{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:35:16Z","timestamp":1791048916890,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,5,19]],"date-time":"2013-05-19T00:00:00Z","timestamp":1368921600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastric Cancer"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s10120-013-0269-3","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T05:45:12Z","timestamp":1368855912000},"page":"226-234","source":"Crossref","is-referenced-by-count":29,"title":["Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection"],"prefix":"10.1007","volume":"17","author":[{"given":"Ujjala","family":"Ghoshal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balraj","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Chourasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Krishnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday C.","family":"Ghoshal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,19]]},"reference":[{"key":"269_CR1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1470-2045(01)00486-7","volume":"2","author":"DM Parkin","year":"2001","unstructured":"Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2:533\u201343.","journal-title":"Lancet Oncol"},{"key":"269_CR2","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.1038\/sj.onc.1207726","volume":"23","author":"DM Parkin","year":"2004","unstructured":"Parkin DM. International variation. Oncogene. 2004;23:6329\u201340.","journal-title":"Oncogene"},{"key":"269_CR3","first-page":"6735","volume":"52","author":"P Correa","year":"1992","unstructured":"Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. First American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res. 1992;52:6735\u201340.","journal-title":"Cancer Res"},{"key":"269_CR4","unstructured":"Nomura A. Stomach cancer. In: Schottenfeld D, Fraumeni JF, editors. Cancer epidemiology and prevention, 2nd edn. New York: Oxford University Press; 1996. p. 707\u2013724."},{"key":"269_CR5","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","volume":"118","author":"DM Parkin","year":"2006","unstructured":"Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118:3030\u201344.","journal-title":"Int J Cancer"},{"key":"269_CR6","unstructured":"Schistosomes, Liver flukes and Helicobacter pylori: IARC working group on the evaluation of carcinogenic risks to humans. IARC Monogr Eval Carcinog Risks Hum. 1994;61:1\u2013241."},{"key":"269_CR7","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/BF01297451","volume":"36","author":"DY Graham","year":"1991","unstructured":"Graham DY, Adam E, Reddy GT, et al. Seroepidemiology of Helicobacter pylori infection in India. Comparison of developing and developed countries. Dig Dis Sci. 1991;36:1084\u20138.","journal-title":"Dig Dis Sci"},{"key":"269_CR8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.40.3.297","volume":"40","author":"J Parsonnet","year":"1997","unstructured":"Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA-positive or CagA-negative Helicobacter pylori infection. Gut. 1997;40:297\u2013301.","journal-title":"Gut"},{"key":"269_CR9","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3748\/wjg.v12.i9.1346","volume":"12","author":"K Singh","year":"2006","unstructured":"Singh K, Ghoshal UC. Causal role of Helicobacter pylori infection in gastric cancer: an Asian enigma. World J Gastroenterol. 2006;12:1346\u201351.","journal-title":"World J Gastroenterol"},{"key":"269_CR10","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1111\/j.1572-0241.2007.01324_13.x","volume":"102","author":"UC Ghoshal","year":"2007","unstructured":"Ghoshal UC, Tripathi S, Ghoshal U. The Indian enigma of frequent H. pylori infection but infrequent gastric cancer: is the magic key in Indian diet, host\u2019s genetic makeup, or friendly bug? Am J Gastroenterol. 2007;102:2113\u20134.","journal-title":"Am J Gastroenterol"},{"key":"269_CR11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0890-6238(96)00154-2","volume":"11","author":"FJ Gonzalez","year":"1997","unstructured":"Gonzalez FJ. The role of carcinogen-metabolizing enzyme polymorphisms in cancer susceptibility. Reprod Toxicol. 1997;11:397\u2013412.","journal-title":"Reprod Toxicol"},{"key":"269_CR12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1081\/DMR-120001386","volume":"34","author":"FP Guengerich","year":"2002","unstructured":"Guengerich FP. Update information on human P450s. Drug Metab Rev. 2002;34:7\u201315.","journal-title":"Drug Metab Rev"},{"key":"269_CR13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0027-5107(98)00037-2","volume":"400","author":"FP Guengerich","year":"1998","unstructured":"Guengerich FP, Shimada T. Activation of procarcinogens by human cytochrome P450 enzymes. Mutat Res. 1998;400:201\u201313.","journal-title":"Mutat Res"},{"key":"269_CR14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1383-5742(01)00059-X","volume":"488","author":"FP Guengerich","year":"2001","unstructured":"Guengerich FP. Forging the links between metabolism and carcinogenesis. Mutat Res. 2001;488:195\u2013209.","journal-title":"Mutat Res"},{"key":"269_CR15","first-page":"2946","volume":"48","author":"FP Guengerich","year":"1988","unstructured":"Guengerich FP. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res. 1988;48:2946\u201354.","journal-title":"Cancer Res"},{"key":"269_CR16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/tx00020a008","volume":"4","author":"FP Guengerich","year":"1991","unstructured":"Guengerich FP, Kim DH, Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol. 1991;4:168\u201379.","journal-title":"Chem Res Toxicol"},{"key":"269_CR17","first-page":"3367","volume":"50","author":"ME McManus","year":"1990","unstructured":"McManus ME, Burgess WM, Veronese ME, et al. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res. 1990;50:3367\u201376.","journal-title":"Cancer Res"},{"key":"269_CR18","first-page":"89","volume":"54","author":"AR Boobis","year":"1994","unstructured":"Boobis AR, Lynch AM, Murray S, et al. CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. Cancer Res. 1994;54:89\u201394.","journal-title":"Cancer Res"},{"key":"269_CR19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/taap.1998.8532","volume":"152","author":"DG McCarver","year":"1998","unstructured":"McCarver DG, Byun R, Hines RN, Hichme M, Wegenek W. A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. Toxicol Appl Pharmacol. 1998;152:276\u201381.","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-5793(90)80721-T","volume":"263","author":"K Kawajiri","year":"1990","unstructured":"Kawajiri K, Nakachi K, Imai K, et al. Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett. 1990;263:131\u20133.","journal-title":"FEBS Lett"},{"key":"269_CR21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1383-5742(00)00051-X","volume":"463","author":"S Pavanello","year":"2000","unstructured":"Pavanello S, Clonfero E. Biological indicators of genotoxic risk and metabolic polymorphisms. Mutat Res. 2000;463:285\u2013308.","journal-title":"Mutat Res"},{"key":"269_CR22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1365-2125.2003.01733.x","volume":"55","author":"C Sachse","year":"2003","unstructured":"Sachse C, Bhambra U, Smith G, et al. Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. Br J Clin Pharmacol. 2003;55:68\u201376.","journal-title":"Br J Clin Pharmacol"},{"key":"269_CR23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/01.fpc.0000204994.99429.46","volume":"16","author":"Z Jiang","year":"2006","unstructured":"Jiang Z, Dragin N, Jorge-Nebert LF, et al. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Pharmacogenet Genomics. 2006;16:359\u201367.","journal-title":"Pharmacogenet Genomics"},{"key":"269_CR24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.canlet.2004.12.010","volume":"229","author":"H Moonen","year":"2005","unstructured":"Moonen H, Engels L, Kleinjans J, Kok T. The CYP1A2-164A\u2013>C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans. Cancer Lett. 2005;229:25\u201331.","journal-title":"Cancer Lett"},{"key":"269_CR25","first-page":"1019","volume":"11","author":"L Marchand Le","year":"2002","unstructured":"Le Marchand L, Donlon T, Seifried A, Wilkens LR. Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2002;11:1019\u201324.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"269_CR26","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1023\/A:1022861414826","volume":"48","author":"E Giannini","year":"2003","unstructured":"Giannini E, Fasoli A, Botta F, et al. Helicobacter pylori infection is associated with greater impairment of cytochrome P-450 liver metabolic activity in anti-HCV positive cirrhotic patients. Dig Dis Sci. 2003;48:802\u20138.","journal-title":"Dig Dis Sci"},{"key":"269_CR27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31\u201349.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"269_CR28","doi-asserted-by":"crossref","unstructured":"Miwa H, Ghoshal UC, Gonlachanvit S, et al. Asian consensus report on functional dyspepsia. J Neurogastroenterol Motil 2012;18:150\u2013168.","DOI":"10.5056\/jnm.2012.18.2.150"},{"key":"269_CR29","first-page":"183","volume":"18","author":"UC Ghoshal","year":"1999","unstructured":"Ghoshal UC, Ghosh TK, Ghoshal U, et al. In-house rapid urease test kit and commercial kit: which is better? Indian J Gastroenterol. 1999;18:183.","journal-title":"Indian J Gastroenterol"},{"key":"269_CR30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/oxfordjournals.jbchem.a123594","volume":"110","author":"S Hayashi","year":"1991","unstructured":"Hayashi S, Watanabe J, Nakachi K, Kawajiri K. Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene. J Biochem (Tokyo). 1991;110:407\u201311.","journal-title":"J Biochem (Tokyo)"},{"key":"269_CR31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","volume":"404","author":"EM El-Omar","year":"2000","unstructured":"El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature (Lond). 2000;404:398\u2013402.","journal-title":"Nature (Lond)"},{"key":"269_CR32","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1093\/jnci\/94.22.1680","volume":"94","author":"C Figueiredo","year":"2002","unstructured":"Figueiredo C, Machado JC, Pharoah P, et al. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst. 2002;94:1680\u20137.","journal-title":"J Natl Cancer Inst"},{"key":"269_CR33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1134\/S0006297908050076","volume":"73","author":"GA Belitsky","year":"2008","unstructured":"Belitsky GA, Yakubovskaya MG. Genetic polymorphism and variability of chemical carcinogenesis. Biochemistry (Mosc). 2008;73:543\u201354.","journal-title":"Biochemistry (Mosc)"},{"key":"269_CR34","doi-asserted-by":"crossref","unstructured":"Malik MA, Upadhyay R, Mittal RD, Zargar SA, Mittal B. Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors. Nutr Cancer 2010;62:734\u201342.","DOI":"10.1080\/01635581003605904"},{"key":"269_CR35","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1081\/DMR-120005668","volume":"34","author":"T Kamataki","year":"2002","unstructured":"Kamataki T, Fujita K, Nakayama K, et al. Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. Drug Metab Rev. 2002;34:667\u201376.","journal-title":"Drug Metab Rev"},{"key":"269_CR36","doi-asserted-by":"crossref","unstructured":"Guo R, Guo X. Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk. Tumour Biol. 2012;33(4):1125\u201332.","DOI":"10.1007\/s13277-012-0353-z"},{"key":"269_CR37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3727\/000000007783980846","volume":"16","author":"M Jain","year":"2007","unstructured":"Jain M, Kumar S, Ghoshal UC, Mittal B. CYP1A1 Msp1 T\/C polymorphism in esophageal cancer: no association and risk modulation. Oncol Res. 2007;16:437\u201343.","journal-title":"Oncol Res"},{"key":"269_CR38","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1158\/1055-9965.EPI-06-0072","volume":"15","author":"A Agudo","year":"2006","unstructured":"Agudo A, Sala N, Pera G, et al. Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2006;15:2427\u201334.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"269_CR39","first-page":"A118","volume":"23","author":"S Tripathi","year":"2008","unstructured":"Tripathi S, Ghoshal U, Mittal B, et al. Glutathione-S-transferase enzyme activity and Helicobacter pylori: does association with GST polymorphisms explain the Indian enigma of gastric cancer? J Gastroenterol Hepatol. 2008;23:A118.","journal-title":"J Gastroenterol Hepatol"},{"key":"269_CR40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/10409239509083491","volume":"30","author":"JD Hayes","year":"1995","unstructured":"Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 1995;30:445\u2013600.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"269_CR41","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1023\/A:1005426130826","volume":"45","author":"ML Verhulst","year":"2000","unstructured":"Verhulst ML, van Oijen AH, Roelofs HM, Peters WH, Jansen JB. Antral glutathione concentration and glutathione S-transferase activity in patients with and without Helicobacter pylori. Dig Dis Sci. 2000;45:629\u201332.","journal-title":"Dig Dis Sci"},{"key":"269_CR42","unstructured":"Tahara E. Genetic pathways of two types of gastric cancer. IARC Sci Publ. 2004;157:327\u201349."},{"key":"269_CR43","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/00365520701742930","volume":"43","author":"S Tripathi","year":"2008","unstructured":"Tripathi S, Ghoshal U, Ghoshal UC, et al. Gastric carcinogenesis: possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Scand J Gastroenterol. 2008;43:431\u20139.","journal-title":"Scand J Gastroenterol"}],"container-title":["Gastric Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-013-0269-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10120-013-0269-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-013-0269-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T19:17:19Z","timestamp":1563045439000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10120-013-0269-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,19]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["269"],"URL":"https:\/\/doi.org\/10.1007\/s10120-013-0269-3","relation":{},"ISSN":["1436-3291","1436-3305"],"issn-type":[{"value":"1436-3291","type":"print"},{"value":"1436-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,19]]}}}