{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:41:57Z","timestamp":1791189717148,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T00:00:00Z","timestamp":1295395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar Biotechnol"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s10126-010-9347-2","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T08:57:25Z","timestamp":1295341045000},"page":"868-882","source":"Crossref","is-referenced-by-count":28,"title":["Cellular Localization of Debromohymenialdisine and Hymenialdisine in the Marine Sponge Axinella sp. Using a Newly Developed Cell Purification Protocol"],"prefix":"10.1007","volume":"13","author":[{"given":"Yue-Fan","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Peng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,19]]},"reference":[{"key":"9347_CR1","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1016\/S0040-4039(99)00881-3","volume":"40","author":"P Andrade","year":"1999","unstructured":"Andrade P, Willoughby R, Pomponi SA, Kerr RG (1999) Biosynthetic studies of the alkaloid, stevensine, in a cell culture of the marine sponge Teichaxinella morchella. Tetrahedron Lett 40:4775\u20134778","journal-title":"Tetrahedron Lett"},{"key":"9347_CR2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0734-9750(03)00100-9","volume":"21","author":"EH Belarbi","year":"2003","unstructured":"Belarbi EH, G\u03ccmez AC, Chisti Y, Camacho FG, Grima EM (2003) Producing drugs from marine sponges. Biotechnol Adv 21:585\u2013598","journal-title":"Biotechnol Adv"},{"key":"9347_CR3","volume-title":"Sponges","author":"PR Bergquist","year":"1978","unstructured":"Bergquist PR (1978) Sponges. Hutchinson, London"},{"key":"9347_CR4","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/BF01925581","volume":"52","author":"CA Bewley","year":"1996","unstructured":"Bewley CA, Holland ND, Faulkner DJ (1996) Two classes of the metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts. Experientia 52:716\u2013722","journal-title":"Experientia"},{"key":"9347_CR5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1039\/b805113p","volume":"26","author":"JW Blunt","year":"2009","unstructured":"Blunt JW, Copp BR, Hu WP, Munro MHG, Northcote PT, Prinsep MR (2009) Marine natural products. Nat Prod Rep 26:170\u2013244","journal-title":"Nat Prod Rep"},{"key":"9347_CR6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/PL00008497","volume":"121","author":"F Bonasoro","year":"2001","unstructured":"Bonasoro F, Wilkie IC, Bavestrello G, Cerrano C, Candia Carnevali MD (2001) Dynamic structure of the mesohyl in the sponge Chondrosia reniformis (Porifera, Demospongiae). Zoomorphology 121:109\u2013121","journal-title":"Zoomorphology"},{"key":"9347_CR7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF00237007","volume":"201","author":"H Bretting","year":"1979","unstructured":"Bretting H, K\u00f6nigsmann K (1979) Investigations on the lectin-producing cells in the sponge Axinella polypoides (Schmidt). Cell Tissue Res 201:487\u2013497","journal-title":"Cell Tissue Res"},{"key":"9347_CR8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF00207698","volume":"229","author":"H Bretting","year":"1983","unstructured":"Bretting H, Jacobs G, Donadey C, Vacelet J (1983) Immunohistochemical studies on the distribution and the function of the d-galactose-specific lectins in the sponge Axinella polypoides (Schmidt). Cell Tissue Res 229:551\u2013571","journal-title":"Cell Tissue Res"},{"key":"9347_CR9","first-page":"239","volume-title":"Sponge biology","author":"W Burkart","year":"1979","unstructured":"Burkart W, Jumblatt J, Simpson TL, Burger MM (1979) Macromolecules which mediate cell\u2013cell recognition in Microciona prolifera. In: L\u00e9vi C, Boury-Esnault N (eds) Sponge biology, 291st edn. Centre National de la Recherche Scientifique, Paris, pp 239\u2013246","edition":"291"},{"key":"9347_CR10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00441-007-0443-1","volume":"329","author":"XP Cao","year":"2007","unstructured":"Cao XP, Fu WT, Yu XJ, Zhang W (2007) Dynamics of spicule production in the marine sponge Hymeniacidon perlevis during in vitro cell culture and seasonal development in the field. Cell Tissue Res 329:595\u2013608","journal-title":"Cell Tissue Res"},{"key":"9347_CR11","unstructured":"Chipman S, Faulkner DJ (1996) Use of debromohymenialdisine and related compounds for treating osteoarthritis. WO 1996\/040147"},{"key":"9347_CR12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0040-4039(00)86943-9","volume":"23","author":"G Cimino","year":"1982","unstructured":"Cimino G, De Rosa S, De Stefano D, Mazzarella L, Puliti R, Sodano G (1982) Isolation and X-ray crystal structure of a novel bromo-compound from two marine sponges. Tetrahedron Lett 23:767\u2013768","journal-title":"Tetrahedron Lett"},{"key":"9347_CR13","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00227-003-1265-7","volume":"144","author":"MR Cust\u00f3dio","year":"2004","unstructured":"Cust\u00f3dio MR, Hajdu E, Muricy G (2004) Cellular dynamics of in vitro allogeneic reactions of Hymeniacidon heliophila (Demospongiae: Halichondrida). Mar Biol 144:999\u20131010","journal-title":"Mar Biol"},{"key":"9347_CR14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s10126-005-6109-7","volume":"9","author":"D Erpenbeck","year":"2007","unstructured":"Erpenbeck D, van Soest RWM (2007) Status and perspective of sponge chemosystematics. Mar Biotechnol 9:2\u201319","journal-title":"Mar Biotechnol"},{"key":"9347_CR15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s004410051089","volume":"292","author":"AE Flowers","year":"1998","unstructured":"Flowers AE, Garson MJ, Webb RI, Dumdei EJ, Charan RD (1998) Cellular origin of chlorinated diketopiperazines in the dictyoceratid sponge Dysidea herbacea (Keller). Cell Tissue Res 292:597\u2013607","journal-title":"Cell Tissue Res"},{"key":"9347_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-169X.2009.01162.x","volume":"52","author":"N Funayama","year":"2010","unstructured":"Funayama N (2010) The stem cell system in demosponges: insights into the origin of somatic stem cells. Dev Growth Differ 52:1\u201314","journal-title":"Dev Growth Differ"},{"key":"9347_CR17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1440-169X.2005.00800.x","volume":"47","author":"N Funayama","year":"2005a","unstructured":"Funayama N, Nakatsukasa M, Hayashi T, Agata K (2005a) Isolation of the choanocyte in the fresh water sponge, Ephydatia fluviatilis and its lineage marker, Ef annexin. Develop Growth Differ 47:243\u2013253","journal-title":"Develop Growth Differ"},{"key":"9347_CR18","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2108\/zsj.22.1113","volume":"22","author":"N Funayama","year":"2005b","unstructured":"Funayama N, Nakatsukasa M, Kuraku S, Takechi K, Dohi M, Iwabe N, Miyata T, Agata K (2005b) Isolation of Ef silicatein and Ef lectin as molecular markers for sclerocytes and cells involved in innate immunity in the freshwater sponge, Ephydatia fluviatilis. Zool Sci 22:1113\u20131122","journal-title":"Zool Sci"},{"key":"9347_CR19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00435-006-0015-z","volume":"125","author":"E Gaino","year":"2006","unstructured":"Gaino E, Scalera Liaci L, Sciscioli M, Corriero G (2006) Investigation of the budding process in Tethya citrina and Tethya aurantium (Porifera, Demospongiae). Zoomorphology 125:87\u201397","journal-title":"Zoomorphology"},{"key":"9347_CR20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02536153","volume":"27","author":"MJ Garson","year":"1992","unstructured":"Garson MJ, Thompson JE, Larsen RM, Battershill CN, Murphy PT, Bergquist PR (1992) Terpenes in sponge cell membranes: cell separation and membrane fractionation studies with the tropical marine sponge Amphimedon sp. Lipids 27:378\u2013388","journal-title":"Lipids"},{"key":"9347_CR21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF02578249","volume":"29","author":"MJ Garson","year":"1994","unstructured":"Garson MJ, Zimmermann MR, Battershill CN, Holden JL, Murphy PT (1994) The distribution of brominated long-chain fatty acids in sponge and symbiont cell types from the tropical marine sponge Amphimedon terpenensis. Lipids 29:509\u2013516","journal-title":"Lipids"},{"key":"9347_CR22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s004410051128","volume":"293","author":"MJ Garson","year":"1998","unstructured":"Garson MJ, Flowers AE, Webb RI, Charan RD, McCaffrey EJ (1998) A sponge\/dinoflagellate association in the haplosclerid sponge Haliclona sp.: cellular origin of cytotoxic alkaloids by Percoll density gradient fractionation. Cell Tissue Res 293:365\u2013373","journal-title":"Cell Tissue Res"},{"key":"9347_CR23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0031-9422(02)00179-6","volume":"60","author":"AU Igamberdiev","year":"2002","unstructured":"Igamberdiev AU, Lea PJ (2002) The role of peroxisomes in the integration of metabolism and evolutionary diversity of photosynthetic organisms. Phytochemistry 60:651\u2013674","journal-title":"Phytochemistry"},{"key":"9347_CR24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/230126a0","volume":"230","author":"HA John","year":"1971","unstructured":"John HA, Campo MS, Mackenzie AM, Kemp RB (1971) Role of different sponge cell types in species specific cell aggregation. Nat New Biol 230:126\u2013128","journal-title":"Nat New Biol"},{"key":"9347_CR25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3354\/ame024009","volume":"24","author":"D Kelman","year":"2001","unstructured":"Kelman D, Kashman Y, Rosenberg E, Ilan M, Ifrach I, Loya Y (2001) Antimicrobial activity of the reef sponge Amphimedon viridis from the Red Sea: evidence for selective toxicity. Aquat Microb Ecol 24:9\u201316","journal-title":"Aquat Microb Ecol"},{"key":"9347_CR26","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00227-006-0572-1","volume":"151","author":"M Laroche","year":"2007","unstructured":"Laroche M, Imperatore C, Grozdanov L, Costantino V, Mangoni A, Hentschel U, Fattorusso E (2007) Cellular localization of secondary metabolites isolated from the Caribbean sponge Plakortis simplex. Mar Biol 151:1365\u20131373","journal-title":"Mar Biol"},{"key":"9347_CR27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/jhered\/93.1.27","volume":"93","author":"JV Lopez","year":"2002","unstructured":"Lopez JV, Peterson CL, Willoughby R, Wright AE, Enright E, Zoladz S, Reed JK, Pomponi SA (2002) Characterization of genetic markers for in vitro cell line identification of the marine sponge Axinella corrugata. J Hered 93:27\u201336","journal-title":"J Hered"},{"key":"9347_CR28","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1017\/S0025315407058080","volume":"87","author":"M Maldonado","year":"2007","unstructured":"Maldonado M (2007) Intergenerational transmission of symbiotic bacteria in oviparous and viviparous demosponges, with emphasis on intracytoplasmically-compartmented bacterial types. J Mar Biol Assoc UK 87:1701\u20131713","journal-title":"J Mar Biol Assoc UK"},{"key":"9347_CR29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1095-8312.2009.01202.x","volume":"97","author":"M Maldonado","year":"2009","unstructured":"Maldonado M (2009) Embryonic development of verongid demosponges supports the independent acquisition of spongin skeletons as an alternative to the siliceous skeleton of sponges. Biol J Linn Soc 97:427\u2013447","journal-title":"Biol J Linn Soc"},{"key":"9347_CR30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1074-5521(00)00063-6","volume":"7","author":"L Meijer","year":"2000","unstructured":"Meijer L, Thunnissen A-MWH, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR (2000) Inhibition of cyclin-dependent kinases, GSK-3\u03b2 and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol 7:51\u201363","journal-title":"Chem Biol"},{"key":"9347_CR31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1039\/b508781n","volume":"23","author":"BS Moore","year":"2006","unstructured":"Moore BS (2006) Biosynthesis of marine natural products: macroorganisms (part B). Nat Prod Rep 23:615\u2013629","journal-title":"Nat Prod Rep"},{"key":"9347_CR32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.semcdb.2006.05.006","volume":"17","author":"WEG M\u00fcller","year":"2006","unstructured":"M\u00fcller WEG (2006) The stem cell concept in sponges (Porifera): metazoan traits. Semin Cell Dev Biol 17:481\u2013491","journal-title":"Semin Cell Dev Biol"},{"key":"9347_CR33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1389-0344(03)00055-8","volume":"20","author":"WEG M\u00fcller","year":"2003","unstructured":"M\u00fcller WEG, Korzhev M, Le Pennec G, M\u00fcller IM, Schr\u00f6der HC (2003) Origin of metazoan stem cell system in sponges: first approach to establish the model (Suberites domuncula). Biomol Eng 20:369\u2013379","journal-title":"Biomol Eng"},{"key":"9347_CR34","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1021\/np000003p","volume":"63","author":"WEG M\u00fcller","year":"2000","unstructured":"M\u00fcller WEG, B\u00f6hm M, Batel R, De Rosa S, Tommonaro G, M\u00fcller IM, Schr\u00f6der HC (2000) Application of cell culture for the production of bioactive compounds from sponges: synthesis of avarol by primmorphs from Dysidea avara. J Nat Prod 63:1077\u20131081","journal-title":"J Nat Prod"},{"key":"9347_CR35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1012717200362","volume":"461","author":"R Osinga","year":"2001","unstructured":"Osinga R, Armstrong E, Burgess JG, Hoffmann F, Reitner J, Schumann-Kindel G (2001) Sponge\u2013microbe associations and their importance for sponge bioprocess engineering. Hydrobiologia 461:55\u201362","journal-title":"Hydrobiologia"},{"key":"9347_CR36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0168-1656(99)00053-X","volume":"70","author":"SA Pomponi","year":"1999","unstructured":"Pomponi SA (1999) The bioprocess\u2013technological potential of the sea. J Biotechnol 70:5\u201313","journal-title":"J Biotechnol"},{"key":"9347_CR37","unstructured":"Pomponi SA, Willoughby R (1994) Sponge cell culture for production of bioactive metabolites. In: van Soest RWM, van Kempen TMG, Braekman JC (eds) Sponges in time and space. Proceedings of the 4th International Porifera Conference, Amsterdam. Balkema, Rotterdam"},{"key":"9347_CR38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s004410100437","volume":"306","author":"E Richelle-Maurer","year":"2001","unstructured":"Richelle-Maurer E, Braekman JC, De Kluijver MJ, Gomez R, van de Vyver G, van Soest RWM, Devijver C (2001) Cellular location of (2R,3R,7Z)-2-aminotetradec-7-ene-1,3-diol, a potent antimicrobial metabolite produced by the Caribbean sponge Haliclona vansoesti. Cell Tissue Res 306:157\u2013165","journal-title":"Cell Tissue Res"},{"key":"9347_CR39","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0305-1978(03)00072-3","volume":"31","author":"E Richelle-Maurer","year":"2003","unstructured":"Richelle-Maurer E, De Kluijver MJ, Feio S, Gaud\u00eancio S, Gaspar H, Gomez R, Tavares R, van de Vyver G, van Soest RWM (2003) Localization and ecological significance of oroidin and sceptrin in the Caribbean sponge Agelas conifera. Biochem Syst Ecol 31:1073\u20131091","journal-title":"Biochem Syst Ecol"},{"key":"9347_CR40","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.2174\/1381612013397230","volume":"7","author":"KK Roy","year":"2001","unstructured":"Roy KK, Sausville EA (2001) Early development of cyclin dependent kinase modulators. Curr Pharm Des 7:1669\u20131687","journal-title":"Curr Pharm Des"},{"key":"9347_CR41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s002270100493","volume":"139","author":"CE Salomon","year":"2001","unstructured":"Salomon CE, Deerinck T, Ellisman MH, Faulkner DJ (2001) The cellular localization of dercitamide in the Palauan sponge Oceanapia sagittaria. Mar Biol 139:313\u2013319","journal-title":"Mar Biol"},{"key":"9347_CR42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jez.1401540109","volume":"154","author":"TL Simpson","year":"1963","unstructured":"Simpson TL (1963) The biology of the marine sponge Microciona prolifera (Ellis and Solander). I. A study of cellular function and differentiation. J Exp Zool 154:135\u2013147","journal-title":"J Exp Zool"},{"key":"9347_CR43","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4612-5214-6","volume-title":"The cell biology of sponges","author":"TL Simpson","year":"1984","unstructured":"Simpson TL (1984) The cell biology of sponges. Springer, New York"},{"key":"9347_CR44","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s10126-004-0405-5","volume":"7","author":"D Sipkema","year":"2005a","unstructured":"Sipkema D, Franssen MCR, Osinga R, Tramper J, Wijffels RH (2005a) Marine sponges as pharmacy. Mar Biotechnol 7:142\u2013162","journal-title":"Mar Biotechnol"},{"key":"9347_CR45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/bit.20404","volume":"90","author":"D Sipkema","year":"2005b","unstructured":"Sipkema D, Osinga R, Schatton W, Mendola D, Tramper J, Wijffels RH (2005b) Large-scale production of pharmaceuticals by marine sponges: sea, cell, or synthesis? Biotechnol Bioeng 90:201\u2013222","journal-title":"Biotechnol Bioeng"},{"key":"9347_CR46","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00441-006-0342-x","volume":"328","author":"LM Sun","year":"2007","unstructured":"Sun LM, Song YF, Qu Y, Yu XJ, Zhang W (2007) Purification and in vitro cultivation of archaeocytes (stem cells) of the marine sponge Hymeniacidon perleve (Demospongiae). Cell Tissue Res 328:223\u2013237","journal-title":"Cell Tissue Res"},{"key":"9347_CR47","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1515\/znc-1995-9-1012","volume":"50","author":"A Supriyono","year":"1995","unstructured":"Supriyono A, Schwarz B, Wray V, Witte L, M\u00fcller WEG, van Soest R, Sumaryono W, Proksch P (1995) Bioactive alkaloids from the tropical marine sponge Axinella carteri. Z Naturforsch C 50:669\u2013674","journal-title":"Z Naturforsch C"},{"key":"9347_CR48","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00227-008-1071-3","volume":"156","author":"C Thoms","year":"2008","unstructured":"Thoms C, Hentschel U, Schmitt S, Peter J, Schupp PJ (2008) Rapid tissue reduction and recovery in the sponge Aplysinella sp. Mar Biol 156:141\u2013153","journal-title":"Mar Biol"},{"key":"9347_CR49","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1463-6395.1983.tb00801.x","volume":"64","author":"JE Thompson","year":"1983","unstructured":"Thompson JE, Barrow KD, Faulkner DJ (1983) Localization of two brominated metabolites, aerothionin and homoaerothionin, in spherulous cells of the marine sponge Aplysina fistularis (=Verongia thiona). Acta Zool 64:199\u2013210","journal-title":"Acta Zool"},{"key":"9347_CR50","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s004410050668","volume":"285","author":"MJ Uriz","year":"1996","unstructured":"Uriz MJ, Turon X, Galera J, Tur JM (1996) New light on the cell location of avarol within the sponge Dysidea avara (Dendroceratida). Cell Tissue Res 285:519\u2013527","journal-title":"Cell Tissue Res"},{"key":"9347_CR51","unstructured":"van Soest R, Richelle-Maurer E, Gomez R, Braekman J-C (2001) Protocols for developing sponge compounds involving the source organism. Final report, Symbiosponge Project"},{"key":"9347_CR52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00441-010-0963-y","volume":"340","author":"E Vilanova","year":"2010","unstructured":"Vilanova E, Coutinho C, Maia G, Mour\u00e3o PA (2010) Sulfated polysaccharides from marine sponges: conspicuous distribution among different cell types and involvement on formation of in vitro cell aggregates. Cell Tissue Res 340:523\u2013531","journal-title":"Cell Tissue Res"},{"key":"9347_CR53","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1023\/A:1020811810223","volume":"25","author":"DM Wilson","year":"1999","unstructured":"Wilson DM, Puyana M, Fenical W, Pawlik JR (1999) Chemical defense of the Caribbean reef sponge Axinella corrugata against predatory fishes. J Chem Ecol 25:2811\u20132823","journal-title":"J Chem Ecol"},{"key":"9347_CR54","volume-title":"Cytochemical and cytobiological techniques","author":"JS Yang","year":"1991","unstructured":"Yang JS (1991) Cytochemical and cytobiological techniques. PUMC & BMU, Beijing"},{"key":"9347_CR55","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/bit.10811","volume":"84","author":"XY Zhang","year":"2003","unstructured":"Zhang XY, Cao XP, Zhang W, Yu XJ, Jin MF (2003) Primmorphs from archaeocytes-dominant cell population of the sponge Hymeniacidon perleve: improved cell proliferation and spiculogenesis. Biotechnol Bioeng 84:583\u2013590","journal-title":"Biotechnol Bioeng"},{"key":"9347_CR56","first-page":"1299","volume":"29","author":"H Zhang","year":"2006","unstructured":"Zhang H, Jin Y, Zhang W (2006) Two bioactive aldisine alkaloids isolated from marine sponge Axinella sp. in the South China Sea. J Chin Med Mater 29:1299\u20131301","journal-title":"J Chin Med Mater"}],"container-title":["Marine Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-010-9347-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10126-010-9347-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-010-9347-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T23:06:17Z","timestamp":1559948777000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10126-010-9347-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,19]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["9347"],"URL":"https:\/\/doi.org\/10.1007\/s10126-010-9347-2","relation":{},"ISSN":["1436-2228","1436-2236"],"issn-type":[{"value":"1436-2228","type":"print"},{"value":"1436-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,19]]}}}