{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:03:33Z","timestamp":1776225813019,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Microbiol"],"DOI":"10.1007\/s10123-026-00788-2","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:09:14Z","timestamp":1773367754000},"page":"499-508","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extract of endophytic fungus Cepalotheca foveolata (N11) inhibits lytic bacteriophage: a study on activity, cytotoxicity, and chemical profiling"],"prefix":"10.1007","volume":"29","author":[{"given":"Aman","family":"Ullah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talmeez UR","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahzar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qurban","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahwish","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Haleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Raashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Haq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safia","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abebe","family":"Bogale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatmah M.","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar A.","family":"Almohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"issue":"3","key":"788_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.5114\/aoms.2010.14256","volume":"6","author":"M Abolhassani","year":"2010","unstructured":"Abolhassani M (2010) Antiviral activity of borage (Echium amoenum). Arch Med Sci 6(3):366\u2013369","journal-title":"Arch Med Sci"},{"issue":"6","key":"788_CR2","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1039\/D0CS01118E","volume":"50","author":"CS Adamson","year":"2021","unstructured":"Adamson CS, Chibale K, Goss RJ, Jaspars M, Newman DJ, Dorrington RA (2021) Antiviral drug discovery: preparing for the next pandemic. Chem Soc Rev 50(6):3647\u20133655","journal-title":"Chem Soc Rev"},{"issue":"2","key":"788_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020261","volume":"9","author":"X Bai","year":"2023","unstructured":"Bai X, Sheng Y, Tang Z, Pan J, Wang S, Tang B, Zhang H (2023) Polyketides as secondary metabolites from the genus Aspergillus. J Fungi 9(2):261","journal-title":"J Fungi"},{"key":"788_CR4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.antiviral.2018.05.005","volume":"155","author":"S Chaudhuri","year":"2018","unstructured":"Chaudhuri S, Symons JA, Deval J (2018) Innovation and trends in the development and approval of antiviral medicines: 1987\u20132017 and beyond. Antiviral Res 155:76\u201388","journal-title":"Antiviral Res"},{"issue":"10","key":"788_CR5","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s11745-006-5044-3","volume":"41","author":"VM Dembitsky","year":"2006","unstructured":"Dembitsky VM (2006) Anticancer activity of natural and synthetic acetylenic lipids. Lipids 41(10):883\u2013924","journal-title":"Lipids"},{"issue":"10","key":"788_CR6","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1128\/AAC.49.10.4046-4051.2005","volume":"49","author":"RG Ferris","year":"2005","unstructured":"Ferris RG, Hazen RJ, Roberts GB, St Clair MH, Chan JH, Romines KR et al (2005) Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother 49(10):4046\u20134051","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"788_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34892-9","volume":"8","author":"J Jakubovska","year":"2018","unstructured":"Jakubovska J, Taurait\u0117 D, Me\u0161kys R (2018) A versatile method for the UVA-induced cross-linking of acetophenone-or benzophenone-functionalized DNA. Sci Rep 8(1):16484","journal-title":"Sci Rep"},{"key":"788_CR28","doi-asserted-by":"crossref","unstructured":"Kheiralla ZMH, Abo-Ghalia HH, Elaasser MM, Hemeda MF, Ibrahim SY (2023) Endophyte chaetomium, potential bioactivity: pharmaceutical and Phytochemical analyses","DOI":"10.21203\/rs.3.rs-3536748\/v1"},{"issue":"24","key":"788_CR8","first-page":"2373","volume":"6","author":"G Kumar","year":"2017","unstructured":"Kumar G, Chandra P, Choudhary M (2017) Endophytic fungi: a potential source of bioactive compounds. Chem Sci Rev Lett 6(24):2373\u20132381","journal-title":"Chem Sci Rev Lett"},{"key":"788_CR10","doi-asserted-by":"crossref","unstructured":"Kuo HY, Bregente CJB, Thuy TTD, Hidrosollo JH, Cruz-Papa DMD, Gutierrez TA, Kao CY (2025) Isolation and characterization of strictly lytic bacteriophages against carbapenem-resistant Enterobacter cloacae complex. Microbiol Spectr, e00835\u2013e00825","DOI":"10.1128\/spectrum.00835-25"},{"key":"788_CR9","doi-asserted-by":"publisher","unstructured":"Kutter E (2009) Phage host range and efficiency of plating. In: Clokie MR, Kropinski AM (eds) Bacteriophages: Methods and Protocols, Volume 1: Isolation, Characterization, and Interactions. Humana, New York, pp 141\u2013149. https:\/\/doi.org\/10.1007\/978-1-60327-164-6_14","DOI":"10.1007\/978-1-60327-164-6_14"},{"issue":"6","key":"788_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100971","volume":"19","author":"\u00cdCDS Lacerda","year":"2022","unstructured":"Lacerda \u00cdCDS, Polonio JC, Golias HC (2022) Endophytic fungi as a source of antiviral compounds\u2013a review. Chem Biodivers 19(6):e202100971","journal-title":"Chem Biodivers"},{"issue":"6","key":"788_CR12","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1016\/j.cell.2021.02.013","volume":"184","author":"L Lu","year":"2021","unstructured":"Lu L, Su S, Yang H, Jiang S (2021) Antivirals with common targets against highly pathogenic viruses. Cell 184(6):1604\u20131620","journal-title":"Cell"},{"issue":"12","key":"788_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8121934","volume":"8","author":"MC Manganyi","year":"2020","unstructured":"Manganyi MC, Ateba CN (2020) Untapped potentials of endophytic fungi: a review of novel bioactive compounds with biological applications. Microorganisms 8(12):1934","journal-title":"Microorganisms"},{"issue":"15","key":"788_CR14","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1016\/j.bmc.2011.06.007","volume":"19","author":"XD Ma","year":"2011","unstructured":"Ma XD, Zhang X, Dai HF, Yang SQ, Yang LM, Gu SX et al (2011) Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg Med Chem 19(15):4601\u20134607","journal-title":"Bioorg Med Chem"},{"issue":"23","key":"788_CR15","doi-asserted-by":"publisher","first-page":"13032","DOI":"10.1080\/07391102.2021.1978322","volume":"40","author":"SM Patil","year":"2022","unstructured":"Patil SM, Martiz RM, Ramu R, Shirahatti PS, Prakash A, Chandra SJ, Ranganatha VL (2022) In silico identification of novel benzophenone\u2013coumarin derivatives as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors. J Biomol Struct Dyn 40(23):13032\u201313048","journal-title":"J Biomol Struct Dyn"},{"key":"788_CR16","doi-asserted-by":"crossref","unstructured":"Pradeep P, Manju V, Ahsan MF (2019) Antiviral potency of mushroom constituents. Medicinal mushrooms. Springer, Cham, pp 1\u201320","DOI":"10.1007\/978-981-13-6382-5_10"},{"issue":"2","key":"788_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/ja.2014.97","volume":"68","author":"C Qin","year":"2015","unstructured":"Qin C, Lin X, Lu X, Wan J, Zhou X, Liao S et al (2015) Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotrys sp. HH1 ZSDS1F1-2. J Antibiot (Tokyo) 68(2):121\u2013125","journal-title":"J Antibiot (Tokyo)"},{"key":"788_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107506","volume":"203","author":"M Rahimian","year":"2025","unstructured":"Rahimian M, Deyhim H, Shirazi-Zavaragh S, Zeynali M, Bonabi E, Zarghami N (2025) Phage isolation, characterization, and antibiotic resistance profiling in avian pathogenic Escherichia coli: integrating data for a possible novel AMR surveillance model. Microb Pathog 203:107506","journal-title":"Microb Pathog"},{"issue":"2","key":"788_CR19","first-page":"273","volume":"22","author":"M Ramezani","year":"2008","unstructured":"Ramezani M, Behravan J, Arab M, Farzad SA (2008) Antiviral activity of Euphorbia helioscopia extract. Phytother Res 22(2):273\u2013275","journal-title":"Phytother Res"},{"key":"788_CR20","doi-asserted-by":"crossref","unstructured":"Said RP, Gawad JB, Kalaskar M, Gurav N, Beldar VG (2025) Isolation, Fractionation, and Purification of Natural Products. Pharmacognosy and phytochemistry: principles, techniques, and clinical applications, 207\u2013234","DOI":"10.1002\/9781394203680.ch11"},{"key":"788_CR21","volume-title":"Prospecting the antibiofilm potential of bioactive secondary metabolites of fungal endophyte Cephalotheca foveolata (N11) Against biofilm-forming bacteria","author":"W Sarwar","year":"2025","unstructured":"Sarwar W, Iqbal I, Ali Q, Ahmed B, Ahmed S (2025) Prospecting the antibiofilm potential of bioactive secondary metabolites of fungal endophyte Cephalotheca foveolata (N11) Against biofilm-forming bacteria. Microscopy research and technique"},{"issue":"12","key":"788_CR22","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1007\/s00217-025-04899-4","volume":"251","author":"E Sonmez","year":"2025","unstructured":"Sonmez E, Yildiz O, Ayaz N (2025) Does propolis have antiviral potential against myoviridae bacteriophage? Eur Food Res Technol 251(12):4429\u20134437. https:\/\/doi.org\/10.1007\/s00217-025-04899-4","journal-title":"Eur Food Res Technol"},{"issue":"3","key":"788_CR23","first-page":"241","volume":"15","author":"C Sukkum","year":"2025","unstructured":"Sukkum C, Lekklar C, Chongsri K, Deeying S, Srisomsap C, Surapanich N, Hongthong S (2025) Anti-cancer activity and brine shrimp lethality assay of the extracts and isolated compounds from Garcinia schomburgkiana Pierre. J Appl Pharm Sci 15(3):241\u2013247","journal-title":"J Appl Pharm Sci"},{"issue":"11","key":"788_CR29","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1039\/C8MD00300A","volume":"9","author":"K Surana","year":"2018","unstructured":"Surana K, Chaudhary B, Diwaker M, Sharma S (2018) Benzophenone: A ubiquitous scaffold in medicinal chemistry. Med Chem Comm 9(11):1803\u20131817","journal-title":"Med Chem Comm"},{"issue":"7","key":"788_CR24","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nrmicro3475","volume":"13","author":"F Vigant","year":"2015","unstructured":"Vigant F, Santos NC, Lee B (2015) Broad-spectrum antivirals against viral fusion. Nat Rev Microbiol 13(7):426\u2013437","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"788_CR25","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1023\/B:WIBI.0000023832.27679.a8","volume":"20","author":"S Wiyakrutta","year":"2004","unstructured":"Wiyakrutta S, Sriubolmas N, Panphut W, Thongon N, Danwisetkanjana K, Ruangrungsi N, Meevootisom V (2004) Endophytic fungi with anti-microbial, anti-cancer and anti-malarial activities isolated from Thai medicinal plants. World J Microbiol Biotechnol 20(3):265\u2013272","journal-title":"World J Microbiol Biotechnol"},{"key":"788_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00720","volume":"8","author":"S Xie","year":"2017","unstructured":"Xie S, Zhou J (2017) Harnessing plant biodiversity for the discovery of novel anticancer drugs targeting microtubules. Front Plant Sci 8:720","journal-title":"Front Plant Sci"},{"issue":"7","key":"788_CR27","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.3390\/md13074520","volume":"13","author":"S Zorofchian Moghadamtousi","year":"2015","unstructured":"Zorofchian Moghadamtousi S, Nikzad S, Abdul Kadir H, Abubakar S, Zandi K (2015) Potential antiviral agents from marine fungi: an overview. Mar Drugs 13(7):4520\u20134538","journal-title":"Mar Drugs"}],"container-title":["International Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10123-026-00788-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10123-026-00788-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10123-026-00788-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:14:24Z","timestamp":1776222864000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10123-026-00788-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["788"],"URL":"https:\/\/doi.org\/10.1007\/s10123-026-00788-2","relation":{},"ISSN":["1618-1905"],"issn-type":[{"value":"1618-1905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"assertion":[{"value":"12 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}