{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:42:50Z","timestamp":1792874570587,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2021LZY030"],"award-info":[{"award-number":["ZR2021LZY030"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2023MD070"],"award-info":[{"award-number":["ZR2023MD070"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key R&D Program of Shandong Province","award":["2021CXGC010508"],"award-info":[{"award-number":["2021CXGC010508"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mar Biotechnol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10126-024-10365-1","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T08:02:09Z","timestamp":1724918529000},"page":"1165-1178","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Laminaria japonica Polysaccharide Regulates Fatty Hepatosis Through Bile Acids and Gut Microbiota in Diabetes Rat"],"prefix":"10.1007","volume":"26","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"10365_CR1","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1016\/S0140-6736(22)01655-5","volume":"400","author":"E Ahmad","year":"2022","unstructured":"Ahmad E, Lim S, Lamptey R, Webb DR, Davies MJ (2022) Type 2 diabetes. Lancet 400:1803\u20131820","journal-title":"Lancet"},{"key":"10365_CR2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41581-021-00488-2","volume":"18","author":"J Baek","year":"2022","unstructured":"Baek J, He C, Afshinnia F, Michailidis G, Pennathur S (2022) Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease. Nat Rev Nephrol 18:38\u201355","journal-title":"Nat Rev Nephrol"},{"key":"10365_CR3","doi-asserted-by":"publisher","first-page":"108238","DOI":"10.1016\/j.pharmthera.2022.108238","volume":"237","author":"J Cai","year":"2022","unstructured":"Cai J, Rimal B, Jiang C, Chiang JYL, Patterson AD (2022) Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharmacol Ther 237:108238","journal-title":"Pharmacol Ther"},{"key":"10365_CR4","doi-asserted-by":"publisher","unstructured":"Chen Q, Liu M, Zhang P, Fan S, Huang J, Yu S, Zhang C, Li H (2019) Fucoidan and galactooligosaccharides ameliorate high-fat diet-induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism. Nutrition 65:50\u201359. https:\/\/doi.org\/10.1016\/j.nut.2019.03.001","DOI":"10.1016\/j.nut.2019.03.001"},{"key":"10365_CR5","doi-asserted-by":"crossref","unstructured":"Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, \u2026, de Aguiar Vallim TQ (2021) FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab 33:1671\u20131684","DOI":"10.1016\/j.cmet.2021.06.012"},{"key":"10365_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","volume":"21","author":"SL Collins","year":"2023","unstructured":"Collins SL, Stine JG, Bisanz JE, Okafor CD, Patterson AD (2023) Bile acids and the gut microbiota: metabolic interactions and impacts on disease. Nat Rev Microbiol 21:236\u2013247","journal-title":"Nat Rev Microbiol"},{"key":"10365_CR7","doi-asserted-by":"publisher","first-page":"fuad014","DOI":"10.1093\/femsre\/fuad014","volume":"47","author":"EH Crost","year":"2023","unstructured":"Crost EH, Coletto E, Bell A, Juge N (2023) Ruminococcus gnavus: friend or foe for human health. FEMS Microbiol Rev 47:fuad014","journal-title":"FEMS Microbiol Rev"},{"key":"10365_CR8","doi-asserted-by":"publisher","first-page":"113154","DOI":"10.1016\/j.biopha.2022.113154","volume":"152","author":"S Duan","year":"2022","unstructured":"Duan S, Li X, Fan G, Liu R (2022) Targeting bile acid signaling for the treatment of liver diseases: From bench to bed. Biomed Pharmacother 152:113154","journal-title":"Biomed Pharmacother"},{"key":"10365_CR9","doi-asserted-by":"publisher","first-page":"8343","DOI":"10.3390\/ijms23158343","volume":"23","author":"X Guo","year":"2022","unstructured":"Guo X, Okpara ES, Hu W, Yan C, Wang Y, Liang Q et al (2022) Interactive relationships between intestinal flora and bile acids. Int J Mol Sci 23:8343","journal-title":"Int J Mol Sci"},{"key":"10365_CR10","doi-asserted-by":"crossref","unstructured":"Hu J, Wang C, Huang X, Yi S, Pan S, Zhang Y, \u2026, Li H (2021) Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling. Cell Rep 36:109726","DOI":"10.1016\/j.celrep.2021.109726"},{"key":"10365_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/nyas.14037","volume":"1461","author":"Y Imai","year":"2020","unstructured":"Imai Y, Cousins RS, Liu S, Phelps BM, Promes JA (2020) Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes. Ann N Y Acad Sci 1461:53\u201372","journal-title":"Ann N Y Acad Sci"},{"key":"10365_CR12","doi-asserted-by":"crossref","unstructured":"Jiang Z, Zhuo LB, He Y, Fu Y, Shen L, Xu F, \u2026, Zheng JS (2022) The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases. Nat Commun 13:3002","DOI":"10.1038\/s41467-022-30712-x"},{"key":"10365_CR13","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1007\/s40200-022-01114-z","volume":"21","author":"S Khanmohammadi","year":"2022","unstructured":"Khanmohammadi S, Tavolinejad H, Aminorroaya A, Rezaie Y, Ashraf H, Vasheghani-Farahani A (2022) Association of lipid accumulation product with type 2 diabetes mellitus, hypertension, and mortality: a systematic review and meta-analysis. J Diabetes Metab Disord 21:1943\u20131973","journal-title":"J Diabetes Metab Disord"},{"key":"10365_CR14","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.ijbiomac.2017.06.058","volume":"105","author":"X Li","year":"2017","unstructured":"Li X, Li X, Zhang Q, Zhao T (2017) Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-beta 1 or FGF-2. Int J Biol Macromol 105:1482\u20131490","journal-title":"Int J Biol Macromol"},{"key":"10365_CR15","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1038\/s41467-022-29589-7","volume":"13","author":"M Li","year":"2022","unstructured":"Li M, Wang S, Li Y, Zhao M, Kuang J, Liang D et al (2022a) Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice. Nat Commun 13:2060","journal-title":"Nat Commun"},{"key":"10365_CR16","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.21037\/atm-22-3967","volume":"10","author":"W Li","year":"2022","unstructured":"Li W, Li L, Yang F, Hu Q, Xiong D (2022b) Correlation between gut bacteria Phascolarctobacterium and exogenous metabolite \u03b1-linolenic acid in T2DM: a case-control study. Ann Transl Med 10:1056","journal-title":"Ann Transl Med"},{"key":"10365_CR17","doi-asserted-by":"publisher","first-page":"14864","DOI":"10.1021\/acs.jafc.2c06417","volume":"70","author":"X Liu","year":"2022","unstructured":"Liu X, Zhang Y, Li W, Zhang B, Yin J, Liuqi S et al (2022) Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis by modulating gut microbiota and bile acid metabolism. J Agric Food Chem 70:14864\u201314876","journal-title":"J Agric Food Chem"},{"key":"10365_CR18","doi-asserted-by":"publisher","first-page":"4254","DOI":"10.1039\/D1FO00311A","volume":"12","author":"F Luan","year":"2021","unstructured":"Luan F, Zou J, Rao Z, Ji Y, Lei Z, Peng L et al (2021) Polysaccharides from Laminaria japonica: an insight into the current research on structural features and biological properties. Food Funct 12:4254\u20134283","journal-title":"Food Funct"},{"key":"10365_CR19","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/S0140-6736(82)91513-6","volume":"2","author":"JF Moorhead","year":"1982","unstructured":"Moorhead JF, Chan MK, El-Nahas M, Varghese Z (1982) Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease. Lancet 2:1309\u20131311","journal-title":"Lancet"},{"key":"10365_CR20","doi-asserted-by":"crossref","unstructured":"M\u00fcnzker J, Haase N, Till A, Sucher R, Haange SB, Nemetschke L, \u2026, Fenske WK (2022) Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity. Microbiome 10:96","DOI":"10.1186\/s40168-022-01264-5"},{"key":"10365_CR21","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s42255-022-00559-z","volume":"4","author":"A Perino","year":"2022","unstructured":"Perino A, Schoonjans K (2022) Metabolic messengers: bile acids. Nat Metab 4:416\u2013423","journal-title":"Nat Metab"},{"key":"10365_CR22","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1099\/ijs.0.007674-0","volume":"59","author":"M Sakamoto","year":"2009","unstructured":"Sakamoto M, Takagaki A, Matsumoto K, Kato Y, Goto K, Benno Y (2009) Butyricimonas synergistica gen. nov., sp. nov. and Butyricimonas virosa sp. nov., butyric acid-producing bacteria in the family \u2018Porphyromonadaceae\u2019 isolated from rat faeces. Int J Syst Evol Microbiol 59:1748\u201353","journal-title":"Int J Syst Evol Microbiol"},{"key":"10365_CR23","doi-asserted-by":"publisher","first-page":"e386","DOI":"10.1002\/edm2.386","volume":"6","author":"K S\u00e1nchez-Alegr\u00eda","year":"2023","unstructured":"S\u00e1nchez-Alegr\u00eda K, Arias C (2023) Functional consequences of brain exposure to saturated fatty acids: from energy metabolism and insulin resistance to neuronal damage. Endocrinol Diabetes Metabo 6:e386","journal-title":"Endocrinol Diabetes Metabo"},{"key":"10365_CR24","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11154-019-09512-0","volume":"20","author":"M Schoeler","year":"2019","unstructured":"Schoeler M, Caesar R (2019) Dietary lipids, gut microbiota and lipid metabolism. Rev Endocr Metab Disord 20:461\u2013472","journal-title":"Rev Endocr Metab Disord"},{"key":"10365_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/B978-0-12-387669-0.00015-6","volume":"64","author":"M Shirosaki","year":"2011","unstructured":"Shirosaki M, Koyama T (2011) Laminaria japonica as a food for the prevention of obesity and diabetes. Adv Food Nutr Res 64:199\u2013212","journal-title":"Adv Food Nutr Res"},{"key":"10365_CR26","first-page":"e28944","volume":"14","author":"S Sinha","year":"2022","unstructured":"Sinha S, Haque M (2022) Insulin resistance and type 2 diabetes mellitus: an ultimatum to renal physiology. Cureus 14:e28944","journal-title":"Cureus"},{"key":"10365_CR27","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1007\/s00125-015-3525-8","volume":"58","author":"B Verg\u00e8s","year":"2015","unstructured":"Verg\u00e8s B (2015) Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia 58:886\u2013899","journal-title":"Diabetologia"},{"key":"10365_CR28","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1007\/s00125-022-05765-8","volume":"65","author":"B Verg\u00e8s","year":"2022","unstructured":"Verg\u00e8s B (2022) Intestinal lipid absorption and transport in type 2 diabetes. Diabetologia 65:1587\u20131600","journal-title":"Diabetologia"},{"key":"10365_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ijbiomac.2010.05.010","volume":"47","author":"J Wang","year":"2010","unstructured":"Wang J, Zhang Q, Zhang Z, Zhang H, Niu X (2010) Structural studies on a novel fucogalactan sulfate extracted from the brown seaweed Laminaria japonica. Int J Biol Macromol 47:126\u2013131","journal-title":"Int J Biol Macromol"},{"key":"10365_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12876-020-01195-1","volume":"20","author":"Q Wang","year":"2020","unstructured":"Wang Q, Hao C, Yao W, Zhu D, Lu H, Li L et al (2020) Intestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation. BMC Gastroenterol 20:59","journal-title":"BMC Gastroenterol"},{"key":"10365_CR31","doi-asserted-by":"publisher","first-page":"7618166","DOI":"10.1155\/2021\/7618166","volume":"2021","author":"Y Wang","year":"2021","unstructured":"Wang Y, Sun Y, Shao F, Zhang B, Wang Z, Li X (2021) Low molecular weight fucoidan can inhibit the fibrosis of diabetic kidneys by regulating the kidney lipid metabolism. J Diabetes Res 2021:7618166","journal-title":"J Diabetes Res"},{"key":"10365_CR32","doi-asserted-by":"crossref","unstructured":"Wei M, Huang F, Zhao L, Zhang Y, Yang W, Wang S, \u2026, Jia W (2020) A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility. E-Bio-Med 55:102766","DOI":"10.1016\/j.ebiom.2020.102766"},{"key":"10365_CR33","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1002\/ptr.6966","volume":"35","author":"J Xu","year":"2021","unstructured":"Xu J, Wang Y, Wang Z, Guo L, Li X (2021) Fucoidan mitigated diabetic nephropathy through the downregulation of PKC and modulation of NF-\u03baB signaling pathway: in vitro and in vivo investigations. Phytother Res 35:2133\u20132144","journal-title":"Phytother Res"},{"key":"10365_CR34","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/foods12010033","volume":"12","author":"C Zhang","year":"2022","unstructured":"Zhang C, Jia J, Zhang P, Zheng W, Guo X, Ai C, Song S (2022) Fucoidan from Laminaria japonica ameliorates type 2 diabetes mellitus in association with modulation of gut microbiota and metabolites in streptozocin-treated mice. Foods 12:33","journal-title":"Foods"},{"key":"10365_CR35","doi-asserted-by":"publisher","first-page":"e1900946","DOI":"10.1002\/mnfr.201900946","volume":"64","author":"P Zhuang","year":"2020","unstructured":"Zhuang P, Zhang Y, Shou Q, Li H, Zhu Y, He L et al (2020) Eicosapentaenoic and docosahexaenoic acids differentially alter gut microbiome and reverse high-fat diet-induced insulin resistance. Mol Nutr Food Res 64:e1900946","journal-title":"Mol Nutr Food Res"}],"container-title":["Marine Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-024-10365-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10126-024-10365-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-024-10365-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:10:00Z","timestamp":1730869800000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10126-024-10365-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10365"],"URL":"https:\/\/doi.org\/10.1007\/s10126-024-10365-1","relation":{},"ISSN":["1436-2228","1436-2236"],"issn-type":[{"value":"1436-2228","type":"print"},{"value":"1436-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"22 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"The animal study was reviewed and approved by Linyi University Animal Ethics Committee. The animal experiments complied with the ARRIVE guidelines. The male rats were relatively strong, while the female rats were relatively weak, and other factors (such as food and living environment) were unlikely to interfere with the experimental effect. One hundred and twenty male Sprague\u2013Dawley rats were randomly divided into six groups after adapting to the environment, with 10 rats in each group. The parallel control group method was used. Rats were numbered first and then randomly divided into six groups. The experimental environment was maintained at a specific-pathogen-free level. The model of diabetes was established by injecting streptozotocin, and fucoidan was administered by gavage. After the experiment, rats were euthanized with CO<sub>2<\/sub>. Written informed consent was obtained from the owners prior to the participation of their animals in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal Ethics"}}]}}