{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:24:26Z","timestamp":1787041466116,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006260","name":"Technion - Israel Institute of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006260","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Facial support is maintained by the vertical anchoring system, a collagen-rich network comprising the dermis, retinacula cutis, superficial musculoaponeurotic system, and retaining ligaments, which progressively deteriorates with age. Noninvasive monopolar radiofrequency (NMRF) induce collagen contraction and remodeling within these structures; however, clinical outcomes with conventional NMRF remain variable. XERF (Cynosure-Lutronic, South Korea) is a dual-frequency NMRF that sequentially delivers 6.78\u00a0MHz and 2\u00a0MHz energy within a single pulse. This study objectively and subjectively evaluated its efficacy for improving facial skin laxity and skin quality. This retrospective study reviewed adult patients who underwent a single XERF treatment session. Outcomes were extracted from routinely collected clinical data obtained immediately post-treatment and at 1- and 3-month follow-up visits relative to baseline. Objective assessments included three-dimensional stereophotogrammetry for volumetric redistribution, standardized morphometric analysis of periorbital lifting, and computerized skin-quality evaluation. Subjective outcomes were derived from completed prefilled questionnaires, including validated FACE-Q instruments, visual analog scales for perceived age and pain, overall satisfaction, willingness to repeat or recommend treatment, and Patient Global Aesthetic Improvement Scale scores. Safety was assessed through retrospective review of documented adverse events in medical records. Sixteen adult female patients completed follow-up. Objective assessments demonstrated volumetric redistribution, characterized by lateral volume augmentation and medial volume reduction. Periorbital morphometric analysis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915) revealed progressive elevation of the eyebrows and upper eyelids. Skin-quality assessment showed improvements in wrinkle severity, skin evenness, pore size, and oiliness, with no significant changes in pigmentation. Subjective outcomes were consistent with objective findings, demonstrating improvements in FACE-Q scores accompanied by a reduction in perceived age. Treatment was well tolerated, with high patient satisfaction and only mild and transient adverse events. In this retrospective study, XERF demonstrates improvements in facial skin laxity and quality, supported by objective and subjective outcomes, with a favorable safety and tolerability profile. These findings should be considered preliminary and require confirmation in larger prospective controlled studies.\n                  <\/jats:p>","DOI":"10.1007\/s10103-026-04996-0","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:29:16Z","timestamp":1787038156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Objective and subjective retrospective evaluation of XERF, a novel single-shot dual-frequency non-invasive monopolar radiofrequency"],"prefix":"10.1007","volume":"41","author":[{"given":"Guy","family":"Erlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliran","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"6","key":"4996_CR1","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.3390\/ijms23062993","volume":"23","author":"S Oh","year":"2022","unstructured":"Oh S, Rho NK, Byun KA, Yang JY, Sun HJ, Jang M et al (2022) Combined Treatment of Monopolar and Bipolar Radiofrequency Increases Skin Elasticity by Decreasing the Accumulation of Advanced Glycated End Products in Aged Animal Skin. 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The IRB application was submitted by Cynosure-Lutronic on behalf of the investigators. The authors are not affiliated with AIRB, which operates as an independent Institutional Review Board. The requirement for informed consent to participate in this retrospective study was waived by AIRB due to the retrospective study design. All patients had provided written informed consent for the clinical procedures performed and written authorization for the use of their anonymized clinical data and clinical photographs for research and publication purposes. The energy-based device used in this study was approved for clinical use by the Israeli Ministry of Health, and all procedures were performed within their approved indications. All data were fully anonymized and securely encrypted to ensure that no individual patient could be identified. Clinical trial registration: Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Conflict of Interest: G.E. serves as an international trainer for Cynosure\u2013Lutronic. E.D. and Y.W. declare that they have no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"194"}}