{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:16:09Z","timestamp":1789100169423,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastric Cancer"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1007\/s10120-008-0493-4","type":"journal-article","created":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T14:48:28Z","timestamp":1240498108000},"page":"23-30","source":"Crossref","is-referenced-by-count":34,"title":["Study of clinicopathological factors associated with the occurrence of synchronous multiple gastric carcinomas"],"prefix":"10.1007","volume":"12","author":[{"given":"Toshikatsu","family":"Nitta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Egashira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Akutagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Edagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kurisu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Tanigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuro","family":"Shibayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"493_CR1","first-page":"316","volume":"15","author":"U. Honmyo","year":"1989","unstructured":"Honmyo U, Misumi A, Murakami, Haga Y, Akai M. Clinicopathological analysis of synchronous multiple gastric carcinoma. Eur J Surg Oncol 1989;15:316\u2013321.","journal-title":"Eur J Surg Oncol"},{"key":"493_CR2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/BF01655194","volume":"9","author":"Y. Noguchi","year":"1985","unstructured":"Noguchi Y, Ohta H, Takagi K, Ike H, Takahashi T, Ohashi I, et al. Synchronous multiple early gastric carcinoma. A study of 178 cases. World J Surg 1985;9:786\u2013793.","journal-title":"World J Surg"},{"key":"493_CR3","first-page":"627","volume":"29","author":"T. Mikami","year":"1994","unstructured":"Mikami T, Takizawa T, Inokari T, Hishima T, Kawamura T, Tei S, et al. Multiple gastric cancer from the pathological viewpoint (in Japanese with English abstract). I to Cho (Stomach and Intestine) 1994;29:627\u2013632.","journal-title":"I to Cho (Stomach and Intestine)"},{"key":"493_CR4","first-page":"667","volume":"29","author":"H. Tomimatsu","year":"1994","unstructured":"Tomimatsu H, Baba Y, Kaku S, Shimizu H, Takemoto N, Maruyama M, et al. Multiple early gastric cancer from the standpoint of endoscopic therapy-with analysis of surgically resected multiple early gastric cancer cases (in Japanese with English abstract). I to Cho (Stomach and Intestine) 1994;29:667\u2013679.","journal-title":"I to Cho (Stomach and Intestine)"},{"key":"493_CR5","first-page":"1602","volume":"40","author":"C. Yokoi","year":"2005","unstructured":"Yokoi C, Nakajima T, Gotoda T, Ikehara H, Nishimoto F, Matsuda N, et al. Metachronous gastric cancer after initial EMR\/ESD (in Japanese with English abstract). I to Cho (Stomach and Intestine) 2005;40:1602\u20131608.","journal-title":"I to Cho (Stomach and Intestine)"},{"key":"493_CR6","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.5833\/jjgs.30.2107","volume":"30","author":"Z. Nihei","year":"1997","unstructured":"Nihei Z, Ichikawa W, Ito M, Yamashita T, Uetake H, Osanai T. Local excision for synchronous multiple gastric cancer (in Japanese with English abstract). Nippon Shoukaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1997;30:2107\u20132111.","journal-title":"Nippon Shoukaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg)"},{"key":"493_CR7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/1097-0142(19870201)59:3<560::AID-CNCR2820590334>3.0.CO;2-G","volume":"59","author":"Y. Esaki","year":"1987","unstructured":"Esaki Y, Hirokawa K, Yamashiro M. Multiple gastric cancers in the aged with special reference to intramucosal cancers. Cancer 1987;59:560\u2013565.","journal-title":"Cancer"},{"key":"493_CR8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/bjs.1800760308","volume":"76","author":"T. Mitsudomi","year":"1989","unstructured":"Mitsudomi T, Watanabe A, Matsusaka T, Fujinaga Y, Fuchigami T, Iwashita A. A clinicopathological study of synchronous multiple gastric cancer. Br J. Surg. 1989;76:237\u2013240.","journal-title":"Br J. Surg."},{"key":"493_CR9","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1002\/1097-0142(19900601)65:11<2602::AID-CNCR2820651134>3.0.CO;2-8","volume":"65","author":"T. Kosaka","year":"1990","unstructured":"Kosaka T, Miwa K, Yonemura Y, Urade M, Ishida T, Takegawa S, et al. A clinicopathological study of multiple gastric cancers with special reference to distal gastrectomy. Cancer 1990;65:2602\u20132605.","journal-title":"Cancer"},{"key":"493_CR10","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1002\/(SICI)1097-0142(19961115)78:10<2078::AID-CNCR7>3.0.CO;2-K","volume":"78","author":"H. Isozaki","year":"1996","unstructured":"Isozaki H, Okajima K, Xiang H, Fujii K, Sako S. Multiple early gastric carcinomas. Clinicopathologic features and histogenesis. Cancer 1996;78:2078\u20132086.","journal-title":"Cancer"},{"key":"493_CR11","volume-title":"The general rules for the gastric cancer study (in Japanese)","author":"Japanese Research Society for Gastric Cancer.","year":"1993","unstructured":"Japanese Research Society for Gastric Cancer. The general rules for the gastric cancer study (in Japanese). Tokyo: Kanehara; 1993."},{"key":"493_CR12","volume-title":"International Union Against Cancer TNM classification of malignant tumors","year":"2002","unstructured":"Sobin LH, Witteking Ch, editors. International Union Against Cancer TNM classification of malignant tumors. 6th ed. New York: Wiley-Liss; 2002.","edition":"6th ed."},{"key":"493_CR13","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0016-5085(57)80113-9","volume":"32","author":"C.G. Moertel","year":"1957","unstructured":"Moertel CG, Bargen JA, Soul EH. Multiple gastric cancers. Gastroenterology 1957;32:1095\u20131103.","journal-title":"Gastroenterology"},{"key":"493_CR14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.47.2.251","volume":"47","author":"R. Schlemper","year":"2000","unstructured":"Schlemper R, Riddell R, Kato Y, Borchard F, Cooper H, Dawsey S, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 2000;47:251\u2013255.","journal-title":"Gut"},{"key":"493_CR15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P. Lauren","year":"1965","unstructured":"Lauren P. Two histological main types of gastric carcinoma: diffuse and so-called intestinal types of carcinoma. Acta Pathol Microbiol Scand 1965;64:31\u201345.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"493_CR16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1699-0463.1951.tb00101.x","volume":"29","author":"O. Jarvi","year":"1951","unstructured":"Jarvi O, Lauren P. On the role of heterotopias of the intestinal epithelium in the pathogenesis of gastric cancer. Acta Pathol Microbiol Scand 1951;29:26\u201343.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"493_CR17","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0140-6736(96)12249-2","volume":"14","author":"R. Schlemper","year":"1997","unstructured":"Schlemper R, Itabashi M, Kato Y, Lewin K, Riddell R, Shimoda T, et al. Differences in the diagnostic criteria of gastric carcinoma between Japanese and Western pathologists. Lancet 1997;14:1725\u20131729.","journal-title":"Lancet"},{"key":"493_CR18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1440-1827.2004.01625.x","volume":"54","author":"H. Shiroshita","year":"2004","unstructured":"Shiroshita H, Watanabe H, Ajioka Y, Watanabe G, Nishikura K, Kitano S. Re-evaluation of mucin phenotypes of gastric minute well-differentiated-type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2, and CD10 stains. Pathol Int 2004;54:311\u2013321.","journal-title":"Pathol Int"},{"key":"493_CR19","first-page":"251","volume":"59","author":"K. Nakamura","year":"1968","unstructured":"Nakamura K, Sugano H, Takagi K. Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann 1968;59:251\u2013258.","journal-title":"Gann"},{"key":"493_CR20","first-page":"435","volume":"23","author":"K. Nakamura","year":"1970","unstructured":"Nakamura K, Sugano H, Takagi K. Histogenesis of gastric cancer (in Japanese). Geka Chiryou (Surgical Therapy) 1970;23:435\u2013448.","journal-title":"Geka Chiryou (Surgical Therapy)"},{"key":"493_CR21","first-page":"236","volume-title":"Structure of the gastric cancer (in Japanese)","author":"K. Nakamura","year":"1982","unstructured":"Nakamura K, Sugano H, Takagi K. Structure of the gastric cancer (in Japanese). Tokyo: Igaku-shoin; 1982. p. 236\u2013243."},{"key":"493_CR22","unstructured":"Statview (computer program). Version 5.0. Berkeley, CA, USA: Abacus Concepts; 1998."},{"key":"493_CR23","unstructured":"SPSS II standard version (computer program). Windows Version; Chicago, IL: SPSS; 2008."},{"key":"493_CR24","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s10120-004-0285-4","volume":"7","author":"T. Arai","year":"2004","unstructured":"Arai T, Esaki Y, Inoshita N, Sawabe M, Kasahara I, Kuroiwa K, et al. Pathologic characteristic of gastric cancer in elderly: retrospective study of 994 surgical patients. Gastric Cancer 2004;7:154\u2013159.","journal-title":"Gastric Cancer"},{"key":"493_CR25","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/1097-0142(19940715)74:2<556::AID-CNCR2820740205>3.0.CO;2-J","volume":"74","author":"G.N. Stemmermann","year":"1994","unstructured":"Stemmermann GN. Intestinal metaplasia of the stomach: a status report. Cancer 1994;74:556\u2013564.","journal-title":"Cancer"},{"key":"493_CR26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/bjc.1955.35","volume":"9","author":"B.C. Morson","year":"1955","unstructured":"Morson BC. Intestinal metaplasia of the gastric mucosa. Br J Cancer 1955;9:365\u2013376.","journal-title":"Br J Cancer"},{"key":"493_CR27","first-page":"6735","volume":"52","author":"P. Correa","year":"1992","unstructured":"Correa P. Human gastric carcinogenesis: multi-step and multifactorial process. Cancer Res 1992;52:6735\u20136740.","journal-title":"Cancer Res"},{"key":"493_CR28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s101200050005","volume":"1","author":"F. Kitahara","year":"1998","unstructured":"Kitahara F, Shimazaki R, Sato T, Kojima Y, Morozumi A, Fujino M. Severe atrophic gastritis with Helicobacter pylori infection and gastric cancer. Gastric Cancer 1998;1:118\u2013124.","journal-title":"Gastric Cancer"},{"key":"493_CR29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.49.3.347","volume":"49","author":"HelicobacterCancer Collaborative Group.","year":"2001","unstructured":"Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001;49:347\u2013353.","journal-title":"Gut"},{"key":"493_CR30","first-page":"1","volume":"6","author":"Schistosomes, liver flukesHelicobacter pylori.","year":"1994","unstructured":"Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7\u201314 June 1994. IARC Monogr Eval Carcinog Risks Hum 1994;6:1\u2013241.","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"493_CR31","first-page":"289","volume":"116","author":"T. Yasuda","year":"2001","unstructured":"Yasuda T, Kashimura H, Ikegami M. Clinicopathological study of diffuse heterotopic submucosal cysts in the stomach \u2014 histogenesis and differentiation evaluated by a classification of mucin phenotype (in Japanese with English abstract). Jikei Idaishi (Tokyo Jikeikai Medical Journal) 2001;116:289\u2013298.","journal-title":"Jikei Idaishi (Tokyo Jikeikai Medical Journal)"},{"key":"493_CR32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/1097-0142(197607)38:1<232::AID-CNCR2820380135>3.0.CO;2-4","volume":"38","author":"H. Watanabe","year":"1976","unstructured":"Watanabe H, Enjyoji M, Imai T. Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer 1976;38:232\u2013243.","journal-title":"Cancer"},{"key":"493_CR33","first-page":"1063","volume":"143","author":"K. Oda","year":"1993","unstructured":"Oda K, Tamaru J, Takenouchi T, Mikata A, Nunomura M, Saitoh N, et al. Association of Epstein-Barr with gastric carcinoma with lymphoid stroma. Am J Pathol 1993;143:1063\u20131071.","journal-title":"Am J Pathol"},{"key":"493_CR34","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1046\/j.1440-1827.2000.01072.x","volume":"50","author":"M. Chang","year":"2000","unstructured":"Chang M, Lee J, Kim J, Kim H, Lee H, Kim C, et al. Microsatellite instability and Epstein-Barr virus infection in gastric remnant cancers. Pathol Int 2000;50:486\u2013492.","journal-title":"Pathol Int"},{"key":"493_CR35","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1042\/bst0230795","volume":"23","author":"J.R. Gum Jr.","year":"1995","unstructured":"Gum JR Jr. Human mucin glycoproteins: varied structures predict diverse properties and specific functions. Biochem Soc Trans 1995;23:795\u2013799.","journal-title":"Biochem Soc Trans"}],"container-title":["Gastric Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-008-0493-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10120-008-0493-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-008-0493-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T10:19:02Z","timestamp":1559125142000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10120-008-0493-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["493"],"URL":"https:\/\/doi.org\/10.1007\/s10120-008-0493-4","relation":{},"ISSN":["1436-3291","1436-3305"],"issn-type":[{"value":"1436-3291","type":"print"},{"value":"1436-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}