{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:45:30Z","timestamp":1781059530349,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Emerg Radiol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s10140-021-01951-0","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T23:05:31Z","timestamp":1624662331000},"page":"977-983","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does the presence of an appendicolith or abscess predict failure of nonoperative management of patients with acute appendicitis?"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-2950","authenticated-orcid":false,"given":"Atsushi","family":"Kohga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshige","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiro","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Isogaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuaki","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"1951_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13017-020-00306-3","volume":"15","author":"S Di Saverio","year":"2020","unstructured":"Di Saverio S, Podda M, De Simone B et al (2020) Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg 15:27. https:\/\/doi.org\/10.1186\/s13017-020-00306-3","journal-title":"World J Emerg Surg"},{"key":"1951_CR2","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1002\/bjs.10147","volume":"103","author":"V Sallinen","year":"2016","unstructured":"Sallinen V, Akl EA, You JJ et al (2016) Meta-analysis of antibiotics versus appendicectomy for nonperforated acute appendicitis. Br J Surg 103:656\u2013667. https:\/\/doi.org\/10.1002\/bjs.10147","journal-title":"Br J Surg"},{"key":"1951_CR3","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1097\/SLA.0000000000002039","volume":"265","author":"JC Harnoss","year":"2017","unstructured":"Harnoss JC, Zelienka I, Probst P et al (2017) Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015: CRD42015016882). Ann Surg 265:889\u2013900. https:\/\/doi.org\/10.1097\/SLA.0000000000002039","journal-title":"Ann Surg"},{"key":"1951_CR4","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1097\/SLA.0000000000003225","volume":"270","author":"M Podda","year":"2019","unstructured":"Podda M, Gerardi C, Cillara N et al (2019) Antibiotic treatment and appendectomy for uncomplicated acute appendicitis in adults and children: a systematic review and meta-analysis. Ann Surg 270:1028\u20131040. https:\/\/doi.org\/10.1097\/SLA.0000000000003225","journal-title":"Ann Surg"},{"key":"1951_CR5","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1001\/jamapediatrics.2017.0057","volume":"171","author":"L Huang","year":"2017","unstructured":"Huang L, Yin Y, Yang L, Wang C, Li Y, Zhou Z (2017) Comparison of antibiotic therapy and appendectomy for acute uncomplicated appendicitis in children: a meta-analysis. JAMA Pediatr 171:426\u2013434. https:\/\/doi.org\/10.1001\/jamapediatrics.2017.0057","journal-title":"JAMA Pediatr"},{"key":"1951_CR6","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.jpedsurg.2017.04.005","volume":"52","author":"RR Gorter","year":"2017","unstructured":"Gorter RR, The SML, Gorter-Stam MAW et al (2017) Systematic review of nonoperative versus operative treatment of uncomplicated appendicitis. J Pediatr Surg 52:1219\u20131227. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.04.005","journal-title":"J Pediatr Surg"},{"key":"1951_CR7","doi-asserted-by":"publisher","first-page":"e20163003","DOI":"10.1542\/peds.2016-3003","volume":"139","author":"R Georgiou","year":"2017","unstructured":"Georgiou R, Eaton S, Stanton MP, Pierro A, Hall NJ (2017) Efficacy and safety of nonoperative treatment for acute appendicitis: a meta-analysis. Pediatrics 139:e20163003. https:\/\/doi.org\/10.1542\/peds.2016-3003","journal-title":"Pediatrics"},{"key":"1951_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00383-019-04610-1","volume":"36","author":"S Maita","year":"2020","unstructured":"Maita S, Andersson B, Svensson JF, Wester T (2020) Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis. Pediatr Surg Int 36:261\u2013269. https:\/\/doi.org\/10.1007\/s00383-019-04610-1","journal-title":"Pediatr Surg Int"},{"key":"1951_CR9","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.surg.2009.11.013","volume":"147","author":"C Simillis","year":"2010","unstructured":"Simillis C, Symeonides P, Shorthouse AJ, Tekkis PP (2010) A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery 147:818\u2013829. https:\/\/doi.org\/10.1016\/j.surg.2009.11.013","journal-title":"Surgery"},{"key":"1951_CR10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12893-019-0578-5","volume":"19","author":"Z Yang","year":"2019","unstructured":"Yang Z, Sun F, Ai S, Wang J, Guan W, Liu S (2019) Meta-analysis of studies comparing conservative treatment with antibiotics and appendectomy for acute appendicitis in the adult. BMC Surg 19:110. https:\/\/doi.org\/10.1186\/s12893-019-0578-5","journal-title":"BMC Surg"},{"key":"1951_CR11","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1016\/j.jpedsurg.2019.01.065","volume":"54","author":"P Fugazzola","year":"2019","unstructured":"Fugazzola P, Coccolini F, Tomasoni M, Stella M, Ansaloni L (2019) Early appendectomy vs. conservative management in complicated acute appendicitis in children: a meta-analysis. J Pediatr Surg 54:2234\u20132241. https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.01.065","journal-title":"J Pediatr Surg"},{"key":"1951_CR12","doi-asserted-by":"publisher","first-page":"5234","DOI":"10.1007\/s00464-020-07822-y","volume":"34","author":"P van Amstel","year":"2020","unstructured":"van Amstel P, Sluckin TC, van Amstel T et al (2020) Management of appendiceal mass and abscess in children; early appendectomy or initial nonoperative treatment? A systematic review and meta-analysis. Surg Endosc 34:5234\u20135249. https:\/\/doi.org\/10.1007\/s00464-020-07822-y","journal-title":"Surg Endosc"},{"key":"1951_CR13","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jpedsurg.2007.01.024","volume":"42","author":"CJ Aprahamian","year":"2007","unstructured":"Aprahamian CJ, Barnhart DC, Bledsoe SE, Vaid Y, Harmon CM (2007) Failure in the nonoperative management of pediatric ruptured appendicitis: predictors and consequences. J Pediatr Surg 42:934\u20138. https:\/\/doi.org\/10.1016\/j.jpedsurg.2007.01.024 (discussion 938)","journal-title":"J Pediatr Surg"},{"key":"1951_CR14","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.jpedsurg.2016.02.056","volume":"51","author":"JB Mahida","year":"2016","unstructured":"Mahida JB, Lodwick DL, Nacion KM et al (2016) High failure rate of nonoperative management of acute appendicitis with an appendicolith in children. J Pediatr Surg 51:908\u2013911. https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.02.056","journal-title":"J Pediatr Surg"},{"key":"1951_CR15","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1055\/s-0040-1718406","volume":"31","author":"AE Fuhrer","year":"2021","unstructured":"Fuhrer AE, Sukhotnik I, Ben-Shahar Y, Weinberg M, Koppelmann T (2021) Predictive value of Alvarado score and pediatric appendicitis score in the success of nonoperative management for simple acute appendicitis in children. Eur J Pediatr Surg 31:95\u2013101. https:\/\/doi.org\/10.1055\/s-0040-1718406","journal-title":"Eur J Pediatr Surg"},{"key":"1951_CR16","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.jpedsurg.2016.01.006","volume":"51","author":"T Talishinskiy","year":"2016","unstructured":"Talishinskiy T, Limberg J, Ginsburg H, Kuenzler K, Fisher J, Tomita S (2016) Factors associated with failure of nonoperative treatment of complicated appendicitis in children. J Pediatr Surg 51:1174\u20131176. https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.01.006","journal-title":"J Pediatr Surg"},{"key":"1951_CR17","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1097\/TA.0000000000000187","volume":"76","author":"MW Maxfield","year":"2014","unstructured":"Maxfield MW, Schuster KM, Bokhari J, McGillicuddy EA, Davis KA (2014) Predictive factors for failure of nonoperative management in perforated appendicitis. J Trauma Acute Care Surg 76:976\u2013981. https:\/\/doi.org\/10.1097\/TA.0000000000000187","journal-title":"J Trauma Acute Care Surg"},{"key":"1951_CR18","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1177\/000313481908500840","volume":"85","author":"C Walker","year":"2019","unstructured":"Walker C, Moosavi A, Young K et al (2019) Factors associated with failure of nonoperative management for complicated appendicitis. Am Surg 85:865\u2013870","journal-title":"Am Surg"},{"key":"1951_CR19","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1056\/NEJMoa2014320","volume":"383","author":"CODA Collaborative","year":"2020","unstructured":"Collaborative CODA, Flum DR, Davidson GH et al (2020) A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med 383:1907\u20131919. https:\/\/doi.org\/10.1056\/NEJMoa2014320","journal-title":"N Engl J Med"},{"key":"1951_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10140-012-1093-5","volume":"20","author":"M Ishiyama","year":"2013","unstructured":"Ishiyama M, Yanase F, Taketa T et al (2013) Significance of size and location of appendicoliths as exacerbating factor of acute appendicitis. Emerg Radiol 20:125\u2013130. https:\/\/doi.org\/10.1007\/s10140-012-1093-5","journal-title":"Emerg Radiol"},{"key":"1951_CR21","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00384-019-03238-w","volume":"34","author":"S Shekarriz","year":"2019","unstructured":"Shekarriz S, Keck T, Kujath P et al (2019) Comparison of conservative versus surgical therapy for acute appendicitis with abscess in five German hospitals. Int J Colorectal Dis 34:649\u2013655. https:\/\/doi.org\/10.1007\/s00384-019-03238-w","journal-title":"Int J Colorectal Dis"},{"key":"1951_CR22","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1463-1318.2007.01377.x","volume":"10","author":"A Tekin","year":"2008","unstructured":"Tekin A, Kurto\u011flu HC, Can I, Oztan S (2008) Routine interval appendectomy is unnecessary after conservative treatment of appendiceal mass. Colorectal Dis 10:465\u2013468. https:\/\/doi.org\/10.1111\/j.1463-1318.2007.01377.x","journal-title":"Colorectal Dis"},{"key":"1951_CR23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1001\/jamasurg.2018.4373","volume":"154","author":"J M\u00e4llinen","year":"2019","unstructured":"M\u00e4llinen J, Rautio T, Gr\u00f6nroos J et al (2019) Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging: 1-year outcomes of the peri-appendicitis acuta randomized clinical trial. JAMA Surg 154:200\u2013207. https:\/\/doi.org\/10.1001\/jamasurg.2018.4373","journal-title":"JAMA Surg"}],"container-title":["Emergency Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10140-021-01951-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10140-021-01951-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10140-021-01951-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T08:11:37Z","timestamp":1631693497000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10140-021-01951-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1951"],"URL":"https:\/\/doi.org\/10.1007\/s10140-021-01951-0","relation":{},"ISSN":["1070-3004","1438-1435"],"issn-type":[{"value":"1070-3004","type":"print"},{"value":"1438-1435","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"4 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}