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This study aimed to identify variables associated with GNL development at long-term follow-up using a Fisher score-based feature-ranking-approach coupled with a One-Class Support-Vector-Machine (SVM) model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A dataset containing 30 clinical, endoscopic, and histological variables from consecutive CAG patients (2001\u20132023) adhering to a surveillance-program was considered. GNL presence at the longest available follow-up was recorded. Gastric biopsies and histological evaluations followed the updated-Sydney-system. A Fisher score-based feature ranking method and a One-Class SVM were employed to select key variables linked to GNL development, and then validated with synthetically generated data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 355 CAG patients were initially considered. Of these, 36 were excluded due to the presence of GNL at baseline gastroscopy, and 216 for missing data. Thus, a total of 103 patients were considered and grouped into: CAG patients with [22 patients (F 68.1%), median-age 68(35\u201383) years] and without GNL at follow-up [81 patients (F 72.8%) median-age 59(26\u201384) years]. After a median follow-up of 60(12\u2013192) months, 13 epithelial GNL (gastric adenocarcinoma or high\/low-grade dysplasia) and nine type-1 gastric-neuroendocrine-tumors (T1gNET) were recorded. Parietal-cell-antibodies and pepsinogen-I\u2009&lt;\u200930\u00a0\u03bcg\/l were associated with epithelial GNL and T1gNET. Antral inflammation and age\u2009&gt;\u200960 were linked to epithelial GNL, while anti-thyroperoxidase-antibodies, smoking, and dyspeptic-symptoms were linked to T1gNET. Low-dose aspirin and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication therapy showed inverse associations with epithelial GNL and T1gNET, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study in which an AI-model simultaneously considers clinical, endoscopic, and histological features from a dataset of CAG patients, showing the potential to identify variables associated with GNL development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10120-025-01679-7","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:45:22Z","timestamp":1761111922000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the potential of artificial intelligence in assessing the risk of gastric neoplastic lesions in patients with corpus atrophic gastritis"],"prefix":"10.1007","volume":"29","author":[{"given":"Emanuele","family":"Dilaghi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Cesaroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Ligato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Liuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Lucidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-5048","authenticated-orcid":false,"given":"Gianluca","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Sciandrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"issue":"3","key":"1679_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1136\/gutjnl-2023-331164","volume":"73","author":"M Rugge","year":"2024","unstructured":"Rugge M, Genta RM, Malfertheiner P, Dinis-Ribeiro M, El-Serag H, Graham DY, et al. 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