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However, copper accumulation generates toxicity by multiple mechanisms, potentially leading to cell death. Due to its toxic nature at high concentrations, different chemical variants of copper have been extensively used as antifungal agents in agriculture and medicine. Most studies on copper homeostasis have been carried out in bacteria, yeast, and mammalian organisms. However, knowledge on filamentous fungi is less well documented. This review summarizes the knowledge gathered in the last few years about copper homeostasis in the filamentous fungi <jats:italic>Aspergillus fumigatu<\/jats:italic>s and <jats:italic>Aspergillus nidulans<\/jats:italic>: The mechanism of action of copper, the uptake and detoxification systems, their regulation at the transcriptional level, and the role of copper homeostasis in fungal pathogenicity are presented.<\/jats:p>","DOI":"10.1007\/s10123-019-00081-5","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T15:49:41Z","timestamp":1557935381000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["New insights into copper homeostasis in filamentous fungi"],"prefix":"10.1007","volume":"23","author":[{"given":"Martzel","family":"Antsotegi-Uskola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane","family":"Markina-I\u00f1arrairaegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unai","family":"Ugalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"81_CR1","doi-asserted-by":"publisher","first-page":"912","DOI":"10.3389\/fmicb.2017.00912","volume":"8","author":"M Antsotegi-Uskola","year":"2017","unstructured":"Antsotegi-Uskola M, Markina-Inarrairaegui A, Ugalde U (2017) Copper resistance in Aspergillus nidulans relies on the PI-type ATPase CrpA, regulated by the transcription factor AceA. 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