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This novel fungus is characterized by its multidrug resistance profile, ability to thrive in harsh and stressful conditions, as well as high temperatures and salt concentrations, persistence on hospital surfaces, causing nosocomial infections and outbreaks, and unique fitness properties. Here, we study the antifungal susceptibility patterns, thermotolerance, and halotolerance of 15 putative <jats:italic>C. auris<\/jats:italic> clinical isolates from Inkosi Albert Academic Hospital, Durban, South Africa. Five of the <jats:italic>C. auris<\/jats:italic> isolates showed resistance to all three antifungals (fluconazole, amphotericin B, and micafungin) and were selected for characterization of their adaptability mechanisms. Four of the tested multidrug-resistant <jats:italic>C. auris<\/jats:italic> isolates (<jats:italic>C. auris<\/jats:italic> strain F25, <jats:italic>C. auris<\/jats:italic> strain F276, <jats:italic>C. auris<\/jats:italic> F283, and <jats:italic>C. auris<\/jats:italic> M153) showed good growth when exposed to high temperature (42\u00a0\u00b0C) and salinity (10% NaCl) conditions whereas one isolate (<jats:italic>C. auris<\/jats:italic> F65) showed moderate growth under these conditions. <jats:italic>Candida parapsilosis<\/jats:italic> showed poor growth whereas <jats:italic>C. albicans<\/jats:italic> no growth under these conditions. The five <jats:italic>C. auris<\/jats:italic> strains were positive for all the adaptive features.<\/jats:p>","DOI":"10.1007\/s10123-024-00563-1","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T02:02:15Z","timestamp":1722996135000},"page":"575-587","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Characterization of susceptibility patterns and adaptability of the newly emerged Candida auris"],"prefix":"10.1007","volume":"28","author":[{"given":"Matlou D.","family":"Semenya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale E.","family":"Aladejana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizwe I.","family":"Ndlovu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"563_CR1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3390\/microorganisms9040807","volume":"9","author":"S Ahmad","year":"2021","unstructured":"Ahmad S, Alfouzan W (2021) Candida auris: epidemiology, diagnosis, pathogenesis, antifungal susceptibility, and infection control measures to combat the spread of infections in healthcare facilities. 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