{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:35:45Z","timestamp":1793298945652,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Central Public-interest Scientific Institution Basal Research Fund CAFS","award":["2025XT0206"],"award-info":[{"award-number":["2025XT0206"]}]},{"name":"the Xinjiang Major Demand Talent Support Program Project","award":["XJRC-2025-ZZB-ZDXQ-011"],"award-info":[{"award-number":["XJRC-2025-ZZB-ZDXQ-011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mar Biotechnol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10126-026-10688-1","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:18:31Z","timestamp":1787041111000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Physiological, Transcriptomic, and Gut Microbial Responses of Chinese Mitten Crab (Eriocheir sinensis) to Acute Salinity Stress"],"prefix":"10.1007","volume":"28","author":[{"given":"Yiming","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongli","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"2","key":"10688_CR1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S1464793105006950","volume":"81","author":"D Dudgeon","year":"2006","unstructured":"Dudgeon D, ArthingtoN AH, Gessner MO, Kawabata Z, Knowler DJ, L\u00e9v\u00eaque C, Naiman RJ, Prieur-Richard AH, Soto D, Stiassny ML, Sullivan CA (2006) Freshwater biodiversity: importance, threats, status and conservation challenges [J]. Biol Rev Camb Philos Soc 81(2):163\u2013182","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10688_CR2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.envpol.2012.10.011","volume":"173","author":"M Caedo-Arg\u00fcelles","year":"2013","unstructured":"Caedo-Arg\u00fcelles M, Kefford BJ, Piscart C, Prat N, Schfer RB, Schulz C-J (2013) Salinisation of rivers: An urgent ecological issue [J]. Environ Pollut 173:157\u2013167","journal-title":"Environ Pollut"},{"key":"10688_CR3","doi-asserted-by":"crossref","unstructured":"Kaushal SS, Likens GE, Mayer PM, Shatkay RR, Shelton SA, Grant SB, Utz RM, Yaculak AM, Maas CM, Reimer JE, Bhide SV, MALIN J T, Rippy MA (2023) The Anthropogenic Salt Cycle [J]. Nat Rev Earth Environ, 4: 770\u2009\u2013\u200984","DOI":"10.1038\/s43017-023-00485-y"},{"issue":"1764","key":"10688_CR4","doi-asserted-by":"publisher","first-page":"2018002","DOI":"10.1098\/rstb.2018.0002","volume":"374","author":"M Ca\u00f1edo-Arg\u00fcelles","year":"2019","unstructured":"Ca\u00f1edo-Arg\u00fcellesM, Kefford B, Sch\u00e4fer R (2019) Salt in freshwaters: Causes, effects and prospects - Introduction to the theme issue [J]. Philosophical Trans Royal Soc B Biol Sci 374(1764):2018002. https:\/\/doi.org\/10.1098\/rstb.2018.0002","journal-title":"Philosophical Trans Royal Soc B Biol Sci"},{"issue":"1","key":"10688_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00027-011-0200-0","volume":"74","author":"B M\u00fcller","year":"2012","unstructured":"M\u00fcller B, G\u00e4chter R (2012) Increasing chloride concentrations in Lake Constance: characterization of sources and estimation of loads [J]. Aquat Sci 74(1):101\u2013112","journal-title":"Aquat Sci"},{"issue":"1","key":"10688_CR6","first-page":"48","volume":"10","author":"E Jeppesen","year":"2007","unstructured":"Jeppesen E, S\u00f8ndergaard M, Pedersen AR, J\u00fcrgens K, Strzelczak A, Lauridsen TL, Johansson LS (2007) Salinity Induc Regime Shift Shallow Brackish Lagoons [J] Ecosyst 10(1):48\u201358","journal-title":"Salinity Induc Regime Shift Shallow Brackish Lagoons [J] Ecosyst"},{"key":"10688_CR7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.fsi.2019.04.034","volume":"90","author":"Y Qin","year":"2019","unstructured":"Qin Y, Jiang S, Huang J, Zhou F, Yang Q, Jiang S, Yang L (2019) C-type lectin response to bacterial infection and ammonia nitrogen stress in tiger shrimp (Penaeus monodon) [J]. Fish Shellfish Immunol 90:188\u2013198","journal-title":"Fish Shellfish Immunol"},{"key":"10688_CR8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s40064-016-1878-1","volume":"5","author":"J Chen","year":"2016","unstructured":"Chen J, Zhou F, Huang J, Ma Z, Jiang S (2016) QIN J G. Ammonia and salinity tolerance of Penaeus monodon across eight breeding families [J]. Springerplus 5:171","journal-title":"Springerplus"},{"key":"10688_CR9","doi-asserted-by":"crossref","first-page":"156502","DOI":"10.1016\/j.scitotenv.2022.156502","volume":"840","author":"Y Xiao","year":"2022","unstructured":"Xiao Y, Zhang YM, Xu WB, Chen DY, Li BW, Cheng YX, Guo XL, Dong WR (2022) SHU M A. The effects of salinities stress on histopathological changes, serum biochemical index, non-specific immune and transcriptome analysis in red swamp crayfish Procambarus clarkii [J]. Sci Total Environ 840:156502","journal-title":"Sci Total Environ"},{"key":"10688_CR10","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ijbiomac.2019.08.223","volume":"140","author":"F Lou","year":"2019","unstructured":"Lou F, Gao T, Han Z (2019) Effect of salinity fluctuation on the transcriptome of the Japanese mantis shrimp Oratosquilla oratoria [J]. Int J Biol Macromol 140:1202\u20131213","journal-title":"Int J Biol Macromol"},{"key":"10688_CR11","doi-asserted-by":"crossref","unstructured":"Jacquin L, Petitjean Q, C\u00f4te J, Laffaille P, Jean S (2020) Effects of Pollution on Fish Behavior, Personality, and Cognition: Some Research Perspectives [J]. Frontiers in Ecology and Evolution, pp 8\u20132020","DOI":"10.3389\/fevo.2020.00086"},{"issue":"6","key":"10688_CR12","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s10695-015-0101-6","volume":"41","author":"Z Yao","year":"2015","unstructured":"Yao Z, Lai Q, Hao Z, Chen L, Lin T, Zhou K, Wang H (2015) Carbonic anhydrase 2-like and Na+-K+-ATPase \u03b1 gene expression in medaka (Oryzias latipes) under carbonate alkalinity stress [J]. Fish Physiol Biochem 41(6):1491\u20131500","journal-title":"Fish Physiol Biochem"},{"issue":"1","key":"10688_CR13","doi-asserted-by":"crossref","first-page":"21771","DOI":"10.1038\/s41598-020-78351-w","volume":"10","author":"J Niu","year":"2020","unstructured":"Niu J, Hu XL, Ip JCH, Ma KY, Tang Y, Wang Y, Qin J, Qiu JW, Chan TF, Chu KH (2020) Multi-omic approach provides insights into osmoregulation and osmoconformation of the crab Scylla paramamosain [J]. Sci Rep 10(1):21771","journal-title":"Sci Rep"},{"issue":"3","key":"10688_CR14","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1007\/s10311-024-01717-3","volume":"22","author":"W Waqas","year":"2024","unstructured":"Waqas W, Yuan Y, Ali S, Zhang M, Shafiq M, Ali W, Chen Y, Xiang Z, Chen R, Ikhwanuddin M, Ma H (2024) Toxic effects of heavy metals on crustaceans and associated health risks in humans: a review [J]. Environ Chem Lett 22(3):1391\u20131411","journal-title":"Environ Chem Lett"},{"issue":"Pt 1","key":"10688_CR15","first-page":"80","volume":"219","author":"GA Rivera-Ingraham","year":"2016","unstructured":"Rivera-Ingraham GA, Barri K, Bo\u00ebl M, Farcy E, Charles AL, Geny B, Lignot JH (2016) Osmoregulation and salinity-induced oxidative stress: is oxidative adaptation determined by gill function? [J]. J Exp Biol 219(Pt 1):80\u201389","journal-title":"J Exp Biol"},{"key":"10688_CR16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.scitotenv.2019.01.245","volume":"662","author":"Q Ruxia","year":"2019","unstructured":"Ruxia Q, Cheng S, Yifeng Y, Zhang, Hongqiang, Ren B (2019) Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish [J]. Sci Total Environ 662:246\u2013253","journal-title":"Sci Total Environ"},{"key":"10688_CR17","unstructured":"Saqib HSA, Yuan Y, Kazmi S, S U H, LI S, Zheng H, Zhang Y, Ikhwanuddin M, MA H (2023) Salinity gradients drove the gut and stomach microbial assemblages of mud crabs (Scylla paramamosain) in marine environments [J]. Ecological Indicators"},{"issue":"6","key":"10688_CR18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3390\/biology14060667","volume":"14","author":"T Dildar","year":"2025","unstructured":"Dildar T, Cui W, Ikhwanuddin M, Ma H (2025) Aquatic Organisms in Response to Salinity Stress: Ecological Impacts, Adaptive Mechanisms, and Resilience Strategies [J]. Biology 14(6):667","journal-title":"Biology"},{"issue":"2","key":"10688_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s10530-004-2286-y","volume":"7","author":"D Rudnick","year":"2005","unstructured":"Rudnick D, Veldhuizen T, Tullis R, Culver C, Hieb K, Tsukimura B (2005) A life history model for the San Francisco Estuary population of the Chinese mitten crab, Eriocheir sinensis (Decapoda: Grapsoidea) [J]. Biol Invasions 7(2):333\u2013350","journal-title":"Biol Invasions"},{"key":"10688_CR20","doi-asserted-by":"publisher","unstructured":"Yan X, Zhang C (2025) The connotation of Chinese crab culture: a comprehensive review from the perspectives of literature, art, and diet [J]. Front Mar Sci, 12:1556758. https:\/\/doi.org\/10.3389\/fmars.2025.1556758","DOI":"10.3389\/fmars.2025.1556758"},{"key":"10688_CR21","first-page":"109908","volume-title":"Untargeted LC\u2013MS metabolomics reveals the metabolic responses in the Eriocheir sinensis gills exposed to salinity and alkalinity stress [J]","author":"S Wang","year":"2024","unstructured":"Wang S, Song Y, Luo L, Zhang R, Guo K, Zhao Z (2024) Untargeted LC\u2013MS metabolomics reveals the metabolic responses in the Eriocheir sinensis gills exposed to salinity and alkalinity stress [J], vol 281. Toxicology & Pharmacology, Comparative Biochemistry and Physiology Part C, p 109908"},{"issue":"8","key":"10688_CR22","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, Bai Y, Bisanz JE, Bittinger K, Brejnrod A, Brislawn CJ, Brown CT, Callahan BJ, Caraballo-Rodr\u00edguez AM, Chase J, Cope EK, Da Silva R, Diener C, Dorrestein PC, Douglas GM, Durall DM, Duvallet C, Edwardson CF, Ernst M, Estaki M, Fouquier J, Gauglitz JM, Gibbons SM, Gibson DL, Gonzalez A, Gorlick K, Guo J, Hillmann B, Holmes S, Holste H, Huttenhower C, Huttley GA, Janssen S, Jarmusch AK, Jiang L, Kaehler BD, Kang KB, Keefe CR, Keim P, Kelley ST, Knights D, Koester I, Kosciolek T, Kreps J, Langille MGI, Lee J, Ley R, Liu Y-X, Loftfield E, Lozupone C, Maher M, Marotz C, Martin BD, Mcdonald D, Mciver LJ, Melnik AV, Metcalf JL, Morgan SC, Morton JT, Naimey AT, Navas-Molina JA, Nothias LF, Orchanian SB, Pearson T, Peoples SL, Petras D, Preuss ML, Pruesse E, Rasmussen LB, Rivers A, Robeson MS, Rosenthal P, Segata N, Shaffer M, Shiffer A, Sinha R, Song SJ, Spear JR, Swafford AD, Thompson LR, Torres PJ, Trinh P, Tripathi A, Turnbaugh PJ, UL-Hasan S, Van Der Hooft JJJ, Vargas F, V\u00e1zquez-Baeza Y, Vogtmann E, Von Hippel M, Walters W, Wan Y, Wang M, Warren J, Zaneveld JR, Zhang Y, Zhu Q, Knight R, Caporaso (2019) Nat Biotechnol 37(8):852\u2013857 J G. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 [J]","journal-title":"Nat Biotechnol"},{"issue":"5","key":"10688_CR23","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/AEM.01996-06","volume":"73","author":"A Lozupone Catherine","year":"2007","unstructured":"Lozupone Catherine A, Hamady M, Kelley Scott T, Knight R (2007) Quantitative and Qualitative \u03b2 Diversity Measures Lead to Different Insights into Factors That Structure Microbial Communities [J]. Appl Environ Microbiol 73(5):1576\u20131585","journal-title":"Appl Environ Microbiol"},{"issue":"4","key":"10688_CR24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2009\u2013 \u2206\u2206CT Method [J]. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"1","key":"10688_CR25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s11802-008-0077-2","volume":"7","author":"H Liu","year":"2008","unstructured":"Liu H, Pan L, Fu L (2008) Effect of salinity on hemolymph osmotic pressure, sodium concentration and Na+-K+-ATPase activity of gill of Chinese crab, Eriocheir sinensis [J]. J Ocean Univ China 7(1):77\u201382","journal-title":"J Ocean Univ China"},{"issue":"1","key":"10688_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/1549010","volume":"15","author":"A P\u00e9queux","year":"1995","unstructured":"P\u00e9queux A (1995) Osmotic Regulation in Crustaceans [J]. J Crustac Biol 15(1):1\u201360","journal-title":"J Crustac Biol"},{"issue":"2","key":"10688_CR27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1095-6433(03)00064-3","volume":"135","author":"C Lucu","year":"2003","unstructured":"Lucu C, Towle DW (2003) Na(+)\u2009+\u2009K(+)-ATPase in gills of aquatic crustacea [J]. Comp Biochem Physiol Mol Integr Physiol 135(2):195\u2013214","journal-title":"Comp Biochem Physiol Mol Integr Physiol"},{"key":"10688_CR28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3389\/fphys.2012.00431","volume":"3","author":"RP Henry","year":"2012","unstructured":"Henry RP, Lucu C, Onken H, Weihrauch D (2012) Multiple functions of the crustacean gill: osmotic\/ionic regulation, acid-base balance, ammonia excretion, and bioaccumulation of toxic metals [J]. Front Physiol 3:431","journal-title":"Front Physiol"},{"issue":"6","key":"10688_CR29","doi-asserted-by":"crossref","first-page":"e0179036","DOI":"10.1371\/journal.pone.0179036","volume":"12","author":"X Long","year":"2017","unstructured":"Long X, Wu X, Zhao L, Ye H, Cheng Y, Zeng C (2017) Effects of salinity on gonadal development, osmoregulation and metabolism of adult male Chinese mitten crab, Eriocheir sinensis [J]. PLoS ONE 12(6):e0179036","journal-title":"PLoS ONE"},{"issue":"10","key":"10688_CR30","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1242\/jeb.135624","volume":"220","author":"GA Rivera-Ingraham","year":"2017","unstructured":"Rivera-Ingraham GA, Lignot J-H, Osmoregulation (2017) bioenergetics and oxidative stress in coastal marine invertebrates: raising the questions for future research [J]. J Exp Biol 220(10):1749\u20131760","journal-title":"J Exp Biol"},{"issue":"5","key":"10688_CR31","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1242\/jeb.204.5.991","volume":"204","author":"RP Henry","year":"2001","unstructured":"Henry RP (2001) Environmentally Mediated Carbonic Anhydrase Induction in the Gills of Euryhaline Crustaceans [J]. J Exp Biol 204(5):991\u20131002","journal-title":"J Exp Biol"},{"issue":"2","key":"10688_CR32","doi-asserted-by":"crossref","first-page":"jeb169219","DOI":"10.1242\/jeb.169219","volume":"221","author":"D Weihrauch","year":"2018","unstructured":"Weihrauch D, Allen GJP (2018) Ammonia excretion in aquatic invertebrates: new insights and questions [J]. J Exp Biol 221(2):jeb169219","journal-title":"J Exp Biol"},{"issue":"26","key":"10688_CR33","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1242\/jeb.01308","volume":"207","author":"D Weihrauch","year":"2004","unstructured":"Weihrauch D, Morris S, Towle DW (2004) Ammonia excretion in aquatic and terrestrial crabs [J]. J Exp Biol 207(26):4491\u20134504","journal-title":"J Exp Biol"},{"issue":"1","key":"10688_CR34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","volume":"82","author":"BA Simms","year":"2014","unstructured":"Simms BA, Zamponi GW (2014) Neuronal voltage-gated calcium channels: structure, function, and dysfunction [J]. Neuron 82(1):24\u201345","journal-title":"Neuron"},{"key":"10688_CR35","doi-asserted-by":"crossref","unstructured":"Patterson RL, Boehning D, Snyder SH (2004) Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators [J]. Annual Review of Biochemistry, 73(Volume 73, 2004): 437\u2009\u2013\u200965","DOI":"10.1146\/annurev.biochem.73.071403.161303"},{"issue":"5","key":"10688_CR36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1152\/physiolgenomics.00191.2013","volume":"46","author":"E LI","year":"2014","unstructured":"LI E, Wang S, Li C, Wang X, Chen K, Chen L (2014) Transcriptome sequencing revealed the genes and pathways involved in salinity stress of Chinese mitten crab, Eriocheir sinensis [J]. Physiol Genom 46(5):177\u2013190","journal-title":"Physiol Genom"},{"issue":"Pt 15","key":"10688_CR37","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1242\/jeb.01730","volume":"208","author":"PH Yancey","year":"2005","unstructured":"Yancey PH (2005) Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses [J]. J Exp Biol 208(Pt 15):2819\u20132830","journal-title":"J Exp Biol"},{"issue":"3","key":"10688_CR38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3390\/md19030153","volume":"19","author":"X Zhang","year":"2021","unstructured":"Zhang X, Yuan J, Li F, Xiang J (2021) Chitin Synthesis and Degradation in Crustaceans: A Genomic View and Application [J]. Mar Drugs 19(3):153","journal-title":"Mar Drugs"},{"issue":"3\u20135","key":"10688_CR39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jsbmb.2010.09.001","volume":"127","author":"DL Mykles","year":"2011","unstructured":"Mykles DL (2011) Ecdysteroid metabolism in crustaceans [J]. J Steroid Biochem Mol Biol 127(3\u20135):196\u2013203","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10688_CR40","doi-asserted-by":"crossref","unstructured":"Hartzell C, Putzier I, Arreola J (2005) Calcium-Activated Chloride Channels [J]. Annual Review of Physiology, 67(Volume 67, 2005): 719\u2009\u2013\u200958","DOI":"10.1146\/annurev.physiol.67.032003.154341"},{"issue":"1","key":"10688_CR41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1741-7007-5-45","volume":"5","author":"AV Kuballa","year":"2007","unstructured":"Kuballa AV, Merritt DJ, Elizur A (2007) Gene expression profiling of cuticular proteins across the moult cycle of the crab Portunus pelagicus [J]. BMC Biol 5(1):45","journal-title":"BMC Biol"},{"issue":"3","key":"10688_CR42","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1152\/physrev.00047.2017","volume":"98","author":"TJ Jentsch","year":"2018","unstructured":"Jentsch TJ, Pusch M (2018) CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease [J]. Physiol Rev 98(3):1493\u20131590","journal-title":"Physiol Rev"},{"issue":"Pt 24","key":"10688_CR43","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1242\/jcs.023820","volume":"123","author":"C Frantz","year":"2010","unstructured":"Frantz C, Stewart KM, Weaver VM (2010) The extracellular matrix at a glance [J]. J Cell Sci 123(Pt 24):4195\u20134200","journal-title":"J Cell Sci"},{"key":"10688_CR44","doi-asserted-by":"crossref","unstructured":"Lozupone CA, Knight R (2007) Global patterns in bacterial diversity [J]. Proceedings of the National Academy of Sciences, 104(27): 11436-40","DOI":"10.1073\/pnas.0611525104"},{"issue":"1","key":"10688_CR45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1746-1448-1-5","volume":"1","author":"MF Roberts","year":"2005","unstructured":"Roberts MF (2005) Organic compatible solutes of halotolerant and halophilic microorganisms [J]. Saline Syst 1(1):5","journal-title":"Saline Syst"},{"issue":"8","key":"10688_CR46","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1007\/s00253-022-11895-1","volume":"106","author":"DQ Hieu","year":"2022","unstructured":"Hieu DQ, Hang BTB, Lokesh J, Garigliany M-M, Huong DT, T, Yen DT, Liem PT, Tam BM, Hai DM, Son VN, Phuong NT, Farnir F, Kestemont P (2022) Salinity significantly affects intestinal microbiota and gene expression in striped catfish juveniles [J]. Appl Microbiol Biotechnol 106(8):3245\u20133264","journal-title":"Appl Microbiol Biotechnol"},{"issue":"6","key":"10688_CR47","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s10126-023-10267-8","volume":"25","author":"W Dai","year":"2023","unstructured":"Dai W, Zhang Z, Dong Y, He L, Xue Q, Lin Z (2023) Acute Salinity Stress Disrupts Gut Microbiota Homeostasis and Reduces Network Connectivity and Cooperation in Razor Clam Sinonovacula constricta [J]. Mar Biotechnol 25(6):1147\u20131157","journal-title":"Mar Biotechnol"},{"key":"10688_CR48","doi-asserted-by":"crossref","first-page":"1153326","DOI":"10.3389\/fmars.2023.1153326","volume":"10","author":"M Niu","year":"2023","unstructured":"Niu M, Li X, Chen Y, Qin K, Liang G, HU Y, Jiang X, Wang H, Zhu R, Wang C, Mu C (2023) Response of intestinal microbiota to saline-alkaline water in mud crab (Scylla paramamosain) based on multiple low salinity culture modes [J]. Front Mar Sci 10:1153326","journal-title":"Front Mar Sci"},{"key":"10688_CR49","doi-asserted-by":"crossref","first-page":"102541","DOI":"10.1016\/j.aqrep.2024.102541","volume":"40","author":"M Liu","year":"2025","unstructured":"Liu M, Li T, Zhang H, Wang Z, Wu X, He J, Dong Z (2025) Salinity affects the lipid metabolism and intestinal microbial composition of swimming crab Portunus trituberculatus [J]. Aquaculture Rep 40:102541","journal-title":"Aquaculture Rep"},{"key":"10688_CR50","doi-asserted-by":"crossref","unstructured":"Liu Z, Zhou Z, Wang L, Li M, Wang W, Yi Q, Huang S, Song L (2018) Dopamine and Serotonin Modulate Free Amino Acids Production and Na+\/K+ Pump Activity in Chinese Mitten Crab Eriocheir sinensis Under Acute Salinity Stress [J]. Frontiers in Physiology, pp 9\u20132018","DOI":"10.3389\/fphys.2018.01080"},{"issue":"2","key":"10688_CR51","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3390\/ijms23020619","volume":"23","author":"A Kloska","year":"2022","unstructured":"Kloska A, Cech GM, Nowicki D, Maci\u0105g-Dorszy\u0144ska M, Bogucka AE, Markert S, Becher D, Potrykus K, Czaplewska P, Szalewska-Pa\u0142asz A (2022) Three Microbial Musketeers of the Seas: Shewanella baltica, Aliivibrio fischeri and Vibrio harveyi, and Their Adaptation to Different Salinity Probed by a Proteomic Approach [J]. Int J Mol Sci 23(2):619","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10688_CR52","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1038\/s41598-017-13450-9","volume":"7","author":"Y-H Chen","year":"2017","unstructured":"Chen Y-H, Lu C-W, Shyu Y-T, Lin S-S (2017) Revealing the Saline Adaptation Strategies of the Halophilic Bacterium Halomonas beimenensis through High-throughput Omics and Transposon Mutagenesis Approaches [J]. Sci Rep 7(1):13037","journal-title":"Sci Rep"},{"issue":"1","key":"10688_CR53","doi-asserted-by":"crossref","first-page":"e0168818","DOI":"10.1371\/journal.pone.0168818","volume":"12","author":"V Kindzierski","year":"2017","unstructured":"Kindzierski V, Raschke S, Knabe N, Siedler F, Scheffer B, Pfl\u00fcger-Grau K, Pfeiffer F, Oesterhelt D, Marin-Sanguino A, Kunte H-J (2017) Osmoregulation in the Halophilic Bacterium Halomonas elongata: A Case Study for Integrative Systems Biology [J]. PLoS ONE 12(1):e0168818","journal-title":"PLoS ONE"},{"issue":"3","key":"10688_CR54","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.syapm.2012.12.003","volume":"36","author":"MA Ruvira","year":"2013","unstructured":"Ruvira MA, Lucena T, Pujalte MJ, Arahal DR, Maci\u00e1n MC (2013) Marinifilum flexuosum sp. nov., a new Bacteroidetes isolated from coastal Mediterranean Sea water and emended description of the genus Marinifilum Na et al., 2009 [J]. Syst Appl Microbiol 36(3):155\u2013159","journal-title":"Syst Appl Microbiol"},{"issue":"2","key":"10688_CR55","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s10499-022-00998-1","volume":"31","author":"X Wang","year":"2023","unstructured":"Wang X, Guo Z-X, Lei X-Y, Wang S, Wan J-W, Liu H-J, Chen Y-K, Zhao Y-L, Wang G-Q, Wang Q-J, Zhang D-M (2023) Osmoregulation, physiological metabolism, and oxidative stress responses to water salinity in adult males of Chinese mitten crabs (Eriocheir sinensis) [J]. Aquacult Int 31(2):583\u2013601","journal-title":"Aquacult Int"},{"issue":"10","key":"10688_CR56","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1128\/AEM.70.10.6166-6172.2004","volume":"70","author":"Y Wang","year":"2004","unstructured":"Wang Y, Stingl U, Anton-Erxleben F, Geisler S, Brune A, Zimmer M (2004) Candidatus Hepatoplasma crinochetorum, a New, Stalk-Forming Lineage of Mollicutes Colonizing the Midgut Glands of a Terrestrial Isopod [J]. Appl Environ Microbiol 70(10):6166\u20136172","journal-title":"Appl Environ Microbiol"},{"key":"10688_CR57","doi-asserted-by":"crossref","first-page":"846677","DOI":"10.3389\/fmicb.2022.846677","volume":"13","author":"K Hobmeier","year":"2022","unstructured":"Hobmeier K, Cantone M, Nguyen QA, Pfl\u00fcger-Grau K, Kremling A, Kunte HJ, Pfeiffer F, Marin-Sanguino A (2022) Adaptation to Varying Salinity in Halomonas elongata: Much More Than Ectoine Accumulation [J]. Front Microbiol 13:846677","journal-title":"Front Microbiol"},{"key":"10688_CR58","doi-asserted-by":"crossref","first-page":"127301","DOI":"10.1016\/j.micres.2023.127301","volume":"269","author":"W Wang","year":"2023","unstructured":"Wang W, Cao Y, Li J, Lu S, Ge H, PAN S, Pan X, Wang L (2023) The impact of osmotic stresses on the biofilm formation, immunodetection, and morphology of Aeromonas hydrophila [J]. Microbiol Res 269:127301","journal-title":"Microbiol Res"},{"key":"10688_CR59","doi-asserted-by":"publisher","unstructured":"Limoli Dominique H, Jones Christopher J, Wozniak Daniel J (2015) Bacterial Extracellular Polysaccharides in Biofilm Formation and Function [J]. Microbiol Spectr 3(3). https:\/\/doi.org\/10.1128\/microbiolspec.mb-0011-2014","DOI":"10.1128\/microbiolspec.mb-0011-2014"},{"issue":"19","key":"10688_CR60","doi-asserted-by":"publisher","first-page":"6365","DOI":"10.1007\/s00253-022-12150-3","volume":"106","author":"Y Wang","year":"2022","unstructured":"Wang Y, Bian Z, Wang Y (2022) Biofilm formation and inhibition mediated by bacterial quorum sensing [J]. Appl Microbiol Biotechnol 106(19):6365\u20136381","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"10688_CR61","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1574-6941.2006.00230.x","volume":"59","author":"AR Johnsen","year":"2007","unstructured":"Johnsen AR, Kroer N (2007) Effects of stress and other environmental factors on horizontal plasmid transfer assessed by direct quantification of discrete transfer events [J]. FEMS Microbiol Ecol 59(3):718\u2013728","journal-title":"FEMS Microbiol Ecol"},{"issue":"6","key":"10688_CR62","doi-asserted-by":"crossref","first-page":"lxae129","DOI":"10.1093\/jambio\/lxae129","volume":"135","author":"K Dadeh Amirfard","year":"2024","unstructured":"Dadeh Amirfard K, Moriyama M, Suzuki S, Sano D (2024) Effect of environmental factors on conjugative transfer of antibiotic resistance genes in aquatic settings [J]. J Appl Microbiol 135(6):lxae129","journal-title":"J Appl Microbiol"},{"key":"10688_CR63","doi-asserted-by":"crossref","first-page":"974501","DOI":"10.3389\/fmars.2022.974501","volume":"9","author":"G Liang","year":"2022","unstructured":"Liang G, Qin K, Chen Y, Niu M, Wang H, Wang C, Mu C, Chen L, Wang F, Su Q, Zhu R (2022) Transcriptomic analysis of adaptive mechanisms in response to inland saline-alkaline water in the mud crab, Scylla paramamosain [J]. Front Mar Sci 9:974501","journal-title":"Front Mar Sci"}],"container-title":["Marine Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-026-10688-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10126-026-10688-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-026-10688-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:02:13Z","timestamp":1793296933000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10126-026-10688-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10688"],"URL":"https:\/\/doi.org\/10.1007\/s10126-026-10688-1","relation":{},"ISSN":["1436-2228","1436-2236"],"issn-type":[{"value":"1436-2228","type":"print"},{"value":"1436-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]},"assertion":[{"value":"24 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declaration"}}],"article-number":"137"}}