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Valeria Sagheddu, Serena Galletti, Alice Casaroli and Sara Soldi are employees of Advanced Analytical Technologies S.r.l. (AAT), which owns L. crispatus M247. Alexander Bertuccioli is a consultant to PharmExtracta S.p.A. Roberto Senatori has received honoraria from PharmExtracta S.p.A. for educational seminars for physicians. Chiara Maria Palazzi, Andrea Carugno, Maxim Olegovich Antipov, Nikolay Ivanovich Briko and Nicola Zerbinati declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}