{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:16:12Z","timestamp":1791807372172,"version":"4.3.4"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"MINECO","award":["BIO2015-64777-P"],"award-info":[{"award-number":["BIO2015-64777-P"]}]},{"name":"InGEMICS-CM","award":["BMD3691"],"award-info":[{"award-number":["BMD3691"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Microbiol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s10123-019-00069-1","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T14:10:53Z","timestamp":1552572653000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-7292","authenticated-orcid":false,"given":"Elvira","family":"Rom\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Pla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"69_CR1","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1128\/JB.181.10.3058-3068.1999","volume":"181","author":"R Alonso-Monge","year":"1999","unstructured":"Alonso-Monge R et al (1999) Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans. J Bacteriol 181:3058\u20133068","journal-title":"J Bacteriol"},{"key":"69_CR2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/EC.2.2.351-361.2003","volume":"2","author":"R Alonso-Monge","year":"2003","unstructured":"Alonso-Monge R, Navarro-Garcia F, Roman E, Negredo AI, Eisman B, Nombela C, Pla J (2003) The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans. Eukaryot Cell 2:351\u2013361","journal-title":"Eukaryot Cell"},{"key":"69_CR3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fgb.2010.03.009","volume":"47","author":"R Alonso-Monge","year":"2010","unstructured":"Alonso-Monge R, Rom\u00e1n E, Arana DM, Prieto AD, Urrialde V, Nombela C, Pla J (2010) The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans. Fungal Genet Biol 47:587\u2013601","journal-title":"Fungal Genet Biol"},{"key":"69_CR4","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1111\/j.1462-5822.2007.00898.x","volume":"9","author":"DM Arana","year":"2007","unstructured":"Arana DM, Alonso-Monge R, Du C, Calderone R, Pla J (2007) Differential susceptibility of mitogen-activated protein kinase pathway mutants to oxidative-mediated killing by phagocytes in the fungal pathogen Candida albicans. Cell Microbiol 9:1647\u20131659. \nhttps:\/\/doi.org\/10.1111\/j.1462-5822.2007.00898.x","journal-title":"Cell Microbiol"},{"key":"69_CR5","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1099\/mic.0.27723-0","volume":"151","author":"DM Arana","year":"2005","unstructured":"Arana DM, Nombela C, Alonso-Monge R, Pla J (2005) The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans. Microbiology 151:1033\u20131049. \nhttps:\/\/doi.org\/10.1099\/mic.0.27723-0","journal-title":"Microbiology"},{"key":"69_CR6","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1091\/mbc.e04-11-0987","volume":"16","author":"YS Bahn","year":"2005","unstructured":"Bahn YS, Kojima K, Cox GM, Heitman J (2005) Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol Biol Cell 16:2285\u20132300. \nhttps:\/\/doi.org\/10.1091\/mbc.e04-11-0987","journal-title":"Mol Biol Cell"},{"key":"69_CR7","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/mmi.13461","volume":"102","author":"D Banerjee","year":"2016","unstructured":"Banerjee D, Bloom AL, Panepinto JC (2016) Opposing PKA and Hog1 signals control the post-transcriptional response to glucose availability in Cryptococcus neoformans. Mol Microbiol 102:306\u2013320. \nhttps:\/\/doi.org\/10.1111\/mmi.13461","journal-title":"Mol Microbiol"},{"key":"69_CR8","doi-asserted-by":"publisher","first-page":"e12943","DOI":"10.1111\/cmi.12943","volume":"20","author":"R Beyer","year":"2018","unstructured":"Beyer R, Jandric Z, Zutz C, Gregori C, Willinger B, Jacobsen ID, Kovarik P, Strauss J, Sch\u00fcller C (2018) Competition of Candida glabrata against Lactobacillus is Hog1 dependent. Cell Microbiol 20:e12943. \nhttps:\/\/doi.org\/10.1111\/cmi.12943","journal-title":"Cell Microbiol"},{"key":"69_CR9","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/IAI.68.2.518-525.2000","volume":"68","author":"JA Calera","year":"2000","unstructured":"Calera JA, Zhao XJ, Calderone R (2000) Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans. Infect Immun 68:518\u2013525","journal-title":"Infect Immun"},{"key":"69_CR10","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1128\/EC.2.5.1018-1024.2003","volume":"2","author":"N Chauhan","year":"2003","unstructured":"Chauhan N, Inglis D, Rom\u00e1n E, Pla J, Li D, Calera JA, Calderone R (2003) Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryot Cell 2:1018\u20131024","journal-title":"Eukaryot Cell"},{"key":"69_CR11","doi-asserted-by":"publisher","first-page":"42002","DOI":"10.1074\/jbc.M111.265231","volume":"286","author":"J Cheetham","year":"2011","unstructured":"Cheetham J, MacCallum DM, Doris KS, da Silva Dantas A, Scorfield S, Odds F, Smith DA, Quinn J (2011) MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans. J Biol Chem 286:42002\u201342016. \nhttps:\/\/doi.org\/10.1074\/jbc.M111.265231","journal-title":"J Biol Chem"},{"key":"69_CR12","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1091\/mbc.e07-06-0581","volume":"18","author":"J Cheetham","year":"2007","unstructured":"Cheetham J, Smith DA, da Silva DA, Doris KS, Patterson MJ, Bruce CR, Quinn J (2007) A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans. Mol Biol Cell 18:4603\u20134614","journal-title":"Mol Biol Cell"},{"key":"69_CR13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1139\/m91-108","volume":"37","author":"GT Cole","year":"1991","unstructured":"Cole GT, Seshan KR, Phaneuf M, Lynn KT (1991) Chlamydospore-like cells of Candida albicans in the gastrointestinal tract of infected, immunocompromised mice. Can J Microbiol 37:637\u2013646","journal-title":"Can J Microbiol"},{"key":"69_CR14","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.3389\/fmicb.2016.02133","volume":"7","author":"I Correia","year":"2016","unstructured":"Correia I, Alonso-Monge R, Pla J (2016) The Hog1 MAP kinase promotes the recovery from cell cycle arrest induced by hydrogen peroxide in Candida albicans. Front Microbiol 7:2133. \nhttps:\/\/doi.org\/10.3389\/fmicb.2016.02133","journal-title":"Front Microbiol"},{"key":"69_CR15","doi-asserted-by":"crossref","unstructured":"Cruz MC, Sia RA, Olson M, Cox GM, Heitman J (2000) Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans Infect Immun 68: 982\u2013985","DOI":"10.1128\/IAI.68.2.982-985.2000"},{"key":"69_CR16","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1101\/gad.1178604","volume":"18","author":"PJ Cullen","year":"2004","unstructured":"Cullen PJ et al (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18:1695\u20131708. \nhttps:\/\/doi.org\/10.1101\/gad.1178604","journal-title":"Genes Dev"},{"issue":"8","key":"69_CR17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/embo-reports\/kvf158","volume":"3","author":"Eul\u00e0lia de Nadal","year":"2002","unstructured":"de Nadal E, Alepuz PM, Posas F (2002) Dealing with osmostress through MAP kinase activation. EMBO Rep 3: 735\u2013740","journal-title":"EMBO reports"},{"key":"69_CR18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/EC.5.2.347-358.2006","volume":"5","author":"B Eisman","year":"2006","unstructured":"Eisman B, Alonso-Monge R, Rom\u00e1n E, Arana DM, Nombela C, Pla J (2006) The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans. Eukaryot Cell 5:347\u2013358","journal-title":"Eukaryot Cell"},{"key":"69_CR19","doi-asserted-by":"publisher","unstructured":"Ene IV, Lohse MB, Vladu AV, Morschhauser J, Johnson AD, Bennett RJ (2016) Phenotypic profiling reveals that Candida albicans opaque cells represent a metabolically specialized cell state compared to default white cells MBio 7 doi:\nhttps:\/\/doi.org\/10.1128\/mBio.01269-16","DOI":"10.1128\/mBio.01269-16"},{"key":"69_CR20","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1091\/mbc.e05-06-0501","volume":"17","author":"B Enjalbert","year":"2006","unstructured":"Enjalbert B, Smith DA, Cornell MJ, Alam I, Nicholls S, Brown AJ, Quinn J (2006) Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans. Mol Biol Cell 17:1018\u20131032","journal-title":"Mol Biol Cell"},{"key":"69_CR21","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1365-2958.2005.04605.x","volume":"56","author":"K Furukawa","year":"2005","unstructured":"Furukawa K, Hoshi Y, Maeda T, Nakajima T, Abe K (2005) Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress. Mol Microbiol 56:1246\u20131261","journal-title":"Mol Microbiol"},{"key":"69_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrmicro2711","volume":"10","author":"NA Gow","year":"2012","unstructured":"Gow NA, van de Veerdonk FL, Brown AJ, Netea MG (2012) Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol 10:112\u2013122. \nhttps:\/\/doi.org\/10.1038\/nrmicro2711","journal-title":"Nat Rev Microbiol"},{"key":"69_CR23","doi-asserted-by":"publisher","first-page":"e80881","DOI":"10.1371\/journal.pone.0080881","volume":"8","author":"D Hagiwara","year":"2013","unstructured":"Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, Kamei K, Gonoi T, Kawamoto S (2013) NikA\/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus. PLoS One 8:e80881. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0080881","journal-title":"PLoS One"},{"key":"69_CR24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.fgb.2012.11.001","volume":"50","author":"Carmen Herrero de Dios","year":"2013","unstructured":"Herrero de Dios C, Rom\u00e1n E, Diez C, Alonso-Monge R, Pla J (2013) The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans. Fungal Genet Biol 50: 21\u201332","journal-title":"Fungal Genetics and Biology"},{"key":"69_CR25","doi-asserted-by":"publisher","first-page":"e02229","DOI":"10.1128\/mBio.02229-17","volume":"9","author":"C Herrero-de-Dios","year":"2018","unstructured":"Herrero-de-Dios C, Day AM, Tillmann AT, Kastora SL, Stead D, Salgado PS, Quinn J, Brown AJP (2018) Redox regulation, rather than stress-induced phosphorylation, of a Hog1 mitogen-activated protein kinase modulates its nitrosative-stress-specific outputs. MBio 9:e02229\u2013e02217. \nhttps:\/\/doi.org\/10.1128\/mBio.02229-17","journal-title":"MBio"},{"issue":"2","key":"69_CR26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0092-8674(95)90402-6","volume":"80","author":"Ira Herskowitz","year":"1995","unstructured":"Herskowitz (1995) MAP kinase pathways in yeast: for mating and more. Cell 80: 187\u2013197","journal-title":"Cell"},{"key":"69_CR27","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00294-015-0475-0","volume":"61","author":"S Hohmann","year":"2015","unstructured":"Hohmann S (2015) An integrated view on a eukaryotic osmoregulation system. Curr Genet 61:373\u2013382. \nhttps:\/\/doi.org\/10.1007\/s00294-015-0475-0","journal-title":"Curr Genet"},{"key":"69_CR28","doi-asserted-by":"crossref","unstructured":"Homman S (2002) Osmotic stress signaling and osmoadaptation in yeasts. Microbiolo Mol Biol Rev 66: 300\u2013372","DOI":"10.1128\/MMBR.66.2.300-372.2002"},{"key":"69_CR29","doi-asserted-by":"crossref","first-page":"12813","DOI":"10.1073\/pnas.0605270103","volume":"103","author":"G Huang","year":"2006","unstructured":"Huang G, Wang H, Chou S, Nie X, Chen J, Liu H (2006) Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans. Proc Natl Acad Sci U S A 103:12813\u201312818","journal-title":"Proc Natl Acad Sci U S A"},{"key":"69_CR30","doi-asserted-by":"publisher","first-page":"e1006414","DOI":"10.1371\/journal.ppat.1006414","volume":"13","author":"X Huang","year":"2017","unstructured":"Huang X, Chen X, He Y, Yu X, Li S, Gao N, Niu L, Mao Y, Wang Y, Wu X, Wu W, Wu J, Zhou D, Zhan X, Chen C (2017) Mitochondrial complex I bridges a connection between regulation of carbon flexibility and gastrointestinal commensalism in the human fungal pathogen Candida albicans. PLoS Pathog 13:e1006414. \nhttps:\/\/doi.org\/10.1371\/journal.ppat.1006414","journal-title":"PLoS Pathog"},{"key":"69_CR31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mrfmmm.2004.09.006","volume":"569","author":"A Ikner","year":"2005","unstructured":"Ikner A, Shiozaki K (2005) Yeast signaling pathways in the oxidative stress response. Mutat Res 569:13\u201327","journal-title":"Mutat Res"},{"key":"69_CR32","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nri.2017.55","volume":"17","author":"ID Iliev","year":"2017","unstructured":"Iliev ID, Leonardi I (2017) Fungal dysbiosis: immunity and interactions at mucosal barriers. Nat Rev Immunol 17:635\u2013646. \nhttps:\/\/doi.org\/10.1038\/nri.2017.55","journal-title":"Nat Rev Immunol"},{"key":"69_CR33","first-page":"571","volume":"46","author":"D Kultz","year":"1998","unstructured":"Kultz D (1998) Phylogenetic and functional classification of mitogen- and stress-activated protein kinases. J MolEvol 46:571\u2013588","journal-title":"J MolEvol"},{"key":"69_CR34","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1126\/science.aao1503","volume":"359","author":"I Leonardi","year":"2018","unstructured":"Leonardi I, Li X, Semon A, Li D, Doron I, Putzel G, Bar A, Prieto D, Rescigno M, McGovern DPB, Pla J, Iliev ID (2018) CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi. Science 359:232\u2013236. \nhttps:\/\/doi.org\/10.1126\/science.aao1503","journal-title":"Science"},{"key":"69_CR35","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1128\/ec.00235-14","volume":"13","author":"SH Liang","year":"2014","unstructured":"Liang SH, Cheng JH, Deng FS, Tsai PA, Lin CH (2014) A novel function for Hog1 stress-activated protein kinase in controlling white-opaque switching and mating in Candida albicans. Eukaryot Cell 13:1557\u20131566. \nhttps:\/\/doi.org\/10.1128\/ec.00235-14","journal-title":"Eukaryot Cell"},{"key":"69_CR36","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1369-5274(01)00275-2","volume":"4","author":"H Liu","year":"2001","unstructured":"Liu H (2001) Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 4:728\u2013735","journal-title":"Curr Opin Microbiol"},{"key":"69_CR37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11046-012-9600-5","volume":"175","author":"D Ma","year":"2013","unstructured":"Ma D, Li R (2013) Current understanding of HOG-MAPK pathway in Aspergillus fumigatus. Mycopathologia 175:13\u201323. \nhttps:\/\/doi.org\/10.1007\/s11046-012-9600-5","journal-title":"Mycopathologia"},{"key":"69_CR38","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1099\/mic.0.28616-0","volume":"152","author":"RA Monge","year":"2006","unstructured":"Monge RA, Roman E, Nombela C, Pla J (2006) The MAP kinase signal transduction network in Candida albicans. Microbiology 152:905\u2013912. \nhttps:\/\/doi.org\/10.1099\/mic.0.28616-0","journal-title":"Microbiology"},{"key":"69_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fcimb.2018.00135","volume":"8","author":"A Morales-Menchen","year":"2018","unstructured":"Morales-Menchen A et al (2018) Non-canonical activities of Hog1 control sensitivity of Candida albicans to killer toxins from Debaryomyces hansenii. Front Cell Infect Microbiol 8:135. \nhttps:\/\/doi.org\/10.3389\/fcimb.2018.00135","journal-title":"Front Cell Infect Microbiol"},{"issue":"5","key":"69_CR40","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1365-2958.2007.05588.x","volume":"63","author":"Carol A. Munro","year":"2007","unstructured":"Munro CA, Selvaggini S, de Bruijin I, Walker L, Lenardon MD, Gerssen B, Milne S, Brown AJ, Gow NA (2007) The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Mol Microbiol 63: 1399\u20131413","journal-title":"Molecular Microbiology"},{"key":"69_CR41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1101\/gad.3.3.283","volume":"3","author":"WS Moye-Rowley","year":"1989","unstructured":"Moye-Rowley WS, Harshman KD, Parker CS (1989) Yeast YAP1 encodes a novel form of the Jun family of transcriptional activator proteins. Genes Dev 3:283\u2013292","journal-title":"Genes Dev"},{"key":"69_CR42","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1093\/emboj\/20.17.4742","volume":"20","author":"AM Murad","year":"2001","unstructured":"Murad AM et al (2001) NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J 20:4742\u20134752","journal-title":"EMBO J"},{"key":"69_CR43","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1099\/mic.0.28038-0","volume":"151","author":"F Navarro-Garc\u00eda","year":"2005","unstructured":"Navarro-Garc\u00eda F, Eisman B, Fiuza SM, Nombela C, Pla J (2005) The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans. Microbiology 151:2737\u20132749","journal-title":"Microbiology"},{"key":"69_CR44","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.mib.2012.07.002","volume":"15","author":"MG Netea","year":"2012","unstructured":"Netea MG, Brown GD (2012) Fungal infections: the next challenge. Curr Opin Microbiol 15:403\u2013405. \nhttps:\/\/doi.org\/10.1016\/j.mib.2012.07.002","journal-title":"Curr Opin Microbiol"},{"key":"69_CR45","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1128\/MCB.22.13.4739-4749.2002","volume":"22","author":"SM O\u2019Rourke","year":"2002","unstructured":"O\u2019Rourke SM, Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22:4739\u20134749","journal-title":"Mol Cell Biol"},{"key":"69_CR46","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.2710","volume":"45","author":"K Pande","year":"2013","unstructured":"Pande K, Chen C, Noble SM (2013) Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism. Nat Genet 45:1088\u20131091","journal-title":"Nat Genet"},{"key":"69_CR47","doi-asserted-by":"crossref","first-page":"680","DOI":"10.2174\/138920310794557718","volume":"11","author":"P Perez","year":"2010","unstructured":"Perez P, Cansado J (2010) Cell integrity signaling and response to stress in fission yeast. Curr Protein Pept Sci 11:680\u2013692","journal-title":"Curr Protein Pept Sci"},{"key":"69_CR48","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1126\/science.276.5319.1702","volume":"276","author":"F Posas","year":"1997","unstructured":"Posas F, Saito H (1997) Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276:1702\u20131705","journal-title":"Science"},{"key":"69_CR49","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0092-8674(00)80162-2","volume":"86","author":"F Posas","year":"1996","unstructured":"Posas F, Wurgler-Murphy SM, Maeda T, Witten EA, Thai TC, Saito H (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 \"two-component\" osmosensor. Cell 86:865\u2013875","journal-title":"Cell"},{"issue":"23","key":"69_CR50","doi-asserted-by":"crossref","first-page":"17249","DOI":"10.1074\/jbc.M910016199","volume":"275","author":"Francesc Posas","year":"2000","unstructured":"Posas F, Chambers JR, Heyman JA, Hoeffler JP, de Nadal E, Ari\u00f1o J (2000) The transcriptional response of yeast to saline stress. J Biol Chem 275: 17249\u201317255","journal-title":"Journal of Biological Chemistry"},{"key":"69_CR51","doi-asserted-by":"crossref","first-page":"e87128","DOI":"10.1371\/journal.pone.0087128","volume":"9","author":"AD Prieto","year":"2014","unstructured":"Prieto AD, Rom\u00e1n E, Correia I, Pla J (2014) The HOG pathway is critical for the colonization of the mouse gastrointestinal tract by Candida albicans. PLoS One 9:e87128","journal-title":"PLoS One"},{"key":"69_CR52","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/emboj\/20.5.1123","volume":"20","author":"M Proft","year":"2001","unstructured":"Proft M, Pascual-Ahuir A, de Nadal E, Arino J, Serrano R, Posas F (2001) Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress. EMBO J 20:1123\u20131133","journal-title":"EMBO J"},{"key":"69_CR53","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1046\/j.1365-2958.2001.02384.x","volume":"40","author":"M Rep","year":"2001","unstructured":"Rep M, Proft M, Remize F, Tamas M, Serrano R, Thevelein JM, Hohmann S (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40:1067\u20131083","journal-title":"Mol Microbiol"},{"key":"69_CR54","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1128\/EC.4.8.1396-1402.2005","volume":"4","author":"MA Rodriguez-Gabriel","year":"2005","unstructured":"Rodriguez-Gabriel MA, Russell P (2005) Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryot Cell 4:1396\u20131402","journal-title":"Eukaryot Cell"},{"key":"69_CR55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tim.2007.02.001","volume":"15","author":"E Rom\u00e1n","year":"2007","unstructured":"Rom\u00e1n E, Arana DM, Nombela C, Alonso-Monge R, Pla J (2007) MAP kinase pathways as regulators of fungal virulence. Trends Microbiol 15:181\u2013190","journal-title":"Trends Microbiol"},{"key":"69_CR56","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1128\/EC.00081-09","volume":"8","author":"E Rom\u00e1n","year":"2009","unstructured":"Rom\u00e1n E, Cottier F, Ernst JF, Pla J (2009) Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans. Eukaryot Cell 8:1235\u20131249","journal-title":"Eukaryot Cell"},{"key":"69_CR57","doi-asserted-by":"crossref","first-page":"10611","DOI":"10.1128\/MCB.25.23.10611-10627.2005","volume":"25","author":"E Rom\u00e1n","year":"2005","unstructured":"Rom\u00e1n E, Nombela C, Pla J (2005) The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans. Mol Cell Biol 25:10611\u201310627","journal-title":"Mol Cell Biol"},{"key":"69_CR58","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nri2939","volume":"11","author":"L Romani","year":"2011","unstructured":"Romani L (2011) Immunity to fungal infections. Nat Rev Immunol 11:275\u2013288. \nhttps:\/\/doi.org\/10.1038\/nri2939","journal-title":"Nat Rev Immunol"},{"key":"69_CR59","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1462-5822.2002.00179.x","volume":"4","author":"PJ Rooney","year":"2002","unstructured":"Rooney PJ, Klein BS (2002) Linking fungal morphogenesis with virulence. Cell Microbiol 4:127\u2013137","journal-title":"Cell Microbiol"},{"key":"69_CR60","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.mib.2010.09.001","volume":"13","author":"H Saito","year":"2010","unstructured":"Saito H (2010) Regulation of cross-talk in yeast MAPK signaling pathways. Curr Opin Microbiol 13:677\u2013683","journal-title":"Curr Opin Microbiol"},{"key":"69_CR61","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1128\/JB.178.19.5850-5852.1996","volume":"178","author":"C San Jos\u00e9","year":"1996","unstructured":"San Jos\u00e9 C, Alonso-Monge R, P\u00e9rez-D\u00edaz RM, Pla J, Nombela C (1996) The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans. J Bacteriol 178:5850\u20135852","journal-title":"J Bacteriol"},{"key":"69_CR62","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0891-5849(00)00432-9","volume":"29","author":"KK Singh","year":"2000","unstructured":"Singh KK (2000) The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion. Free RadicBiol Med 29:1043\u20131050","journal-title":"Free RadicBiol Med"},{"key":"69_CR63","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1128\/IAI.67.10.5514-5517.1999","volume":"67","author":"A Sonneborn","year":"1999","unstructured":"Sonneborn A, Bockmuhl DP, Ernst JF (1999) Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator. Infect Immun 67:5514\u20135517","journal-title":"Infect Immun"},{"key":"69_CR64","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1128\/EC.00252-06","volume":"5","author":"T Srikantha","year":"2006","unstructured":"Srikantha T, Borneman AR, Daniels KJ, Pujol C, Wu W, Seringhaus MR, Gerstein M, Yi S, Snyder M, Soll DR (2006) TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell 5:1674\u20131687","journal-title":"Eukaryot Cell"},{"key":"69_CR65","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-2958.2004.04414.x","volume":"55","author":"P Staib","year":"2005","unstructured":"Staib P, Morschhauser J (2005) Differential expression of the NRG1 repressor controls species-specific regulation of chlamydospore development in Candida albicans and Candida dubliniensis. Mol Microbiol 55:637\u2013652","journal-title":"Mol Microbiol"},{"key":"69_CR66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0507.2006.01308.x","volume":"50","author":"P Staib","year":"2007","unstructured":"Staib P, Morschhauser J (2007) Chlamydospore formation in Candida albicans and Candida dubliniensis --an enigmatic developmental programme. Mycoses 50:1\u201312","journal-title":"Mycoses"},{"key":"69_CR67","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1091\/mbc.E12-06-0477","volume":"24","author":"C Su","year":"2013","unstructured":"Su C, Lu Y, Liu H (2013) Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity. Mol Biol Cell 24:385\u2013397. \nhttps:\/\/doi.org\/10.1091\/mbc.E12-06-0477","journal-title":"Mol Biol Cell"},{"key":"69_CR68","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.micres.2017.06.004","volume":"203","author":"V Urrialde","year":"2017","unstructured":"Urrialde V, Alburquerque B, Guirao-Abad JP, Pla J, Arg\u00fcelles JC, Alonso-Monge R (2017) Arsenic inorganic compounds cause oxidative stress mediated by the transcription factor PHO4 in Candida albicans. Microbiol Res 203:10\u201318. \nhttps:\/\/doi.org\/10.1016\/j.micres.2017.06.004","journal-title":"Microbiol Res"},{"key":"69_CR69","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fmicb.2015.00118","volume":"6","author":"V Urrialde","year":"2015","unstructured":"Urrialde V, Prieto D, Pla J, Alonso-Monge R (2015) The Pho4 transcription factor mediates the response to arsenate and arsenite in Candida albicans. Front Microbiol 6:118. \nhttps:\/\/doi.org\/10.3389\/fmicb.2015.00118","journal-title":"Front Microbiol"},{"key":"69_CR70","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","volume":"79","author":"C Widmann","year":"1999","unstructured":"Widmann C, Gibson S, Jarpe MB, Johnson GL (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79:143\u2013180","journal-title":"Physiol Rev"},{"key":"69_CR71","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1365-2958.2000.01877.x","volume":"36","author":"X Zhang","year":"2000","unstructured":"Zhang X, De Micheli M, Coleman ST, Sanglard D, Moye-Rowley WS (2000) Analysis of the oxidative stress regulation of the Candida albicans transcription factor. Cap1p Mol Microbiol 36:618\u2013629","journal-title":"Cap1p Mol Microbiol"}],"container-title":["International Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10123-019-00069-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10123-019-00069-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10123-019-00069-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:37:54Z","timestamp":1584059874000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10123-019-00069-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["69"],"URL":"https:\/\/doi.org\/10.1007\/s10123-019-00069-1","relation":{},"ISSN":["1139-6709","1618-1905"],"issn-type":[{"value":"1139-6709","type":"print"},{"value":"1618-1905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,14]]},"assertion":[{"value":"5 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}