{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:06:24Z","timestamp":1765634784343,"version":"3.48.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Emerg Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate whether admission C-reactive protein (CRP) can triage patients with suspected renal colic to low dose non contrast CT KUB or contrast enhanced CT of the abdomen and pelvis (CTAP) at first presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective single centre diagnostic accuracy study in a United Kingdom emergency department. Index test was admission CRP with a prespecified cut-off of 5\u00a0mg\/L (positive if CRP\u2009\u2265\u20095\u00a0mg\/L). Reference standard was CT classified a priori as: A normal, B simple calculus, C complicated calculus, D alternative acute diagnosis. The target condition for accuracy analyses was C or D. We constructed a 2\u2009\u00d7\u20092 table and calculated sensitivity, specificity, predictive values and likelihood ratios with 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1,096 CT examinations during the study window, 233 were for suspected renal colic; 58 patients met eligibility and had admission CRP available (29 with CRP\u2009&lt;\u20095\u00a0mg\/L and 29 with CRP\u2009\u2265\u20095\u00a0mg\/L). The target condition was present in 26\/58 (44.8%). Using CRP\u2009\u2265\u20095\u00a0mg\/L, sensitivity was 0.73 (95% CI 0.54\u20130.86), specificity 0.69 (0.51\u20130.82), positive predictive value 0.66 (0.47\u20130.80), negative predictive value 0.76 (0.58\u20130.88), likelihood ratio positive 2.34 (1.16\u20134.70) and likelihood ratio negative 0.39 (0.20\u20130.77).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRP provided modest but clinically interpretable probability shifts for complicated stones or alternative acute pathology. A CRP first approach may support initial imaging selection between CTAP and CT KUB. Prospective multicentre validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10140-025-02411-9","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:57:38Z","timestamp":1762563458000},"page":"939-945","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cCRP-first\u201d algorithm to guide imaging in suspected renal colic: a retrospective UK cohort study"],"prefix":"10.1007","volume":"32","author":[{"given":"Sayed Borna","family":"Farzaneh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Antram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Naunton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obi","family":"Ajuluchukwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naren","family":"Govindarajah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Ratnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bolgeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirav","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-4670","authenticated-orcid":false,"given":"Anita","family":"Wale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"2411_CR1","unstructured":"PHE and IIAC (2018) Occupational risks for urolithiasis: IIAC information note. 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