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High-quality draft genomes obtained by Illumina sequencing technology were used to determine their resistome, virulome, mobile genetic elements, and CRISPR-Cas types.<\/jats:p>\n            <jats:p>The relatedness of three CoNS species with publicly available genomes was assessed by core-genome single nucleotide\u00a0polymorphisms (SNPs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>AMR genes to all classes of antibiotics in staphylococci were detected including unusual ones (<jats:italic>mecC<\/jats:italic>, <jats:italic>ermT<\/jats:italic>, and <jats:italic>cfr<\/jats:italic>), of which their corresponding genetic organizations were analyzed. About 96.1% of the MDR-CoNS strains harbored diverse adherence or immune evasion genes. Remarkably, one enterotoxin-C and -L-carrying <jats:italic>S. epidermidis<\/jats:italic>-ST595 strain from a nestling stork was detected. Moreover, various plasmid bound-biocide resistance genes (<jats:italic>qacACGJ<\/jats:italic>) were identified in 34.6% of the MDR-CoNS. Two genes that encode for cadmium and zinc resistance (<jats:italic>cadD<\/jats:italic>, <jats:italic>czrC<\/jats:italic>) were found, of which <jats:italic>czrC<\/jats:italic> predominated (42.3%). Complete CRISPR-Cas system was detected in 19.2% of the CoNS strains, of which <jats:italic>cas<\/jats:italic>-1, -2, and -9 predominated, especially in 75% of the <jats:italic>S. borealis<\/jats:italic> strains. The phylogenetic analysis identified clusters of related <jats:italic>S. epidermidis<\/jats:italic> lineages with those of other countries (SNP &lt; 100). Also, highly related <jats:italic>S. borealis<\/jats:italic> isolates (SNP &lt; 10) from pigs was confirmed for the first time in Spain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These findings showed that various ecological niches harbor CoNS that presented MDR phenotypes mediated by multiple AMR genes carried by mobile genetic elements with relatively low frequency of intact CRISPR-Cas systems. Furthermore, the transmission of some CoNS species in humans and animals is strongly suggested.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10123-024-00577-9","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T12:53:40Z","timestamp":1726664020000},"page":"941-963","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Genomic analysis of multi-drug resistant coagulase-negative staphylococci from healthy humans and animals revealed unusual mechanisms of resistance and CRISPR-Cas system"],"prefix":"10.1007","volume":"28","author":[{"given":"Idris Nasir","family":"Abdullahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Latorre-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Zarazaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Stegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"issue":"12","key":"577_CR1","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.3390\/antibiotics10121556","volume":"10","author":"IN Abdullahi","year":"2021","unstructured":"Abdullahi IN, Fern\u00e1ndez-Fern\u00e1ndez R, Ju\u00e1rez-Fern\u00e1ndez G, Mart\u00ednez-\u00c1lvarez S, Eguiz\u00e1bal P, Zarazaga M, Lozano C, Torres C (2021) Wild animals are reservoirs and sentinels of Staphylococcus aureus and MRSA clones: a problem with \u201cOne Health\u201d concern. 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