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All fungal isolates were morphologically recognized down to the species level. Methanol extracts of fungal mycelia and ethyl acetate extracts of culture filtrate from the isolated fungi were evaluated for antimicrobial activity against six pathogenic bacteria and one pathogenic yeast (\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ATCC20231). Only ethyl acetate extracts of\n                    <jats:italic>Fusarium circinatum<\/jats:italic>\n                    ,\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    , and\n                    <jats:italic>Aspergillus terreus<\/jats:italic>\n                    culture filtrates showed significant antimicrobial activity against the majority of the investigated pathogens. The culture filtrate extract of\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    exhibited notable cytotoxicity towards the breast cancer (MCF-7) cell line, with the lowest detected IC\n                    <jats:sub>50<\/jats:sub>\n                    recorded at 8 \u03bcg\/\u03bcl. Whereas\n                    <jats:italic>Fusarium circinatum<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus terreus<\/jats:italic>\n                    had IC\n                    <jats:sub>50<\/jats:sub>\n                    s of 15.91 \u03bcg\/\u03bcl and 18 \u03bcg\/\u03bcl, respectively. A gas chromatography-mass spectroscopy (GC\u2013MS) investigation of\n                    <jats:italic>A. niger\u2019<\/jats:italic>\n                    s potent extract revealed 23 compounds with different biological activities. Glycidyleoleate was found to be the main extract component.\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    extract was chosen to study its possible cytotoxic mechanism. The extract was found to induce apoptosis and cell cycle arrest at the\u2009&lt;\u20092n stage. Despite a significant increase in caspases 8 and 9, the production levels of tumor necrosis factor \u03b1 (TNF-\u03b1) and interleukin 6 (IL-6) have shown a significant decrease. The high interaction of glycidyleoleate against the studied cytokines\u2019 binding receptors was demonstrated via docking studies. In conclusion, the available data revealed that the culture filtrate extract of\n                    <jats:italic>A. niger<\/jats:italic>\n                    possesses promising antimicrobial, cytotoxic, and immunomodulatory properties.\n                  <\/jats:p>","DOI":"10.1007\/s10123-024-00503-z","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T12:02:55Z","timestamp":1710936175000},"page":"1677-1691","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Metabolic profiling, antimicrobial, anticancer, and in vitro and in silico immunomodulatory investigation of Aspergillus niger OR730979 isolated from the Western Desert, Egypt"],"prefix":"10.1007","volume":"27","author":[{"given":"Amira M.","family":"Baz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmat","family":"Elwy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa A.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-6755","authenticated-orcid":false,"given":"Heba","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"503_CR1","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.26355\/eurrev_202208_29424","volume":"26","author":"AAH Abdellatif","year":"2022","unstructured":"Abdellatif AAH, Osman SK, Alsharidah M et al (2022) Green synthesis of silver nanoparticles reduced with Trigonella foenum-graecum and their effect on tumor necrosis factor-\u03b1 in MCF7 cells. 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