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Emerging non-invasive treatments include laser-assisted delivery of biomimetic growth factor\u2013based serums. The aim of the study was to evaluate the safety and efficacy of non-ablative fractional laser (NAFL)\u2013assisted delivery, with or without adjunct red light therapy, in patients with AGA. In this pilot study, patients were randomly assigned to: (I) NAFL-assisted serum delivery plus red light therapy (triple), (II) NAFL-assisted serum delivery alone (dual), or (III) NAFL plus red light therapy without serum (EBD-only). Primary outcomes were hair density and thickness. Secondary outcomes included patient satisfaction, tolerability, and adverse events. Hair density increased in all groups, with greater improvement in the triple (25.6 \u00b1 7.0 %) and dual (22.7 \u00b1 3.4 %) groups compared to EBD-only (4.9 \u00b1 9.2 %). Hair thickness improved in both serum groups but not in the EBD-only group. Clinical outcomes were similar between triple and dual treatments, though satisfaction was higher with triple therapy. No severe adverse events occurred. Preliminary evidence suggests that NAFL-assisted delivery of biomimetic growth factors is a safe and effective non-invasive treatment for AGA.<\/jats:p>","DOI":"10.1007\/s10103-026-05066-1","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:05:40Z","timestamp":1792659940000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thulium laser-assisted delivery of growth factors for treating androgenetic alopecia \u2013 a randomized, controlled, clinical study"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-6390","authenticated-orcid":false,"given":"Lynhda","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan W.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Herberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"issue":"6","key":"5066_CR1","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1111\/j.1365-2133.2003.05565.x","volume":"149","author":"G Severi","year":"2003","unstructured":"Severi G, Sinclair R, Hopper J et al (2003) Androgenetic alopecia in men aged 40\u201369 years: prevalence and risk factors. 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