"Sisto M, Ribatti D, Lisi S (2020) Understanding the complexity of Sj\u00f6gren\u2019s syndrome: remarkable progress in elucidating NF-\u03baB mechanisms. J Clin Med 9:2821. https:\/\/doi.org\/10.3390\/jcm9092821","journal-title":"J Clin Med"},{"key":"4991_CR49","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12967-019-2017-x","volume":"17","author":"P Li","year":"2019","unstructured":"Li P, Yang Y, Jin Y et al (2019) B7-H3 participates in human salivary gland epithelial cells apoptosis through NF-\u03baB pathway in primary Sj\u00f6gren\u2019s syndrome. J Transl Med 17:268. https:\/\/doi.org\/10.1186\/s12967-019-2017-x","journal-title":"J Transl Med"},{"key":"4991_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300156","author":"CC Cotomacio","year":"2023","unstructured":"Cotomacio CC, Yshikawa BK, Calarga CC et al (2023) Red, infrared, and simultaneous laser-wavelengths irradiation effects on 5\u2010fluorouracil\u2010induced oral mucositis in hamsters. J Biophotonics. https:\/\/doi.org\/10.1002\/jbio.202300156","journal-title":"J Biophotonics"},{"key":"4991_CR51","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1186\/s40001-024-02167-x","volume":"29","author":"M-S Hosseini","year":"2024","unstructured":"Hosseini M-S, Sanaie S, Mahmoodpoor A et al (2024) Cancer treatment-related xerostomia: basics, therapeutics, and future perspectives. Eur J Med Res 29:571. https:\/\/doi.org\/10.1186\/s40001-024-02167-x","journal-title":"Eur J Med Res"},{"key":"4991_CR52","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bcp.2017.08.024","volume":"145","author":"LE Bomfin","year":"2017","unstructured":"Bomfin LE, Braga CM, Oliveira TA et al (2017) 5-Fluorouracil induces inflammation and oxidative stress in the major salivary glands affecting salivary flow and saliva composition. Biochem Pharmacol 145:34\u201345. https:\/\/doi.org\/10.1016\/j.bcp.2017.08.024","journal-title":"Biochem Pharmacol"},{"key":"4991_CR53","doi-asserted-by":"publisher","unstructured":"Golnarnik G, S\u00f8land TM, Galtung HK, Haug TM (2024) Hydrogen peroxide disrupts the regulatory pathway of saliva secretion in two salivary acinar rat cell lines. Front Mol Biosci 11. https:\/\/doi.org\/10.3389\/fmolb.2024.1480721","DOI":"10.3389\/fmolb.2024.1480721"},{"key":"4991_CR54","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04767-8","author":"GER Silva","year":"2025","unstructured":"Silva GER, Padovezi ACE, Barzotti RJ et al (2025) Induction of oxidative stress and functional impairment by Doxorubicin in rat salivary glands. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-025-04767-8","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4991_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411654","volume":"24","author":"T-H Nguyen","year":"2023","unstructured":"Nguyen T-H, Chiu K-C, Shih Y-H et al (2023) Protective effect of electroacupuncture on chemotherapy-induced salivary gland hypofunction in a mouse model. Int J Mol Sci 24:11654. https:\/\/doi.org\/10.3390\/ijms241411654","journal-title":"Int J Mol Sci"},{"key":"4991_CR56","doi-asserted-by":"publisher","first-page":"6510159","DOI":"10.1155\/2018\/6510159","volume":"2018","author":"K Rupel","year":"2018","unstructured":"Rupel K, Zupin L, Colliva A et al (2018) Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo. Oxid Med Cell Longev 2018:6510159. https:\/\/doi.org\/10.1155\/2018\/6510159","journal-title":"Oxid Med Cell Longev"},{"key":"4991_CR57","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-025-02915-4","author":"L Chen","year":"2026","unstructured":"Chen L, Chen J, Huang Y et al (2026) The Prevalence of Radiation-Induced Xerostomia in Patients with Head and Neck Cancer: A Systematic Review and Meta-analysis. J Maxillofac Oral Surg. https:\/\/doi.org\/10.1007\/s12663-025-02915-4","journal-title":"J Maxillofac Oral Surg"},{"key":"4991_CR58","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.archoralbio.2015.09.014","volume":"60","author":"MD Acauan","year":"2015","unstructured":"Acauan MD, Figueiredo MAZ, Cherubini K et al (2015) Radiotherapy-induced salivary dysfunction: Structural changes, pathogenetic mechanisms and therapies. Arch Oral Biol 60:1802\u20131810. https:\/\/doi.org\/10.1016\/j.archoralbio.2015.09.014","journal-title":"Arch Oral Biol"},{"key":"4991_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111666","volume":"10","author":"Z Liu","year":"2021","unstructured":"Liu Z, Dong L, Zheng Z et al (2021) Mechanism, prevention, and treatment of radiation-induced salivary gland injury related to oxidative stress. Antioxidants (Basel) 10:1666. https:\/\/doi.org\/10.3390\/antiox10111666","journal-title":"Antioxidants (Basel)"},{"key":"4991_CR60","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.ijrobp.2004.12.051","volume":"62","author":"AWT Konings","year":"2005","unstructured":"Konings AWT, Coppes RP, Vissink A (2005) On the mechanism of salivary gland radiosensitivity. Int J Radiat Oncol Biol Phys 62:1187\u20131194. https:\/\/doi.org\/10.1016\/j.ijrobp.2004.12.051","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4991_CR61","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/j.bbamcr.2018.07.002","volume":"1865","author":"I Ambudkar","year":"2018","unstructured":"Ambudkar I (2018) Calcium signaling defects underlying salivary gland dysfunction. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:1771\u20131777. https:\/\/doi.org\/10.1016\/j.bbamcr.2018.07.002","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"4991_CR62","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1667\/RR3569.1","volume":"165","author":"Z Li","year":"2006","unstructured":"Li Z, Zhao D, Gong B et al (2006) Decreased Saliva Secretion and Down-Regulation of AQP5 in Submandibular Gland in Irradiated Rats. Radiat Res 165:678\u2013687. https:\/\/doi.org\/10.1667\/RR3569.1","journal-title":"Radiat Res"},{"key":"4991_CR63","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.tice.2018.06.006","volume":"53","author":"MVT Araujo","year":"2018","unstructured":"Araujo MVT, Spadella MA, Chies AB et al (2018) Effect of low radiation dose on the expression and location of aquaporins in rat submandibular gland. Tissue Cell 53:104\u2013110. https:\/\/doi.org\/10.1016\/j.tice.2018.06.006","journal-title":"Tissue Cell"},{"key":"4991_CR64","doi-asserted-by":"publisher","first-page":"262","DOI":"10.34172\/jlms.2020.44","volume":"11","author":"GF Krueger","year":"2020","unstructured":"Krueger GF, de Oliveira MC, Gassen HT et al (2020) Evaluation of aquaporins 1 and 5 expression in rat parotid glands after volumetric modulated arc radiotherapy and use of low-level laser therapy at different times. J Lasers Med Sci 11:262\u2013267. https:\/\/doi.org\/10.34172\/jlms.2020.44","journal-title":"J Lasers Med Sci"},{"key":"4991_CR65","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00784-021-03995-5","volume":"26","author":"TMO Ventura","year":"2022","unstructured":"Ventura TMO, Ribeiro NR, Taira EA et al (2022) Radiotherapy changes the salivary proteome in head and neck cancer patients: evaluation before, during, and after treatment. Clin Oral Investig 26:225\u2013258. https:\/\/doi.org\/10.1007\/s00784-021-03995-5","journal-title":"Clin Oral Investig"},{"key":"4991_CR66","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3233\/CBM-2011-0205","volume":"8","author":"A Vidotto","year":"2011","unstructured":"Vidotto A, Henrique T, Raposo LS et al (2011) Salivary and serum proteomics in head and neck carcinomas: before and after surgery and radiotherapy. Cancer Biomark 8:95\u2013107. https:\/\/doi.org\/10.3233\/CBM-2011-0205","journal-title":"Cancer Biomark"},{"key":"4991_CR67","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jprot.2015.04.030","volume":"125","author":"N Jehmlich","year":"2015","unstructured":"Jehmlich N, Stegmaier P, Golatowski C et al (2015) Differences in the whole saliva baseline proteome profile associated with development of oral mucositis in head and neck cancer patients undergoing radiotherapy. J Proteom 125:98\u2013103. https:\/\/doi.org\/10.1016\/j.jprot.2015.04.030","journal-title":"J Proteom"},{"key":"4991_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073714","volume":"23","author":"H Hynne","year":"2022","unstructured":"Hynne H, Aqrawi LA, Jensen JL et al (2022) Proteomic profiling of saliva and tears in radiated head and neck cancer patients as compared to primary Sj\u00f6gren\u2019s syndrome patients. Int J Mol Sci 23:3714. https:\/\/doi.org\/10.3390\/ijms23073714","journal-title":"Int J Mol Sci"},{"key":"4991_CR69","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.radonc.2005.10.002","volume":"77","author":"AP Jellema","year":"2005","unstructured":"Jellema AP, Doornaert P, Slotman BJ et al (2005) Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy? Radiother Oncol 77:164\u2013171. https:\/\/doi.org\/10.1016\/j.radonc.2005.10.002","journal-title":"Radiother Oncol"},{"key":"4991_CR70","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","volume":"12","author":"CM Nutting","year":"2011","unstructured":"Nutting CM, Morden JP, Harrington KJ et al (2011) Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 12:127\u2013136. https:\/\/doi.org\/10.1016\/S1470-2045(10)70290-4","journal-title":"Lancet Oncol"},{"key":"4991_CR71","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/02841868709089980","volume":"26","author":"TA Makkonen","year":"1987","unstructured":"Makkonen TA, Nordman E (1987) Estimation of Long-Term Salivary Gland Damage Induced by Radiotherapy. Acta Oncol (Madr) 26:307\u2013312. https:\/\/doi.org\/10.3109\/02841868709089980","journal-title":"Acta Oncol (Madr)"},{"key":"4991_CR72","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.radmp.2026.02.003","volume":"7","author":"D You","year":"2026","unstructured":"You D, Zhou J, Zhu G et al (2026) Association of irradiation dose and increased incidence of xerostomia inpatients with nasopharyngeal carcinoma. Radiat Med Prot 7:73\u201380. https:\/\/doi.org\/10.1016\/j.radmp.2026.02.003","journal-title":"Radiat Med Prot"},{"key":"4991_CR73","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-025-02737-1","volume":"20","author":"A Abou-Bakr","year":"2025","unstructured":"Abou-Bakr A, Hassanein FEA, William H, Ibrahim SS (2025) Prevalence of late xerostomia and hyposalivation with associated risk factors in survivors of head and neck cancer after radiotherapy: a multi-centric cross-sectional study. Radiat Oncol 20:162. https:\/\/doi.org\/10.1186\/s13014-025-02737-1","journal-title":"Radiat Oncol"},{"key":"4991_CR74","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.radonc.2010.10.013","volume":"98","author":"M-B Me\u00dfmer","year":"2011","unstructured":"Me\u00dfmer M-B, Thomsen A, Kirste S et al (2011) Xerostomia after radiotherapy in the head&neck area: Long-term observations. Radiother Oncol 98:48\u201350. https:\/\/doi.org\/10.1016\/j.radonc.2010.10.013","journal-title":"Radiother Oncol"},{"key":"4991_CR75","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00066-012-0289-7","volume":"189","author":"M Lambrecht","year":"2013","unstructured":"Lambrecht M, Nevens D, Nuyts S (2013) Intensity-modulated radiotherapy vs. parotid-sparing 3D conformal radiotherapy. Strahlenther Onkol 189:223\u2013229. https:\/\/doi.org\/10.1007\/s00066-012-0289-7","journal-title":"Strahlenther Onkol"},{"key":"4991_CR76","doi-asserted-by":"publisher","DOI":"10.20517\/2394-4722.2024.79","author":"P Kiafi","year":"2024","unstructured":"Kiafi P, Chalkia M, Kouri MA et al (2024) Photon vs proton radiation therapy in head and neck cancer: a review of dosimetric advantages and patient quality of life. J Cancer Metastasis Treat. https:\/\/doi.org\/10.20517\/2394-4722.2024.79","journal-title":"J Cancer Metastasis Treat"},{"key":"4991_CR77","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/jmp.JMP_19_19","volume":"44","author":"H Zhang","year":"2019","unstructured":"Zhang H, Cao Y, Antone J et al (2019) A Model-based method for assessment of salivary gland and planning target volume dosimetry in volumetric-modulated arc therapy planning on head-and-neck cancer. J Med Phys 44:201. https:\/\/doi.org\/10.4103\/jmp.JMP_19_19","journal-title":"J Med Phys"},{"key":"4991_CR78","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.oooo.2013.01.006","volume":"115","author":"K Randall","year":"2013","unstructured":"Randall K, Stevens J, Yepes JF et al (2013) Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol 115:772\u2013779. https:\/\/doi.org\/10.1016\/j.oooo.2013.01.006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4991_CR79","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1177\/154411130301400305","volume":"14","author":"A Vissink","year":"2003","unstructured":"Vissink A, Jansma J, Spijkervet FKL et al (2003) Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med 14:199\u2013212. https:\/\/doi.org\/10.1177\/154411130301400305","journal-title":"Crit Rev Oral Biol Med"},{"key":"4991_CR80","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1089\/pho.2008.2300","volume":"27","author":"L Campos","year":"2009","unstructured":"Campos L, Sim\u00f5es A, S\u00e1 PHRN, Eduardo CDP (2009) Improvement in quality of life of an oncological patient by laser phototherapy. Photomed Laser Surg 27:371\u2013374. https:\/\/doi.org\/10.1089\/pho.2008.2300","journal-title":"Photomed Laser Surg"},{"key":"4991_CR81","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/hed.21737","volume":"34","author":"AF Oton-Leite","year":"2012","unstructured":"Oton-Leite AF, De Corr\u00eaa AC, Morais MO et al (2012) Effect of intraoral low-level laser therapy on quality of life of patients with head and neck cancer undergoing radiotherapy. Head Neck 34:398\u2013404. https:\/\/doi.org\/10.1002\/hed.21737","journal-title":"Head Neck"},{"key":"4991_CR82","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1590\/0100-3984.2014.0144","volume":"49","author":"FAS Gonnelli","year":"2016","unstructured":"Gonnelli FAS, Palma LF, Giordani AJ et al (2016) Low-level laser therapy for the prevention of low salivary flow rate after radiotherapy and chemotherapy in patients with head and neck cancer. Radiol Bras 49:86\u201391. https:\/\/doi.org\/10.1590\/0100-3984.2014.0144","journal-title":"Radiol Bras"},{"key":"4991_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40268-016-0153-9","volume":"17","author":"A Wolff","year":"2017","unstructured":"Wolff A, Joshi RK, Ekstr\u00f6m J et al (2017) A guide to medications inducing salivary gland dysfunction, xerostomia, and subjective sialorrhea: a systematic review sponsored by the World Workshop on Oral Medicine VI. Drugs R D 17:1\u201328. https:\/\/doi.org\/10.1007\/s40268-016-0153-9","journal-title":"Drugs R D"},{"key":"4991_CR84","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/prd.12116","volume":"70","author":"GB Proctor","year":"2016","unstructured":"Proctor GB (2016) The physiology of salivary secretion. Periodontol 2000 70:11\u201325. https:\/\/doi.org\/10.1111\/prd.12116","journal-title":"Periodontol 2000"},{"key":"4991_CR85","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1177\/2380084419844511","volume":"5","author":"A Tiisanoja","year":"2020","unstructured":"Tiisanoja A, Syrj\u00e4l\u00e4 A-M, Kullaa A, Yl\u00f6stalo P (2020) Anticholinergic burden and dry mouth in middle-aged people. JDR Clin Transl Res 5:62\u201370. https:\/\/doi.org\/10.1177\/2380084419844511","journal-title":"JDR Clin Transl Res"},{"key":"4991_CR86","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.archoralbio.2014.10.004","volume":"60","author":"J Saleh","year":"2015","unstructured":"Saleh J, Figueiredo MAZ, Cherubini K, Salum FG (2015) Salivary hypofunction: An update on aetiology, diagnosis and therapeutics. Arch Oral Biol 60:242\u2013255. https:\/\/doi.org\/10.1016\/j.archoralbio.2014.10.004","journal-title":"Arch Oral Biol"},{"key":"4991_CR87","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.oooo.2021.08.015","volume":"132","author":"S Arany","year":"2021","unstructured":"Arany S, Kopycka-Kedzierawski DT, Caprio TV, Watson GE (2021) Anticholinergic medication: Related dry mouth and effects on the salivary glands. Oral Surg Oral Med Oral Pathol Oral Radiol 132:662\u2013670. https:\/\/doi.org\/10.1016\/j.oooo.2021.08.015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4991_CR88","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1741-2358.1997.00033.x","volume":"14","author":"LM Sreebny","year":"1997","unstructured":"Sreebny LM, Schwartz SS (1997) A reference guide to drugs and dry mouth \u2013 2nd edition. Gerodontology 14:33\u201347. https:\/\/doi.org\/10.1111\/j.1741-2358.1997.00033.x","journal-title":"Gerodontology"},{"key":"4991_CR89","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1752-7325.2000.tb03286.x","volume":"60","author":"WM Thomson","year":"2000","unstructured":"Thomson WM, Chalmers JM, Spencer AJ, Slade GD (2000) Medication and Dry Mouth: Findings from a Cohort Study of Older People. J Public Health Dent 60:12\u201320. https:\/\/doi.org\/10.1111\/j.1752-7325.2000.tb03286.x","journal-title":"J Public Health Dent"},{"key":"4991_CR90","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s40266-026-01286-w","volume":"43","author":"IB Ringstad","year":"2026","unstructured":"Ringstad IB, Skovlund E, Roa Santervas L et al (2026) Association Between Anticholinergic Burden and Dry Mouth Severity in Acutely Ill Older Adults. Drugs Aging 43:361\u2013371. https:\/\/doi.org\/10.1007\/s40266-026-01286-w","journal-title":"Drugs Aging"},{"key":"4991_CR91","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/jgs.15151","volume":"66","author":"ECK Tan","year":"2018","unstructured":"Tan ECK, Lexomboon D, Sandborgh-Englund G et al (2018) Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis. J Am Geriatr Soc 66:76\u201384. https:\/\/doi.org\/10.1111\/jgs.15151","journal-title":"J Am Geriatr Soc"},{"key":"4991_CR92","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065358","volume":"24","author":"Y-J Kim","year":"2023","unstructured":"Kim Y-J (2023) Xerostomia and its cellular targets. Int J Mol Sci 24:5358. https:\/\/doi.org\/10.3390\/ijms24065358","journal-title":"Int J Mol Sci"},{"key":"4991_CR93","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/geriatrics5040070","volume":"5","author":"F Mizuhashi","year":"2020","unstructured":"Mizuhashi F, Morita T, Toya S et al (2020) Protein Ingredient in Saliva on Oral Dryness Patients Caused by Calcium Blocker. Geriatrics 5:70. https:\/\/doi.org\/10.3390\/geriatrics5040070","journal-title":"Geriatrics"},{"key":"4991_CR94","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1001\/archinte.167.8.781","volume":"167","author":"SN Hilmer","year":"2007","unstructured":"Hilmer SN (2007) A Drug Burden Index to Define the Functional Burden of Medications in Older People. Arch Intern Med 167:781. https:\/\/doi.org\/10.1001\/archinte.167.8.781","journal-title":"Arch Intern Med"},{"key":"4991_CR95","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1023\/B:BGEN.0000038023.36727.50","volume":"5","author":"RM Nagler","year":"2004","unstructured":"Nagler RM (2004) Salivary Glands and the Aging Process: Mechanistic Aspects, Health-Status and Medicinal-Efficacy Monitoring. Biogerontology 5:223\u2013233. https:\/\/doi.org\/10.1023\/B:BGEN.0000038023.36727.50","journal-title":"Biogerontology"},{"key":"4991_CR96","doi-asserted-by":"crossref","unstructured":"Chavantes MC, Ribeiro MS, Pinto NC (2015) Low power lasers. Lasers in Dentistry. Wiley, pp 19\u201322","DOI":"10.1002\/9781118987742.ch3"},{"key":"4991_CR97","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1089\/pho.2016.4109","volume":"34","author":"D Terlevi\u0107 Dabi\u0107","year":"2016","unstructured":"Terlevi\u0107 Dabi\u0107 D, Juri\u0161i\u0107 S, Vu\u010di\u0107evi\u0107 Boras V et al (2016) The Effectiveness of Low-Level Laser Therapy in Patients with Drug-Induced Hyposalivation: A Pilot Study. Photomed Laser Surg 34:389\u2013393. https:\/\/doi.org\/10.1089\/pho.2016.4109","journal-title":"Photomed Laser Surg"},{"key":"4991_CR98","doi-asserted-by":"publisher","unstructured":"Sharifnia AM, Chu G, Zhang X et al (2024) Comparative efficacy of non-pharmacological interventions on xerostomia and salivary flow rate among haemodialysis patients: A systematic review and network meta-analysis. Clin Kidney J 17. https:\/\/doi.org\/10.1093\/ckj\/sfae334","DOI":"10.1093\/ckj\/sfae334"},{"key":"4991_CR99","doi-asserted-by":"publisher","first-page":"297","DOI":"10.4103\/0972-124X.154178","volume":"19","author":"B Anuradha","year":"2015","unstructured":"Anuradha B, Katta S, Kode V et al (2015) Oral and salivary changes in patients with chronic kidney disease: A clinical and biochemical study. J Indian Soc Periodontol 19:297. https:\/\/doi.org\/10.4103\/0972-124X.154178","journal-title":"J Indian Soc Periodontol"},{"key":"4991_CR100","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s10103-020-03158-0","volume":"36","author":"VCS Pavesi","year":"2021","unstructured":"Pavesi VCS, Martins MD, Coracin FL et al (2021) Effects of photobiomodulation in salivary glands of chronic kidney disease patients on hemodialysis. Lasers Med Sci 36:1209\u20131217. https:\/\/doi.org\/10.1007\/s10103-020-03158-0","journal-title":"Lasers Med Sci"},{"key":"4991_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/4372852","volume":"2016","author":"RM L\u00f3pez-Pintor","year":"2016","unstructured":"L\u00f3pez-Pintor RM, Casa\u00f1as E, Gonz\u00e1lez-Serrano J et al (2016) Xerostomia, Hyposalivation, and Salivary Flow in Diabetes Patients. J Diabetes Res 2016:1\u201315. https:\/\/doi.org\/10.1155\/2016\/4372852","journal-title":"J Diabetes Res"},{"key":"4991_CR102","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.archoralbio.2012.02.016","volume":"57","author":"AC Romero","year":"2012","unstructured":"Romero AC, Ibuki FK, Nogueira FN (2012) Sialic acid reduction in the saliva of streptozotocin induced diabetic rats. Arch Oral Biol 57:1189\u20131193. https:\/\/doi.org\/10.1016\/j.archoralbio.2012.02.016","journal-title":"Arch Oral Biol"},{"key":"4991_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2024.101845","volume":"56","author":"MLZ Varellis","year":"2024","unstructured":"Varellis MLZ, Bussadori SK, Pavesi VCS et al (2024) Evaluation of photobiomodulation in the salivary production of patients with hyposalivation induced by antihypertensive drugs \u2013 a blind, randomized, controlled clinical trial. Complement Ther Clin Pract 56:101845. https:\/\/doi.org\/10.1016\/j.ctcp.2024.101845","journal-title":"Complement Ther Clin Pract"},{"key":"4991_CR104","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1159\/000077760","volume":"38","author":"C Dawes","year":"2004","unstructured":"Dawes C (2004) How Much Saliva Is Enough for Avoidance of Xerostomia? Caries Res 38:236\u2013240. https:\/\/doi.org\/10.1159\/000077760","journal-title":"Caries Res"},{"key":"4991_CR105","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.archoralbio.2015.03.004","volume":"60","author":"C Dawes","year":"2015","unstructured":"Dawes C, Pedersen AML, Villa A et al (2015) The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol 60:863\u2013874. https:\/\/doi.org\/10.1016\/j.archoralbio.2015.03.004","journal-title":"Arch Oral Biol"},{"key":"4991_CR106","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1600-0722.2010.00728.x","volume":"118","author":"R Pramanik","year":"2010","unstructured":"Pramanik R, Osailan SM, Challacombe SJ et al (2010) Protein and mucin retention on oral mucosal surfaces in dry mouth patients. Eur J Oral Sci 118:245\u2013253. https:\/\/doi.org\/10.1111\/j.1600-0722.2010.00728.x","journal-title":"Eur J Oral Sci"},{"key":"4991_CR107","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23996","author":"M Fusconi","year":"2021","unstructured":"Fusconi M, Candelori F, Weiss L et al (2021) Qualitative mucin disorders in patients with primary Sj\u00f6gren\u2019s syndrome: a literature review. Med Oral Patol Oral Cir Bucal. https:\/\/doi.org\/10.4317\/medoral.23996","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"4991_CR108","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.exphem.2006.10.009","volume":"35","author":"MM Imanguli","year":"2007","unstructured":"Imanguli MM, Atkinson JC, Harvey KE et al (2007) Changes in salivary proteome following allogeneic hematopoietic stem cell transplantation. Exp Hematol 35:184\u2013192. https:\/\/doi.org\/10.1016\/j.exphem.2006.10.009","journal-title":"Exp Hematol"},{"key":"4991_CR109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135792","volume":"10","author":"A Vijay","year":"2015","unstructured":"Vijay A, Inui T, Dodds M et al (2015) Factors that influence the extensional rheological property of saliva. PLoS One 10:e0135792. https:\/\/doi.org\/10.1371\/journal.pone.0135792","journal-title":"PLoS One"},{"key":"4991_CR110","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3322\/caac.21157","volume":"62","author":"JB Epstein","year":"2012","unstructured":"Epstein JB, Thariat J, Bensadoun R-J et al (2012) Oral complications of cancer and cancer therapy: From cancer treatment to survivorship. CA Cancer J Clin 62:400\u2013422. https:\/\/doi.org\/10.3322\/caac.21157","journal-title":"CA Cancer J Clin"},{"key":"4991_CR111","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/10454411900010040201","volume":"1","author":"LA Tabak","year":"1990","unstructured":"Tabak LA (1990) Structure And Function of Human Salivary Mucins. Crit Reviews Oral Biology Med 1:229\u2013234. https:\/\/doi.org\/10.1177\/10454411900010040201","journal-title":"Crit Reviews Oral Biology Med"},{"key":"4991_CR112","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.job.2022.09.005","volume":"64","author":"M Faruque","year":"2022","unstructured":"Faruque M, Wanschers M, Ligtenberg AJ et al (2022) A review on the role of salivary MUC5B in oral health. J Oral Biosci 64:392\u2013399. https:\/\/doi.org\/10.1016\/j.job.2022.09.005","journal-title":"J Oral Biosci"},{"key":"4991_CR113","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1177\/0022034515609070","volume":"94","author":"NMA Chaudhury","year":"2015","unstructured":"Chaudhury NMA, Shirlaw P, Pramanik R et al (2015) Changes in Saliva Rheological Properties and Mucin Glycosylation in Dry Mouth. J Dent Res 94:1660\u20131667. https:\/\/doi.org\/10.1177\/0022034515609070","journal-title":"J Dent Res"},{"key":"4991_CR114","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1136\/ard.2007.078246","volume":"67","author":"C Alliende","year":"2008","unstructured":"Alliende C, Kwon Y-J, Brito M et al (2008) Reduced sulfation of MUC5B is linked to xerostomia in patients with Sj\u00f6gren syndrome. Ann Rheum Dis 67:1480\u20131487. https:\/\/doi.org\/10.1136\/ard.2007.078246","journal-title":"Ann Rheum Dis"},{"key":"4991_CR115","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2019.151451","volume":"121","author":"DJ Aframian","year":"2019","unstructured":"Aframian DJ, Keshet N, Nadler C et al (2019) Minor salivary glands: clinical, histological and immunohistochemical features of common and less common pathologies. Acta Histochem 121:151451. https:\/\/doi.org\/10.1016\/j.acthis.2019.151451","journal-title":"Acta Histochem"},{"key":"4991_CR116","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-026-07798-6","volume":"26","author":"SS Kumar","year":"2026","unstructured":"Kumar SS, Arany-Lao-Kan G, Xu X et al (2026) Minor salivary flow as a diagnostic tool for screening hyposalivation in medication-induced xerostomia. BMC Oral Health 26:454. https:\/\/doi.org\/10.1186\/s12903-026-07798-6","journal-title":"BMC Oral Health"},{"key":"4991_CR117","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.archoralbio.2016.05.012","volume":"69","author":"Z Wang","year":"2016","unstructured":"Wang Z, Li W, Hong X et al (2016) Minor salivary glands function is decreased in hyposalivation-related diseases. Arch Oral Biol 69:63\u201370. https:\/\/doi.org\/10.1016\/j.archoralbio.2016.05.012","journal-title":"Arch Oral Biol"},{"key":"4991_CR118","doi-asserted-by":"publisher","DOI":"10.1007\/s41547-025-00279-z","volume":"9","author":"IH Carvalho","year":"2025","unstructured":"Carvalho IH, Barros EF, de Lima BH et al (2025) Photobiomodulation as a therapeutic alternative to improve xerostomia and hyposalivation in a Sj\u00f6gren\u2019s disease patient: case report. Lasers Dent Sci 9:5. https:\/\/doi.org\/10.1007\/s41547-025-00279-z","journal-title":"Lasers Dent Sci"},{"key":"4991_CR119","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-026-05931-1","volume":"20","author":"C Sanchez-Ramirez","year":"2026","unstructured":"Sanchez-Ramirez C, Bernotti AL, De Jes\u00fas E et al (2026) Diode-laser-assisted biopsy and photobiomodulation therapy in the management of Sj\u00f6gren\u2019s disease: a case report. J Med Case Rep 20:228. https:\/\/doi.org\/10.1186\/s13256-026-05931-1","journal-title":"J Med Case Rep"},{"key":"4991_CR120","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1186\/s12903-025-06735-3","volume":"25","author":"M Lopez-Garzon","year":"2025","unstructured":"Lopez-Garzon M, Plata-Peregrina M, del Perez-Sanchez C EI, et al (2025) Photobiomodulation for restoring salivary flow after radiotherapy in head and neck cancer: a randomised placebo-controlled trial. BMC Oral Health 25:1468. https:\/\/doi.org\/10.1186\/s12903-025-06735-3","journal-title":"BMC Oral Health"},{"key":"4991_CR121","first-page":"157","volume":"51","author":"F Arbabi-Kalati","year":"2013","unstructured":"Arbabi-Kalati F, Arbabi-Kalati F, Moridi T (2013) Evaluation of the effect of low level laser on prevention of chemotherapy-induced mucositis. Acta Med Iran 51:157\u2013162","journal-title":"Acta Med Iran"},{"key":"4991_CR122","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.canrad.2012.05.005","volume":"16","author":"E Caillot","year":"2012","unstructured":"Caillot E, Denis F (2012) Radio-induced oral and pharyngeal mucositis: management updates. Cancer Radiother 16:358\u2013363. https:\/\/doi.org\/10.1016\/j.canrad.2012.05.005","journal-title":"Cancer Radiother"},{"key":"4991_CR123","doi-asserted-by":"publisher","first-page":"102485","DOI":"10.1016\/j.jormas.2025.102485","volume":"126","author":"CP Dur\u00e3es","year":"2025","unstructured":"Dur\u00e3es CP, Fonseca LL, Santos SHS et al (2025) Effect of photobiomodulation on rat parotid gland cells after ionizing radiation \u2013 an experimental study in animal model \u2013 Part 1. J Stomatol Oral Maxillofac Surg 126:102485. https:\/\/doi.org\/10.1016\/j.jormas.2025.102485","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"4991_CR124","doi-asserted-by":"publisher","first-page":"103115","DOI":"10.1016\/j.critrevonc.2020.103115","volume":"156","author":"GC Louzeiro","year":"2020","unstructured":"Louzeiro GC, Teixeira Dda, Cherubini S K, et al (2020) Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials. Crit Rev Oncol Hematol 156:103115. https:\/\/doi.org\/10.1016\/j.critrevonc.2020.103115","journal-title":"Crit Rev Oncol Hematol"},{"key":"4991_CR125","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-09120-y","volume":"33","author":"N Schepanski","year":"2025","unstructured":"Schepanski N, da Silva Liebl BM, Mendes RT et al (2025) Effects of photobiomodulation and bethanechol chloride treatment on salivary composition and flow rate in head and neck cancer patients undergoing radiotherapy: longitudinal interventional experimental clinical study. Support Care Cancer 33:113. https:\/\/doi.org\/10.1007\/s00520-024-09120-y","journal-title":"Support Care Cancer"},{"key":"4991_CR126","doi-asserted-by":"publisher","DOI":"10.3390\/dj6040064","volume":"6","author":"M El Mobadder","year":"2018","unstructured":"El Mobadder M, Farhat F, El Mobadder W, Nammour S (2018) Photobiomodulation therapy in the treatment of oral mucositis, dysgeusia and oral dryness as side-effects of head and neck radiotherapy in a cancer patient: a case report. Dent J (Basel) 6:64. https:\/\/doi.org\/10.3390\/dj6040064","journal-title":"Dent J (Basel)"},{"key":"4991_CR127","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2024.04","volume":"15","author":"P Mosannen Mozaffari","year":"2024","unstructured":"Mosannen Mozaffari P, Delavarian Z, Fekrazad R et al (2024) Evaluation of the effect of photobiomodulation on radiation-induced xerostomia in head and neck cancer patients: a randomized clinical trial. J Lasers Med Sci 15:e4. https:\/\/doi.org\/10.34172\/jlms.2024.04","journal-title":"J Lasers Med Sci"},{"key":"4991_CR128","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.oooo.2023.11.007","volume":"137","author":"N Schepanski","year":"2024","unstructured":"Schepanski N, Costa FS, Machado EFM et al (2024) Evaluation of photobiomodulation therapy (PBMT) on salivary flow and composition in head and neck cancer patients undergoing radiation therapy. Oral Surg Oral Med Oral Pathol Oral Radiol 137:253\u2013263. https:\/\/doi.org\/10.1016\/j.oooo.2023.11.007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4991_CR129","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s10103-017-2180-3","volume":"32","author":"LF Palma","year":"2017","unstructured":"Palma LF, Gonnelli FAS, Marcucci M et al (2017) Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci 32:827\u2013832. https:\/\/doi.org\/10.1007\/s10103-017-2180-3","journal-title":"Lasers Med Sci"},{"key":"4991_CR130","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-025-04292-3","volume":"40","author":"A Alsoghier","year":"2025","unstructured":"Alsoghier A, Mutaieb S, Bukhari A et al (2025) Management of radiotherapy-induced hyposalivation using photobiomodulation therapy: a case series. Lasers Med Sci 40:25. https:\/\/doi.org\/10.1007\/s10103-025-04292-3","journal-title":"Lasers Med Sci"},{"key":"4991_CR131","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10103-023-03760-y","volume":"38","author":"ESRM de Carvalho","year":"2023","unstructured":"de Carvalho ESRM, Mendes FM, Degasperi GR, Pinheiro SL (2023) Photobiomodulation for the management of xerostomia and oral mucositis in patients with cancer: a randomized clinical trial. Lasers Med Sci 38:101. https:\/\/doi.org\/10.1007\/s10103-023-03760-y","journal-title":"Lasers Med Sci"},{"key":"4991_CR132","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10103-025-04539-z","volume":"40","author":"G Borghesi Brunelli","year":"2025","unstructured":"Borghesi Brunelli G, Pinheiro SL (2025) Combined extraoral and intraoral photobiomodulation for the prevention and management of oral mucositis and Xerostomia caused by the treatment of head and neck cancers. Lasers Med Sci 40:295. https:\/\/doi.org\/10.1007\/s10103-025-04539-z","journal-title":"Lasers Med Sci"},{"key":"4991_CR133","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/jop.70072","volume":"55","author":"WWP Melo","year":"2026","unstructured":"Melo WWP, Arag\u00e3o WAB, Ferreira MKM et al (2026) Effects of Clarified A\u00e7a\u00ed Supplementation and Photobiomodulation on the Parotid Glands of Rats Submitted to Chemotherapy. J Oral Pathol Med 55:120\u2013132. https:\/\/doi.org\/10.1111\/jop.70072","journal-title":"J Oral Pathol Med"},{"key":"4991_CR134","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12903-025-05579-1","volume":"25","author":"M Khalil","year":"2025","unstructured":"Khalil M, Hamadah O, Saifo M (2025) Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial. BMC Oral Health 25:190. https:\/\/doi.org\/10.1186\/s12903-025-05579-1","journal-title":"BMC Oral Health"},{"key":"4991_CR135","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1754-4505.2009.00078.x","volume":"29","author":"A Sim\u00f5es","year":"2009","unstructured":"Sim\u00f5es A, Platero MD, Campos L et al (2009) Laser as a therapy for dry mouth symptoms in a patient with Sj\u00f6gren\u2019s syndrome: a case report. Spec Care Dentist 29:134\u2013137. https:\/\/doi.org\/10.1111\/j.1754-4505.2009.00078.x","journal-title":"Spec Care Dentist"},{"key":"4991_CR136","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1007\/s10103-014-1590-8","volume":"30","author":"A Cafaro","year":"2015","unstructured":"Cafaro A, Arduino PG, Gambino A et al (2015) Effect of laser acupuncture on salivary flow rate in patients with Sj\u00f6gren\u2019s syndrome. Lasers Med Sci 30:1805\u20131809. https:\/\/doi.org\/10.1007\/s10103-014-1590-8","journal-title":"Lasers Med Sci"},{"key":"4991_CR137","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s10067-017-3898-9","volume":"37","author":"T Fidelix","year":"2018","unstructured":"Fidelix T, Czapkowski A, Azjen S et al (2018) Low-level laser therapy for xerostomia in primary Sj\u00f6gren\u2019s syndrome: a randomized trial. Clin Rheumatol 37:729\u2013736. https:\/\/doi.org\/10.1007\/s10067-017-3898-9","journal-title":"Clin Rheumatol"},{"key":"4991_CR138","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s10103-025-04512-w","volume":"40","author":"DF Colares","year":"2025","unstructured":"Colares DF, de Souto Medeiros MR, de Ara\u00fajo ACG et al (2025) Photobiomodulation therapy for salivary gland hypofunction: a preliminary human study. Lasers Med Sci 40:264. https:\/\/doi.org\/10.1007\/s10103-025-04512-w","journal-title":"Lasers Med Sci"},{"key":"4991_CR139","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1200\/JCO.21.01208","volume":"39","author":"V Mercadante","year":"2021","unstructured":"Mercadante V, Jensen SB, Smith DK et al (2021) Salivary Gland Hypofunction and\/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO\/MASCC\/ASCO Guideline. J Clin Oncol 39:2825\u20132843. https:\/\/doi.org\/10.1200\/JCO.21.01208","journal-title":"J Clin Oncol"},{"key":"4991_CR140","doi-asserted-by":"publisher","first-page":"5515","DOI":"10.2174\/138161212803307509","volume":"18","author":"A Wolff","year":"2012","unstructured":"Wolff A, Fox C, Porter P, Konttinen ST Y (2012) Established and Novel Approaches for the Management of Hyposalivation and Xerostomia. Curr Pharm Des 18:5515\u20135521. https:\/\/doi.org\/10.2174\/138161212803307509","journal-title":"Curr Pharm Des"},{"key":"4991_CR141","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.21395","author":"C Carrara-Cotomacio","year":"2016","unstructured":"Carrara-Cotomacio C, Campos L, Simoes A et al (2016) Influence of bethanechol on salivary parameters in irradiated patients. Med Oral Patol Oral Cir Bucal. https:\/\/doi.org\/10.4317\/medoral.21395","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"4991_CR142","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.oraloncology.2006.01.013","volume":"43","author":"BC Jham","year":"2007","unstructured":"Jham BC, Teixeira IV, Aboud CG et al (2007) A randomized phase III prospective trial of bethanechol to prevent radiotherapy-induced salivary gland damage in patients with head and neck cancer. Oral Oncol 43:137\u2013142. https:\/\/doi.org\/10.1016\/j.oraloncology.2006.01.013","journal-title":"Oral Oncol"},{"key":"4991_CR143","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1200\/JCO.2000.18.19.3339","volume":"18","author":"DM Brizel","year":"2000","unstructured":"Brizel DM, Wasserman TH, Henke M et al (2000) Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer. J Clin Oncol 18:3339\u20133345. https:\/\/doi.org\/10.1200\/JCO.2000.18.19.3339","journal-title":"J Clin Oncol"},{"key":"4991_CR144","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.rdc.2016.03.010","volume":"42","author":"FB Vivino","year":"2016","unstructured":"Vivino FB, Carsons SE, Foulks G et al (2016) New Treatment Guidelines for Sj\u00f6gren\u2019s Disease. Rheumatic Disease Clin North Am 42:531\u2013551","journal-title":"Rheumatic Disease Clin North Am"},{"key":"4991_CR145","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.7150\/ijms.110366","volume":"22","author":"R-Y Tsai","year":"2025","unstructured":"Tsai R-Y, Lin S-Y, Chen C-C, Hsiao Y (2025) Efficacy of Acupuncture in Managing Radiation-Induced Xerostomia: An Updated Meta-Analysis. Int J Med Sci 22:2802\u20132815. https:\/\/doi.org\/10.7150\/ijms.110366","journal-title":"Int J Med Sci"},{"key":"4991_CR146","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-026-06864-1","author":"ED Martins","year":"2026","unstructured":"Martins ED, Rebou\u00e7as NIC, Dos Santos SQM et al (2026) Efficacy of artificial saliva in preventing oral changes in patients admitted to the ICU: a controlled clinical trial. Clin Oral Investig. https:\/\/doi.org\/10.1007\/s00784-026-06864-1","journal-title":"Clin Oral Investig"},{"key":"4991_CR147","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41591-018-0300-7","volume":"25","author":"EJ Topol","year":"2019","unstructured":"Topol EJ (2019) High-performance medicine: the convergence of human and artificial intelligence. Nat Med 25:44\u201356. https:\/\/doi.org\/10.1038\/s41591-018-0300-7","journal-title":"Nat Med"},{"key":"4991_CR148","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/stem.1327","volume":"31","author":"S Pringle","year":"2013","unstructured":"Pringle S, Van Os R, Coppes RP (2013) Concise review: adult salivary gland stem cells and a potential therapy for xerostomia. Stem Cells 31:613\u2013619. https:\/\/doi.org\/10.1002\/stem.1327","journal-title":"Stem Cells"},{"key":"4991_CR149","doi-asserted-by":"publisher","first-page":"683","DOI":"10.4196\/kjpp.25.149","volume":"29","author":"H-J Park","year":"2025","unstructured":"Park H-J, Cho J, Oh S-J, Kim H-S (2025) Organoid-based modeling and regenerative strategies for salivary gland dysfunction. Korean J Physiol Pharmacol 29:683\u2013698. https:\/\/doi.org\/10.4196\/kjpp.25.149","journal-title":"Korean J Physiol Pharmacol"},{"key":"4991_CR150","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41405-024-00219-2","volume":"10","author":"J Klangprapan","year":"2024","unstructured":"Klangprapan J, Souza GR, Ferreira JN (2024) Bioprinting salivary gland models and their regenerative applications. BDJ Open 10:39. https:\/\/doi.org\/10.1038\/s41405-024-00219-2","journal-title":"BDJ Open"},{"key":"4991_CR151","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1039\/C5BM00358J","volume":"4","author":"T Ozdemir","year":"2016","unstructured":"Ozdemir T, Fowler EW, Hao Y et al (2016) Biomaterials-based strategies for salivary gland tissue regeneration. Biomater Sci 4:592\u2013604. https:\/\/doi.org\/10.1039\/C5BM00358J","journal-title":"Biomater Sci"},{"key":"4991_CR152","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bjoms.2025.10.003","volume":"64","author":"ON Shrateh","year":"2026","unstructured":"Shrateh ON, Habib A, Ur Rehman Shamsi H et al (2026) Treatment options for radiation-induced xerostomia in patients with head and neck cancer: a systematic review and meta-analysis. Br J Oral Maxillofac Surg 64:24\u201332. https:\/\/doi.org\/10.1016\/j.bjoms.2025.10.003","journal-title":"Br J Oral Maxillofac Surg"},{"key":"4991_CR153","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.72295","author":"MU Bilal","year":"2026","unstructured":"Bilal MU, Alvi S, Humayune F et al (2026) Advances in gene therapy for xerostomia: current perspectives and future directions: a narrative review. Health Sci Rep. https:\/\/doi.org\/10.1002\/hsr2.72295","journal-title":"Health Sci Rep"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04991-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-026-04991-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-026-04991-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:02:44Z","timestamp":1787158964000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-026-04991-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":153,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4991"],"URL":"https:\/\/doi.org\/10.1007\/s10103-026-04991-5","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"assertion":[{"value":"18 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"During manuscript preparation, the authors used OpenAI\u2019s ChatGPT (GPT-5) to assist with readability and refinement of graphical elements used in figures. All content was critically reviewed and approved by the authors, who assume full responsibility for the final manuscript.","order":1,"name":"Ethics","label":"AI Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"196"}}