{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:48:49Z","timestamp":1793137729825,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010905","name":"Major Research Plan","doi-asserted-by":"publisher","award":["81772518"],"award-info":[{"award-number":["81772518"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010905","name":"Major Research Plan","doi-asserted-by":"publisher","award":["82002463"],"award-info":[{"award-number":["82002463"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010905","name":"Major Research Plan","doi-asserted-by":"publisher","award":["82173219"],"award-info":[{"award-number":["82173219"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gastric Cancer"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s10120-023-01368-3","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T05:03:12Z","timestamp":1675486992000},"page":"364-378","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Exosomal hsa-let-7g-3p and hsa-miR-10395-3p derived from peritoneal lavage predict peritoneal metastasis and the efficacy of neoadjuvant intraperitoneal and systemic chemotherapy in patients with gastric cancer"],"prefix":"10.1007","volume":"26","author":[{"given":"Jiaxin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Yin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Gang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3397-1992","authenticated-orcid":false,"given":"Chao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,4]]},"reference":[{"key":"1368_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394\u2013424.","journal-title":"CA Cancer J Clin"},{"key":"1368_CR2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/ijc.28999","volume":"136","author":"M Plummer","year":"2015","unstructured":"Plummer M, Franceschi S, Vignat J, Forman D, de Martel C. Global burden of gastric cancer attributable to Helicobacter pylori. Int J Cancer. 2015;136:487\u201390.","journal-title":"Int J Cancer"},{"key":"1368_CR3","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet. 2020;396:635\u201348.","journal-title":"Lancet"},{"key":"1368_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7\u201334.","journal-title":"CA Cancer J Clin"},{"key":"1368_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7\u201330.","journal-title":"CA Cancer J Clin"},{"key":"1368_CR6","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.3748\/wjg.v22.i8.2403","volume":"22","author":"A Digklia","year":"2016","unstructured":"Digklia A, Wagner AD. Advanced gastric cancer: current treatment landscape and future perspectives. World J Gastroenterol. 2016;22:2403\u201314.","journal-title":"World J Gastroenterol"},{"issue":"Suppl 1","key":"1368_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s10120-016-0684-3","volume":"20","author":"H Ishigami","year":"2017","unstructured":"Ishigami H, Yamaguchi H, Yamashita H, Asakage M, Kitayama J. Surgery after intraperitoneal and systemic chemotherapy for gastric cancer with peritoneal metastasis or positive peritoneal cytology findings. Gastric Cancer. 2017;20(Suppl 1):128\u201334.","journal-title":"Gastric Cancer"},{"key":"1368_CR8","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1245\/s10434-013-3208-y","volume":"21","author":"J Kitayama","year":"2014","unstructured":"Kitayama J, Ishigami H, Yamaguchi H, Yamashita H, Emoto S, Kaisaki S, et al. Salvage gastrectomy after intravenous and intraperitoneal paclitaxel (PTX) administration with oral S-1 for peritoneal dissemination of advanced gastric cancer with malignant ascites. Ann Surg Oncol. 2014;21:539\u201346.","journal-title":"Ann Surg Oncol"},{"key":"1368_CR9","first-page":"S10","volume":"5","author":"J Kitayama","year":"2012","unstructured":"Kitayama J, Ishigami H, Yamaguchi H, Yamashita H, Emoto S, Kaisaki S. S-1 plus intravenous and intraperitoneal paclitaxel for gastric cancer with peritoneal metastasis. Gastrointest Cancer Res. 2012;5:S10\u20133.","journal-title":"Gastrointest Cancer Res"},{"key":"1368_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13045-021-01089-z","volume":"14","author":"G Chen","year":"2021","unstructured":"Chen G, Peng J, Xiao Q, Wu HX, Wu X, Wang F, et al. Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer. J Hematol Oncol. 2021;14:80.","journal-title":"J Hematol Oncol"},{"key":"1368_CR11","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1038\/s41591-022-01886-0","volume":"28","author":"A Sartore-Bianchi","year":"2022","unstructured":"Sartore-Bianchi A, Pietrantonio F, Lonardi S, Mussolin B, Rua F, Crisafulli G, et al. Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial. Nat Med. 2022;28:1612\u20138.","journal-title":"Nat Med"},{"key":"1368_CR12","doi-asserted-by":"publisher","first-page":"7098","DOI":"10.1158\/1078-0432.CCR-19-1704","volume":"25","author":"SB Maron","year":"2019","unstructured":"Maron SB, Chase LM, Lomnicki S, Kochanny S, Moore KL, Joshi SS, et al. Circulating tumor DNA sequencing analysis of gastroesophageal adenocarcinoma. Clin Cancer Res. 2019;25:7098\u2013112.","journal-title":"Clin Cancer Res"},{"key":"1368_CR13","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/his.14120","volume":"77","author":"JI Quezada-Mar\u00edn","year":"2020","unstructured":"Quezada-Mar\u00edn JI, Lam AK, Ochiai A, Odze RD, Washington KM, Fukayama M, et al. Gastrointestinal tissue-based molecular biomarkers: a practical categorisation based on the 2019 World Health Organization classification of epithelial digestive tumours. Histopathology. 2020;77:340\u201350.","journal-title":"Histopathology"},{"key":"1368_CR14","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","volume":"141","author":"TX Lu","year":"2018","unstructured":"Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141:1202\u20137.","journal-title":"J Allergy Clin Immunol"},{"key":"1368_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.critrevonc.2015.10.003","volume":"98","author":"S Mishra","year":"2016","unstructured":"Mishra S, Yadav T, Rani V. Exploring miRNA based approaches in cancer diagnostics and therapeutics. Crit Rev Oncol Hematol. 2016;98:12\u201323.","journal-title":"Crit Rev Oncol Hematol"},{"key":"1368_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.canlet.2009.04.031","volume":"285","author":"K Ruan","year":"2009","unstructured":"Ruan K, Fang X, Ouyang G. MicroRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett. 2009;285:116\u201326.","journal-title":"Cancer Lett"},{"key":"1368_CR17","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nature03702","volume":"435","author":"J Lu","year":"2005","unstructured":"Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435:834\u20138.","journal-title":"Nature"},{"key":"1368_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12943-018-0897-7","volume":"17","author":"Z Sun","year":"2018","unstructured":"Sun Z, Shi K, Yang S, Liu J, Zhou Q, Wang G, et al. Effect of exosomal miRNA on cancer biology and clinical applications. Mol Cancer. 2018;17:147.","journal-title":"Mol Cancer"},{"key":"1368_CR19","doi-asserted-by":"publisher","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","volume":"285","author":"N Kosaka","year":"2010","unstructured":"Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem. 2010;285:17442\u201352.","journal-title":"J Biol Chem"},{"key":"1368_CR20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"C He","year":"2018","unstructured":"He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8:237\u201355.","journal-title":"Theranostics"},{"key":"1368_CR21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","author":"R Kalluri","year":"2020","unstructured":"Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020. https:\/\/doi.org\/10.1126\/science.aau6977.","journal-title":"Science"},{"key":"1368_CR22","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1172\/JCI81135","volume":"126","author":"R Kalluri","year":"2016","unstructured":"Kalluri R. The biology and function of exosomes in cancer. J Clin Invest. 2016;126:1208\u201315.","journal-title":"J Clin Invest"},{"key":"1368_CR23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12943-021-01396-6","volume":"20","author":"XH Tang","year":"2021","unstructured":"Tang XH, Guo T, Gao XY, Wu XL, Xing XF, Ji JF, et al. Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications. Mol Cancer. 2021;20:99.","journal-title":"Mol Cancer"},{"key":"1368_CR24","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:98\u2013102.","journal-title":"Nucleic Acids Res"},{"key":"1368_CR25","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47:556\u201360.","journal-title":"Nucleic Acids Res"},{"key":"1368_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1021\/pr060427q","volume":"6","author":"P Conrotto","year":"2007","unstructured":"Conrotto P, Yakymovych I, Yakymovych M, Souchelnytskyi S. Interactome of transforming growth factor-beta type I receptor (TbetaRI): inhibition of TGFbeta signaling by Epac1. J Proteome Res. 2007;6:287\u201397.","journal-title":"J Proteome Res"},{"key":"1368_CR27","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1158\/1078-0432.CCR-18-0776","volume":"25","author":"J Hess","year":"2019","unstructured":"Hess J, Unger K, Maihoefer C, Sch\u00fcttrumpf L, Wintergerst L, Heider T, et al. A five-microRNA signature predicts survival and disease control of patients with head and neck cancer negative for HPV infection. Clin Cancer Res Off J Am Assoc Cancer Res. 2019;25:1505\u201316.","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"1368_CR28","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.61.11.4","volume":"61","author":"M Asakage","year":"2020","unstructured":"Asakage M, Usui Y, Nezu N, Shimizu H, Tsubota K, Yamakawa N, et al. Comprehensive miRNA analysis using serum from patients with noninfectious uveitis. Invest Ophthalmol Vis Sci. 2020;61:4.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1368_CR29","doi-asserted-by":"publisher","first-page":"10269","DOI":"10.1038\/s41598-022-14379-4","volume":"12","author":"X Zhang","year":"2022","unstructured":"Zhang X, Wang X, Li W, Sun T, Diao D, Dang C. Predictive value of neutrophil-to-lymphocyte ratio for distant metastasis in gastric cancer patients. Sci Rep. 2022;12:10269.","journal-title":"Sci Rep"},{"key":"1368_CR30","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12876-020-01255-6","volume":"20","author":"K Wang","year":"2020","unstructured":"Wang K, Jiang X, Ren Y, Ma Z, Cheng X, Li F, et al. The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis. BMC Gastroenterol. 2020;20:100.","journal-title":"BMC Gastroenterol"},{"key":"1368_CR31","doi-asserted-by":"crossref","unstructured":"Wehbe N, Slika H, Mesmar J, Nasser SA, Pintus G, Baydoun S, et al. The role of epac in cancer progression. Int J Mol Sci. 2020;21.","DOI":"10.3390\/ijms21186489"},{"key":"1368_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s11010-017-2959-3","volume":"430","author":"N Kumar","year":"2017","unstructured":"Kumar N, Gupta S, Dabral S, Singh S, Sehrawat S. Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis. Mol Cell Biochem. 2017;430:115\u201325.","journal-title":"Mol Cell Biochem"},{"key":"1368_CR33","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1093\/carcin\/bgy090","volume":"39","author":"N Kumar","year":"2018","unstructured":"Kumar N, Prasad P, Jash E, Jayasundar S, Singh I, Alam N, et al. cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer. Carcinogenesis. 2018;39:1245\u201353.","journal-title":"Carcinogenesis"},{"key":"1368_CR34","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbrc.2017.10.142","volume":"495","author":"H Ichikawa","year":"2018","unstructured":"Ichikawa H, Itsumi M, Kajioka S, Maki T, Lee K, Tomita M, et al. Overexpression of exchange protein directly activated by cAMP-1 (EPAC1) attenuates bladder cancer cell migration. Biochem Biophys Res Commun. 2018;495:64\u201370.","journal-title":"Biochem Biophys Res Commun"},{"key":"1368_CR35","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nature02006","volume":"425","author":"R Derynck","year":"2003","unstructured":"Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003;425:577\u201384.","journal-title":"Nature"}],"container-title":["Gastric Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-023-01368-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10120-023-01368-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-023-01368-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T20:05:57Z","timestamp":1706990757000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10120-023-01368-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,4]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["1368"],"URL":"https:\/\/doi.org\/10.1007\/s10120-023-01368-3","relation":{},"ISSN":["1436-3291","1436-3305"],"issn-type":[{"value":"1436-3291","type":"print"},{"value":"1436-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,4]]},"assertion":[{"value":"16 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent to be included in the study, or the equivalent, was obtained from all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}