{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:36:06Z","timestamp":1787337366199,"version":"build-2736575974"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 3240484"],"award-info":[{"award-number":["FONDECYT 3240484"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 1210852"],"award-info":[{"award-number":["FONDECYT 1210852"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 11220307"],"award-info":[{"award-number":["FONDECYT 11220307"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mar Biotechnol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10126-026-10663-w","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:05:19Z","timestamp":1783130719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Protection of Atlantic Salmon Against Caligus Rogercresseyi and Piscirickettsia Salmonis Using IPath\u00ae and Commercial Vaccines"],"prefix":"10.1007","volume":"28","author":[{"given":"Antonio","family":"Casuso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeny","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Gallardo-Esc\u00e1rate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-6695","authenticated-orcid":false,"given":"Valentina","family":"Valenzuela-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"10663_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163943","volume":"11","author":"CA \u00c1lvarez","year":"2016","unstructured":"\u00c1lvarez CA, Gomez FA, Mercado L, Ram\u00edrez R, Marshall SH (2016) Piscirickettsia salmonis imbalances the innate immune response to succeed in a productive infection in a salmonid cell line model. PLoS ONE 11:e0163943","journal-title":"PLoS ONE"},{"key":"10663_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2019.104771","volume":"171","author":"G Arriagada","year":"2019","unstructured":"Arriagada G, Hamilton-West C, Nekouei O, Foerster C, M\u00fcller A, Lara M, Gallardo-Esc\u00e1rate C (2019) Caligus rogercresseyi infestation is associated with Piscirickettsia salmonis-attributed mortalities in farmed salmonids in Chile. Prev Vet Med 171:104771","journal-title":"Prev Vet Med"},{"key":"10663_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5432497","volume":"2018","author":"A Assefa","year":"2018","unstructured":"Assefa A, Abunna F (2018) Maintenance of fish health in aquaculture: review of epidemiological approaches for prevention and control of infectious disease of fish. Vet Med Int 2018:5432497","journal-title":"Vet Med Int"},{"key":"10663_CR4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.fsi.2019.02.014","volume":"88","author":"P Bao","year":"2019","unstructured":"Bao P, Sun X, Liu Q, Zhang Y, Liu X (2019) Synergistic effect of a combined live Vibrio anguillarum and Edwardsiella piscicida vaccine in turbot. Fish Shellfish Immunol 88:84\u201390","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR5","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1111\/raq.12456","volume":"12","author":"LT Barrett","year":"2020","unstructured":"Barrett LT, Oppedal F, Robinson N, Dempster T (2020) Prevention not cure: a review of methods to avoid sea lice infestations in salmon aquaculture. Rev Aquac 12:2527\u20132543","journal-title":"Rev Aquac"},{"key":"10663_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12731","volume":"42","author":"LM Braden","year":"2020","unstructured":"Braden LM, Monaghan SJ, Fast MD (2020) Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis. Parasite Immunol 42:e12731","journal-title":"Parasite Immunol"},{"key":"10663_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.exppara.2009.12.001","volume":"125","author":"S Bravo","year":"2010","unstructured":"Bravo S (2010) The reproductive output of sea lice Caligus rogercresseyi under controlled conditions. Exp Parasitol 125:51\u201354","journal-title":"Exp Parasitol"},{"key":"10663_CR8","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1111\/raq.12815","volume":"15","author":"S Bravo","year":"2023","unstructured":"Bravo S, Treasurer J (2023) The management of the sea lice in Chile: a review. Rev Aquac 15:1749\u20131764","journal-title":"Rev Aquac"},{"key":"10663_CR9","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1111\/jfd.13851","volume":"46","author":"P Bustos","year":"2023","unstructured":"Bustos P, Figueroa C, C\u00e1diz B, Santander T, Dixon B, Gallardo JA, Conejeros P (2023) Immune response induced by coinfection of the sea louse Caligus rogercresseyi and the intracellular bacteria Piscirickettsia salmonis in vaccinated Atlantic salmon. J Fish Dis 46:1337\u20131342","journal-title":"J Fish Dis"},{"key":"10663_CR10","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/jfd.12745","volume":"41","author":"P Calqu\u00edn","year":"2018","unstructured":"Calqu\u00edn P, Ruiz P, Oliver C, S\u00e1nchez P, Haro R, Oliva H, Vargas-Chacoff L, Avenda\u00f1o-Herrera R, Y\u00e1\u00f1ez A (2018) Physiological evidence that Piscirickettsia salmonis produces siderophores and uses iron from different sources. J Fish Dis 41:553\u2013558","journal-title":"J Fish Dis"},{"key":"10663_CR11","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.dci.2010.02.014","volume":"34","author":"TM Carland","year":"2010","unstructured":"Carland TM, Gerwick L (2010) The C1q domain containing proteins: where do they come from and what do they do? Dev Comp Immunol 34:785\u2013790","journal-title":"Dev Comp Immunol"},{"key":"10663_CR12","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.3390\/vaccines10071063","volume":"10","author":"A Casuso","year":"2022","unstructured":"Casuso A, Valenzuela-Mu\u00f1oz V, Benavente BP, Valenzuela-Miranda D, Gallardo-Esc\u00e1rate C (2022a) Exploring sea lice vaccines against early stages of infestation in Atlantic salmon (Salmo salar). Vaccines 10:1063","journal-title":"Vaccines"},{"key":"10663_CR13","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.3390\/vaccines10111875","volume":"10","author":"A Casuso","year":"2022","unstructured":"Casuso A, Valenzuela-Mu\u00f1oz V, Gallardo-Esc\u00e1rate C (2022b) Dual RNA-Seq Analysis Reveals Transcriptome Effects during the Salmon-Louse Interaction in Fish Immunized with Three Lice Vaccines. Vaccines 10:1875","journal-title":"Vaccines"},{"key":"10663_CR14","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.molp.2020.06.009","volume":"13","author":"C Chen","year":"2020","unstructured":"Chen C, Chen H, Zhang Y, Thomas HR, Frank MH, He Y, Xia R (2020) TBtools: an integrative toolkit developed for interactive analyses of big biological data. Mol Plant 13:1194\u20131202","journal-title":"Mol Plant"},{"key":"10663_CR15","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1016\/j.molimm.2007.02.014","volume":"44","author":"E Csomor","year":"2007","unstructured":"Csomor E, Bajtay Z, S\u00e1ndor N, Krist\u00f3f K, Arlaud GJ, Thiel S, Erdei A (2007) Complement protein C1q induces maturation of human dendritic cells. Mol Immunol 44:3389\u20133397","journal-title":"Mol Immunol"},{"key":"10663_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13657305.2018.1449271","volume":"23","author":"J Dresdner","year":"2019","unstructured":"Dresdner J, Chavez C, Quiroga M, Jimenez D, Artacho P, Tello A (2019) Impact of Caligus treatments on unit costs of heterogeneous salmon farms in Chile. Aquac Econ Manag 23:1\u201327","journal-title":"Aquac Econ Manag"},{"key":"10663_CR17","doi-asserted-by":"publisher","first-page":"1040336","DOI":"10.3389\/fimmu.2022.1040336","volume":"13","author":"Y Du","year":"2022","unstructured":"Du Y, Hu X, Miao L, Chen J (2022) Current status and development prospects of aquatic vaccines. Front Immunol 13:1040336","journal-title":"Front Immunol"},{"key":"10663_CR18","doi-asserted-by":"crossref","unstructured":"Edholm ES, Du Pasquier L, Wiegertjes GF, Boudinot P (2022) Major histocompatibility complex (MHC) in fish. Principles of fish immunology: from cells and molecules to host protection. Springer","DOI":"10.1007\/978-3-030-85420-1_11"},{"key":"10663_CR19","doi-asserted-by":"publisher","first-page":"17817","DOI":"10.1038\/s41598-017-18180-6","volume":"7","author":"C Figueroa","year":"2017","unstructured":"Figueroa C, Bustos P, Torrealba D, Dixon B, Soto C, Conejeros P, Gallardo JA (2017) Coinfection takes its toll: sea lice override the protective effects of vaccination against a bacterial pathogen in Atlantic salmon. Sci Rep 7:17817","journal-title":"Sci Rep"},{"key":"10663_CR20","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/jfd.13333","volume":"44","author":"J Figueroa","year":"2021","unstructured":"Figueroa J, Villagr\u00e1n D, Cartes C, Solis C, Nourdin-Galindo G, Haussmann D (2021) Analysis of genes encoding for proteolytic enzymes and cytotoxic proteins as virulence factors of Piscirickettsia salmonis in SHK-1 cells. J Fish Dis 44:495\u2013504","journal-title":"J Fish Dis"},{"key":"10663_CR21","doi-asserted-by":"publisher","first-page":"1424218","DOI":"10.3389\/fonc.2024.1424218","volume":"14","author":"AA Firouzjaei","year":"2024","unstructured":"Firouzjaei AA, Mohammadi-Yeganeh S (2024) The intricate interplay between ferroptosis and efferocytosis in cancer: unraveling novel insights and therapeutic opportunities. Front Oncol 14:1424218","journal-title":"Front Oncol"},{"key":"10663_CR22","doi-asserted-by":"publisher","DOI":"10.1093\/conphys\/coaa023","volume":"8","author":"PG Fjelldal","year":"2020","unstructured":"Fjelldal PG, Hansen TJ, Karlsen \u00d8 (2020) Effects of laboratory salmon louse infection on osmoregulation, growth and survival in Atlantic salmon. Conserv Physiol 8:coaa023","journal-title":"Conserv Physiol"},{"key":"10663_CR23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.fsi.2019.12.093","volume":"98","author":"C Flores-Kossack","year":"2020","unstructured":"Flores-Kossack C, Montero R, K\u00f6llner B, Maisey K (2020) Chilean aquaculture and the new challenges: pathogens, immune response, vaccination and fish diversification. Fish Shellfish Immunol 98:52\u201367","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/raq.12334","volume":"11","author":"C Gallardo-Esc\u00e1rate","year":"2019","unstructured":"Gallardo-Esc\u00e1rate C, Arriagada G, Carrera C, Goncalves AT, Nunez-Acuna G, Valenzuela-Miranda D, Valenzuela-Munoz V (2019a) The race between host and sea lice in the Chilean salmon farming: a genomic approach. Rev Aquac 11:325\u2013339","journal-title":"Rev Aquac"},{"key":"10663_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.fsi.2019.04.065","volume":"90","author":"C Gallardo-Esc\u00e1rate","year":"2019","unstructured":"Gallardo-Esc\u00e1rate C, Valenzuela-Mu\u00f1oz V, N\u00fa\u00f1ez-Acu\u00f1a G, Carrera C, Gon\u00e7alves AT, Valenzuela-Miranda D, Benavente BP, Roberts S (2019b) Catching the complexity of salmon-louse interactions. Fish Shellfish Immunol 90:199\u2013209","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0044-8486(02)00512-4","volume":"220","author":"L Gonz\u00e1lez","year":"2003","unstructured":"Gonz\u00e1lez L, Carvajal J (2003) Life cycle of Caligus rogercresseyi, (Copepoda: Caligidae) parasite of Chilean reared salmonids. Aquaculture 220:101\u2013117","journal-title":"Aquaculture"},{"key":"10663_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.aquaculture.2016.01.027","volume":"457","author":"MP Gonz\u00e1lez","year":"2016","unstructured":"Gonz\u00e1lez MP, Mu\u00f1oz JL, Valerio V, Vargas-Chacoff L (2016) Effects of the ectoparasite Caligus rogercresseyi on Salmo salar blood parameters under farm conditions. Aquaculture 457:29\u201334","journal-title":"Aquaculture"},{"key":"10663_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-018-2885-6","volume":"11","author":"S Hamilton","year":"2018","unstructured":"Hamilton S, Mclean K, Monaghan SJ, Mcnair C, Inglis NF, Mcdonald H, Adams S, Richards R, Roy W, Smith P (2018) Characterisation of proteins in excretory\/secretory products collected from salmon lice, Lepeophtheirus salmonis. Parasites Vectors 11:1\u20139","journal-title":"Parasites Vectors"},{"key":"10663_CR29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.prevetmed.2011.12.002","volume":"104","author":"C Hamilton- West","year":"2012","unstructured":"Hamilton- West C, Arriagada G, Yatabe T, Vald\u00e9s P, Herv\u00e9-Claude LP, Urcelay S (2012) Epidemiological description of the sea lice (Caligus rogercresseyi) situation in southern Chile in August 2007. Prev Vet Med 104:341\u2013345","journal-title":"Prev Vet Med"},{"key":"10663_CR30","doi-asserted-by":"publisher","first-page":"734968","DOI":"10.1016\/j.aquaculture.2020.734968","volume":"520","author":"J Happold","year":"2020","unstructured":"Happold J, Sadler R, Meyer A, Hillman A, Cowled B, Mackenzie C, Lagno ALG, Cameron A (2020) Effectiveness of vaccination for the control of salmonid rickettsial septicaemia in commercial salmon and trout farms in Chile. Aquaculture 520:734968","journal-title":"Aquaculture"},{"key":"10663_CR31","doi-asserted-by":"publisher","first-page":"111197","DOI":"10.1016\/j.molbiopara.2019.111197","volume":"232","author":"EI Heggland","year":"2019","unstructured":"Heggland EI, Tr\u00f6\u00dfe C, Eichner C, Nilsen F (2019) Heavy and light chain homologs of ferritin are essential for blood-feeding and egg production of the ectoparasitic copepod Lepeophtheirus salmonis. Mol Biochem Parasitol 232:111197","journal-title":"Mol Biochem Parasitol"},{"key":"10663_CR32","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.fsi.2014.10.038","volume":"42","author":"H Holm","year":"2015","unstructured":"Holm H, Santi N, Kj\u00f8glum S, Perisic N, Skugor S, Evensen \u00d8 (2015) Difference in skin immune responses to infection with salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar L.) of families selected for resistance and susceptibility. Fish Shellfish Immunol 42:384\u2013394","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR33","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.dci.2016.10.008","volume":"67","author":"HJ Holm","year":"2017","unstructured":"Holm HJ, Skugor S, Bjelland A, Radunovic S, Wadsworth S, Koppang E, Evensen \u00d8 (2017) Contrasting expression of immune genes in scaled and scaleless skin of Atlantic salmon infected with young stages of Lepeophtheirus salmonis. Dev Comp Immunol 67:153\u2013165","journal-title":"Dev Comp Immunol"},{"key":"10663_CR34","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.vetmic.2014.08.014","volume":"173","author":"A Isla","year":"2014","unstructured":"Isla A, Haussmann D, Vera T, Kausel G, Figueroa J (2014) Identification of the clpB and bipA genes and an evaluation of their expression as related to intracellular survival for the bacterial pathogen Piscirickettsia salmonis. Vet Microbiol 173:390\u2013394","journal-title":"Vet Microbiol"},{"key":"10663_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.aquaculture.2009.02.002","volume":"290","author":"L-H Johansen","year":"2009","unstructured":"Johansen L-H, Eggset G, Sommer A-I (2009) Experimental IPN virus infection of Atlantic salmon parr; recurrence of IPN and effects on secondary bacterial infections in post-smolts. Aquaculture 290:9\u201314","journal-title":"Aquaculture"},{"key":"10663_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12050456","volume":"12","author":"A Johny","year":"2024","unstructured":"Johny A, Ilardi P, Olsen RE, Egelandsdal B, Slinde E (2024) A proof-of-concept study to develop a peptide-based vaccine against salmon lice infestation in Atlantic salmon (Salmo salar L.). Vaccines (Basel) 12:456","journal-title":"Vaccines (Basel)"},{"key":"10663_CR37","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.3389\/fimmu.2017.01863","volume":"8","author":"N Karaji","year":"2017","unstructured":"Karaji N, Sattentau QJ (2017) Efferocytosis of pathogen-infected cells. Front Immunol 8:1863","journal-title":"Front Immunol"},{"key":"10663_CR38","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fimmu.2015.00317","volume":"6","author":"L Kouser","year":"2015","unstructured":"Kouser L, Madhukaran SP, Shastri A, Saraon A, Ferluga J, Al-Mozaini M, Kishore U (2015) Emerging and novel functions of complement protein C1q. Front Immunol 6:317","journal-title":"Front Immunol"},{"key":"10663_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095397","volume":"9","author":"JP Lhorente","year":"2014","unstructured":"Lhorente JP, Gallardo JA, Villanueva B, Caraba\u00f1o MJ, Neira R (2014) Disease resistance in Atlantic salmon (Salmo salar): coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi. PLoS One 9:e95397","journal-title":"PLoS One"},{"key":"10663_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2022.108472","volume":"132","author":"M-F Li","year":"2023","unstructured":"Li M-F, Zhang H-Q, Sun J-S (2023) A novel C1qDC (PoC1qDC) with a collagen domain in Paralichthys olivaceus mediates complement activation and against bacterial infection. Fish Shellfish Immunol 132:108472","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.dci.2017.09.014","volume":"78","author":"Z Lv","year":"2018","unstructured":"Lv Z, Qiu L, Wang M, Jia Z, Wang W, Xin L, Liu Z, Wang L, Song L (2018) Comparative study of three C1q domain containing proteins from pacific oyster Crassostrea gigas. Dev Comp Immunol 78:42\u201351","journal-title":"Dev Comp Immunol"},{"key":"10663_CR42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.margen.2014.04.006","volume":"15","author":"W Maldonado-Aguayo","year":"2014","unstructured":"Maldonado-Aguayo W, Gallardo-Esc\u00e1rate C (2014) Increasing transcriptome response of serpins during the ontogenetic stages in the salmon louse Caligus rogercresseyi (Copepoda: Caligidae). Mar Genomics 15:55\u201364","journal-title":"Mar Genomics"},{"key":"10663_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8040676","volume":"8","author":"AR Mawson","year":"2020","unstructured":"Mawson AR, Croft AM (2020) Multiple vaccinations and the enigma of vaccine injury. Vaccines (Basel) 8:676","journal-title":"Vaccines (Basel)"},{"key":"10663_CR44","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.fsi.2008.07.005","volume":"25","author":"\u00daM Mccarthy","year":"2008","unstructured":"Mccarthy \u00daM, Bron JE, Brown L, Pourahmad F, Bricknell IR, Thompson KD, Adams A, Ellis AE (2008) Survival and replication of Piscirickettsia salmonis in rainbow trout head kidney macrophages. Fish Shellfish Immunol 25:477\u2013484","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR45","doi-asserted-by":"publisher","first-page":"W182","DOI":"10.1093\/nar\/gkm321","volume":"35","author":"Y Moriya","year":"2007","unstructured":"Moriya Y, Itoh M, Okuda S, Yoshizawa AC, Kanehisa M (2007) KAAS: an automatic genome annotation and pathway reconstruction server. Nucleic Acids Res 35:W182\u2013W185","journal-title":"Nucleic Acids Res"},{"key":"10663_CR46","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.aquaculture.2013.10.016","volume":"420","author":"K Oelckers","year":"2014","unstructured":"Oelckers K, Vike S, Duesund H, Gonzalez J, Wadsworth S, Nylund A (2014) Caligus rogercresseyi as a potential vector for transmission of Infectious Salmon Anaemia (ISA) virus in Chile. Aquaculture 420:126\u2013132","journal-title":"Aquaculture"},{"key":"10663_CR47","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/microorganisms8121845","volume":"8","author":"J Ortiz-Sever\u00edn","year":"2020","unstructured":"Ortiz-Sever\u00edn J, Travisany D, Maass A, Cambiazo V, Ch\u00e1vez FP (2020) Global proteomic profiling of Piscirickettsia salmonis and salmon macrophage-like cells during intracellular infection. Microorganisms 8:1845","journal-title":"Microorganisms"},{"key":"10663_CR48","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.dci.2015.08.011","volume":"54","author":"G Pei","year":"2016","unstructured":"Pei G, Liu G, Pan X, Pang Y, Li Q (2016) L-C1qDC-1, a novel C1q domain-containing protein from Lethenteron camtschaticum that is involved in the immune response. Dev Comp Immunol 54:66\u201374","journal-title":"Dev Comp Immunol"},{"key":"10663_CR49","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3389\/fimmu.2019.00434","volume":"10","author":"D P\u00e9rez-Stuardo","year":"2019","unstructured":"P\u00e9rez-Stuardo D, Morales-Reyes J, Tapia S, Ahumada DE, Espinoza A, Soto-Herrera V, Brianson B, Ibaceta V, Sandino AM, Spencer E (2019) Non-lysosomal activation in macrophages of atlantic salmon (Salmo salar) after infection with Piscirickettsia salmonis. Front Immunol 10:434","journal-title":"Front Immunol"},{"key":"10663_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-015-1716-9","volume":"16","author":"R Pulgar","year":"2015","unstructured":"Pulgar R, H\u00f6dar C, Travisany D, Zu\u00f1iga A, Dom\u00ednguez C, Maass A, Gonz\u00e1lez M, Cambiazo V (2015) Transcriptional response of Atlantic salmon families to Piscirickettsia salmonis infection highlights the relevance of the iron-deprivation defence system. BMC Genomics 16:1\u201321","journal-title":"BMC Genomics"},{"key":"10663_CR51","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/raq.12337","volume":"11","author":"RA Qui\u00f1ones","year":"2019","unstructured":"Qui\u00f1ones RA, Fuentes M, Montes RM, Soto D, Le\u00f3n-Mu\u00f1oz J (2019) Environmental issues in Chilean salmon farming: a review. Rev Aquac 11:375\u2013402","journal-title":"Rev Aquac"},{"key":"10663_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsle\/fnu012","volume":"362","author":"R Ram\u00edrez","year":"2015","unstructured":"Ram\u00edrez R, G\u00f3mez FA, Marshall SH (2015) The infection process of Piscirickettsia salmonis in fish macrophages is dependent upon interaction with host-cell clathrin and actin. FEMS Microbiol Lett 362:1\u20138","journal-title":"FEMS Microbiol Lett"},{"key":"10663_CR53","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.dci.2017.02.005","volume":"80","author":"B Robertsen","year":"2018","unstructured":"Robertsen B (2018) The role of type I interferons in innate and adaptive immunity against viruses in Atlantic salmon. Dev Comp Immunol 80:41\u201352","journal-title":"Dev Comp Immunol"},{"key":"10663_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1570948","volume":"16","author":"A Rodr\u00edguez","year":"2025","unstructured":"Rodr\u00edguez A, Gadan K, P\u00e9rez L, Evensen \u00d8, Estrada MP, Carpio Y (2025) Prime-boost vaccination with chimeric antigens adjuvanted in Montanide\u2122 ISA50 V2 confers protection against experimental Lepeophtheirus salmonis infestation in Atlantic salmon (Salmo salar L.). Front Immunol 16:1570948","journal-title":"Front Immunol"},{"key":"10663_CR55","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/jcb.22295","volume":"108","author":"V Rojas","year":"2009","unstructured":"Rojas V, Galanti N, Bols NC, Marshall SH (2009) Productive infection of Piscirickettsia salmonis in macrophages and monocyte-like cells from rainbow trout, a possible survival strategy. J Cell Biochem 108:631\u2013637","journal-title":"J Cell Biochem"},{"key":"10663_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.856896","volume":"13","author":"M Rozas-Serri","year":"2022","unstructured":"Rozas-Serri M (2022) Why does Piscirickettsia salmonis break the immunological paradigm in farmed salmon? Biological context to understand the relative control of piscirickettsiosis. Front Immunol 13:856896","journal-title":"Front Immunol"},{"key":"10663_CR57","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.dci.2017.12.023","volume":"81","author":"M Rozas-Serri","year":"2018","unstructured":"Rozas-Serri M, Pena A, Maldonado L (2018) Transcriptomic profiles of post-smolt Atlantic salmon challenged with Piscirickettsia salmonis reveal a strategy to evade the adaptive immune response and modify cell-autonomous immunity. Dev Comp Immunol 81:348\u2013362","journal-title":"Dev Comp Immunol"},{"key":"10663_CR58","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1111\/jfd.12671","volume":"40","author":"M Rozas-Serri","year":"2017","unstructured":"Rozas-Serri M, Ildefonso R, Pe\u00f1a A, Enr\u00edquez R, Barrientos S, Maldonado L (2017) Comparative pathogenesis of piscirickettsiosis in Atlantic salmon (Salmo salar L.) post-smolt experimentally challenged with LF-89-like and EM-90-like Piscirickettsia salmonis isolates. J Fish Dis 40:1451\u20131472","journal-title":"J Fish Dis"},{"key":"10663_CR59","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/jfd.12756","volume":"41","author":"M Rozas-Serri","year":"2018","unstructured":"Rozas-Serri M, Pe\u00f1a A, Arriagada G, Enr\u00edquez R, Maldonado L (2018) Comparison of gene expression in post-smolt Atlantic salmon challenged by LF-89-like and EM-90-like Piscirickettsia salmonis isolates reveals differences in the immune response associated with pathogenicity. J Fish Dis 41:539\u2013552","journal-title":"J Fish Dis"},{"key":"10663_CR60","unstructured":"SAG (2023). Provisional registration of immunologics biologics products, use in salmonids. Chile: Ministerio de Econom\u00eda, Fomento y turisto Gobierno de Chile. https:\/\/www.sag.gob.cl\/sites\/default\/files\/lista_salmonidos_registro_provisional_17122024.pdf"},{"key":"10663_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-141","volume":"12","author":"TM Tadiso","year":"2011","unstructured":"Tadiso TM, Krasnov A, Skugor S, Afanasyev S, Hordvik I, Nilsen F (2011) Gene expression analyses of immune responses in Atlantic salmon during early stages of infection by salmon louse (Lepeophtheirus salmonis) revealed bi-phasic responses coinciding with the copepod-chalimus transition. BMC Genomics 12:141","journal-title":"BMC Genomics"},{"key":"10663_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12070732","volume":"12","author":"I Tammas","year":"2024","unstructured":"Tammas I, Bitchava K, Gelasakis AI (2024) Transforming aquaculture through vaccination: a review on recent developments and milestones. Vaccines 12:732","journal-title":"Vaccines"},{"key":"10663_CR63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294236","volume":"18","author":"D Tang","year":"2023","unstructured":"Tang D, Chen M, Huang X, Zhang G, Zeng L, Zhang G, Wu S, Wang Y (2023) SRplot: a free online platform for data visualization and graphing. PLoS ONE 18:e0294236","journal-title":"PLoS ONE"},{"key":"10663_CR64","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.3390\/ijms21072417","volume":"21","author":"N Umasuthan","year":"2020","unstructured":"Umasuthan N, Xue X, Caballero-Solares A, Kumar S, Westcott JD, Chen Z, Fast MD, Skugor S, Nowak BF, Taylor RG (2020) Transcriptomic profiling in fins of Atlantic salmon parasitized with sea lice: evidence for an early imbalance between chalimus-induced immunomodulation and the host\u2019s defense response. Int J Mol Sci 21:2417","journal-title":"Int J Mol Sci"},{"key":"10663_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1019404","volume":"13","author":"P Valenzuela-Aviles","year":"2022","unstructured":"Valenzuela-Aviles P, Torrealba D, Figueroa C, Mercado L, Dixon B, Conejeros P, Gallardo-Matus J (2022) Why vaccines fail against Piscirickettsiosis in farmed salmon and trout and how to avoid it: a review. Front Immunol 13:1019404","journal-title":"Front Immunol"},{"key":"10663_CR66","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.fsi.2016.11.001","volume":"59","author":"D Valenzuela-Miranda","year":"2016","unstructured":"Valenzuela-Miranda D, Gallardo-Esc\u00e1rate C (2016) Novel insights into the response of Atlantic salmon (Salmo salar) to Piscirickettsia salmonis: interplay of coding genes and lncRNAs during bacterial infection. Fish Shellfish Immunol 59:427\u2013438","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR67","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3390\/vaccines9040361","volume":"9","author":"V Valenzuela-Mu\u00f1oz","year":"2021","unstructured":"Valenzuela-Mu\u00f1oz V, Benavente BP, Casuso A, Leal Y, Gallardo-Esc\u00e1rate C (2021a) Chimeric protein IPath\u00ae with chelating activity improves atlantic salmon\u2019s immunity against infectious diseases. Vaccines 9:361","journal-title":"Vaccines"},{"key":"10663_CR68","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.fsi.2021.08.005","volume":"117","author":"V Valenzuela-Mu\u00f1oz","year":"2021","unstructured":"Valenzuela-Mu\u00f1oz V, Benavente BP, Casuso A, Leal Y, Valenzuela-Miranda D, N\u00fa\u00f1ez-Acu\u00f1a G, S\u00e1ez-Vera C, Gallardo-Esc\u00e1rate C (2021) Transcriptome and morphological analysis in Caligus rogercresseyi uncover the effects of Atlantic salmon vaccination with IPath\u00ae. Fish Shellfish Immunol 117:169\u2013178","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR69","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.fsi.2016.10.046","volume":"59","author":"V Valenzuela-Mu\u00f1oz","year":"2016","unstructured":"Valenzuela-Mu\u00f1oz V, Bolta\u00f1a S, Gallardo-Esc\u00e1rate C (2016) Comparative immunity of Salmo salar and Oncorhynchus kisutch during infestation with the sea louse Caligus rogercresseyi: an enrichment transcriptome analysis. Fish Shellfish Immunol 59:276\u2013287","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR70","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/jfd.12592","volume":"40","author":"V Valenzuela-Mu\u00f1oz","year":"2017","unstructured":"Valenzuela-Mu\u00f1oz V, Bolta\u00f1a S, Gallardo-Esc\u00e1rate C (2017) Uncovering iron regulation with species-specific transcriptome patterns in Atlantic and coho salmon during a Caligus rogercresseyi infestation. J Fish Dis 40:1169\u20131184","journal-title":"J Fish Dis"},{"key":"10663_CR71","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.fsi.2016.11.045","volume":"60","author":"V Valenzuela-Mu\u00f1oz","year":"2017","unstructured":"Valenzuela-Mu\u00f1oz V, Gallardo-Escarate C (2017) Iron metabolism modulation in Atlantic salmon infested with the sea lice Lepeophtheirus salmonis and Caligus rogercresseyi: a matter of nutritional immunity? Fish Shellfish Immunol 60:97\u2013102","journal-title":"Fish Shellfish Immunol"},{"key":"10663_CR72","doi-asserted-by":"publisher","DOI":"10.3390\/ani11113240","volume":"11","author":"AL Wise","year":"2021","unstructured":"Wise AL, Lafrentz BR, Kelly AM, Khoo LH, Xu T, Liles MR, Bruce TJ (2021) A review of bacterial co-infections in farmed catfish: components, diagnostics, and treatment directions. Animals (Basel) 11:3240","journal-title":"Animals (Basel)"},{"key":"10663_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00426","volume":"9","author":"A Z\u00fa\u00f1iga","year":"2020","unstructured":"Z\u00fa\u00f1iga A, Aravena P, Pulgar R, Travisany D, Ortiz-Sever\u00edn J, Ch\u00e1vez FP, Maass A, Gonz\u00e1lez M, Cambiazo V (2020) Transcriptomic changes of Piscirickettsia salmonis during intracellular growth in a salmon macrophage-like cell line. Front Cell Infect Microbiol 9:426","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Marine Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-026-10663-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10126-026-10663-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-026-10663-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:02:49Z","timestamp":1787335369000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10126-026-10663-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10663"],"URL":"https:\/\/doi.org\/10.1007\/s10126-026-10663-w","relation":{},"ISSN":["1436-2228","1436-2236"],"issn-type":[{"value":"1436-2228","type":"print"},{"value":"1436-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"30 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"116"}}