{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:14:57Z","timestamp":1793297697645,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Akita University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gastric Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Although hemostatic radiotherapy has been reported as an effective treatment for gastric cancer bleeding, its mechanism and immediate effects remain unclear. We experienced a case of gastric cancer bleeding originating from both the whole gastric tumor and a left gastric arterial pseudoaneurysm at the tumor-associated ulcer. The patient was treated with radiotherapy for bleeding from the whole gastric tumor, followed by transcatheter arterial embolization for the left gastric arterial pseudoaneurysm. Angiography performed two hours after radiotherapy with an X-ray of 8\u00a0Gy in a single fraction revealed the disappearance of both tumor vessels and tumor stain from not only the embolized left gastric artery but also both the non-embolized right gastric artery and common trunk of the left gastric and the left hepatic arteries, which indicated these angiographic changes of the non-embolized arteries were presumed to reflect an immediate effect of hemostatic radiotherapy. Following hemostatic treatments, the patient\u2019s vital signs stabilized, and hemoglobin levels did not decrease, indicating immediate hemostasis. This case suggests a link between hemostatic mechanism and early tumor vessel changes, indicating that hemostatic radiotherapy can achieve rapid bleeding control. Therefore, hemostatic radiotherapy should be considered an emergency treatment option for gastric cancer bleeding.<\/jats:p>","DOI":"10.1007\/s10120-025-01616-8","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:19:25Z","timestamp":1746184765000},"page":"712-717","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early angiographic changes after hemostatic radiotherapy for gastric cancer bleeding, mentioning the mechanism and potential immediate effects of the treatment"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-7413","authenticated-orcid":false,"given":"Yuki","family":"Wada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Konno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Tozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomochika","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsugaku","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"1616_CR1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00423-012-0902-3","volume":"397","author":"Y Dittmar","year":"2012","unstructured":"Dittmar Y, Rauchfuss F, Goetz M, Jandt K, Scheuerlein H, Heise M, et al. Non-curative gastric resection for patients with stage 4 gastric cancer\u2013a single center experience and current review of literature. Langenbecks Arch Surg. 2012;397:745\u201353.","journal-title":"Langenbecks Arch Surg"},{"key":"1616_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/apt.12347","volume":"38","author":"S Sheibani","year":"2013","unstructured":"Sheibani S, Kim JJ, Chen B, Park S, Saberi B, Keyashian K, et al. Natural history of acute upper GI bleeding due to tumours: short-term success and long-term recurrence with or without endoscopic therapy. Aliment Pharmacol Ther. 2013;38:144\u201350.","journal-title":"Aliment Pharmacol Ther"},{"key":"1616_CR3","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/cam4.2021","volume":"8","author":"J Tey","year":"2019","unstructured":"Tey J, Zheng H, Soon YY, Leong CN, Koh WY, Lim K, et al. Palliative radiotherapy in symptomatic locally advanced gastric cancer: a phase II trial. Cancer Med. 2019;8:1447\u201358.","journal-title":"Cancer Med"},{"key":"1616_CR4","doi-asserted-by":"publisher","first-page":"20190958","DOI":"10.1259\/bjr.20190958","volume":"93","author":"O Tanaka","year":"2020","unstructured":"Tanaka O, Sugiyama A, Omatsu T, Tawada M, Makita C, Matsuo M. Hemostatic radiotherapy for inoperable gastric cancer: a pilot study. Br J Radiol. 2020;93:20190958.","journal-title":"Br J Radiol"},{"key":"1616_CR5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10120-021-01254-w","volume":"25","author":"T Saito","year":"2022","unstructured":"Saito T, Kosugi T, Nakamura N, Wada H, Tonari A, Ogawa H, et al. Treatment response after palliative radiotherapy for bleeding gastric cancer: a multicenter prospective observational study (JROSG 17\u20133). Gastric Cancer. 2022;25:411\u201321.","journal-title":"Gastric Cancer"},{"key":"1616_CR6","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.4251\/wjgo.v16.i5.2261","volume":"16","author":"V Rao","year":"2024","unstructured":"Rao V, Singh S, Zade B. Hemostatic radiotherapy for bleeding gastrointestinal tumors. World J Gastrointest Oncol. 2024;16:2261\u20133.","journal-title":"World J Gastrointest Oncol"},{"key":"1616_CR7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.25259\/IJPC_1_2023","volume":"29","author":"A Andleeb","year":"2023","unstructured":"Andleeb A, Fatima K, Nasreen S, Sofi MA, Najmi AM, Qadri S, et al. Bleeding control in advanced gastric cancer; Role of radiotherapy. Indian J Palliat Care. 2023;29:279\u201384.","journal-title":"Indian J Palliat Care"},{"key":"1616_CR8","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.21037\/apm-24-26","volume":"13","author":"P Verschuren","year":"2024","unstructured":"Verschuren P, Christiaens M, Oldenburger E. Hemostatic radiotherapy: a narrative review of the literature. Ann Palliat Med. 2024;13:1114\u201332.","journal-title":"Ann Palliat Med"},{"key":"1616_CR9","first-page":"70","volume":"15","author":"J Strijbos","year":"2019","unstructured":"Strijbos J, van der Linden YM, Vos-Westerman H, van Baardwijk A, Dutch Platform Palliation, Radiotherapy. Patterns of practice in palliative radiotherapy for bleeding tumours in the Netherlands; a survey study among radiation oncologists. Clin Transl Radiat Oncol. 2019;15:70\u20135.","journal-title":"Clin Transl Radiat Oncol"},{"key":"1616_CR10","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1667\/RR2773.1","volume":"177","author":"HJ Park","year":"2012","unstructured":"Park HJ, Griffin RJ, Hui S, Levitt SH, Song CW. Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). Radiat Res. 2012;177:311\u201327.","journal-title":"Radiat Res"},{"key":"1616_CR11","doi-asserted-by":"publisher","first-page":"5685","DOI":"10.1158\/0008-5472.CAN-19-1323","volume":"79","author":"KD Castle","year":"2019","unstructured":"Castle KD, Kirsch DG. Establishing the impact of vascular damage on tumor response to high-dose radiation therapy. Cancer Res. 2019;79:5685\u201392.","journal-title":"Cancer Res"},{"key":"1616_CR12","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s13566-018-0363-6","volume":"7","author":"JM van der Velden","year":"2018","unstructured":"van der Velden JM, van der Linden YM, Versteeg AL, Verlaan J-J, Sophie Gerlich A, Pielkenrood BJ, et al. Evaluation of effectiveness of palliative radiotherapy for bone metastases: a prospective cohort study. J Radiat Oncol. 2018;7:325\u201333.","journal-title":"J Radiat Oncol"},{"key":"1616_CR13","first-page":"574","volume":"93","author":"A Lachgar","year":"2015","unstructured":"Lachgar A, Toulba A, Kebdani T, Elgueddari BK, Benjaafar N. Radiotherapy in the management of painful bone metastases at The National Institute of Oncology in Morocco: data from one year follow-up of 86 patients. Tunis Med. 2015;93:574\u20137.","journal-title":"Tunis Med"},{"key":"1616_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12904-015-0034-y","volume":"14","author":"C Kondoh","year":"2015","unstructured":"Kondoh C, Shitara K, Nomura M, Takahari D, Ura T, Tachibana H, et al. Efficacy of palliative radiotherapy for gastric bleeding in patients with unresectable advanced gastric cancer: a retrospective cohort study. BMC Palliat Care. 2015;14:37.","journal-title":"BMC Palliat Care"}],"container-title":["Gastric Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-025-01616-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10120-025-01616-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-025-01616-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T13:58:11Z","timestamp":1750168691000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10120-025-01616-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["1616"],"URL":"https:\/\/doi.org\/10.1007\/s10120-025-01616-8","relation":{},"ISSN":["1436-3291","1436-3305"],"issn-type":[{"value":"1436-3291","type":"print"},{"value":"1436-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]},"assertion":[{"value":"25 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare the following financial interests\/personal relationships, which may be considered potential competing interests: HS has received grants or contracts from Phizer Inc., S&B FOODS Inc., and Japan Association for Development of Community Medicine. HS has received payment of honoraria for lectures, presentations, speaker\u2019s bureaus, manuscript writing or educational events from Daiichi Sankyo Co. Ltd., Japanese Association of Medical Technologists, The Japanese Society of Gastroenterology, AstraZeneca plc, The Japanese Society of Medical Imaging, and TAIHO Pharmaceutical Co., Ltd. All remaining authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}