{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:01:39Z","timestamp":1789740099003,"version":"4.0.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62372141"],"award-info":[{"award-number":["62372141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gastric Cancer"],"DOI":"10.1007\/s10120-026-01802-2","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:01:58Z","timestamp":1789736518000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IGF2-associated tumor cells and APOE-positive macrophages define an imatinib resistance-associated niche in gastrointestinal stromal tumors"],"prefix":"10.1007","author":[{"given":"Mu","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyang","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peishen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinJing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5307-2484","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"1802_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153689","author":"J Khan","year":"2022","unstructured":"Khan J, Ullah A, Waheed A, Karki NR, Adhikari N, Vemavarapu L, et al. Gastrointestinal stromal tumors (GIST): a population-based study using the SEER database, including management and recent advances in targeted therapy. Cancers (Basel). 2022. https:\/\/doi.org\/10.3390\/cancers14153689.","journal-title":"Cancers (Basel)"},{"key":"1802_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11080694","author":"G Gheorghe","year":"2021","unstructured":"Gheorghe G, Bacalbasa N, Ceobanu G, Ilie M, Enache V, Constantinescu G, et al. Gastrointestinal stromal tumors-a mini review. J Pers Med. 2021. https:\/\/doi.org\/10.3390\/jpm11080694.","journal-title":"J Pers Med"},{"key":"1802_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00254-5","volume":"7","author":"JY Blay","year":"2021","unstructured":"Blay JY, Kang YK, Nishida T, von Mehren M. Gastrointestinal stromal tumours. Nat Rev Dis Primers. 2021;7:22.","journal-title":"Nat Rev Dis Primers"},{"key":"1802_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-pathol-042220-021510","volume":"17","author":"JK Dermawan","year":"2022","unstructured":"Dermawan JK, Rubin BP. Molecular pathogenesis of gastrointestinal stromal tumor: a paradigm for personalized medicine. Annu Rev Pathol Mech Dis. 2022;17:323\u201344.","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"1802_CR5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41419-024-06571-3","volume":"15","author":"X Liu","year":"2024","unstructured":"Liu X, Yu J, Li Y, Shi H, Jiao X, Liu X, et al. Deciphering the tumor immune microenvironment of imatinib-resistance in advanced gastrointestinal stromal tumors at single-cell resolution. Cell Death Dis. 2024;15:190.","journal-title":"Cell Death Dis"},{"key":"1802_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1431535","volume":"15","author":"SM Xiao","year":"2024","unstructured":"Xiao SM, Xu R, Yang YX, Zhao R, Xie Y, Lei XD, et al. Gastrointestinal stromal tumors regulate macrophage M2 polarization through the MIF\/CXCR4 axis to immune escape. Front Immunol. 2024;15:1431535.","journal-title":"Front Immunol"},{"key":"1802_CR7","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1111\/cas.14795","volume":"112","author":"X Mao","year":"2021","unstructured":"Mao X, Yang X, Chen X, Yu S, Yu S, Zhang B, et al. Single-cell transcriptome analysis revealed the heterogeneity and microenvironment of gastrointestinal stromal tumors. Cancer Sci. 2021;112:1262\u201374.","journal-title":"Cancer Sci"},{"key":"1802_CR8","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.7150\/thno.123923","volume":"16","author":"P Tao","year":"2026","unstructured":"Tao P, Wang J, Fan P, Liu W, Lu W, Hu Y, et al. Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in gastrointestinal stromal tumors after imatinib targeted therapy. Theranostics. 2026;16:2829\u201344.","journal-title":"Theranostics"},{"key":"1802_CR9","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1084\/jem.20130875","volume":"210","author":"MJ Cavnar","year":"2013","unstructured":"Cavnar MJ, Zeng S, Kim TS, Sorenson EC, Ocuin LM, Balachandran VP, et al. KIT oncogene inhibition drives intratumoral macrophage M2 polarization. J Exp Med. 2013;210:2873\u201386.","journal-title":"J Exp Med"},{"key":"1802_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2022.104642","volume":"384","author":"H Cai","year":"2023","unstructured":"Cai H, Chen Y, Chen X, Sun W, Li Y. Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2\/CXCR2. Cell Immunol. 2023;384:104642.","journal-title":"Cell Immunol"},{"key":"1802_CR11","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1007\/s00464-024-10782-2","volume":"38","author":"K Park","year":"2024","unstructured":"Park K, Ahn JY, Na HK, Jung KW, Lee JH, Kim DH, et al. Natural history of gastric leiomyoma. Surg Endosc. 2024;38:2726\u201333.","journal-title":"Surg Endosc"},{"key":"1802_CR12","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.3748\/wjg.v29.i16.2452","volume":"29","author":"WJ Yang","year":"2023","unstructured":"Yang WJ, Zhao HP, Yu Y, Wang JH, Guo L, Liu JY, et al. Updates on global epidemiology, risk and prognostic factors of gastric cancer. World J Gastroenterol. 2023;29:2452\u201368.","journal-title":"World J Gastroenterol"},{"key":"1802_CR13","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1158\/2159-8290.CD-21-0316","volume":"12","author":"Y Wu","year":"2022","unstructured":"Wu Y, Yang S, Ma J, Chen Z, Song G, Rao D, et al. Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level. Cancer Discov. 2022;12:134\u201353.","journal-title":"Cancer Discov"},{"key":"1802_CR14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41467-017-02391-6","volume":"9","author":"M Schubert","year":"2018","unstructured":"Schubert M, Klinger B, Kl\u00fcnemann M, Sieber A, Uhlitz F, Sauer S, et al. Perturbation-response genes reveal signaling footprints in cancer gene expression. Nat Commun. 2018;9:20.","journal-title":"Nat Commun"},{"key":"1802_CR15","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nbt.2859","volume":"32","author":"C Trapnell","year":"2014","unstructured":"Trapnell C, Cacchiarelli D, Grimsby J, Pokharel P, Li S, Morse M, et al. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol. 2014;32:381\u20136.","journal-title":"Nat Biotechnol"},{"key":"1802_CR16","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","volume":"560","author":"G La Manno","year":"2018","unstructured":"La Manno G, Soldatov R, Zeisel A, Braun E, Hochgerner H, Petukhov V, et al. RNA velocity of single cells. Nature. 2018;560:494\u20138.","journal-title":"Nature"},{"key":"1802_CR17","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","volume":"38","author":"V Bergen","year":"2020","unstructured":"Bergen V, Lange M, Peidli S, Wolf FA, Theis FJ. Generalizing RNA velocity to transient cell states through dynamical modeling. Nat Biotechnol. 2020;38:1408\u201314.","journal-title":"Nat Biotechnol"},{"key":"1802_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","volume":"19","author":"FA Wolf","year":"2018","unstructured":"Wolf FA, Angerer P, Theis FJ. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 2018;19:15.","journal-title":"Genome Biol"},{"key":"1802_CR19","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","volume":"14","author":"S Aibar","year":"2017","unstructured":"Aibar S, Gonz\u00e1lez-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G, et al. SCENIC: single-cell regulatory network inference and clustering. Nat Methods. 2017;14:1083\u20136.","journal-title":"Nat Methods"},{"key":"1802_CR20","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1126\/science.1254257","volume":"344","author":"AP Patel","year":"2014","unstructured":"Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014;344:1396\u2013401.","journal-title":"Science"},{"key":"1802_CR21","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41587-020-00795-2","volume":"39","author":"R Gao","year":"2021","unstructured":"Gao R, Bai S, Henderson YC, Lin Y, Schalck A, Yan Y, et al. Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes. Nat Biotechnol. 2021;39:599\u2013608.","journal-title":"Nat Biotechnol"},{"key":"1802_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12:1088.","journal-title":"Nat Commun"},{"key":"1802_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-01137-1","author":"K Troul\u00e9","year":"2025","unstructured":"Troul\u00e9 K, Petryszak R, Cakir B, Cranley J, Harasty A, Prete M, et al. CellPhoneDB v5: inferring cell-cell communication from single-cell multiomics data. Nat Protoc. 2025. https:\/\/doi.org\/10.1038\/s41596-024-01137-1.","journal-title":"Nat Protoc"},{"key":"1802_CR24","doi-asserted-by":"publisher","first-page":"gkaf569","DOI":"10.1093\/nar\/gkaf569","volume":"53","author":"R Zheng","year":"2025","unstructured":"Zheng R, Zhang Y, Tsuji T, Gao X, Shamsi F, Wagner A, et al. MEBOCOST maps metabolite-mediated intercellular communications using single-cell RNA-seq. Nucleic Acids Res. 2025;53:gkaf569.","journal-title":"Nucleic Acids Res"},{"key":"1802_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2023.100498","volume":"3","author":"S Morabito","year":"2023","unstructured":"Morabito S, Reese F, Rahimzadeh N, Miyoshi E, Swarup V. hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data. Cell Rep Methods. 2023;3:100498.","journal-title":"Cell Rep Methods"},{"key":"1802_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab043","volume":"49","author":"M Elosua-Bayes","year":"2021","unstructured":"Elosua-Bayes M, Nieto P, Mereu E, Gut I, Heyn H. SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes. Nucleic Acids Res. 2021;49:e50.","journal-title":"Nucleic Acids Res"},{"key":"1802_CR27","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41587-020-0605-1","volume":"39","author":"MA Skinnider","year":"2021","unstructured":"Skinnider MA, Squair JW, Kathe C, Anderson MA, Gautier M, Matson KJE, et al. Cell type prioritization in single-cell data. Nat Biotechnol. 2021;39:30\u20134.","journal-title":"Nat Biotechnol"},{"key":"1802_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.patter.2022.100434","volume":"3","author":"D Osorio","year":"2022","unstructured":"Osorio D, Zhong Y, Li G, Xu Q, Yang Y, Tian Y, et al. ScTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation. Patterns (N Y). 2022;3:100434.","journal-title":"Patterns (N Y)"},{"key":"1802_CR29","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/nmeth.2728","volume":"10","author":"JI Fuxman Bass","year":"2013","unstructured":"Fuxman Bass JI, Diallo A, Nelson J, Soto JM, Myers CL, Walhout AJ. Using networks to measure similarity between genes: association index selection. Nat Methods. 2013;10:1169\u201376.","journal-title":"Nat Methods"},{"key":"1802_CR30","doi-asserted-by":"publisher","first-page":"508","DOI":"10.18632\/oncotarget.28209","volume":"13","author":"L Gorunova","year":"2022","unstructured":"Gorunova L, Boye K, Panagopoulos I, Berner JM, Bjerkehagen B, Hompland I, et al. Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity. Oncotarget. 2022;13:508\u201317.","journal-title":"Oncotarget"},{"key":"1802_CR31","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1158\/2159-8290.CD-14-0985","volume":"5","author":"L Ran","year":"2015","unstructured":"Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, et al. Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer Discov. 2015;5:304\u201315.","journal-title":"Cancer Discov"},{"key":"1802_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13045-020-00904-3","volume":"13","author":"H Hua","year":"2020","unstructured":"Hua H, Kong Q, Yin J, Zhang J, Jiang Y. Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy. J Hematol Oncol. 2020;13:64.","journal-title":"J Hematol Oncol"},{"key":"1802_CR33","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41392-023-01468-7","volume":"8","author":"C Xue","year":"2023","unstructured":"Xue C, Yao Q, Gu X, Shi Q, Yuan X, Chu Q, et al. Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer. Signal Transduct Target Ther. 2023;8:204.","journal-title":"Signal Transduct Target Ther"},{"key":"1802_CR34","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","volume":"6","author":"X Hu","year":"2021","unstructured":"Hu X, Li J, Fu M, Zhao X, Wang W. The JAK\/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021;6:402.","journal-title":"Signal Transduct Target Ther"},{"key":"1802_CR35","first-page":"728","volume":"11","author":"M Sarlomo-Rikala","year":"1998","unstructured":"Sarlomo-Rikala M, Kovatich AJ, Barusevicius A, Miettinen M. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol Off J USA Can Acad Pathol. 1998;11:728\u201334.","journal-title":"Mod Pathol Off J USA Can Acad Pathol"},{"key":"1802_CR36","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1309\/AJCP0PPKOBNDT9LB","volume":"135","author":"DG Hwang","year":"2011","unstructured":"Hwang DG, Qian X, Hornick JL. DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks. Am J Clin Pathol. 2011;135:448\u201353.","journal-title":"Am J Clin Pathol"},{"key":"1802_CR37","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nature09409","volume":"467","author":"P Chi","year":"2010","unstructured":"Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, Shamu T, et al. ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature. 2010;467:849\u201353.","journal-title":"Nature"},{"key":"1802_CR38","first-page":"4089","volume":"10","author":"P Blay","year":"2004","unstructured":"Blay P, Astudillo A, Buesa JM, Campo E, Abad M, Garc\u00eda-Garc\u00eda J, et al. Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias, Clinical cancer research\u202f: an official journal of the American Association for. Can Res. 2004;10:4089\u201395.","journal-title":"Can Res"},{"key":"1802_CR39","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s40364-023-00515-3","volume":"11","author":"Y Wang","year":"2023","unstructured":"Wang Y, Kang X, Kang X, Yang F. S100A6: molecular function and biomarker role. Biomark Res. 2023;11:78.","journal-title":"Biomark Res"},{"key":"1802_CR40","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1158\/0008-5472.CAN-17-0917","volume":"77","author":"W Chen","year":"2017","unstructured":"Chen W, Kuang Y, Qiu HB, Cao Z, Tu Y, Sheng Q, et al. Dual targeting of insulin receptor and KIT in imatinib-resistant gastrointestinal stromal tumors. Cancer Res. 2017;77:5107\u201317.","journal-title":"Cancer Res"},{"key":"1802_CR41","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/annonc\/mdn040","volume":"19","author":"C Braconi","year":"2008","unstructured":"Braconi C, Bracci R, Bearzi I, Bianchi F, Sabato S, Mandolesi A, et al. Insulin-like growth factor (IGF) 1 and 2 help to predict disease outcome in GIST patients. Ann Oncol. 2008;19:1293\u20138.","journal-title":"Ann Oncol"},{"key":"1802_CR42","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.4251\/wjgo.v16.i8.3585","volume":"16","author":"DG Li","year":"2024","unstructured":"Li DG, Jiang JP, Chen FY, Wu W, Fu J, Wang GH, et al. Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors. World J Gastrointest Oncol. 2024;16:3585\u201399.","journal-title":"World J Gastrointest Oncol"},{"key":"1802_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061333","author":"WK Huang","year":"2020","unstructured":"Huang WK, Gao J, Chen Z, Shi H, Yuan J, Cui HL, et al. Heterogeneity of metabolic vulnerability in imatinib-resistant gastrointestinal stromal tumor. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9061333.","journal-title":"Cells"},{"key":"1802_CR44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-3-030-36667-4_3","volume":"1231","author":"N Mukaida","year":"2020","unstructured":"Mukaida N, Sasaki SI, Baba T. CCL4 signaling in the tumor microenvironment. Adv Exp Med Biol. 2020;1231:23\u201332.","journal-title":"Adv Exp Med Biol"},{"key":"1802_CR45","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1393598","volume":"7","author":"F Allen","year":"2018","unstructured":"Allen F, Bobanga ID, Rauhe P, Barkauskas D, Teich N, Tong C, et al. CCL3 augments tumor rejection and enhances CD8(+) T cell infiltration through NK and CD103(+) dendritic cell recruitment via IFN\u03b3. Oncoimmunology. 2018;7:e1393598.","journal-title":"Oncoimmunology"},{"key":"1802_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.coche.2017.11.006","volume":"19","author":"J Rosenberg","year":"2018","unstructured":"Rosenberg J, Huang J. CD8(+) T cells and NK cells: parallel and complementary soldiers of immunotherapy. Curr Opin Chem Eng. 2018;19:9\u201320.","journal-title":"Curr Opin Chem Eng"},{"key":"1802_CR47","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.ccell.2022.10.011","volume":"40","author":"M Han","year":"2022","unstructured":"Han M, Li F, Zhang Y, Dai P, He J, Li Y, et al. FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer. Cancer Cell. 2022;40:1306-1323.e1308.","journal-title":"Cancer Cell"},{"key":"1802_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202401061","volume":"11","author":"C Liu","year":"2024","unstructured":"Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, et al. Pan-cancer single-cell and spatial-resolved profiling reveals the immunosuppressive role of APOE+ macrophages in immune checkpoint inhibitor therapy. Adv Sci (Weinh). 2024;11:e2401061.","journal-title":"Adv Sci (Weinh)"},{"key":"1802_CR49","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/1878-0261.13373","volume":"17","author":"J Wei","year":"2023","unstructured":"Wei J, Yu W, Chen J, Huang G, Zhang L, Chen Z, et al. Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers. Mol Oncol. 2023;17:611\u201328.","journal-title":"Mol Oncol"},{"key":"1802_CR50","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13046-020-01646-3","volume":"39","author":"Z Liu","year":"2020","unstructured":"Liu Z, Gu S, Lu T, Wu K, Li L, Dong C, et al. IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress. J Exp Clin Cancer Res. 2020;39:144.","journal-title":"J Exp Clin Cancer Res"},{"key":"1802_CR51","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41416-018-0137-3","volume":"119","author":"V Cheriyath","year":"2018","unstructured":"Cheriyath V, Kaur J, Davenport A, Khalel A, Chowdhury N, Gaddipati L. G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS. Br J Cancer. 2018;119:52\u201364.","journal-title":"Br J Cancer"},{"key":"1802_CR52","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41419-025-07650-9","volume":"16","author":"Y Sui","year":"2025","unstructured":"Sui Y, Shen Z, Pan R, Ma R, Si R, Feng J, et al. AHSA1-HSP90AA1 complex stabilized IFI6 and TGFB1 promotes mitochondrial stability and EMT in EGFR-mutated lung adenocarcinoma under Osimertinib pressure. Cell Death Dis. 2025;16:298.","journal-title":"Cell Death Dis"},{"key":"1802_CR53","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00262-004-0645-2","volume":"54","author":"E Tahara Jr","year":"2005","unstructured":"Tahara E Jr, Tahara H, Kanno M, Naka K, Takeda Y, Matsuzaki T, et al. G1P3, an interferon inducible gene 6\u201316, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. Cancer Immunol Immunother CII. 2005;54:729\u201340.","journal-title":"Cancer Immunol Immunother CII"},{"key":"1802_CR54","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00262-022-03288-0","volume":"72","author":"J Liu","year":"2023","unstructured":"Liu J, Chen H, Qiao G, Zhang JT, Zhang S, Zhu C, et al. PLEK2 and IFI6, representing mesenchymal and immune-suppressive microenvironment, predicts resistance to neoadjuvant immunotherapy in esophageal squamous cell carcinoma. Cancer Immunol Immunother. 2023;72:881\u201393.","journal-title":"Cancer Immunol Immunother"},{"key":"1802_CR55","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1038\/onc.2011.393","volume":"31","author":"V Cheriyath","year":"2012","unstructured":"Cheriyath V, Kuhns MA, Jacobs BS, Evangelista P, Elson P, Downs-Kelly E, et al. G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer. Oncogene. 2012;31:2222\u201336.","journal-title":"Oncogene"},{"key":"1802_CR56","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1248\/bpb.b22-00439","volume":"46","author":"C Huang","year":"2023","unstructured":"Huang C, Zhou T, Ma L, Zhao S. IFI6 downregulation reverses oxaliplatin resistance of colorectal cancer cells by activating the ROS-induced p38MAPK signaling pathway. Biol Pharm Bull. 2023;46:26\u201334.","journal-title":"Biol Pharm Bull"},{"key":"1802_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.677697","volume":"9","author":"H Zhao","year":"2021","unstructured":"Zhao H, Li Z, Gao Y, Li J, Zhao X, Yue W. Single-cell RNA-sequencing portraying functional diversity and clinical implications of IFI6 in ovarian cancer. Front Cell Dev Biol. 2021;9:677697.","journal-title":"Front Cell Dev Biol"},{"key":"1802_CR58","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1093\/biolre\/ioaf271","volume":"114","author":"H Liu","year":"2026","unstructured":"Liu H, Wang C, Shang C, Liu S, Li Z, Jin Y, et al. Interferon-tau-induced IFI6 sustains bovine endometrial epithelial cell proliferation by activating AP-1 via the JAK-STAT signaling pathway. Biol Reprod. 2026;114:598\u2013609.","journal-title":"Biol Reprod"}],"container-title":["Gastric Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-026-01802-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10120-026-01802-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10120-026-01802-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:02:00Z","timestamp":1789736520000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10120-026-01802-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":58,"alternative-id":["1802"],"URL":"https:\/\/doi.org\/10.1007\/s10120-026-01802-2","relation":{},"ISSN":["1436-3291","1436-3305"],"issn-type":[{"value":"1436-3291","type":"print"},{"value":"1436-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"23 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Second Affiliated Hospital of Harbin Medical University (KY2024-179). All participants provided written informed consent prior to tissue collection.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}