{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:04:30Z","timestamp":1781762670490,"version":"3.54.5"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T00:00:00Z","timestamp":1527897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Marine Economic Development Demonstration Project in Xiamen","award":["16CZB023SF12"],"award-info":[{"award-number":["16CZB023SF12"]}]},{"name":"Public Science and Technology Research Funds Projects of Ocean of China","award":["201305016"],"award-info":[{"award-number":["201305016"]}]},{"name":"Open Fund of Key Laboratory of Integrated Marine Monitoring and Applied Technologies for Harmful Algal Blooms, State Oceanic Administration","award":["MATHAB201808"],"award-info":[{"award-number":["MATHAB201808"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mar Biotechnol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s10126-018-9834-4","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T04:02:46Z","timestamp":1527912166000},"page":"623-638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Plant Alkaloid Camptothecin as a Novel Antifouling Compound for Marine Paints: Laboratory Bioassays and Field Trials"],"prefix":"10.1007","volume":"20","author":[{"given":"Dan Qing","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai Huan","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,2]]},"reference":[{"key":"9834_CR1","doi-asserted-by":"publisher","first-page":"5169","DOI":"10.1016\/S0040-4039(00)97833-X","volume":"31","author":"N Aimi","year":"1990","unstructured":"Aimi N, Hoshino H, Nishimura M, Sakai S, Haginiwa J (1990) Chaboside, first natural glycocamptothecin found from Ophiorrhiza pumila. Tetrahedron Lett 31:5169\u20135172","journal-title":"Tetrahedron Lett"},{"key":"9834_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.porgcoat.2007.01.017","volume":"59","author":"E Almeida","year":"2007","unstructured":"Almeida E, Diamantino TC, Sousa O (2007) Marine paints: the particular case of antifouling paints. Prog Org Coat 59:2\u201320","journal-title":"Prog Org Coat"},{"key":"9834_CR3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1139\/w05-122","volume":"52","author":"T Amna","year":"2006","unstructured":"Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J, Spiteller M, Qazi GN (2006) Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin. Can J Microbiol 52:189\u2013196","journal-title":"Can J Microbiol"},{"key":"9834_CR4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/08927010701371439","volume":"23","author":"M\u2013B Angarano","year":"2007","unstructured":"Angarano M\u2013B, McMahon RF, Hawkins DL, Schetz JA (2007) Exploration of structure\u2013antifouling relationships of capsaicin-like compounds that inhibit zebra mussel (Dreissena polymorpha) macrofouling. Biofouling 23:295\u2013305","journal-title":"Biofouling"},{"key":"9834_CR5","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.fct.2017.05.036","volume":"109","author":"P Aqueveque","year":"2017","unstructured":"Aqueveque P, C\u00e9spedes CL, Becerra J, Aranda M, Sterner O (2017) Antifungal activities of secondary metabolites isolated from liquid fermentations of Stereum hirsutum (Sh134-11) against Botrytis cinerea (grey mould agent). Food Chem Toxicol 109:1048\u20131054","journal-title":"Food Chem Toxicol"},{"key":"9834_CR6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1055\/s-2007-971533","volume":"43","author":"M Arisawa","year":"1981","unstructured":"Arisawa M, Gunasekera SP, Cordell GA, Farnsworth NR (1981) Plant anticancer agents XXI. Constituents of Merrilliodendron megacarpum. Planta Med 43:404\u2013407","journal-title":"Planta Med"},{"key":"9834_CR7","volume-title":"Artemia toxicity screening test for estuarine and marine waters. Standard Operational Procedure","author":"M Artoxkit","year":"1990","unstructured":"Artoxkit M (1990) Artemia toxicity screening test for estuarine and marine waters. Standard Operational Procedure. Creasel, Deinze"},{"key":"9834_CR8","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.funbio.2016.04.003","volume":"120","author":"BN Bhalkar","year":"2016","unstructured":"Bhalkar BN, Patil SM, Govindwar SP (2016) Camptothecine production by mixed fermentation of two endophytic fungi from Nothapodytes nimmoniana. Fungal Biol 120:873\u2013883","journal-title":"Fungal Biol"},{"key":"9834_CR9","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0006-2952(97)00556-X","volume":"55","author":"AL Bodley","year":"1998","unstructured":"Bodley AL, Cummings JN, Shapiro TA (1998) Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum. Biochem Pharmacol 55:709\u2013711","journal-title":"Biochem Pharmacol"},{"key":"9834_CR10","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/08927010902745316","volume":"25","author":"JF Briand","year":"2009","unstructured":"Briand JF (2009) Marine antifouling laboratory bioassays: an overview of their diversity. Biofouling 25:297\u2013311","journal-title":"Biofouling"},{"key":"9834_CR11","unstructured":"Chen PH (2006) Factors affecting the growth and settlement of barnacle Balanus albicostatus. PhD Thesis, Taiwan, National Sun Yat-sen University"},{"key":"9834_CR12","doi-asserted-by":"publisher","first-page":"11049","DOI":"10.1016\/S0040-4020(97)00365-7","volume":"53","author":"MA Ciufolini","year":"1997","unstructured":"Ciufolini MA, Roschangar F (1997) Practical total synthesis of (+)-camptothecin: the full story. Tetrahedron 53:11049\u201311060","journal-title":"Tetrahedron"},{"key":"9834_CR13","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1021\/jo00902a034","volume":"40","author":"EJ Corey","year":"1975","unstructured":"Corey EJ, Crouse DN, Anderson JE (1975) A total synthesis of natural 20(S)-camptothecin. J Org Chem 40:2140\u20132141","journal-title":"J Org Chem"},{"key":"9834_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ijantimicag.2014.06.001","volume":"44","author":"TP Cushnie","year":"2014","unstructured":"Cushnie TP, Cushnie B, Lamb AJ (2014) Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. Int J Antimicrob Agents 44:377\u2013386","journal-title":"Int J Antimicrob Agents"},{"key":"9834_CR15","first-page":"171","volume":"42","author":"M Dahlstr\u00f6m","year":"2006","unstructured":"Dahlstr\u00f6m M, Elwing H (2006) Adrenoceptor and other pharmacoactive compounds as putative antifoulants. Prog Mol Subcell Biol 42:171\u2013202","journal-title":"Prog Mol Subcell Biol"},{"key":"9834_CR16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/08927010009378444","volume":"16","author":"M Dahlstr\u00f6m","year":"2000","unstructured":"Dahlstr\u00f6m M, Martensson LGE, Jonsson PR, Arnebrant T, Elwing H (2000) Surface active adrenoceptor compounds prevent the settlement of cyprid larvae of Balanus improvisus. Biofouling 16:191\u2013203","journal-title":"Biofouling"},{"key":"9834_CR17","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1021\/np990100m","volume":"62","author":"JR Dai","year":"1999","unstructured":"Dai JR, Hallock YF, Cardellina JH, Boyd MR (1999) 20-O-\u03b2-Glucopyranosyl camptothecin from Mostuea brunonis: a potential camptothecin pro-drug with improved solubility. J Nat Prod 62:1427\u20131429","journal-title":"J Nat Prod"},{"key":"9834_CR18","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jep.2007.10.014","volume":"115","author":"L Farouk","year":"2008","unstructured":"Farouk L, Laroubi AR, Benharref A, Chait A (2008) Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved. J Ethnopharmacol 115:449\u2013454","journal-title":"J Ethnopharmacol"},{"key":"9834_CR19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/08927010802669210","volume":"25","author":"DQ Feng","year":"2009","unstructured":"Feng DQ, Ke CH, Lu CY, Li SJ (2009) Herbal plants as a promising source of natural antifoulants: evidence from barnacle settlement inhibition. Biofouling 25:181\u2013190","journal-title":"Biofouling"},{"key":"9834_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.ibiod.2013.08.014","volume":"85","author":"DQ Feng","year":"2013","unstructured":"Feng DQ, Qiu Y, Wang W, Wang X, Ouyang PG, Ke CH (2013) Antifouling activities of hymenialdisine and debromohymenialdisine from the sponge Axinella sp. Int Biodeter Biodegr 85:359\u2013364","journal-title":"Int Biodeter Biodegr"},{"key":"9834_CR21","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1021\/ol802506n","volume":"40","author":"LS Fernandez","year":"2009","unstructured":"Fernandez LS, Buchanan MS, Carroll AR, Feng YJ, Quinn RJ, Avery VM (2009) Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species. Org Lett 40:329\u2013332","journal-title":"Org Lett"},{"key":"9834_CR22","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s10811-015-0606-5","volume":"28","author":"H F\u00f8rde","year":"2016","unstructured":"F\u00f8rde H, Forbord S, Hand\u00e5 A, Fossberg J, Arff J, Johnsen G, Reitan KI (2016) Development of bryozoan fouling on cultivated kelp (Saccharina latissima) in Norway. J Appl Phycol 28:1225\u20131234","journal-title":"J Appl Phycol"},{"key":"9834_CR23","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1039\/C0NP00034E","volume":"28","author":"N Fusetani","year":"2011","unstructured":"Fusetani N (2011) Antifouling marine natural products. Nat Prod Rep 28:400\u2013410","journal-title":"Nat Prod Rep"},{"key":"9834_CR24","first-page":"641","volume":"8","author":"R Garcia-Carbonero","year":"2002","unstructured":"Garcia-Carbonero R, Supko JG (2002) Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins. Clin Cancer Res 8:641\u2013661","journal-title":"Clin Cancer Res"},{"key":"9834_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0031-9422(00)89852-0","volume":"11","author":"TR Govindachari","year":"1972","unstructured":"Govindachari TR, Viswanathan N (1972) Alkaloids of Mappia foetida. Phytochemistry 11:35\u201329","journal-title":"Phytochemistry"},{"key":"9834_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1139\/m62-029","volume":"8","author":"RRL Guillard","year":"1962","unstructured":"Guillard RRL, Ryther JH (1962) Studies of marine planktonic diatoms I. Cyclotella nana Hustedt and Detonula confervacea Cleve. Can J Microbiol 8:229\u2013239","journal-title":"Can J Microbiol"},{"key":"9834_CR27","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1021\/np50005a006","volume":"42","author":"SP Gunasekera","year":"1979","unstructured":"Gunasekera SP, Badawi MM, Cordell GA, Farnsworth NR, Chitnis M (1979) Plant anticancer agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana. J Nat Prod 42:475\u2013477","journal-title":"J Nat Prod"},{"key":"9834_CR28","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1021\/es60130a004","volume":"11","author":"MA Hamilton","year":"1977","unstructured":"Hamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 11:714\u2013719","journal-title":"Environ Sci Technol"},{"key":"9834_CR29","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1021\/es60130a004","volume":"11","author":"MA Hamilton","year":"1978","unstructured":"Hamilton MA, Russo RC, Thurston RV (1978) Correction to: Hamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 11:714\u2013719","journal-title":"Environ Sci Technol"},{"key":"9834_CR30","first-page":"329","volume":"8","author":"F He","year":"2013","unstructured":"He F, Han Z, Peng J, Qian PY, Qi SH (2013) Antifouling indole alkaloids from two marine derived fungi. Nat Prod Commun 8:329\u2013332","journal-title":"Nat Prod Commun"},{"key":"9834_CR31","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10126-004-3150-x","volume":"7","author":"C Hellio","year":"2005","unstructured":"Hellio C, Tsoukatou M, JP M\u2019c, Aldred N, Beaupoil C, Clare AS, Vagias C, Roussis V (2005) Inhibitory effects of Mediterranean sponge extracts and metabolites on larval settlement of the barnacle Balanus amphitrite. Mar Biotechnol 7:297\u2013305","journal-title":"Mar Biotechnol"},{"key":"9834_CR32","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.bmc.2009.12.028","volume":"18","author":"T Hertiani","year":"2010","unstructured":"Hertiani T, Edrada-Ebel R, Ortlepp S, van Soest RWM, de Voogd NJ, Wray V, Hentschel U, Kozytska S, WEG M, Proksch P (2010) From anti\u2013fouling to biofilm inhibition: new cytotoxic secondary metabolites from two Indonesian Agelas sponges. Bioorg Med Chem 18:1297\u20131311","journal-title":"Bioorg Med Chem"},{"key":"9834_CR33","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1093\/icb\/ics042","volume":"52","author":"ER Holm","year":"2012","unstructured":"Holm ER (2012) Barnacles and biofouling. Integr Comp Biol 52:348\u2013355","journal-title":"Integr Comp Biol"},{"key":"9834_CR34","volume-title":"Marine fouling organisms and their control","author":"ZG Huang","year":"1984","unstructured":"Huang ZG, Cai RX (1984) Marine fouling organisms and their control, vol 1. Oceanic Press, Beijing"},{"key":"9834_CR35","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/08927014.2014.889688","volume":"30","author":"XZ Huang","year":"2014","unstructured":"Huang XZ, Xu Y, Zhang YF, Zhang Y, Wong YH, Han Z, Yin Y, Qian PY (2014) Nontoxic piperamides and their synthetic analogues as novel antifouling reagents. Biofouling 30:473\u2013481","journal-title":"Biofouling"},{"key":"9834_CR36","unstructured":"International Maritime Organization (IMO) (2008) International convention on the control of harmful anti-fouling systems on ships. International Maritime Organization, Adoption: 5 October 2001; Entry into force: 17 September 2008"},{"key":"9834_CR37","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s11738-015-1854-3","volume":"37","author":"T Isah","year":"2015","unstructured":"Isah T, Mujib A (2015) Camptothecin from Nothapodytes nimmoniana: review on biotechnology applications. Acta Physiol Plant 37:106","journal-title":"Acta Physiol Plant"},{"key":"9834_CR38","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.1016\/j.bmcl.2014.05.001","volume":"24","author":"SK Jain","year":"2014","unstructured":"Jain SK, Meena S, Gupta AP, Kushwaha M, Shaanker RU, Jaglan S, Bharate SB, Vishwakarma RA (2014) Dysoxylum binectariferum bark as a new source of anticancer drug camptothecin: bioactivity-guided isolation and LCMS-based quantification. Bioorg Med Chem Lett 24:3146\u20133149","journal-title":"Bioorg Med Chem Lett"},{"key":"9834_CR39","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/md15040084","volume":"15","author":"B Kebede","year":"2017","unstructured":"Kebede B, Wrigley SK, Prashar A, Rahlff J, Wolf M, Reinshagen J, Gribbon P, Imhoff JF, Silber J, Labes A, Ellinger B (2017) Establishing the secondary metabolite profile of the marine fungus: Tolypocladium geodes sp. MF458 and subsequent optimisation of bioactive secondary metabolite production. Mar Drugs 15:84","journal-title":"Mar Drugs"},{"key":"9834_CR40","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/0892701042000205334","volume":"20","author":"Y Kitano","year":"2004","unstructured":"Kitano Y, Nogata Y, Shinshima K, Yoshimura E, Chiba K, Tada M, Sakaguchi I (2004) Synthesis and anti-barnacle activities of novel isocyanocyclohexane compounds containing an ester or an ether functional group. Biofouling 20:93\u2013100","journal-title":"Biofouling"},{"key":"9834_CR41","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2174\/1568026613666131216105049","volume":"14","author":"P Kittakoop","year":"2014","unstructured":"Kittakoop P, Mahidol C, Ruchirawat S (2014) Alkaloids as important scaffolds in therapeutic drugs for the treatments of cancer, tuberculosis, and smoking cessation. Curr Top Med Chem 14:239\u2013252","journal-title":"Curr Top Med Chem"},{"key":"9834_CR42","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.scitotenv.2007.07.023","volume":"387","author":"A Koutsaftis","year":"2007","unstructured":"Koutsaftis A, Aoyama I (2007) Toxicity of four antifouling biocides and their mixtures on the brine shrimp Artemia salina. Sci Total Environ 387:166\u2013174","journal-title":"Sci Total Environ"},{"key":"9834_CR43","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1039\/B913772F","volume":"12","author":"JB Kristensen","year":"2010","unstructured":"Kristensen JB, Meyer RL, Poulsen CH, Kragh KM, Besenbacher F, Laursen BS (2010) Biomimetic silica encapsulation of enzymes for replacement of biocides in antifouling coatings. Green Chem 12:387\u2013394","journal-title":"Green Chem"},{"key":"9834_CR44","first-page":"296","volume":"2","author":"AV Kulkarni","year":"2010","unstructured":"Kulkarni AV, Patwardhan AA, Lele U, Malpathak NP (2010) Production of camptothecin in cultures of Chonemorpha grandiflora. Pharm Res 2:296\u2013299","journal-title":"Pharm Res"},{"key":"9834_CR45","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0022-0981(91)90184-X","volume":"147","author":"C Lee","year":"1991","unstructured":"Lee C, Kim CH (1991) Larval development of Balanus albicostatus Pilsbry (Cirripedia, Thoracica) reared in the laboratory. J Exp Mar Biol Ecol 147:231\u2013244","journal-title":"J Exp Mar Biol Ecol"},{"key":"9834_CR46","doi-asserted-by":"publisher","first-page":"14778","DOI":"10.1002\/anie.201607832","volume":"55","author":"K Li","year":"2016","unstructured":"Li K, Ou J, Gao S (2016) Total synthesis of camptothecin and related natural products by a flexible strategy. Angew Chem Int Ed 55:14778\u201314783","journal-title":"Angew Chem Int Ed"},{"key":"9834_CR47","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s13131-012-0220-1","volume":"31","author":"Z Luo","year":"2012","unstructured":"Luo Z, Pan W, Li L, Zhang G (2012) The study on three-dimensional numerical model and fronts of the Jiulong Estuary and the Xiamen Bay. Acta Oceanol Sin 31:55\u201364","journal-title":"Acta Oceanol Sin"},{"key":"9834_CR48","doi-asserted-by":"publisher","first-page":"6304","DOI":"10.1021\/acssuschemeng.7b01385","volume":"5","author":"C Ma","year":"2017","unstructured":"Ma C, Zhang W, Zhang G, Qian PY (2017) Environmentally friendly antifouling coatings based on biodegradable polymer and natural antifoulant. ACS Sustain Chem Eng 5:6304\u20136309","journal-title":"ACS Sustain Chem Eng"},{"key":"9834_CR49","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.3390\/ijms10114623","volume":"10","author":"JP Mar\u00e9chal","year":"2009","unstructured":"Mar\u00e9chal JP, Hellio C (2009) Challenges for the development of new non\u2013toxic antifouling solutions. Int J Mol Sci 10:4623\u20134637","journal-title":"Int J Mol Sci"},{"key":"9834_CR50","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0022-0981(93)90205-3","volume":"173","author":"D Mart\u00edn","year":"1993","unstructured":"Mart\u00edn D, Uriz MJ (1993) Chemical bioactivity of Mediterranean benthic organisms against embryos and larvae of marine invertebrates. J Exp Mar Biol Ecol 173:11\u201327","journal-title":"J Exp Mar Biol Ecol"},{"key":"9834_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1080\/08927014.2017.1404036","volume":"34","author":"SE Martins","year":"2017","unstructured":"Martins SE, Fillmann G, Lillicrap A, Thomas KV (2017) Review: ecotoxicity of organic and organo-metallic antifouling co-biocides and implications for environmental hazard and risk assessments in aquatic ecosystems. Biofouling 34:34\u201352","journal-title":"Biofouling"},{"key":"9834_CR52","volume-title":"Acute toxicity handbook of chemicals to estuarine organisms","author":"FL Mayer Jr","year":"1987","unstructured":"Mayer FL Jr (1987) Acute toxicity handbook of chemicals to estuarine organisms. US Environmental Protection Agency, Gulf Breeze"},{"key":"9834_CR53","volume-title":"Ecotoxicology of antifouling biocideds","author":"K Mochida","year":"2009","unstructured":"Mochida K, Fujii K (2009) Toxicity in plankton and fish. In: Arai T, Harino H, Ohji M, Langston WJ (eds) Ecotoxicology of antifouling biocideds. Springer, Japan"},{"key":"9834_CR54","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1021\/acs.jnatprod.6b01056","volume":"80","author":"LWK Moodie","year":"2017","unstructured":"Moodie LWK, Trepos R, Cervin G, Larsen L, Larsen DS, Pavia H, Hellio C, Cahill P, Svenson J (2017a) Probing the structure-activity relationship of the natural antifouling agent polygodial against both micro- and macrofoulers by semisynthetic modification. J Nat Prod 80:515\u2013525","journal-title":"J Nat Prod"},{"key":"9834_CR55","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1021\/acs.jnatprod.7b00129","volume":"80","author":"LWK Moodie","year":"2017","unstructured":"Moodie LWK, Trepos R, Cervin G, Brathen KA, Lindgard B, Reiersen R, Cahill P, Pavia H, Hellio C, Svenson J (2017b) Prevention of marine biofouling using the natural allelopathic compound batatasin-III and synthetic analogues. J Nat Prod 80:2001\u20132011","journal-title":"J Nat Prod"},{"key":"9834_CR56","doi-asserted-by":"crossref","unstructured":"Moodie LWK, Cervin G, Trepos R, Labriere C, Hellio C, Pavia H, Svenson J (2018) Design and biological evaluation of antifouling dihydrostilbene oxime hybrids. Mar Biotechnol 20:257\u2013267","DOI":"10.1007\/s10126-018-9802-z"},{"key":"9834_CR57","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1080\/10915810290096360","volume":"21","author":"B Panagoula","year":"2002","unstructured":"Panagoula B, Panayiota M, Iliopoulou-Georgudaki J (2002) Acute toxicity of TBT and Irgarol in Artemia salina. Int J Toxicol 21:231\u2013233","journal-title":"Int J Toxicol"},{"key":"9834_CR58","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1021\/np200537v","volume":"74","author":"N P\u00e9nez","year":"2011","unstructured":"P\u00e9nez N, Culioli G, P\u00e9rez T, Briand JF, Thomas OP, Blache Y (2011) Antifouling properties of simple indole and purine alkaloids from the Mediterranean gorgonian Paramuricea clavata. J Nat Prod 74:2304\u20132308","journal-title":"J Nat Prod"},{"key":"9834_CR59","volume-title":"Late lessons from early warnings: science, precaution, innovation. Part B\u2014Emerging lessons from ecosystems","author":"ARG Price","year":"2013","unstructured":"Price ARG, Readman JW (2013) Booster biocide antifoulants: is history repeating itself? In: The European Environment Agency (ed) Late lessons from early warnings: science, precaution, innovation. Part B\u2014Emerging lessons from ecosystems. Publications Office of the European Union, Luxembourg"},{"key":"9834_CR60","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/08927019209386223","volume":"6","author":"RR Price","year":"1992","unstructured":"Price RR, Patchan M, Clare A, Rittschof D, Bonaventura J (1992) Performance enhancement of natural antifouling compounds and their analogs through microencapsulation and controlled release. Biofouling 6:207\u2013216","journal-title":"Biofouling"},{"key":"9834_CR61","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/aid.1991.7.65","volume":"7","author":"E Priel","year":"1991","unstructured":"Priel E, Showllter SD, Blair DG (1991) Inhibition of human immunodeficiency virus (HIV\u20131) replication in vitro by noncytotoxic doses of camptothecin, a topoisomerase I inhibitor. AIDS Res Hum Retroviruses 7:65\u201372","journal-title":"AIDS Res Hum Retroviruses"},{"key":"9834_CR62","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1080\/14786410701642441","volume":"22","author":"SH Qi","year":"2008","unstructured":"Qi SH, Zhang S, Yang LH, Qian PY (2008) Antifouling and antibacterial compounds from the gorgonians Subergorgia suberojjsa and Scripearia gracillis. Nat Prod Res 22:154\u2013166","journal-title":"Nat Prod Res"},{"key":"9834_CR63","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/08927010903470815","volume":"26","author":"PY Qian","year":"2010","unstructured":"Qian PY, Xu Y, Fusetani N (2010) Natural products as antifouling compounds: recent progress and future perspectives. Biofouling 26:223\u2013234","journal-title":"Biofouling"},{"key":"9834_CR64","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/08927014.2014.997226","volume":"31","author":"PY Qian","year":"2015","unstructured":"Qian PY, Li Z, Xu Y, Li Y, Fusetani N (2015) Mini-review: marine natural products and their synthetic analogs as antifouling compounds: 2009\u20132014. Biofouling 31:101\u2013122","journal-title":"Biofouling"},{"key":"9834_CR65","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.aquatox.2005.05.011","volume":"74","author":"AJ Reichelt-Brushett","year":"2005","unstructured":"Reichelt-Brushett AJ, Michalek-Wagner K (2005) Effects of copper on the fertilization success of the soft coral Lobophytum compactum. Aquat Toxicol 74:280\u2013284","journal-title":"Aquat Toxicol"},{"key":"9834_CR66","volume-title":"Marine chemical ecology","author":"D Rittschof","year":"2001","unstructured":"Rittschof D (2001) Natural product antifoulants and coatings developments. In: JB MC, Baker BJ (eds) Marine chemical ecology. CRC Press, Boca Raton"},{"key":"9834_CR67","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/0892701021000083769","volume":"19S","author":"D Rittschof","year":"2003","unstructured":"Rittschof D, Lai CH, Kok LM, Teo SLM (2003) Pharmaceuticals as antifoulants: concept and principles. Biofouling 19S:207\u2013212","journal-title":"Biofouling"},{"key":"9834_CR68","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ejbt.2016.02.002","volume":"21","author":"S Satheesh","year":"2016","unstructured":"Satheesh S, MA B\u2013a, AA A\u2013S (2016) Natural antifouling compound production by microbes associated with marine macroorganisms\u2014a review. Electron J Biotechnol 21:26\u201335","journal-title":"Electron J Biotechnol"},{"key":"9834_CR69","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.phytochem.2005.02.010","volume":"66","author":"F Shaheen","year":"2005","unstructured":"Shaheen F, Ahmad M, Khan MTH, Jalil S, Ejaz A, Sultankhodjaev MN, Arfan M, Choudhary MI, Atta-ur-Rahman (2005) Alkaloids of Aconitum laeve and their anti-inflammatory, antioxidant and tyrosinase inhibition activities. Phytochemistry 66:935\u2013940","journal-title":"Phytochemistry"},{"key":"9834_CR70","doi-asserted-by":"publisher","first-page":"8515","DOI":"10.3390\/molecules16108515","volume":"16","author":"AL Souto","year":"2011","unstructured":"Souto AL, Tavares JF, da Silva MS, Diniz MFFM, de Athayde-Filho PF, Filho JMB (2011) Anti-inflammatory activity of alkaloids: an update from 2000 to 2010. Molecules 16:8515\u20138534","journal-title":"Molecules"},{"key":"9834_CR71","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1080\/14786410412331299005","volume":"19","author":"D Sriram","year":"2005","unstructured":"Sriram D, Yogeeswari P, Thirumurugan R, Bal TR (2005) Camptothecin and its analogues: a review on their chemotherapeutic potential. Nat Prod Res 19:393\u2013412","journal-title":"Nat Prod Res"},{"key":"9834_CR72","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.fitote.2014.05.017","volume":"97","author":"HK Suma","year":"2014","unstructured":"Suma HK, Kumar V, Senthilkumar U, Kumara PM, Ravikanth G, Santhoshkumar TR, Shaanker RU (2014) Pyrenacantha volubilis Wight, (Icacinaceae) a rich source of camptothecine and its derivatives, from the Coromandel Coast forests of India. Fitoterapia 97:105\u2013110","journal-title":"Fitoterapia"},{"key":"9834_CR73","doi-asserted-by":"publisher","first-page":"172","DOI":"10.22146\/ijc.21211","volume":"15","author":"Suratno","year":"2015","unstructured":"Suratno, Puspitasari R, Purbonegoro T, Mansur D (2015) Copper and cadmium toxicity to marine phytoplankton, Chaetoceros gracilis and Isochrysis sp. Indones J Chem 15:172\u2013178","journal-title":"Indones J Chem"},{"key":"9834_CR74","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/0022-2836(91)90503-X","volume":"222","author":"JQ Svejstrup","year":"1991","unstructured":"Svejstrup JQ, Christiansen K, Gromova II, Andersen AH, Westergaard O (1991) New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I: The mode of action of camptothecin at a specific recognition site. J Mol Biol 222:669\u2013678","journal-title":"J Mol Biol"},{"key":"9834_CR75","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/08927010903216564","volume":"26","author":"KV Thomas","year":"2010","unstructured":"Thomas KV, Brooks S (2010) The environmental fate and effects of antifouling paint biocides. Biofouling 26:73\u201388","journal-title":"Biofouling"},{"key":"9834_CR76","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s10340-015-0717-4","volume":"89","author":"SM Tong","year":"2016","unstructured":"Tong SM, Feng MG (2016) A mixture of putative sodium salts of camptothecin and bamboo tar is a novel botanical insecticide against rice planthoppers and stem borers. J Pest Sci 89:1003\u20131011","journal-title":"J Pest Sci"},{"issue":"Suppl","key":"9834_CR77","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/0892701031000088535","volume":"19","author":"RL Townsin","year":"2003","unstructured":"Townsin RL (2003) The ship hull fouling penalty. Biofouling 19(Suppl):9\u201315","journal-title":"Biofouling"},{"key":"9834_CR78","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1021\/np5005032","volume":"77","author":"R Trepos","year":"2014","unstructured":"Trepos R, Cervin G, Hellio C, Pavia H, Stensen W, Stensvag K, Svendsen JS, Haug T, Svenson J (2014) Antifouling compounds from the sub-Arctic ascidian Synoicum pulmonaria: synoxazolidinones A and C, pulmonarins A and B, and synthetic analogues. J Nat Prod 77:2105\u20132113","journal-title":"J Nat Prod"},{"key":"9834_CR79","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.2165\/00003495-200262140-00004","volume":"62","author":"H Ulukan","year":"2002","unstructured":"Ulukan H, Swaan PW (2002) Camptothecins: a review of their chemotherapeutic potential. Drugs 62:2039\u20132057","journal-title":"Drugs"},{"key":"9834_CR80","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1021\/ja00968a057","volume":"88","author":"ME Wall","year":"1966","unstructured":"Wall ME, Wani MC, Cook CE, Palmer KH (1966) Plant antitumor agents I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 88:3888\u20133890","journal-title":"J Am Chem Soc"},{"key":"9834_CR81","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1007\/s10126-015-9656-6","volume":"17","author":"KL Wang","year":"2015","unstructured":"Wang KL, Xu Y, Lu L, Li Y, Han Z, Zhang J, Shao CL, Wang CY, Qian PY (2015) Low-toxicity diindol-3-ylmethanes as potent antifouling compounds. Mar Biotechnol 17:624\u2013632","journal-title":"Mar Biotechnol"},{"key":"9834_CR82","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/tox.20134","volume":"20","author":"Q Xu","year":"2005","unstructured":"Xu Q, Barrios CA, Cutright T, Newby BZ (2005) Evaluation of toxicity of capsaicin and zosteric acid and their potential application as antifoulants. Environ Toxicol 20:467\u2013474","journal-title":"Environ Toxicol"},{"key":"9834_CR83","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.porgcoat.2003.06.001","volume":"50","author":"DM Yebra","year":"2004","unstructured":"Yebra DM, Kiil S, Dam-Johansen K (2004) Antifouling technology-past, present and future steps towards efficient and environmentally friendly antifouling coatings. Prog Org Coat 50:75\u2013104","journal-title":"Prog Org Coat"},{"key":"9834_CR84","first-page":"16849","volume":"37","author":"M Zeng","year":"2009","unstructured":"Zeng M, Yu F, Wang L, Xu K (2009) Research progress on cultivation technique and alkali accumulation of Camptotheca acuminata Decne. J Anhui Agric Sci 37:16849\u201316850","journal-title":"J Anhui Agric Sci"},{"key":"9834_CR85","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.marpolbul.2008.01.021","volume":"57","author":"AQ Zhang","year":"2008","unstructured":"Zhang AQ, Leung KMY, Kwok KWH, Bao VWW, Lam MHW (2008) Toxicities of antifouling biocide Irgarol 1051 and its major degraded product to marine primary producers. Mar Pollut Bull 57:575\u2013586","journal-title":"Mar Pollut Bull"},{"key":"9834_CR86","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1021\/np000058r","volume":"63","author":"BN Zhou","year":"2000","unstructured":"Zhou BN, Hoch JM, Johnson RK, Mattern MR, Eng WK, Ma J, Hecht SM, Newman DJ, Kingston DG (2000) Use of compare analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source. J Nat Prod 63:1273\u20131276","journal-title":"J Nat Prod"},{"key":"9834_CR87","volume-title":"From sources to solution","author":"SZ Zulkifli","year":"2014","unstructured":"Zulkifli SZ, Aziz FZA, Ajis SZM, Ismail A (2014) Nauplii of brine shrimp (Artemia salina) as a potential toxicity testing organism for heavy metals contamination. In: Aris AZ, Tengku Ismail TH, Harun R, Abdullah AM, Ishak MY (eds) From sources to solution. Springer, Singapore"}],"container-title":["Marine Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10126-018-9834-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-018-9834-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-018-9834-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T05:46:49Z","timestamp":1559454409000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10126-018-9834-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,2]]},"references-count":87,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["9834"],"URL":"https:\/\/doi.org\/10.1007\/s10126-018-9834-4","relation":{},"ISSN":["1436-2228","1436-2236"],"issn-type":[{"value":"1436-2228","type":"print"},{"value":"1436-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,2]]},"assertion":[{"value":"6 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}