{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:38:06Z","timestamp":1793133486126,"version":"4.5.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Hellenic Center of Marine Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mar Biotechnol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fanconi anaemia (FA) is a rare autosomal recessive disease in humans that is distributed worldwide. Fanconi anemia complementation (Fanc) proteins are essential for the appropriate functioning of the FA DNA repair pathway. They are also linked to a number of other biological processes, including oxygen metabolism, cell cycle regulation, haematopoiesis and apoptosis. So far, little research has been conducted on teleosts, but evidence shows that Fanc proteins play a significant role in immune response and sex reversal. For the examination of the expression of three\n                    <jats:italic>fanc<\/jats:italic>\n                    genes (\n                    <jats:italic>fancc<\/jats:italic>\n                    <jats:italic>,<\/jats:italic>\n                    <jats:italic>fancl,<\/jats:italic>\n                    and\n                    <jats:italic>fancd2<\/jats:italic>\n                    ), as well as the potential regulation of these genes by microRNAs (miRNAs) in gonadal tissues at different stages of development, the present study has selected the gilthead seabream (\n                    <jats:italic>Sparus aurata<\/jats:italic>\n                    ), a significant aquaculture species that exhibits protandrous hermaphroditism. The obtained data suggested the role of\n                    <jats:italic>fancl<\/jats:italic>\n                    and\n                    <jats:italic>fancd2<\/jats:italic>\n                    in the maturation of female gonads and the miRNAs miR-210, miR-217 and miR-10926 have been identified as putative regulators of\n                    <jats:italic>fancd2<\/jats:italic>\n                    ,\n                    <jats:italic>fancc<\/jats:italic>\n                    and\n                    <jats:italic>fancl<\/jats:italic>\n                    , respectively. Overall, the data indicated the potential use of\n                    <jats:italic>fancl<\/jats:italic>\n                    and\n                    <jats:italic>fancd2<\/jats:italic>\n                    genes as sex biomarkers in conjunction with their respective regulation by miRNAs. To the best of our knowledge, this is the first study demonstrating the importance of\n                    <jats:italic>fanc<\/jats:italic>\n                    genes, along with putative regulatory miRNAs, in the reproduction of an important marine aquaculture species.\n                  <\/jats:p>","DOI":"10.1007\/s10126-025-10444-x","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T04:16:30Z","timestamp":1744344990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the Fanconi Anemia Gene Expression and Regulation by MicroRNAs in Gilthead Seabream (Sparus aurata) at Different Gonadal Development Stages"],"prefix":"10.1007","volume":"27","author":[{"given":"Maria","family":"Papadaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc-Son","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos C.","family":"Mylonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sarropoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"10444_CR1","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.toxrep.2020.03.010","volume":"7","author":"JK Ahkin Chin Tai","year":"2020","unstructured":"Ahkin Chin Tai JK, Freeman JL (2020) Zebrafish as an integrative vertebrate model to identify miRNA mechanisms regulating toxicity. Toxicol Rep 7:559\u2013570","journal-title":"Toxicol Rep"},{"key":"10444_CR2","doi-asserted-by":"publisher","first-page":"e40701","DOI":"10.1371\/journal.pone.0040701","volume":"7","author":"JL Anderson","year":"2012","unstructured":"Anderson JL, Rodriguez Mari A, Braasch I, Amores A, Hohenlohe P, Batzel P, Postlethwait JH (2012) Multiple sex-associated regions and a putative sex chromosome in zebrafish revealed by RAD mapping and population genomics. PLoS One 7:e40701","journal-title":"PLoS One"},{"key":"10444_CR3","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1006\/anbe.1997.0703","volume":"55","author":"Anonymous","year":"1998","unstructured":"Anonymous (1998) Guidelines for the treatment of animals in behavioural research and teaching. Anim Behav 55:251\u2013257","journal-title":"Anim Behav"},{"key":"10444_CR4","doi-asserted-by":"publisher","first-page":"W147","DOI":"10.1093\/nar\/gkw419","volume":"44","author":"S Babicki","year":"2016","unstructured":"Babicki S, Arndt D, Marcu A, Liang Y, Grant JR, Maciejewski A, Wishart DS (2016) Heatmapper: web-enabled heat mapping for all. Nucleic Acids Res 44:W147\u2013W153","journal-title":"Nucleic Acids Res"},{"key":"10444_CR5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000223077","volume":"3","author":"JF Baroiller","year":"2009","unstructured":"Baroiller JF, D\u2019cotta H, Saillant E (2009) Environmental effects on fish sex determination and differentiation. Sex Dev 3:118\u2013135","journal-title":"Sex Dev"},{"key":"10444_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ygcen.2008.01.016","volume":"156","author":"D Baron","year":"2008","unstructured":"Baron D, Houlgatte R, Fostier A, Guiguen Y (2008) Expression profiling of candidate genes during ovary-to-testis trans-differentiation in rainbow trout masculinized by androgens. Gen Comp Endocrinol 156:369\u2013378","journal-title":"Gen Comp Endocrinol"},{"key":"10444_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3109\/10520297609116677","volume":"51","author":"HS Bennett","year":"1976","unstructured":"Bennett HS, Wyrick AD, Lee SW, Mcneil JH (1976) Science and art in preparing tissues embedded in plastic for light microscopy, with special reference to glycol methacrylate, glass knives and simple stains. Stain Technol 51:71\u201397","journal-title":"Stain Technol"},{"key":"10444_CR8","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1186\/s12864-016-3178-0","volume":"17","author":"A Bohne","year":"2016","unstructured":"Bohne A, Wilson CA, Postlethwait JH, Salzburger W (2016) Variations on a theme: Genomics of sex determination in the cichlid fish Astatotilapia burtoni. BMC Genomics 17:883","journal-title":"BMC Genomics"},{"key":"10444_CR9","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B (2014) Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinform 30:2114\u20132120","journal-title":"Bioinform"},{"key":"10444_CR10","doi-asserted-by":"publisher","first-page":"40241","DOI":"10.1038\/srep40241","volume":"7","author":"A Bouchareb","year":"2017","unstructured":"Bouchareb A, Le Cam A, Montfort J, Gay S, Nguyen T, Bobe J, Thermes V (2017) Genome-wide identification of novel ovarian-predominant miRNAs: new insights from the medaka (Oryzias latipes). Sci Rep 7:40241","journal-title":"Sci Rep"},{"key":"10444_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3390\/jmse3020329","volume":"3","author":"A Budd","year":"2015","unstructured":"Budd A, Banh Q, Domingos J, Jerry D (2015) Sex Control in Fish: Approaches, Challenges and Opportunities for Aquaculture. Journal of Marine Science and Engineering 3:329\u2013355","journal-title":"Journal of Marine Science and Engineering"},{"key":"10444_CR12","doi-asserted-by":"publisher","unstructured":"Cappelli, E., Ravera, S., Bertola, N., Grilli, F., Squillario, M., Regis, S. & Degan, P. (2024). Advanced Analysis and Validation of a microRNA Signature for Fanconi Anemia. Genes (Basel), 15. https:\/\/doi.org\/10.3390\/genes15070820","DOI":"10.3390\/genes15070820"},{"key":"10444_CR13","doi-asserted-by":"publisher","first-page":"35461","DOI":"10.1038\/srep35461","volume":"6","author":"L Casas","year":"2016","unstructured":"Casas L, Saborido-Rey F, Ryu T, Michell C, Ravasi T, Irigoien X (2016) Sex Change in Clownfish: Molecular Insights from Transcriptome Analysis. Sci Rep 6:35461","journal-title":"Sci Rep"},{"key":"10444_CR14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/met.2018.0085","volume":"17","author":"P Degan","year":"2019","unstructured":"Degan P, Cappelli E, Longobardi M, Pulliero A, Cuccarolo P, Dufour C, Ravera S, Calzia D, Izzotti A (2019) A Global MicroRNA Profile in Fanconi Anemia: A Pilot Study. Metab Syndr Relat Disord 17:53\u201359","journal-title":"Metab Syndr Relat Disord"},{"key":"10444_CR15","doi-asserted-by":"publisher","first-page":"e314","DOI":"10.1371\/journal.pbio.0030314","volume":"3","author":"P Dehal","year":"2005","unstructured":"Dehal P, Boore JL (2005) Two rounds of whole genome duplication in the ancestral vertebrate. PLoS Biol 3:e314","journal-title":"PLoS Biol"},{"key":"10444_CR16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0044-8486(02)00057-1","volume":"208","author":"RH Devlin","year":"2002","unstructured":"Devlin RH, Nagahama Y (2002) Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. Aquaculture 208:191\u2013364","journal-title":"Aquaculture"},{"key":"10444_CR17","first-page":"33","volume":"276","author":"Eu","year":"2010","unstructured":"Eu (2010) Directive 2010\/63\/EU of the European parliament and the council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union, L 276:33\u201379","journal-title":"Official Journal of the European Union, L"},{"key":"10444_CR18","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fphys.2020.00754","volume":"11","author":"Y Fu","year":"2020","unstructured":"Fu Y, Xu Z, Wen B, Gao J, Chen Z (2020) Gonad-Specific Transcriptomes Reveal Differential Expression of Gene and miRNA Between Male and Female of the Discus Fish (Symphysodon aequifasciatus). Front Physiol 11:754","journal-title":"Front Physiol"},{"key":"10444_CR19","doi-asserted-by":"publisher","first-page":"e1007593","DOI":"10.1371\/journal.pgen.1007593","volume":"14","author":"S Gay","year":"2018","unstructured":"Gay S, Bugeon J, Bouchareb A, Henry L, Delahaye C, Legeai F, Montfort J, Le Cam A, Siegel A, Bobe J, Thermes V (2018) MiR-202 controls female fecundity by regulating medaka oogenesis. PLoS Genet 14:e1007593","journal-title":"PLoS Genet"},{"key":"10444_CR20","doi-asserted-by":"publisher","first-page":"R149","DOI":"10.1530\/REP-17-0408","volume":"154","author":"A Goikoetxea","year":"2017","unstructured":"Goikoetxea A, Todd EV, Gemmell NJ (2017) Stress and sex: does cortisol mediate sex change in fish? Reproduction 154:R149\u2013R160","journal-title":"Reproduction"},{"key":"10444_CR21","doi-asserted-by":"publisher","first-page":"D154","DOI":"10.1093\/nar\/gkm952","volume":"36","author":"S Griffiths-Jones","year":"2008","unstructured":"Griffiths-Jones S, Saini HK, Van Dongen S, Enright AJ (2008) miRBase: tools for microRNA genomics. Nucleic Acids Res 36:D154\u2013D158","journal-title":"Nucleic Acids Res"},{"key":"10444_CR22","first-page":"177","volume-title":"Reproduction in Fish - Basic and Applied Aspects in Endocrinology and Genetics","author":"A Happe","year":"1998","unstructured":"Happe A, Zohar I (1998) Self-fertilization in the protandrous hermaphrodite Sparus aurata: development of the technology. In: Zohar Y, Breton B (eds) Reproduction in Fish - Basic and Applied Aspects in Endocrinology and Genetics. INRA Press, pp 177\u2013180"},{"key":"10444_CR23","doi-asserted-by":"publisher","unstructured":"He Z, Deng F, Yang D, He Z, Hu J, Ma Z, Zhang Q, He J, Ye L, Chen H, He L, Luo J, Xiong S, Luo W, Yang S, Gu X and Yan T (2022) Crosstalk between sex-related genes and apoptosis signaling reveals molecular insights into sex change in a protogynous hermaphroditic teleost fish, ricefield eel Monopterus albus. Aquaculture 552. https:\/\/doi.org\/10.1016\/j.aquaculture.2022.737918","DOI":"10.1016\/j.aquaculture.2022.737918"},{"key":"10444_CR24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000509280","volume":"84","author":"X Hui","year":"2019","unstructured":"Hui X, Al-Ward H, Shaher F, Liu CY, Liu N (2019) The Role of miR-210 in the Biological System: A Current Overview. Hum Hered 84:233\u2013239","journal-title":"Hum Hered"},{"key":"10444_CR25","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1051\/rnd:2005019","volume":"45","author":"B Jalabert","year":"2005","unstructured":"Jalabert B (2005) Particularities of reproduction and oogenesis in teleost fish compared to mammals. Reprod Nutr Dev 45:261\u2013279","journal-title":"Reprod Nutr Dev"},{"key":"10444_CR26","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1093\/nar\/gkad1154","volume":"52","author":"S Janati-Idrissi","year":"2024","unstructured":"Janati-Idrissi S, De Abreu MR, Guyomar C, De Mello F, Nguyen T, Mechkouri N, Gay S, Montfort J, Gonzalez AA, Abbasi M, Bugeon J, Thermes V, Seitz H, Bobe J (2024) Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production. Nucleic Acids Res 52:738\u2013754","journal-title":"Nucleic Acids Res"},{"key":"10444_CR27","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1039\/C8TX00065D","volume":"7","author":"L Jia","year":"2018","unstructured":"Jia L, Zhang D, Huang H, Zhou Y, Zhou S, Guo J (2018) Triazophos-induced toxicity in zebrafish: miRNA-217 inhibits nup43. Toxicol Res (Camb) 7:913\u2013922","journal-title":"Toxicol Res (Camb)"},{"key":"10444_CR28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1095\/biolreprod.112.105361","volume":"88","author":"A Juanchich","year":"2013","unstructured":"Juanchich A, Le Cam A, Montfort J, Guiguen Y, Bobe J (2013) Identification of differentially expressed miRNAs and their potential targets during fish ovarian development. Biol Reprod 88:128","journal-title":"Biol Reprod"},{"key":"10444_CR29","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1101\/gad.1955310","volume":"24","author":"Y Kee","year":"2010","unstructured":"Kee Y, D\u2019andrea AD (2010) Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev 24:1680\u20131694","journal-title":"Genes Dev"},{"key":"10444_CR30","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1146\/annurev-animal-021122-113935","volume":"12","author":"J Kitano","year":"2024","unstructured":"Kitano J, Ansai S, Takehana Y, Yamamoto Y (2024) Diversity and Convergence of Sex-Determination Mechanisms in Teleost Fish. Annu Rev Anim Biosci 12:233\u2013259","journal-title":"Annu Rev Anim Biosci"},{"key":"10444_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000342009","volume":"7","author":"Y Kobayashi","year":"2012","unstructured":"Kobayashi Y, Nagahama Y, Nakamura M (2012) Diversity and plasticty of sex determination and differentiation in fishes. Sex Dev 7:115\u2013125","journal-title":"Sex Dev"},{"key":"10444_CR32","doi-asserted-by":"publisher","first-page":"W451","DOI":"10.1093\/nar\/gkl243","volume":"34","author":"J Kruger","year":"2006","unstructured":"Kruger J, Rehmsmeier M (2006) RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res 34:W451\u2013W454","journal-title":"Nucleic Acids Res"},{"key":"10444_CR33","doi-asserted-by":"publisher","unstructured":"Li R, Wang Y, Xie F, Tong X, Li X, Ren M, Hu Q and Li S (2024) Construction and Analysis of miRNA\u2013mRNA Interaction Network in Ovarian Tissue of Wanxi White Geese Across Different Breeding Stages. Animals 14. https:\/\/doi.org\/10.3390\/ani14223258","DOI":"10.3390\/ani14223258"},{"key":"10444_CR34","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1477-7827-5-20","volume":"5","author":"S Liarte","year":"2007","unstructured":"Liarte S, Chaves-Pozo E, Garcia-Alcazar A, Mulero V, Meseguer J, Garcia-Ayala A (2007) Testicular involution prior to sex change in gilthead seabream is characterized by a decrease in DMRT1 gene expression and by massive leukocyte infiltration. Reprod Biol Endocrinol 5:20","journal-title":"Reprod Biol Endocrinol"},{"key":"10444_CR35","doi-asserted-by":"publisher","first-page":"9999","DOI":"10.1038\/srep09999","volume":"5","author":"J Liu","year":"2015","unstructured":"Liu J, Luo M, Sheng Y, Hong Q, Cheng H, Zhou R (2015) Dynamic evolution and biogenesis of small RNAs during sex reversal. Sci Rep 5:9999","journal-title":"Sci Rep"},{"key":"10444_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"10444_CR37","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.fsi.2016.03.008","volume":"53","author":"DL Makrinos","year":"2016","unstructured":"Makrinos DL, Bowden TJ (2016) Natural environmental impacts on teleost immune function. Fish Shellfish Immunol 53:50\u201357","journal-title":"Fish Shellfish Immunol"},{"key":"10444_CR38","first-page":"405","volume":"100","author":"EM Mcdowell","year":"1976","unstructured":"Mcdowell EM, Trump BF (1976) Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med 100:405\u2013414","journal-title":"Arch Pathol Lab Med"},{"key":"10444_CR39","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/j.1095-8649.2010.02900.x","volume":"78","author":"JD Metcalfe","year":"2011","unstructured":"Metcalfe JD, Craig JF (2011) Ethical justification for the use and treatment of fishes in research: an update. J Fish Biol 78:393\u2013394","journal-title":"J Fish Biol"},{"key":"10444_CR40","doi-asserted-by":"publisher","unstructured":"Muncaster, S., Goikoetxea, A., Lokman, P.M., De Farias E Moraes, C.E., Damsteegt, E.L., Edgecombe, J., Gemmell, N.J. & Todd, E.V. (2023). Genes involved in sex differentiation, epigenetic reprogramming, and cell fate regulate sex change in a wrasse. Rev Fish Biol Fish. https:\/\/doi.org\/10.1007\/s11160-022-09755-2","DOI":"10.1007\/s11160-022-09755-2"},{"key":"10444_CR41","doi-asserted-by":"crossref","unstructured":"Mylonas, C.C., Zohar, Y., Pankhurst, N.W. & Kagawa, H. (2011). Reproduction and broodstock management. IN Pavlidis, M. & Mylonas, C.C. (Eds.) Sparidae: biology and aquaculture of gilthead seabream and related species. London: Blackwell Science Publishers","DOI":"10.1002\/9781444392210.ch4"},{"key":"10444_CR42","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1152\/physrev.00044.2019","volume":"101","author":"Y Nagahama","year":"2021","unstructured":"Nagahama Y, Chakraborty T, Paul-Prasanth B, Ohta K, Nakamura M (2021) Sex determination, gonadal sex differentiation, and plasticity in vertebrate species. Physiol Rev 101:1237\u20131308","journal-title":"Physiol Rev"},{"key":"10444_CR43","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1530\/REP-19-0436","volume":"159","author":"Y Nie","year":"2020","unstructured":"Nie Y, Wilson AF, Defalco T, Meetei AR, Namekawa SH, Pang Q (2020) FANCD2 is required for the repression of germline transposable elements. Reproduction 159:659\u2013668","journal-title":"Reproduction"},{"key":"10444_CR44","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1146\/annurev-animal-021419-083634","volume":"8","author":"O Ortega-Recalde","year":"2020","unstructured":"Ortega-Recalde O, Goikoetxea A, Hore TA, Todd EV, Gemmell NJ (2020) The Genetics and Epigenetics of Sex Change in Fish. Annu Rev Anim Biosci 8:47\u201369","journal-title":"Annu Rev Anim Biosci"},{"key":"10444_CR45","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10126-020-09991-2","volume":"22","author":"M Papadaki","year":"2020","unstructured":"Papadaki M, Kaitetzidou E, Mylonas CC, Sarropoulou E (2020) Non-coding RNA Expression Patterns of Two Different Teleost Gonad Maturation Stages. Mar Biotechnol (NY) 22:683\u2013695","journal-title":"Mar Biotechnol (NY)"},{"key":"10444_CR46","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.aaf.2022.10.006","volume":"9","author":"M Papadaki","year":"2024","unstructured":"Papadaki M, Karamanlidis D, Sigelaki E, Fakriadis I, Mylonas CC (2024a) Evolution of sex ratio and egg production of gilthead seabream (Sparus aurata) over the course of five reproductive seasons. Aquaculture and Fisheries 9:534\u2013542","journal-title":"Aquaculture and Fisheries"},{"key":"10444_CR47","doi-asserted-by":"publisher","first-page":"114581","DOI":"10.1016\/j.ygcen.2024.114581","volume":"357","author":"M Papadaki","year":"2024","unstructured":"Papadaki M, Mylonas CC, Sarropoulou E (2024b) MicroRNAs are involved in ovarian physiology of greater amberjack (Seriola dumerili) under captivity. Gen Comp Endocrinol 357:114581","journal-title":"Gen Comp Endocrinol"},{"key":"10444_CR48","first-page":"311","volume-title":"Fish Reproduction","author":"RA Patzner","year":"2008","unstructured":"Patzner RA (2008) Reproductive strategies of fish. In: Rocha MJ, Arukwe A, Kapoor BG (eds) Fish Reproduction. Science Publishers, pp 311\u2013350"},{"key":"10444_CR49","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/10641260802324644","volume":"16","author":"F Piferrer","year":"2008","unstructured":"Piferrer F, Guiguen Y (2008) Fish Gonadogenesis. Part II: Molecular Biology and Genomics of Sex Differentiation. Rev Fish Sci 16:35\u201355","journal-title":"Rev Fish Sci"},{"key":"10444_CR50","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s10126-012-9445-4","volume":"14","author":"F Piferrer","year":"2012","unstructured":"Piferrer F, Ribas L, Diaz N (2012) Genomic approaches to study genetic and environmental influences on fish sex determination and differentiation. Mar Biotechnol (NY) 14:591\u2013604","journal-title":"Mar Biotechnol (NY)"},{"key":"10444_CR51","unstructured":"R Core Team (2022) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna.\u00a0https:\/\/www.R-project.org"},{"key":"10444_CR52","doi-asserted-by":"publisher","unstructured":"Ramanagoudr-Bhojappa R, Carrington B, Ramaswami M, Bishop K, Robbins GM, Jones M, Harper U, Frederickson SC, Kimble DC, Sood R & Chandrasekharappa SC (2018) Multiplexed CRISPR\/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. PLOS Genet 14. https:\/\/doi.org\/10.1371\/journal.pgen.1007821","DOI":"10.1371\/journal.pgen.1007821"},{"key":"10444_CR53","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/B978-0-12-381320-6.00020-5","volume":"105","author":"A Rodriguez-Mari","year":"2011","unstructured":"Rodriguez-Mari A, Postlethwait JH (2011) The role of Fanconi anemia\/BRCA genes in zebrafish sex determination. Methods Cell Biol 105:461\u2013490","journal-title":"Methods Cell Biol"},{"key":"10444_CR54","doi-asserted-by":"publisher","first-page":"e1001034","DOI":"10.1371\/journal.pgen.1001034","volume":"6","author":"A Rodriguez-Mari","year":"2010","unstructured":"Rodriguez-Mari A, Canestro C, Bremiller RA, Nguyen-Johnson A, Asakawa K, Kawakami K, Postlethwait JH (2010) Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis. PLoS Genet 6:e1001034","journal-title":"PLoS Genet"},{"key":"10444_CR55","doi-asserted-by":"publisher","unstructured":"Rodr\u00edguez-Mar\u00ed A, Wilson C, Titus TA, Ca\u00f1estro C, Bremiller RA, Yan Y-L, Nanda I, Johnston A, Kanki JP, Gray EM, He X, Spitsbergen J, Schindler D and Postlethwait JH (2011) Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish. PLoS Genet 7. https:\/\/doi.org\/10.1371\/journal.pgen.1001357","DOI":"10.1371\/journal.pgen.1001357"},{"key":"10444_CR56","doi-asserted-by":"publisher","first-page":"e0149711","DOI":"10.1371\/journal.pone.0149711","volume":"11","author":"I Rojo-Bartolome","year":"2016","unstructured":"Rojo-Bartolome I, Diaz De Cerio O, Diez G, Cancio I (2016) Identification of Sex and Female\u2019s Reproductive Stage in Commercial Fish Species through the Quantification of Ribosomal Transcripts in Gonads. PLoS ONE 11:e0149711","journal-title":"PLoS ONE"},{"key":"10444_CR57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cbpa.2017.05.018","volume":"211","author":"I Rojo-Bartolome","year":"2017","unstructured":"Rojo-Bartolome I, Martinez-Miguel L, Lafont AG, Vilchez MC, Asturiano JF, Perez L, Cancio I (2017a) Molecular markers of oocyte differentiation in European eel during hormonally induced oogenesis. Comp Biochem Physiol A Mol Integr Physiol 211:17\u201325","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10444_CR58","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.marpolbul.2017.06.027","volume":"121","author":"I Rojo-Bartolome","year":"2017","unstructured":"Rojo-Bartolome I, Valencia A, Cancio I (2017b) Transcription of ribogenesis genes in fish gonads: Applications in the identification of stages of oogenesis and in environmental monitoring of intersex condition. Mar Pollut Bull 121:292\u2013301","journal-title":"Mar Pollut Bull"},{"key":"10444_CR59","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3324\/haematol.12234","volume":"93","author":"PS Rosenberg","year":"2008","unstructured":"Rosenberg PS, Alter BP, Ebell W (2008) Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry. Haematologica 93:511\u2013517","journal-title":"Haematologica"},{"key":"10444_CR60","doi-asserted-by":"publisher","first-page":"104583","DOI":"10.1016\/j.dci.2022.104583","volume":"143","author":"AR Salifu","year":"2023","unstructured":"Salifu AR, Pang Y, He Y, Liu Y, Shen Y, Xu X, Li J (2023) MiR-217 targets TBK1 to modulate inflammatory response in grass carp following infection with Aeromonashydrophila. Dev Comp Immunol 143:104583","journal-title":"Dev Comp Immunol"},{"key":"10444_CR61","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1038\/s41598-017-04327-y","volume":"7","author":"ZG Shen","year":"2017","unstructured":"Shen ZG, Yao H, Guo L, Li XX, Wang HP (2017) Ribosome RNA Profiling to Quantify Ovarian Development and Identify Sex in Fish. Sci Rep 7:4196","journal-title":"Sci Rep"},{"key":"10444_CR62","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1186\/s12864-016-2636-z","volume":"17","author":"W Tao","year":"2016","unstructured":"Tao W, Sun L, Shi H, Cheng Y, Jiang D, Fu B, Conte MA, Gammerdinger WJ, Kocher TD, Wang D (2016) Integrated analysis of miRNA and mRNA expression profiles in tilapia gonads at an early stage of sex differentiation. BMC Genomics 17:328","journal-title":"BMC Genomics"},{"key":"10444_CR63","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.mrfmmm.2008.11.017","volume":"668","author":"TA Titus","year":"2009","unstructured":"Titus TA, Yan YL, Wilson C, Starks AM, Frohnmayer JD, Bremiller RA, Canestro C, Rodriguez-Mari A, He X, Postlethwait JH (2009) The Fanconi anemia\/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Mutat Res 668:117\u2013132","journal-title":"Mutat Res"},{"key":"10444_CR64","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.aquatox.2015.06.002","volume":"165","author":"AC Tse","year":"2015","unstructured":"Tse AC, Li JW, Chan TF, Wu RS, Lai KP (2015) Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma. Aquat Toxicol 165:189\u2013196","journal-title":"Aquat Toxicol"},{"key":"10444_CR65","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tig.2018.12.007","volume":"35","author":"V Tsui","year":"2019","unstructured":"Tsui V, Crismani W (2019) The Fanconi Anemia Pathway and Fertility. Trends Genet 35:199\u2013214","journal-title":"Trends Genet"},{"key":"10444_CR66","doi-asserted-by":"publisher","first-page":"110820","DOI":"10.1016\/j.ygeno.2024.110820","volume":"116","author":"TA Van Gelderen","year":"2024","unstructured":"Van Gelderen TA, Ribas L (2024) miR-210 promotes immune- and suppresses oocyte meiosis-related genes in the zebrafish ovarian cells. Genomics 116:110820","journal-title":"Genomics"},{"key":"10444_CR67","doi-asserted-by":"publisher","first-page":"e0157022","DOI":"10.1371\/journal.pone.0157022","volume":"11","author":"H Varet","year":"2016","unstructured":"Varet H, Brillet-Gueguen L, Coppee JY, Dillies MA (2016) SARTools: a DESeq2-and EdgeR-based R pipeline for comprehensive differential analysis of RNA-Seq data. PLoS One 11:e0157022","journal-title":"PLoS One"},{"key":"10444_CR68","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/or.2016.5236","volume":"37","author":"JW Wei","year":"2017","unstructured":"Wei JW, Huang K, Yang C, Kang CS (2017) Non-coding RNAs as regulators in epigenetics (Review). Oncol Rep 37:3\u20139","journal-title":"Oncol Rep"},{"key":"10444_CR69","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ygcen.2014.12.012","volume":"221","author":"TT Wong","year":"2015","unstructured":"Wong TT, Zohar Y (2015) Production of reproductively sterile fish: A mini-review of germ cell elimination technologies. Gen Comp Endocrinol 221:3\u20138","journal-title":"Gen Comp Endocrinol"},{"key":"10444_CR70","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1095\/biolreprod.105.045351","volume":"74","author":"T-T Wong","year":"2006","unstructured":"Wong T-T, Ijiri S, Zohar Y (2006) Molecular Biology of Ovarian Aromatase in Sex Reversal: Complementary DNA and 5\u2032-Flanking Region Isolation and Differential Expression of Ovarian Aromatase in the Gilthead Seabream (Sparus aurata). Biol Reprod 74:857\u2013864","journal-title":"Biol Reprod"},{"key":"10444_CR71","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/bs.ctdb.2019.02.003","volume":"134","author":"Y Yamamoto","year":"2019","unstructured":"Yamamoto Y, Hattori RS, Patino R, Strussmann CA (2019) Environmental regulation of sex determination in fishes: Insights from Atheriniformes. Curr Top Dev Biol 134:49\u201369","journal-title":"Curr Top Dev Biol"},{"key":"10444_CR72","doi-asserted-by":"publisher","first-page":"7459","DOI":"10.1038\/s41598-021-83891-w","volume":"11","author":"H Yan","year":"2021","unstructured":"Yan H, Liu Q, Jiang J, Shen X, Zhang L, Yuan Z, Wu Y, Liu Y (2021) Identification of sex differentiation-related microRNA and long non-coding RNA in Takifugu rubripes gonads. Sci Rep 11:7459","journal-title":"Sci Rep"},{"key":"10444_CR73","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.4049\/jimmunol.2000341","volume":"205","author":"L Zhang","year":"2020","unstructured":"Zhang L, Chu Q, Chang R, Xu T (2020) Inducible MicroRNA-217 Inhibits NF-kappaB- and IRF3-Driven Immune Responses in Lower Vertebrates through Targeting TAK1. J Immunol 205:1620\u20131632","journal-title":"J Immunol"}],"container-title":["Marine Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-025-10444-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10126-025-10444-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-025-10444-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:09:37Z","timestamp":1745467777000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10126-025-10444-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10444"],"URL":"https:\/\/doi.org\/10.1007\/s10126-025-10444-x","relation":{},"ISSN":["1436-2228","1436-2236"],"issn-type":[{"value":"1436-2228","type":"print"},{"value":"1436-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"17 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"74"}}